Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease

Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program

(2021) Daniel Taliun et al.   NATURE

Respiratory exacerbations are associated with muscle loss in current and former smokers

(2021) Stefanie Elizabeth Mason et al.   THORAX

Pathological Comparisons of Paraseptal and Centrilobular Emphysema in COPD

(2020) Naoya Tanabe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Peroxisomes in host defense

(2020) Francesca Di Cara   PLoS Pathogens

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

(2019) Victor E Ortega et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort

(2018) Samuel Y. Ash et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Genome-wide association study of lung function and clinical implication in heavy smokers

(2018) Xingnan Li et al.   BMC Medical Genetics

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update

(2017) Ignacio Blanco et al.   International Journal of Chronic Obstructive Pulmonary Disease

A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes

(2015) Michael H. Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clarification of the Risk of Chronic Obstructive Pulmonary Disease in α1-Antitrypsin Deficiency PiMZ Heterozygotes

(2014) Kevin Molloy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis

(2014) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SERPINA1 PiZ and PiS Heterozygotes and Lung Function Decline in the SAPALDIA Cohort

(2012) Gian-Andri Thun et al.   PLoS One

Serum levels and genotype distribution of α1-antitrypsin in the general population

(2012) Ilaria Ferrarotti et al.   THORAX

Changes in Forced Expiratory Volume in 1 Second over Time in COPD

(2011) Jørgen Vestbo et al.   NEW ENGLAND JOURNAL OF MEDICINE

α; 1 -Antitrypsin Protease Inhibitor MZ Heterozygosity Is Associated With Airflow Obstruction in Two Large Cohorts

(2010) Inga-Cecilie Sørheim et al.   CHEST

Genetic Epidemiology of COPD (COPDGene) Study Design

(2010) Elizabeth A. Regan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Alpha1-Antitrypsin Deficiency

(2009) Edwin K. Silverman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Longitudinal Decline of Diffusing Capacity of the Lung for Carbon Monoxide in Community Subjects With the PiMZ α 1 -Antitrypsin Phenotype

(2008) Graciela E. Silva et al.   CHEST

α1-Antitrypsin Augmentation Therapy for PI*MZ Heterozygotes

(2008) Robert A. Sandhaus et al.   CHEST

Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)

(2008) J. Vestbo et al.   EUROPEAN RESPIRATORY JOURNAL

Increased expression of placenta growth factor in COPD

(2008) S-L Cheng et al.   THORAX