Article
Chemistry, Multidisciplinary
Thomas J. Neal, Nicholas J. W. Penfold, Steven P. Armes
Summary: This study reports a new aqueous polymerization-induced self-assembly (PISA) formulation that utilizes a reverse sequence approach to prepare hydrophobic blocks and produce charge-stabilized latex particles. The latex is then converted into smaller sterically stabilized diblock copolymer nanoparticles, which exhibit thermoresponsive behavior.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Coralie Lebleu, Laetitia Plet, Florene Moussy, Gatan Gitton, Rudy Da Costa Moreira, Ludmilla Guduff, Barbara Burlot, Rodolphe Godiveau, Anhoa Merry, Sebastien Lecommandoux, Gauthier Errasti, Christiane Philippe, Thomas Delacroix, Raj Chakrabarti
Summary: New stealth amphiphilic copolymers based on polysarcosine (PSar) have been studied for their potential use as excipients in nanomedicine. The copolymers were synthesized by ring opening polymerization of N-carboxyanhydrides (NCAs) and characterized by FTIR, 1H NMR, and SEC. Nanoparticles loaded with paclitaxel were obtained and showed improved water solubility.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Honggui Chen, Xiang Zhang, Ziyu Lin, Rui Zhang, Bingran Yu, Yang Li, Fu-Jian Xu
Summary: This study reports a simple one-step polymerization method for in situ preparation of hydrogels in aqueous solutions, where water-miscible monomers are copolymerized to enhance the mechanical properties of the hydrogels. This strategy provides an effective approach to design mechanically enhanced hydrogels for a wide range of applications.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Matthew A. H. Farmer, Osama M. Musa, Steven P. Armes
Summary: Hydrolytically degradable block copolymer nanoparticles were prepared via a method called reverse sequence polymerization-induced self-assembly (PISA) in water. This approach involved the reversible addition-fragmentation chain transfer (RAFT) polymerization of DMAC using a poly(lactone) precursor. The resulting nanoparticles showed controlled sizes and confirmed hydrolytic degradation in both acidic and alkaline solutions. However, no degradation was observed when stored in deionized water. Additionally, the nanoparticles showed potential as a dispersant in an agrochemical formulation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Junpeng Cao, Yingxin Tan, Xiaocong Dai, Ying Chen, Li Zhang, Jianbo Tan
Summary: In this study, the intrinsic monomer-feeding mechanism of RAFT-mediated emulsion polymerization was utilized to delay in situ crosslinking during PISA, enabling the preparation of cross-linked block copolymer nano-objects with high crosslinker contents. The use of various cross-linkers with different properties was demonstrated to promote the formation of higher-order morphologies.
Article
Multidisciplinary Sciences
Martin Hjort, Abdelrazek H. Mousa, David Bliman, Muhammad Anwar Shameem, Karin Hellman, Amit Singh Yadav, Peter Ekstrom, Fredrik Ek, Roger Olsson
Summary: Temporary bioelectronics can complement classical therapies in non-chronic treatments. Here, the authors describe the minimally invasive implantation of bioresorbable electrodes in the brain that form in situ from water-dispersed nanoparticles and show no tissue damage after bioresorption.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Wen-Jian Zhang, Zi-Xuan Chang, Wei Bai, Chun-Yan Hong
Summary: Significantly enhanced accessibility and reproducibility of worm-like micelles are achieved through in situ crosslinking polymerization-induced self-assembly (PISA), paving the way for further application of worm-like micelles with various compositions and functionalities.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Nanoscience & Nanotechnology
Yuexin Cui, Liying Yin, Xiaoya Sun, Ning Zhang, Nan Gao, Guangshan Zhu
Summary: A novel non-catechol-based wet adhesive is reported, which is formed by self-assembly in aqueous solution, showing reversible, tunable, and strong adhesion, as well as high efficacy in promoting biological wound healing with inherent antimicrobial properties.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Hien Phan, Melissande Cossutta, Claire Houppe, Clemence Le Coeur, Sylvain Prevost, Ilaria Cascone, Jose Courty, Jacques Penelle, Benoit Couturaud
Summary: The study explores the possibility of using the same block copolymer carriers for in situ drug encapsulation or drug conjugation. The experiments demonstrate that the prepared nanocarriers undergo size and shape transformations, with high encapsulation efficiency of DOX and potential for future drug delivery and biomedical applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Yu Chen, Jiaqi Li, Liping Zhao, Huan Chen, Xia Xin, Haihua Wang, Shenshen Li, Wenbing Kang
Summary: Due to the high electronegativity of fluorine atoms, incorporating fluorinated moieties in a polymer can result in unique properties such as low surface energy and self-assembling ability in solution. In this study, a series of amphiphilic copolymers were prepared using three monomers, and their properties were regulated by changing the length of the fluorinated block. One specific copolymer (FAA02) demonstrated low surface tension and self-assembled into pH-sensitive micelles in water.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Materials Science, Ceramics
Evelyn L. Bonifazi, Andrea S. Mac Cormack, Veronica M. Busch, M. Laura Japas, Lorenzo Di Bari, Pablo H. Di Chenna
Summary: This article reports on the stabilizing effect of water and the chiral self-assembly mode of a cholesterol-based low-molecular-weight supramolecular organogelator. Experimental results show that water enhances the strength and rigidity of the gel without affecting the chirality of the supramolecular structure.
