Review
Nutrition & Dietetics
Camilla Fiorindi, Edda Russo, Lucrezia Balocchini, Amedeo Amedei, Francesco Giudici
Summary: This article discusses the factors and management methods of inflammatory bowel disease, focusing on the impact of different dietary plans on gut microbiota and inflammation, aiming to better customize nutritional interventions.
Article
Medicine, Research & Experimental
Cheng Li
Summary: Human responses to the same diets vary due to complex diet-host-microbiota interactions. Recent advances show that quantifying this interaction could lead to personalized nutrition strategies for improving individual health. The gut microbiome, compared to host related factors, can be easily modulated by dietary exposures and plays a crucial role in human health. However, limitations in processing and analyzing 'big-data' on the human microbiome hinder the translation of diet-host-microbiota interactions into tools for personalized health improvement. This review aims to summarize recent advances in understanding diet-host-microbiota interactions to aid in the development of personalized nutrition strategies.
Review
Food Science & Technology
Lili Jiang, Dandan Han, Youling Hao, Zhuan Song, Zhiyuan Sun, Zhaolai Dai
Summary: Serotonin produced by EC cells in the gut is crucial for maintaining gut function and homeostasis. The interactions between dietary factors, gut microbiota, and gut serotonin play important roles in gut metabolism and immune function, but the underlying mechanisms are not fully understood.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Virna Margarita Martin Gimenez, Natalia Lucia Rukavina Mikusic, Hyun Jin Lee, Sebastian Garcia Menendez, Marcelo Roberto Choi, Walter Manucha
Summary: Gut microbiota dysbiosis can trigger cardiovascular diseases, including hypertension, and directly damage organs such as the brain, heart, blood vessels, and kidneys. Nutritional and pharmacological interventions can influence gut microbiota composition and potentially prevent or treat hypertension. Understanding the complex interactions between gut microbiota and drug/food response is crucial for developing improved therapies for hypertension.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Emidio Scarpellini, Maria Rosaria Paravati, Giuseppe Guido Maria Scarlata, Luigi Boccuto, Bruno Tilocca, Paola Roncada, Francesco Luzza
Summary: Critically ill patients often experience a hyper-inflammatory response, which can cause severe damage to tissues and organs. It has been found that this harmful inflammatory cascade can be traced back to imbalances in the gut microbiota. Understanding the dysfunction and pathophysiology of the gut microbiota in critical patients is crucial for managing the systemic inflammatory response syndrome and multiple organ dysfunction syndrome. Various studies have shown that probiotics and immunonutrition can help attenuate systemic inflammation in critically ill patients.
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Sonia Croci, Lina Ilaras D'Apolito, Valeria Gasperi, Maria Valeria Catani, Isabella Savini
Summary: This passage discusses the relationship between metabolic syndrome and gut microbiota, indicating that dysbiosis may play a role in the pathogenesis of various chronic diseases; certain metabolites derived from microorganisms can trigger subclinical inflammatory processes related to MetS.
Article
Biochemistry & Molecular Biology
Shin Young Park, Sang Pyung Lee, Dongin Kim, Woo Jin Kim
Summary: A stroke is a serious condition that occurs when blood vessels in the brain are blocked or burst. This study aimed to explore the differences in gut microbiota between stroke patients and healthy controls. The results showed taxonomic and functional dysbiosis in stroke patients, suggesting a possible link between malnutrition and stroke. Manipulation of nutrition could potentially alleviate gut dysbiosis and improve the prognosis, disability, and mortality of stroke management.
Article
Nutrition & Dietetics
Valentina Cecarini, Olee Gogoi, Laura Bonfili, Iolanda Veneruso, Giada Pacinelli, Sara De Carlo, Federica Benvenuti, Valeria D'Argenio, Mauro Angeletti, Nazzareno Cannella, Anna Maria Eleuteri
Summary: A yeast-enriched beer has beneficial effects on Alzheimer's disease by improving cognition, reducing protein aggregation and inflammation, increasing anti-inflammatory cytokines, improving gut bacterial population, and decreasing gut inflammatory fungi.
