期刊
ANDROLOGIA
卷 54, 期 2, 页码 -出版社
WILEY
DOI: 10.1111/and.14298
关键词
biomarker; male infertility; microRNAs; spermatogenesis
类别
Male infertility is a complex disorder with more than half of cases attributed to men, and the limitations of semen analysis highlight the need for novel diagnostic tools. MicroRNAs have the potential to serve as candidate biomarkers for diagnosing male infertility, indicating a specific disease through abnormal alterations in their expression levels.
Infertility is a multiplex disorder in the reproductive system, and men are responsible for more than half of the cases. Nowadays, semen analysis has been considered the critical assessment test to diagnose infertile men; however, it has limitations so that the cause behind infertility in 40% of infertile men is unrevealed. Weaknesses of semen assessment indicate a global need for novel and better diagnostic tools and biomarkers. MicroRNAs are short (about 18-22 nucleotide length) non-coding RNAs that control most (>60%) of our protein-coding genes post-transcriptionally. These molecules are aberrant in the body fluids, and abnormal alterations in their expression level can signify a specific disease such as infertility. Therefore, microRNAs can be novel candidate biomarkers that can diagnose different types of male infertility, including azoospermia, oligozoospermia, asthenozoospermia and teratozoospermia. This narrative review aimed to collect and sum up new papers published about the significant role of microRNAs in different male infertility categories.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据