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2022)
Article
Polymer Science
Maelle Lages, Noemie Gil, Paul Galanopoulo, Julie Mougin, Catherine Lefay, Yohann Guillaneuf, Muriel Lansalot, Franck D'Agosto, Julien Nicolas
Summary: The synthesis of degradable vinyl polymer nanoparticles/latexes in aqueous dispersed media is important for biomedical applications and plastic pollution control. Polymerization-induced self-assembly (PISA) has become a popular process for generating aqueous suspensions of diblock copolymer nano-objects. However, the direct aqueous PISA method for degradable vinyl polymer nanoparticles has not been reported. This study presents a novel aqueous emulsion PISA method for generating degradable vinyl polymer nanoparticles, which has the potential to greatly expand the use of PISA in various fields.
Article
Polymer Science
Hyun Jin Kim, Fumi Ishizuka, Rhiannon P. Kuchel, Yin Yao, Shunsuke Chatani, Hiroshi Niino, Per B. Zetterlund
Summary: Polymerization-induced self-assembly (PISA) was used to synthesize spheres and worms comprising poly(n-butyl acrylate) as core-forming block. The nanoparticle morphology was dependent on the system pH, with spheres formed at natural pH and worms formed at pH 5. Films prepared from these nanoparticles demonstrated that the initial morphology significantly influenced the mechanical properties, with worm films showing higher tensile strength and strain at break compared to sphere films.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jing Wan, Bo Fan, Kevin Putera, Jinhee Kim, Mark M. Banaszak Holl, San H. Thang
Summary: A sequential one-pot synthesis of hierarchically self-assembled polymer colloids with diverse morphologies has been achieved via aqueous PISA, overcoming the limitations of traditional methods. This approach provides a scalable method for the production of colloidal molecules and other hierarchical nanostructures, with the potential to enrich the complexity of morphology and enable diverse functions of nano-objects.
Article
Polymer Science
Steven W. Thompson, Thiago R. Guimaraes, Per B. Zetterlund
Summary: Reversible addition-fragmentation chain transfer (RAFT) polymerization-induced self-assembly (PISA) emulsion polymerization is a method to prepare high molecular weight multiblock copolymers. The system has higher livingness and can achieve high solid content, making it suitable for industrial scale up.
Article
Chemistry, Multidisciplinary
Min Zhou, Ximian Xiao, Zihao Cong, Yueming Wu, Wenjing Zhang, Pengcheng Ma, Sheng Chen, Haodong Zhang, Danfeng Zhang, Donghui Zhang, Xiangfeng Luan, Yiyong Mai, Runhui Liu
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Chemistry, Multidisciplinary
Yueming Wu, Yaofa Lin, Zihao Cong, Kang Chen, Ximian Xiao, Xue Wu, Longqiang Liu, Yunrui She, Shiqi Liu, Ruiyi Zhou, Gang Yin, Xiaoyan Shao, Yidong Dai, Haodong Lin, Runhui Liu
Summary: The PMMA@polymer, designed as a synthetic mimic of host defense peptide, shows potent activity against MRSA, superior therapeutic efficacy in vivo, and low toxicity, suggesting great potential as an effective treatment for MRSA-infected chronic osteomyelitis.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Polymer Science
Jingcheng Zou, Min Zhou, Zhemin Ji, Ximian Xiao, Yueming Wu, Ruxin Cui, Shuai Deng, Runhui Liu
Summary: This study presents a novel method for the synthesis of peptide/peptoid hybrid polymers with alternating distribution of residues, controlled molecular weight, and narrow dispersity. This method allows for quick synthesis of peptide mimicking peptide/peptoid hybrid polymers with adjustable proteolysis and opens up new possibilities for preparing novel peptide mimics with tunable proteolysis and large structural diversity.