Article
Medicine, Research & Experimental
Kaijun Wang, Miao Zhou, Hongbin Si, Jie Ma
Summary: Low-grade chronic inflammation, also known as metabolic inflammation, promotes the development of metabolic diseases. Changes in gut microbes and metabolites can reduce inflammation via IL-22, highlighting the potential of IL-22 as a therapeutic target for the management of metabolic inflammation and related diseases.
Review
Nutrition & Dietetics
Paulina Mertowska, Sebastian Mertowski, Julia Wojnicka, Izabela Korona-Glowniak, Ewelina Grywalska, Anna Blazewicz, Wojciech Zaluska
Summary: Chronic kidney disease is a progressive and irreversible condition that can lead to alterations in the gut microbiota and activation of the immune system, with dietary factors playing a significant role in immune cell activation and microbiota balance. Understanding the relationship between intestinal microbiota and kidney dysfunction is crucial in the progression of kidney diseases.
Review
Cell Biology
Xiao-hang Qian, Xiao-xuan Song, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang
Summary: Multiple studies in the past decade have shown the close relationship between gut microbiota and Alzheimer's disease (AD), but the specific mechanism is still unclear. Inflammation, both neuroinflammation and systemic inflammation, play a key role in accelerating the process of AD. Gut microbiota regulation of inflammation is crucial in the development of AD.
AGEING RESEARCH REVIEWS
(2021)
Review
Nutrition & Dietetics
Damiano Terenzi, Anne-Katrin Muth, Soyoung Q. Park
Summary: This paper reviews the current literature on the relationship between nutritive patterns, inflammatory markers, and the detection of Parkinson's disease (PD). The findings suggest that long-term gut inflammation may contribute to the development of PD, and specific nutritive patterns could improve gut health and reduce the risk of PD.
Article
Ecology
Kate A. Sabey, Se Jin Song, Anna Jolles, Rob Knight, Vanessa O. Ezenwa
Summary: Studies have shown that variation in infection and the duration of infection can have significant effects on gut microbiota, impacting microbial patterns as much as demographic and environmental factors commonly examined in microbiota research.
Article
Infectious Diseases
Wenpei Shi, Yi Hu, Zhu Ning, Fan Xia, Meiying Wu, Yue O. O. Hu, Cheng Chen, Stefanie Prast-Nielsen, Biao Xu
Summary: There were significant differences in gut microbiota composition and metabolic pathways between tuberculosis patients and healthy controls. Antibiotic exposure was found to further reduce diversity and deplete beneficial bacteria in the gut microbiota of TB patients. Microbial functional analysis showed lower biosynthesis capacity of amino acids and fatty acids in TB patients compared to healthy controls.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
Saurabh Mehta, Samantha L. Huey, Padmini S. Ghugre, Ramesh D. Potdar, Sudha Venkatramanan, Jesse T. Krisher, Caleb J. Ruth, Harsha Chopra, Aparna Thorat, Varsha Thakker, Lynn Johnson, Laura Powis, Yadurshini Raveendran, Jere D. Haas, Julia L. Finkelstein, Shobha A. Udipi
Summary: Daily consumption of iron and zinc biofortified pearl millet-based complementary foods did not significantly improve iron biomarkers or growth in children living in Mumbai's urban slums. However, the intervention had a significant impact on hemoglobin concentrations in male children and those with iron deficiency or iron depletion at baseline.
CLINICAL NUTRITION
(2022)
Article
Medicine, Research & Experimental
Stacy P. Griswold, Anastasia Marshak, Merry Fitzpatrick, Daniele Lantagne, Kate Shoenmakers, Marlene Hebie, Anne Radday, Hugo De Groote, Saurabh Mehta, Greg Gottlieb, Patrick Webb, Shibani Ghosh
Summary: This study aims to implement and measure the effects of a multi-level multi-sectoral social behavior change intervention in Agago District of Northern Uganda and determine its potential for scale-up. The study design utilizes a cluster-randomized controlled trial, comparing two intervention approaches (Nutrition Impact and Positive Practice vs. NIPP+) and a control group. The findings will contribute to understanding the impact of different interventions on improving farm and water quality practices.
