Article
Immunology
Tomohiro Watanabe, Kosuke Minaga, Akane Hara, Tomoe Yoshikawa, Ken Kamata, Masatoshi Kudo
Summary: COVID-19 vaccination may induce autoimmune responses, leading to the development of autoimmune diseases. This article reports a case of new-onset rheumatoid arthritis (RA) following COVID-19 vaccination, and the study found that the production of cytokines IL-6, TNF-α, and type I IFN may be involved in this new-onset RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Guy Witberg, Noam Barda, Sara Hoss, Ilan Richter, Maya Wiessman, Yaron Aviv, Tzlil Grinberg, Oren Auster, Noa Dagan, Ran D. Balicer, Ran Kornowski
Summary: Among 2.5 million patients who received the BNT162b2 mRNA vaccine in a large Israeli health care system, the incidence of myocarditis at 42 days was 2.13 cases per 100,000 persons, with the highest incidence (10.69 per 100,000 persons) among male patients between the ages of 16 and 29 years. Most cases of myocarditis were mild or moderate.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Immunology
Jie Liu, Hui Wu, Sheng-Li Xia
Summary: This systematic review examined the incidence and symptoms of new-onset arthritis after COVID-19 vaccination. Most patients developed joint-related symptoms after the first dose of vaccine, with the most common symptoms being joint swelling and joint pain. Treatment mainly involved glucocorticoid drugs and nonsteroidal anti-inflammatory drugs, and most patients showed significant improvement in symptoms with no relapse after follow-up.
Article
Rheumatology
Angel Y. S. Wong, Brian MacKenna, Caroline E. Morton, Anna Schultze, Alex J. Walker, Krishnan Bhaskaran, Jeremy P. Brown, Christopher T. Rentsch, Elizabeth Williamson, Henry Drysdale, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J. Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen McDonald, Laurie Tomlinson, Rohini Mathur, Kevin Wing, Harriet Forbes, Rosalind M. Eggo, John Parry, Frank Hester, Sam Harper, Stephen J. W. Evans, Liam Smeeth, Ian J. Douglas, Ben Goldacre
Summary: Two cohort studies were conducted to assess the association between routinely prescribed NSAIDs and COVID-19 related deaths, finding no evidence of a harmful effect. Therefore, the risks of COVID-19 do not need to influence decisions about the routine therapeutic use of NSAIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Mariam R. Elkhayat, Maiada K. Hashem, Ahmed T. Helal, Omar M. Shaaban, Ahmed K. Ibrahim, Taghreed S. Meshref, Hussein Elkhayat, Mohamed Moustafa, Mohammed Nahed Attia Mohammed, Azza M. Ezzeldin, Hebatallah G. Rashed, Alaa Bazeed, Islam H. Ibrahim, Ahmed Mokhtar Mahmoud, Moaiad Eldin Ahmed Mohamed, Reem Sayad, Shimaa A. Elghazally
Summary: This study aimed to investigate the determinants of healthcare workers' attitudes towards receiving or refusing the COVID-19 vaccine. The results showed that only half of the healthcare workers accepted the vaccine, with common reasons for refusal including previous infection, lack of time, and doctor's advice. This suggests that misinformation and negative perceptions continue to hinder healthcare workers' vaccination.
Article
Public, Environmental & Occupational Health
Stacey Orangi, John Ojal, Samuel P. C. Brand, Cameline Orlendo, Angela Kairu, Rabia Aziza, Morris Ogero, Ambrose Agweyu, George M. Warimwe, Sophie Uyoga, Edward Otieno, Lynette Ochola-Oyier, Charles N. Agoti, Kadondi Kasera, Patrick Amoth, Mercy Mwangangi, Rashid Aman, Wangari Ng'ang'a, Ifedayo M. O. Adetifa, J. Anthony G. Scott, Philip Bejon, Matt J. Keeling, Stefan Flasche, D. James Nokes, Edwine Barasa
Summary: This study conducted a cost-effectiveness analysis of COVID-19 vaccine in Kenya. The findings showed that a slow roll-out with 30% coverage was effective in reducing deaths and cost-saving, while increasing coverage to 50% and 70% had limited effectiveness and was not cost-effective. Therefore, vaccinating young adults may no longer be cost-effective in settings where prior exposure has provided partial protection.