Article
Chemistry, Medicinal
Yueming Wu, Weinan Jiang, Zihao Cong, Kang Chen, Yunrui She, Chao Zhong, Wenjing Zhang, Minzhang Chen, Min Zhou, Ning Shao, Guohui Xiao, Xiaoyan Shao, Yidong Dai, Jian Fei, Gonghua Song, Runhui Liu
Summary: By elongating the polymeric peptide chain and incorporating glutamic acid residues, a potent antifungal peptide polymer has been developed with superior efficacy against drug-resistant fungi. This polymer exhibits excellent stability and therapeutic effects, while also showing low susceptibility to antifungal resistance.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ning Shao, Ling Yuan, Pengcheng Ma, Min Zhou, Ximian Xiao, Zihao Cong, Yueming Wu, Guohui Xiao, Jian Fei, Runhui Liu
Summary: The study presents a rational design of heterochiral beta-peptide polymers as anticancer agents for combating multidrug-resistant cancers. The optimal polymer shows potent and broad-spectrum anticancer activities against multidrug-resistant cancer cells by damaging cell membranes. In vivo experiments demonstrate that the polymer efficiently inhibits the growth and transfer of solid tumors and the metastasis and seeding of circulating tumor cells. Additionally, the beta-peptide polymers have excellent biocompatibility, superior stability against proteolysis, easy large-scale synthesis, and low cost compared to anticancer peptides.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Ruiyi Zhou, Yueming Wu, Kang Chen, Deteng Zhang, Qi Chen, Donghui Zhang, Yunrui She, Wenjing Zhang, Longqiang Liu, Yueqi Zhu, Changyou Gao, Runhui Liu
Summary: This study reports a polymeric strategy for designing and finding endothelial cell (EC)-selective biomaterials by tuning serum protein adsorption. The optimal beta-peptide polymer shows superior EC versus smooth muscle cell (SMC) selectivity compared to the commonly used EC-selective peptides. Surface adsorption of bovine serum albumin plays a critical role in the selectivity of the beta-peptide polymer. Surface modification of the optimal polymer promotes the endothelialization of vascular implants and inhibits intimal hyperplasia.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Weinan Jiang, Yueming Wu, Min Zhou, Gonghua Song, Runhui Liu
Summary: Host defense peptides and cell-penetrating peptides are important strategies in designing synthetic antifungal agents, but the potential of cell-penetrating peptides has been overlooked in this field. This article describes the structural design of synthetic antifungal polymers and highlights the effectiveness of the cell-penetrating peptide-inspired strategy, as well as presents an outlook for future research.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yueming Wu, Yunrui She, Zi Yan, Sheng Chen, Jiangzhou Wang, Alideertu Dong, Jing Wang, Runhui Liu
Summary: This study reports a facile construction of antimicrobial surface via one-step co-deposition of peptide polymer and dopamine, with the significant killing efficacy against methicillin-resistant Staphylococcus aureus and Escherichia coli. The method is fast and effective, providing a promising approach for antimicrobial surface modification of implantable biomaterials and medical devices.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Weinan Jiang, Min Zhou, Sheng Chen, Jiayang Xie, Minzhang Chen, Haodong Zhang, Yueming Wu, Xin Chen, Runhui Liu
Summary: In this study, we designed and synthesized a novel antifungal polymer that showed promising efficacy against drug-resistant fungi and biofilm. The polymer also demonstrated the potential to treat meningitis by breaking through the blood-brain barrier. This research provides a new strategy for the design of effective antifungal agents.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Biomaterials
Pengcheng Ma, Yueming Wu, Weinan Jiang, Ning Shao, Min Zhou, Yuan Chen, Jiayang Xie, Zhongqian Qiao, Runhui Liu
Summary: This study explores the issue of antimicrobial resistance in aquaculture and proposes an alternative method by preparing peptide polymers. These polymers demonstrate potent and broad-spectrum activity against common pathogenic bacteria, low toxicity, and resistance-free characteristics. The findings of this study offer new hope in addressing the global challenge of antimicrobial resistance.
BIOMATERIALS SCIENCE
(2022)
Review
Materials Science, Biomaterials
Yueming Wu, Guixue Xia, Weiwei Zhang, Kang Chen, Yufang Bi, Shiqi Liu, Wenjing Zhang, Runhui Liu
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Materials Science, Biomaterials
Weinan Jiang, Ximian Xiao, Yueming Wu, Weiwei Zhang, Zihao Cong, Jingjing Liu, Sheng Chen, Haodong Zhang, Jiayang Xie, Shuai Deng, Minzhang Chen, Yun Wang, Xiaoyan Shao, Yidong Dai, Yun Sun, Jian Fei, Runhui Liu
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Bing Li, Yueming Wu, Wenjing Zhang, Si Zhang, Ning Shao, Weiwei Zhang, Lixin Zhang, Jian Fei, Yidong Dai, Runhui Liu
BIOMATERIALS SCIENCE
(2019)
Article
Materials Science, Biomaterials
Weiwei Zhang, Yueming Wu, Longqiang Liu, Ximian Xiao, Zihao Cong, Ning Shao, Zhongqian Qiao, Kang Chen, Shiqi Liu, Haodong Zhang, Zhemin Ji, Xiaoyan Shao, Yidong Dai, Hongyan He, Jiang Xia, Jian Fei, Runhui Liu
Summary: The study successfully synthesized antibacterial polypeptide-conjugated gold nanoparticles to combat multidrug-resistant bacteria, demonstrating potent antibacterial activity and excellent biocompatibility, implying potential applications in treating bacterial infections.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)