Article
Oncology
Nicola Fossati, Gianluca Giannarini, Steven Joniau, Michiel Sedelaar, Prasanna Sooriakumaran, Martin Spahn, Morgan Roupret
Summary: This report presents a case of a 56-year-old man with newly diagnosed metastatic prostate cancer. The report discusses the staging, treatment plan, and important questions regarding the use of molecular imaging, local treatment in the metastatic setting, and the consideration of metastasis-directed therapy.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wen Dongxiang, Liu Liting, Liang Yujing, Luo Meijuan, Guo Shanshan, Xiong Longbin, Chen Yanzhou, Chen Meiling, Ning Kang, Mai Haiqiang, Tang Linquan, Chen Qiuyan
Summary: This study found that [F-18]FDG PET/CT parameters were valuable in predicting overall survival (OS) and progression-free survival (PFS) for locally recurrent nasopharyngeal carcinoma (lrNPC) patients. The 4-factor prognostic model combining baseline patient characteristics with [F-18]FDG PET/CT parameters showed good discrimination, agreement, and potential for clinical application in lrNPC patients.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Tae Hoon Lee, Hyun Gee Ryoo, Reeree Lee, Jin Chul Paeng, Hyunsoo Chung, Hak Jae Kim
Summary: This study aimed to compare the longitudinal location of endoscopically-defined gross tumor volume (GTV) and positron emission tomography-based metabolic tumor volume (MTV) of esophageal cancer. The results showed that the fixed absolute threshold method was more consistent and SUV of 2.5 was appropriate for esophageal tumors with a maximum SUV > 20. Endoscopic hemoclips were stable enough for use as fiducial markers.
Article
Oncology
Chonji Fukumoto, Ryo Oshima, Yuta Sawatani, Ryo Shiraishi, Toshiki Hyodo, Ryouta Kamimura, Tomonori Hasegawa, Yuske Komiyama, Sayaka Izumi, Atsushi Fujita, Takahiro Wakui, Hitoshi Kawamata
Summary: For surveillance of patients with oral squamous cell carcinoma (OSCC) after primary surgery, it is recommended to perform FDG-PET/CT within 3-6 months and at 1 year after surgery, with the option of considering CECT in between, while continuing history and physical examinations for about 5 years based on individual risk assessment.
Review
Endocrinology & Metabolism
Jie Jiang, Xiaoxia Tang, Yongzhu Pu, Yong Yang, Conghui Yang, Fake Yang, Yadong Tian, Jindan Li, Hua Sun, Sheng Zhao, Long Chen
Summary: This article reviews the progress of PET/CT research in biochemical recurrence of prostate cancer, aiming to introduce new technologies and provide more direction for future research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wenjie Miao, Pei Nie, Guangjie Yang, Yangyang Wang, Lei Yan, Yujun Zhao, Ting Yu, Mingming Yu, Fengyu Wu, Wei Rao, Zhenguang Wang
Summary: The study demonstrated that a model based on FDG PET/CT metabolic parameters could effectively predict early recurrence of hepatocellular carcinoma after liver transplantation, with higher clinical practicability compared to traditional Milan criteria and UCSF criteria.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Yu-ping Wu, Sun Tang, Bang-guo Tan, Li-qin Yang, Fu-lin Lu, Tian-wu Chen, Jing Ou, Xiao-ming Zhang, Dan Gao, Ke-ying Li, Zi-yi Yu, Zhao Tang
Summary: GTV and cT stage can be independent risk factors of ER in ESCC after esophagectomy, and tumor stage-based GTV measured on CT can help predict ER.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Max L. Goldman, Jimmy J. Mao, Christopher S. Strouse, Wanqi Chen, Manali Rupji, Zhengjia Chen, Matthew J. Maurer, Oscar Calzada, Michael Churnetski, Christopher R. Flowers, James R. Cerhan, Brian K. Link, Carrie A. Thompson, Jonathon B. Cohen
Summary: The study found limited role for routine surveillance imaging in FL patients who complete front-line therapy. Future studies should evaluate which patients may benefit from a more aggressive surveillance approach and explore novel methods of relapse detection.
Article
Urology & Nephrology
Dennie Meijer, Henk B. Luiting, Pim J. van Leeuwen, Sebastiaan Remmers, Bernard H. E. Jansen, Yves J. L. Bodar, Thelma Witteveen, Eva E. Schaake, Henk G. van der Poel, Maurits Wondergem, Martijn B. Busstra, Jakko A. Nieuwenhuijzen, Philip Meijnen, Tessa Brabander, R. Jeroen A. van Moorselaar, N. Harry Hendrikse, Daniela E. Oprea-Lager, Monique J. Roobol, Andre N. Vis
Summary: Salvage radiation therapy in patients without evidence of metastases on prostate specific membrane antigen positron emission tomography/computerized tomography showed a good overall treatment response of 75%. Predictors of treatment response included lower prostate specific antigen values at initiation of salvage radiation therapy, local recurrent disease on imaging, and lower pathological T stage (pT2 vs pT3a/b).