Article
Nutrition & Dietetics
Samantha L. Huey, Jesse T. Krisher, Arini Bhargava, Valerie M. Friesen, Elsa M. Konieczynski, Mduduzi N. N. Mbuya, Neel H. Mehta, Eva Monterrosa, Annette M. Nyangaresi, Saurabh Mehta
Summary: Biofortification, by increasing the concentrations of micronutrients in staple crops, has the potential to combat global micronutrient deficiencies. Evidence from controlled interventions shows that consuming biofortified crops, particularly vitamin A from orange sweet potato, can improve the micronutrient status of farmer households. Ongoing and future research will further elucidate the potential of biofortified crops in scaling up interventions to reduce micronutrient deficiencies.
Review
Chemistry, Multidisciplinary
Samantha L. Huey, Jesse T. Krisher, David Morgan, Penjani Mkambula, Balaji Srinivasan, Bryan M. Gannon, Mduduzi N. N. Mbuya, Saurabh Mehta
Summary: Vitamin A deficiency is a global health issue. Portable quantitative and semiquantitative devices and test kits have been found to analyze the concentration of VA in edible oil, with iCheck CHROMA and QuickView showing high accuracy and precision. Further validation is needed for the SAFO test kit.
Article
Nutrition & Dietetics
Julia L. Finkelstein, Amy Fothergill, Heather M. Guetterman, Christina B. Johnson, Beena Bose, Yan Ping Qi, Charles E. Rose, Jennifer L. Williams, Saurabh Mehta, Rebecca Kuriyan, Wesley Bonam, Krista S. Crider
Summary: Reproductive-age women in India are at a higher risk of anemia and iron deficiency, especially in rural areas. This study emphasizes the importance of screening and interventions to address these health issues.
CLINICAL NUTRITION ESPEN
(2022)
Article
Public, Environmental & Occupational Health
Melisa Medina-Rivera, Washington B. Cardenas, David Erickson, Saurabh Mehta
Summary: Chagas disease, a neglected parasitic infection and a major public health problem in the Americas, remains underdiagnosed due to the lack of affordable testing and healthcare disparities. The study presents a proof-of-concept lateral flow immunoassay using a recombinant Chagas multiantigen conjugated to gold nanoshells for detecting anti-Chagas IgG antibodies. The results show that this rapid testing method has comparable performance to commercial methods.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Multidisciplinary Sciences
Elaine A. Yu, Jose O. Aleman, Donald R. Hoover, Qiuhu Shi, Michael Verano, Kathryn Anastos, Phyllis C. Tien, Anjali Sharma, Ani Kardashian, Mardge H. Cohen, Elizabeth T. Golub, Katherine G. Michel, Deborah R. Gustafson, Marshall J. Glesby
Summary: This study compared the non-targeted plasma metabolomic profiles of women with and without diabetes mellitus. The results showed that flavonoids were associated with a lower incidence of diabetes, while sorbic acid was associated with a higher incidence of diabetes.
Review
Food Science & Technology
Samantha L. L. Huey, Neel H. H. Mehta, Elsa M. M. Konieczynski, Arini Bhargava, Valerie M. M. Friesen, Jesse T. T. Krisher, Mduduzi N. N. Mbuya, Eva Monterrosa, Annette M. M. Nyangaresi, Erick Boy, Saurabh Mehta
Summary: This study examined the bioavailability of target micronutrients enriched in conventionally biofortified crops post-harvest storage and/or processing. Conventional biofortified crops generally had higher bioaccessibility and bioavailability compared to conventional counterparts, though the estimates varied depending on cultivar, processing method, context, and experimental method used.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Environmental Sciences
Balaji Srinivasan, Shibani Ghosh, Patrick Webb, Stacy P. Griswold, Kathy S. Xue, Jia-Sheng Wang, Saurabh Mehta
Summary: Exposure to dietary aflatoxins is a potential threat to child nutrition and growth. Accurately assessing the concentration of aflatoxin in blood is important for informing public health policies. This study investigates the correlation and interchangeability of capillary and venous human blood samples in quantifying aflatoxin concentration. The results show a positive correlation between the two sample types.