Article
Medicine, General & Internal
Sandip Mandal, Nimalan Arinaminpathy, Balram Bhargava, Samiran Panda
Summary: The study shows that a targeted vaccination strategy can significantly mitigate the impact of COVID-19 in a country like India with wide heterogeneity. Model projections suggest that in settings with weakest transmission, such as sparsely populated rural areas, individuals with comorbidities should be prioritized for vaccination.
Article
Immunology
Kirill Lomonosov, Alyona Lomonosova, Alla Mindlina, Roman Polibin, Maksim Antipov, Gleb Grimm
Summary: This study evaluated the effect of vaccination against COVID-19 on the outcome of the disease in patients with multimorbidity. The results showed that receiving two doses of Sputnik V vaccine significantly reduced the risk of death and increased the likelihood of recovery in patients with multimorbidity.
Article
Multidisciplinary Sciences
Md Rayhanul Islam Rayhan, Jannatul Mawya Liza, Md Mostafizur Rahman
Summary: The COVID-19 pandemic has led to an increased volume of medical waste worldwide, including in Bangladesh, where the medical waste management system is fragile. This study investigates the current COVID-19 vaccine waste management practices in Bangladesh and compares them to international standards and practices in the USA and India. The study found that while waste segregation was good, waste handling, disposal of syringes and sharps, and disposal of vials were poor. The study highlights the importance of implementing a suitable vaccine waste management system in Bangladesh to protect human and environmental health.
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: The study found that patients with immune-mediated inflammatory diseases (IMIDs) have a higher risk of hospitalization with COVID-19, partly due to their comorbidities.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Hannah Bower, Thomas Frisell, Daniela Di Giuseppe, Benedicte Delcoigne, Gerd-Marie Ahlenius, Eva Baecklund, Katerina Chatzidionysiou, Nils Feltelius, Helena Forsblad-d'Elia, Alf Kastbom, Lars Klareskog, Elisabet Lindqvist, Ulf Lindstrom, Carl Turesson, Christopher Sjowall, Johan Askling
Summary: The study estimated the absolute and relative risks for all-cause mortality and severe COVID-19 in patients with inflammatory joint diseases (IJDs) and antirheumatic therapies. Results showed that while the all-cause mortality in patients with IJDs was higher in 2020 compared to previous years, the relative risks were similar. The risks of hospitalization, admission to intensive care, and death due to COVID-19 were low among patients with IJDs.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Elsa Tesfa Berhe, Adisu Tafari Shama, Mohammed Musa Ahmed, Hailay Abrha Gesesew, Paul R. Ward, Teferi Gebru Gebremeskel
Summary: This study investigated the acceptance/refusal of COVID-19 vaccination among healthcare workers in Ethiopia and identified predictors for refusal. The study found that approximately 38.5% of healthcare workers refused vaccination, with younger age groups and medical doctors more likely to refuse.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Qian Huang, Melissa B. Gilkey, Peyton Thompson, Brigid K. Grabert, Susan Alton Dailey, Noel T. Brewer
Summary: This research examines the disparity in Covid-19 vaccine uptake between physicians and nurses. The study finds that physicians have higher vaccine uptake compared to nurses and advanced practice providers, which can be attributed to their stronger confidence in vaccination and more positive social experiences. The findings suggest that increasing confidence in vaccination, promoting positive social norms, providing recommendations, and improving access to vaccines can help enhance vaccination rates.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Medicine, General & Internal
Rosemarie de Souza, Sharayu Mhatre, Burhanuddin Qayyumi, Garvit Chitkara, Tushar Madke, Mohan Joshi, Ramesh Bharmal, D. S. Asgaonkar, Prem Lakhani, Sudeep Gupta, Pankaj Chaturvedi, Rajesh Dikshit, Rajendra Badwe
Summary: The study included 689 COVID-19 patients from Mumbai, India, with a median age of 44 years. 77.36% of patients were discharged alive, while 22.64% died. Older age, comorbidities, history of hypertension, and presence of symptoms at admission were associated with increased risk of in-hospital mortality. Patients in Mumbai were younger, less symptomatic, and required less ventilator and oxygen support compared to Western countries.
Article
Gastroenterology & Hepatology
Xiaobo Li, Jinghua Pan, Tongzheng Liu, Wenqian Yin, Qun Miao, Zhan Zhao, Yufeng Gao, Wei Zheng, Hang Li, Rong Deng, Dandan Huang, Shenghui Qiu, Yiran Zhang, Qi Qi, Lijuan Deng, Maohua Huang, Patrick Ming-Kuen Tang, Yihai Cao, Minfeng Chen, Wencai Ye, Dongmei Zhang
Summary: This study discovered a previously unidentified subset of TPCs, TCF21(high) TPCs, which were associated with liver metastasis in patients with CRC. TCF21 in TPCs increased perivascular ECM stiffness, collagen rearrangement, and basement membrane degradation, establishing a perivascular metastatic microenvironment for colorectal cancer liver metastasis. Furthermore, loss of integrin alpha 5 inhibited the FAK/PI3K/AKT/DNMT1 axis, impairing TCF21 DNA hypermethylation in TCF21(high) TPCs. Overall, this study uncovers a new role of TPCs in haematogenous metastasis and provides potential diagnostic and therapeutic targets for CRC metastasis.
Article
Public, Environmental & Occupational Health
Celine S. L. Chui, Ka Shing Cheung, Jeremy P. Brown, Ian J. Douglas, Ian C. K. Wong, Esther W. Chan, Angel Y. S. Wong
Summary: This study used a self-controlled case series (SCCS) with an active comparator to investigate the association between proton pump inhibitors (PPIs) and the short-term risk of myocardial infarction (MI). The results showed an increased risk of MI following PPI and H(2)RA use, but no significant difference compared with baseline. The elevated risk is likely due to protopathic bias. Further studies are needed to explore the feasibility of using active comparators to address protopathic bias in addition to confounding.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kathy Leung, Eric H. Y. Lau, Carlos K. H. Wong, Gabriel M. Leung, Joseph T. Wu
Summary: We tracked the effective reproduction number (R-t) of the Omicron BF.7 variant of SARS-CoV-2 in Beijing from November to December 2022. After China's shift from the zero-COVID policy, R-t increased to 3.44, and the infection incidence peaked on December 11. The cumulative infection attack rate in Beijing was estimated to be 75.7% on December 22, 2022, and 92.3% on January 31, 2023.
Article
Transplantation
Franco Wing Tak Cheng, Carlos King Ho Wong, Simon Xiwen Qin, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Xue Li, Eric Yuk Fai Wan, Esther W. Chan, Chi Ho Au, Xuxiao Ye, Sydney Chi Wai Tang, Ian Chi Kei Wong
Summary: A study conducted in Hong Kong using vaccination records found no evidence to suggest an increased risk of glomerular diseases following the BNT162b2 or CoronaVac vaccines.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Letter
Infectious Diseases
Eric Yuk Fai Wan, Boyuan Wang, Sukriti Mathur, Cheyenne I. Ying Chan, Vincent Ka Chun Yan, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Philip Hei Li, Chak Sing Lau, Ian Chi Kei Wong, Esther Wai Yin Chan
JOURNAL OF INFECTION
(2023)
Article
Public, Environmental & Occupational Health
Eric Yuk Fai Wan, Ran Zhang, Sukriti Mathur, Vincent Ka Chun Yan, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Xue Li, Carlos King Ho Wong, Esther Wai Yin Chan, Chak Sing Lau, Ian Chi Kei Wong
Summary: This study evaluates the long-term associations between COVID-19 and risks of multi-organ complications and mortality in older adults. The results show that COVID-19 is significantly associated with cardiovascular, respiratory, neuropsychiatric, renal complications, and all-cause mortality. Thus, infected individuals aged 60 and above may benefit from appropriate monitoring for these complications.