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Chi Qi, Shasha He, Liang Cai, Li Zhang, Haoyuan Ding, Yue Chen
Summary: The study evaluated the clinical value of PET/CT combined with serum SCC-Ag in detecting postoperative recurrence/metastases in early stage CC patients. Results showed high diagnostic sensitivity and specificity of the combined method, indicating its clinical utility for early detection of recurrence/metastatic lesions.
Article
Oncology
Rustain L. Morgan, Megan M. Eguchi, Jessica McDermott, Adam C. Mueller, Arya Amini, Julie A. Goddard, Premal S. Trivedi, Sana D. Karam
Summary: The study found that posttreatment imaging with PET was associated with improved survival in patients with advanced laryngeal carcinoma compared to CT imaging. There was a trend towards improved cancer-specific survival in patients with oral cavity or oropharyngeal malignancies who underwent PET/CT imaging, but it did not reach statistical significance.
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Masahiko Kubo, Shogo Kobayashi, Kunihito Gotoh, Hirotoshi Takayama, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Takehiro Noda, Hiroki Kato, Eku Shimosegawa, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study validated the usability of FDG-PET for biliary tract cancer lymph nodes and found that high FDG uptake is an adverse prognostic factor for postoperative outcomes in resectable BTC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Freba Grawe, Franziska Blom, Michael Winkelmann, Caroline Burgard, Christine Schmid-Tannwald, Lena M. Unterrainer, Gabriel T. Sheikh, Paulo L. Pfitzinger, Philipp Kazmierczak, Clemens C. Cyran, Jens Ricke, Christian G. Stief, Peter Bartenstein, Johannes Ruebenthaler, Matthias P. Fabritius, Thomas Geyer
Summary: PSMA-RADS 1.0 is a reliable method for assessing PSMA-PET/CT with strong consistency and agreement among readers. It shows great potential for establishing a standard approach to diagnosing and planning treatment for prostate cancer patients, and can be used confidently even by readers with less experience.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Freba Grawe, Ricarda Ebner, Thomas Geyer, Leonie Beyer, Michael Winkelmann, Gabriel T. Sheikh, Ralf Eschbach, Christine Schmid-Tannwald, Clemens C. Cyran, Jens Ricke, Peter Bartenstein, Maurice M. Heimer, Lorenzo Faggioni, Christine Spitzweg, Matthias P. Fabritius, Christoph J. Auernhammer, Johannes Ruebenthaler
Summary: This study aimed to determine the intra- and interreader agreement of SSTR-RADS 1.0. The results showed high consistency among readers in assessing target lesions using SSTR-RADS 1.0, indicating that the system can effectively standardize the diagnosis and treatment planning in NET patients.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
Saqib A. Rahman, Robert C. Walker, Nick Maynard, Nigel Trudgill, Tom A. Crosby, David J. Cromwell, Timothy Underwood, NOGCA Project Team AUGIS
Summary: This study developed a predictive model for overall survival after esophagectomy using pre/postoperative clinical data and machine learning. The model showed excellent discrimination and well-calibrated predictions, providing more accuracy than TNM staging alone.
Article
Oncology
N. Schuring, E. Jezerskyte, M. I. van Berge Henegouwen, M. A. G. Sprangers, P. Lagergren, A. Johar, S. R. Markar, S. S. Gisbertz
Summary: This study aimed to investigate the relationship between postoperative complications and long-term health-related quality of life (HRQL) in patients who underwent esophagectomy for cancer. The study found that patients with complications reported more dyspnea compared to those without complications, but these differences were not clinically significant. The severity of complications also had an impact on the patients' mood. Overall, HRQL in esophageal cancer patients is more likely affected by the complexity of the surgical procedure itself.
Article
Immunology
Ben Nicholas, Alistair Bailey, Katy J. McCann, Oliver Wood, Robert C. Walker, Robert Parker, Nicola Ternette, Tim Elliott, Tim J. Underwood, Peter Johnson, Paul Skipp
Summary: This study analyzed the mutational and immunopeptidomic landscapes of oesophageal adenocarcinoma (OAC) and identified potential immunogenic neoantigens in some patients. However, the success rate for identifying these neoantigens was low, emphasizing the need for improved strategies.
Article
Surgery
John Reynolds, Noel E. Donlon, Jessie A. Elliott, Brendan Moran, Hugo Temperley, Tim S. Nugent, Maria Davern, Sinead King, Melissa Conroy, Joanne Lysaght, Narayanasamy Ravi, Carmel Ryan, Stephen Finn, Suzanne Norris, Clare L. Donohoe
Summary: This study establishes for the first time the incidence and clinical impact of NAFLD in EAC patients undergoing surgery and highlights no major impact on oncologic outcomes, nor in the severity of complications.
WORLD JOURNAL OF SURGERY
(2023)
Review
Oncology
Nora Wangari Murage, Nada Mabrouk Ahmed, Timothy J. Underwood, Zoe S. Walters, Stella Panagio Breininger
Summary: Pseudomyxoma peritonei (PMP) is a rare neoplastic condition with a low survival rate. Understanding the genetic profile of PMP can help develop targeted treatments and predict patient survival.
