期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 51, 页码 26571-26576出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202112876
关键词
germylation; nickel; organogermanes; synthetic methods
资金
- National Natural Science Foundation of China [22071084, 21772072]
A novel cross-electrophile C-Ge coupling reaction has been reported, showing the potential of obtaining diverse organogermanes under mild conditions, with applications demonstrated in the synthesis and derivatization of complex molecules.
Cross-electrophile coupling has emerged as a promising tool for molecular synthesis; however, current studies have focused mainly on forging C-C bonds. We report a cross-electrophile C-Ge coupling reaction and thereby demonstrate the possibility of constructing organogermanes from carbon electrophiles and chlorogermanes. The reaction proceeds under mild conditions and offers access to both aryl and alkenyl germanes. Electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles, as well as cyclic and acyclic alkenyl electrophiles, were coupled. Gram-scale reaction, incorporation of the -GeR3 moiety into complex biologically active molecules, and derivatization of formed organogermanes are demonstrated.
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