JOURNAL OF TRAVEL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Francisco Tsz Tsun Lai, Min Fan, Caige Huang, Celine Sze Ling Chui, Eric Yuk Fai Wan, Xue Li, Carlos King Ho Wong, Ching-Lung Cheung, Ian Chi Kei Wong, Esther Wai Yin Chan
Summary: Extending the interval between doses of mRNA Covid-19 vaccines has been linked with a reduced risk of myocarditis in children and adolescents, but impacts on vaccine effectiveness are not known.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Vincent Ka Chun Yan, Franco Wing Tak Cheng, Celine Sze Ling Chui, Francisco Tsz Tsun Lai, Carlos King Ho Wong, Xue Li, Eric Yuk Fai Wan, Joshua Sung Chih Wong, Esther Wai Yin Chan, Ian Chi Kei Wong, Mike Yat Wah Kwan, Patrick Ip
Summary: Severe COVID-19 is more common in children and adolescents since the emergence of Omicron. This case-control study in Hong Kong showed that three doses of BNT162b2 or CoronaVac were effective in preventing COVID-19, hospitalizations, and severe outcomes among the pediatric population during the Omicron-dominant pandemic, with increased effectiveness after a booster dose.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Anesthesiology
Xiaodong Liu, Carlos K. H. Wong, Tingting Wu, Eric H. M. Tang, Ivan C. H. Au, Lanlan Li, Chi W. Cheung, Brian H. -H. Lang
Summary: This is a retrospective cohort study investigating the risk factors for persistent opioid use after surgical discharge and the association between opioid prescription at discharge and postoperative emergency department visits, readmission, and mortality. The study found that prescribing opioids on discharge was associated with an increased risk of persistent opioid use, 30-day emergency department visits, 30-day readmission, and 30-day all-cause mortality. Therefore, minimizing opioid prescriptions at discharge could improve perioperative patient outcomes.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Immunology
Carlos K. H. Wong, Kristy T. K. Lau, Ivan C. H. Au, Eric H. Y. Lau, Benjamin J. Cowling
Summary: This cohort study conducted in Hong Kong found no significant differences in mortality or hospitalization between individuals who received bivalent and monovalent mRNA as their second booster. Both bivalent and monovalent mRNA boosters provide equal protection against clinical outcomes.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Psychiatry
Hei Hang Edmund Yiu, Vincent K. C. Yan, Yue Wei, Xuxiao Ye, Caige Huang, David J. Castle, Celine S. L. Chui, Francisco T. T. Lai, Xue Li, Carlos K. H. Wong, Eric Y. F. Wan, Ian C. K. Wong, Esther W. Chan
Summary: This study investigated the risks of COVID-19-related hospitalisation and mortality among individuals with mental disorders following one to three doses of BNT162b2 and CoronaVac vaccines. The results showed that two doses of the vaccines significantly reduced the risk of COVID-19-related hospitalisation and mortality, and further protection was provided after three doses. The effectiveness of BNT162b2 vaccine was generally higher than CoronaVac, but the difference diminished after the third dose.
PSYCHIATRY RESEARCH
(2023)
Article
Medicine, General & Internal
Xi Xiong, David Tak Wai Lui, Matthew Shing Hin Chung, Ivan Chi Ho Au, Francisco Tsz Tsun Lai, Eric Yuk Fai Wan, Celine Sze Ling Chui, Xue Li, Franco Wing Tak Cheng, Ching-Lung Cheung, Esther Wai Yin Chan, Chi Ho Lee, Yu Cho Woo, Kathryn Choon Beng Tan, Carlos King Ho Wong, Ian Chi Kei Wong
Summary: This study aimed to investigate the risk of incident diabetes following COVID-19 vaccination. The results showed no increased risk of incident diabetes after COVID-19 vaccination. However, SARS-CoV-2 infection was associated with a significantly higher risk of incident diabetes, especially type 2 diabetes.
Article
Health Care Sciences & Services
Xuxiao Ye, Caige Huang, Yue Wei, Silvia T. H. Li, Vincent K. C. Yan, Kai -Hang Yiu, Hung-Fat Tse, Tiantian Ma, Xiwen Qin, Celine S. L. Chui, Francisco T. T. Lai, Xue Li, Eric Y. F. Wan, Carlos K. H. Wong, Ian C. K. Wong, Esther W. Chan
Summary: This study aimed to investigate the safety of two COVID-19 vaccines, BNT162b2 and CoronaVac, in patients with heart failure (HF). The study found that there were no increased risks of hospitalization for HF, major adverse cardiovascular events (MACE), or all hospitalization after receiving these vaccines in patients with HF.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Review
Clinical Neurology
Dawn Hei Lum, Mandy Man Choi, Jacky On Hei Cheung, Dora Wai Yee Ng, Janice Ching Nam Leung, Lingyue Zhou, Francisco Tsz Tsun Lai
Summary: This study investigated the representation of multimorbidity in randomized controlled trials (RCTs) of selective serotonin reuptake inhibitors (SSRIs). The results showed that only a minority of RCTs considered multimorbidity, and studies based in Asia were more likely to exclude multimorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Meeting Abstract
Pharmacology & Pharmacy
Min Fan, Kuan Peng, Yin Zhang, Francisco Tsz Tsun Lai, Celine Sze Ling Chui, Eric Yuk Fai Wan, Carlos King Ho Wong, Esther Wai Yin Chan, Xue Li, Ian Wong
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