CANCER AND METASTASIS REVIEWS
(2023)
Review
Gastroenterology & Hepatology
Navamayooran Thavanesan, Ganesh Vigneswaran, Indu Bodala, Timothy J. J. Underwood
Summary: The complexity of the upper gastrointestinal multidisciplinary team is increasing, resulting in inconsistent treatment decisions for patients with oesophageal cancer. Artificial intelligence and machine learning have been successfully applied in the healthcare field, but not yet in the MDT where it can benefit from diverse datasets. ML offers the potential to standardize and automate decisions within the MDT using data-driven approaches.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
A. Broadbent, S. Rahman, B. Grace, R. Walker, F. Noble, J. Kelly, J. Byrne, T. Underwood
Summary: Complications have a significant impact on long-term survival after oesophagectomy for cancer, especially the cumulative effect of multiple complications. Interestingly, multiple minor complications have a worse effect on survival than major complications.
Review
Oncology
Hollie A. Clements, Tim J. Underwood, Russell D. Petty
Summary: Adenocarcinoma of the oesophagus and gastro-oesophageal junction is a major cause of cancer death in the Western World, with increasing incidence. The overall survival of patients on a potentially curative treatment pathway has significantly improved by adding perioperative oncological therapies to surgery. However, patients often have poor response to oncological treatment or struggle to complete their treatment after surgery.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Navamayooran Thavanesan, Indu Bodala, Zoe Walters, Sarvapali Ramchurn, Timothy J. Underwood, Ganesh Vigneswaran
Summary: This experimental pilot study developed machine learning models to predict treatment decisions in oesophageal cancer multidisciplinary teams. Results showed that multinomial logistic regression outperformed other algorithms in terms of performance metrics. Age was identified as a major factor in the decision-making process.
Article
Gastroenterology & Hepatology
Mark Donnelly, Dorothee Driever, Eanna J. Ryan, Jessie A. Elliott, John Finnegan, Deirdre McNamara, Ian Murphy, Kevin C. Conlon, Paul C. Neary, Dara O. Kavanagh, James M. O'Riordan
Summary: This study assessed the nutritional status and body composition of patients undergoing resectional surgery for Crohn's disease (CD) and found that myosteatosis is associated with nutritional impairment and predicts increased postoperative complications. Although obesity is associated with specific increased postoperative risks, it does not increase overall morbidity, reflecting the preservation of nutritional status and relatively more quiescent disease phenotype. Improving muscle mass and function can be an important target for optimizing surgical outcomes in CD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Jonathan L. Moore, Michael Green, Aida Santaolalla, Harriet Deere, Richard P. T. Evans, Mona Elshafie, Anita Lavery, Damian T. McManus, Andrew McGuigan, Rosalie Douglas, Joanne Horne, Robert Walker, Hira Mir, Monica Terlizzo, Sivesh K. Kamarajah, Mieke Van Hemelrijck, Nick Maisey, Ailsa Sita-Lumsden, Sarah Ngan, Mark Kelly, Cara R. Baker, Sacheen Kumar, Jesper Lagergren, William H. Allum, James A. Gossage, Ewen A. Griffiths, Heike I. Grabsch, Richard C. Turkington, Tim J. Underwood, Elizabeth C. Smyth, Rebecca C. Fitzgerald, David Cunningham, Andrew R. Davies
Summary: This study aimed to evaluate the influence of lymph node (LN) regression on survival after surgery for esophageal adenocarcinoma. The results showed that patients with complete LN regression, partial LN regression, or negative LNs had a lower mortality rate compared to those with poor/no LN regression.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Eleanor O'Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J. Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J. Underwood, Janet Shipley, Zoe S. Walters
Summary: This study demonstrates the potential utility of combining EZH2 inhibitors with differentiation agents for the treatment of paediatric rhabdomyosarcomas, providing a basis for further research and clinical application.
CLINICAL EPIGENETICS
(2023)
Article
Gastroenterology & Hepatology
Emily L. Black, Emma Ococks, Ginny Devonshire, Alvin Wei Tian Ng, Maria O'Donovan, Shalini Malhotra, Monika Tripathi, Ahmad Miremadi, Adam Freeman, Hannah Coles, Rebecca C. Fitzgerald
Summary: The controversy of whether gastric metaplasia should be considered as Barrett's esophagus is explored in this study. Through clinical and genomic analysis, the researchers found that the malignant potential of gastric metaplasia is lower than intestinal metaplasia. Therefore, the inclusion of gastric metaplasia in the surveillance of Barrett's esophagus is questionable.
Article
Surgery
Tamara M. H. Gall, Gautam Malhotra, Jessie A. Elliott, John B. Conneely, Yuman Fong, Long R. Jiao
Summary: The uptake of robotic surgery is increasing worldwide, but there is a higher usage in the USA compared to the UK and Ireland. This difference in exposure to robotic surgery during general surgical training was assessed through a survey among trainees. The results showed that US trainees had significantly more experience and training in robotic surgery than their UK and Irish counterparts.
JOURNAL OF ROBOTIC SURGERY
(2023)