Identification of Inhibitors of Cholesterol Transport Proteins Through the Synthesis of a Diverse, Sterol‐Inspired Compound Collection

Pseudo Natural Products ‐ Chemical Evolution of Natural Product Structure

(2021) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small molecule probes for targeting autophagy

(2021) Thomas Whitmarsh-Everiss et al.   Nature Chemical Biology

Principle and design of pseudo-natural products

(2020) George Karageorgis et al.   Nature Chemistry

Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds

(2020) Robert A. Lowe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

(2020) Jun Zhang et al.   EMBO REPORTS

Aster-B coordinates with Arf1 to regulate mitochondrial cholesterol transport

(2020) John-Paul Andersen et al.   Molecular Metabolism

A liposomal FRET assay identifies potent drug‐like inhibitors of the ceramide transport protein CERT

(2020) Doaa Samaha et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms

(2020) Xu Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

(2019) Luca Laraia et al.   Nature Chemical Biology

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

(2018) Jaspreet Sandhu et al.   CELL

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

(2018) Jie Luo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cholesterol and ORP1L-mediated ER contact sites control autophagosome transport and fusion with the endocytic pathway

(2016) Ruud H. Wijdeven et al.   Nature Communications

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells

(2013) Jonathan J Hulce et al.   NATURE METHODS

Novel supported and unsupported prolinamides as organocatalysts for enantioselective cyclization of triketones

(2013) Rafael Pedrosa et al.   TETRAHEDRON LETTERS

Biology-Oriented Synthesis

(2011) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sterol Regulation of Metabolism, Homeostasis, and Development

(2011) Joshua Wollam et al.   Annual Review of Biochemistry

A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

(2011) Sangmi Oh et al.   CHEMICAL COMMUNICATIONS

Small molecule inhibitors reveal Niemann–Pick C1 is essential for Ebola virus infection

(2011) Marceline Côté et al.   NATURE

The Diverse Functions of Oxysterol-Binding Proteins

(2010) Sumana Raychaudhuri et al.   Annual Review of Cell and Developmental Biology

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Efficient Solvent-Free Robinson Annulation Protocols for the Highly Enantioselective Synthesis of the Wieland-Miescher Ketone and Analogues

(2009) Ben Bradshaw et al.   ADVANCED SYNTHESIS & CATALYSIS

Diversity-Oriented Synthesis of Privileged Benzopyranyl Heterocycles froms-cis-Enones

(2008) Heeseon An et al.   JOURNAL OF ORGANIC CHEMISTRY

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH