期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 322, 期 4, 页码 G397-G404出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00054.2021
关键词
exosomes; liver disease; role; therapeutic potential
资金
- Natural Science Foundation of Shanghai Science and Technology Commission [18ZR1400100]
- Natural Science Foundation of China [81970565, 82072647]
- Basic Research projects of Shanghai Municipal Science and Technology Commission [18JC1414000]
- Shanghai Pujiang Program [18PJ1409300]
- National Institutes of Health (NIH) [LTCDS N276201200017C]
- NIH NIDDK Pittsburgh Liver Research Center P30 Grants [1P30DK120531-01]
- Shanghai Municipal Science and Technology Commission [18JC1414000]
Exosomes are small nanovesicles secreted from cells, with a size of approximately 40-120 nm. They play a role in regulating cell homeostasis and mediating intercellular communication. Recent studies have shown their importance in liver diseases.
Exosomes are small nanovesicles with a size of approximately 40-120 nm that are secreted from cells. They are involved in the regulation of cell homeostasis and mediate intercellular communication. In addition, they carry proteins, nucleic acids, and lipids that regulate the biological activity of receptor cells. Recent studies have shown that exosomes perform important functions in liver diseases. This review will focus on liver diseases (drug-induced liver injury, hepatic ischemia-reperfusion injury, liver fibrosis, acute liver failure, and hepatocellular carcinoma) and summarize the therapeutic potential of exosomes from different cell sources in liver disease.
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