ENVIRONMENTAL RESEARCH
(2022)
Review
Nutrition & Dietetics
Elaine A. Yu, Rachael P. Jackman, Marshall J. Glesby, K. M. Venkat Narayan
Summary: Cardiometabolic diseases have been found to be associated with COVID-19 severity, but the specific mechanisms are unclear. Studies have shown that obesity is related to higher neutralizing antibody titers after SARS-CoV-2 infection, while diabetes, hypertension, and cardiovascular diseases are not associated with antibody levels.
ADVANCES IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Andrea Orellana-Manzano, Fernanda B. Cordeiro, Andrea Garcia-Angulo, Elizabeth Centeno, Maria Jose Vizcaino-Tumbaco, Sebastian Poveda, Ricardo Murillo, Derly Andrade-Molina, Mariuxi Miraba, Saurabh Mehta, Washington Cardenas
Summary: This retrospective study investigated 10,175 individuals who underwent RT-PCR tests in Ecuador from July to November 2020. The results showed no association between RT-PCR results and sex, age, or comorbidities in positive COVID-19 cases. Cotopaxi and Napo had the highest rates of positive cases, while Manabi, Santa Elena, and Guayas regions had lower rates. Drug consumption was higher in negative COVID-19 cases compared to positive cases, and acetaminophen was the most commonly consumed medication in both groups. Acetaminophen and antihistamines had higher odds of consumption in positive cases. Symptoms like fever and cough were more related to positive RT-PCR results.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Julia L. Finkelstein, Heather M. Guetterman, Amy Fothergill, Christina B. Johnson, Yan Ping Qi, Shameem Jabbar, Mindy Zhang, Christine M. Pfeiffer, Charles E. Rose, Lorraine F. Yeung, Jennifer L. Williams, Jesse T. Krisher, Caleb Ruth, Dripta Roy Choudhury, Sudha Venkatramanan, Jere D. Haas, Rebecca Kuriyan, Saurabh Mehta, Wesley Bonam, Krista S. Crider
Summary: This randomized trial aims to evaluate the efficacy of quadruple-fortified salt (iron, iodine, folic acid, vitamin B12) in preventing anemia and micronutrient deficiencies among 1,000 households in Southern India. Interviews and biological sample analysis will be conducted to assess the effectiveness of the fortified salt.
CURRENT DEVELOPMENTS IN NUTRITION
(2023)
Review
Nutrition & Dietetics
Samantha L. Huey, Arini Bhargava, Valerie M. Friesen, Elsa M. Konieczynski, Jesse T. Krisher, Mduduzi N. N. Mbuya, Neel H. Mehta, Eva Monterrosa, Annette M. Nyangaresi, Saurabh Mehta
Summary: This review summarizes the sensory acceptability of conventionally bred iron-, zinc-, and provitamin A-biofortified food products. The findings suggest that biofortified food products made from mineral and provitamin A-biofortified crops are generally acceptable, although there are limited studies on mineral-enhanced crops and stored biofortified food products. Determining the sensory acceptability of biofortified food products is important for informing programmatic scale-up and implementation.
Meeting Abstract
Pharmacology & Pharmacy
Andrea Orellana Manzano, Fernanda B. Cordeiro, Andrea Garcia-Angulo, Diana Carvajal-Aldaz, Elizabeth Centeno, Maria J. Vizcaino, Sebastian Poveda, Ricardo Murillo, Derly Andrade-Molina, Saurabh Mehta, Washinton Cardenas
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Samantha L. Huey, Jesse T. Krisher, David Morgan, Penjani Mkambula, Bryan M. Gannon, Mduduzi N. N. Mbuya, Saurabh Mehta
Summary: This study cataloged and summarized the performance and availability of portable devices for assessing vitamin A levels and VAD, identifying that iCheck Fluoro and iCheck Carotene are commercially available and suitable for measuring vitamin A in blood and milk samples, while most other devices are still at the proof-of-concept stage.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2022)