Review
Ophthalmology
Blanche L. Kuo, Rishi P. Singh
Summary: Brolucizumab shows superior anatomical outcomes in treating DME and reduces treatment burden, but poses a risk for intraocular inflammation.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Dilsher S. Dhoot, Hadi Moini, Kimberly Reed, Weiming Du, Robert Vitti, Alyson J. Berliner, Rishi P. Singh
Summary: This study aimed to assess the time to, cumulative incidence of, and functional benefit of achieving sustained improvement in diabetic macular oedema (DMO) in terms of the Diabetic Retinopathy Severity Scale (DRSS). The results showed that patients treated with intravitreal aflibercept injections achieved sustained improvement in DRSS earlier and more frequently compared to laser treatment, and this improvement was associated with greater improvement in visual acuity, independent of central subfield thickness reduction.
Article
Ophthalmology
Pravin U. Dugel, Rishi P. Singh, Adrian Koh, Yuichiro Ogura, Georges Weissgerber, Kinfemichael Gedif, Glenn J. Jaffe, Ramin Tadayoni, Ursula Schmidt-Erfurth, Frank G. Holz
Summary: The study reported the 96-week outcomes of nAMD patients treated with brolucizumab and aflibercept, showing that brolucizumab was more effective in improving vision and reducing retinal fluid compared to aflibercept. The results from both studies confirmed that the efficacy observed at 48 weeks was maintained at 96 weeks.
Article
Ophthalmology
Justus G. G. Garweg, Claudine A. A. Blum, Rene-Pierre Copt, Chiara M. M. Eandi, Katja Hatz, Christian F. F. Pruente, Eleonora Seelig, Gabor M. Somfai
Summary: Anti-vascular endothelial growth factor (anti-VEGF) therapies have become standard treatment for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). However, the need for regular injections is burdensome and long-term vision improvement may not be maintained. Brolucizumab, an intravitreal anti-VEGF therapy, shows potential to decrease injection frequency and provide effective treatment, but there are risks associated with it.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Alaa Din Abdin, Wissam Aljundi, Khalil El Jawhari, Shady Suffo, Isabel Weinstein, Berthold Seitz
Summary: The study aimed to evaluate the morphological and functional outcomes of intravitreal brolucizumab treatment for refractory neovascular age-related macular degeneration (nAMD) in the first year. Results showed that brolucizumab could stabilize visual acuity and reduce the number of injections. It also improved anatomical outcomes by reducing subretinal fluid and pigment epithelial detachment. However, adverse events such as intraocular inflammation were observed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yukihisa Suzuki, Motohiro Kiyosawa
Summary: This study examined the relationship between diabetic retinopathy (DR) and systemic factors in 261 patients with type 2 diabetes. Logistic regression analyses revealed that the duration of diabetes, average and highest HbA1c levels, and grade of diabetic nephropathy (DN) significantly correlated with the development of DR. Additionally, the severity of DR was significantly correlated with the duration of diabetes, average HbA1c level, and severity of DN. Logistic regression analyses also showed a significant correlation between the development of diabetic macular edema (DME) and the grade of DN. DN grade is associated with the development of DR and DME, and decreased renal function predicts the onset of DR.
Review
Biochemistry & Molecular Biology
Cameron D. Haydinger, Genevieve F. Oliver, Liam M. Ashander, Justine R. Smith
Summary: Diabetic retinopathy is a retinal disease associated with hyperglycemia in diabetes patients, affecting both the central and peripheral retina. Its major mechanism involves oxidative stress caused by elevated production of reactive oxygen species, which is particularly harmful to the retina due to its high metabolic activity. This review provides an overview of the role of oxidative stress in diabetic retinopathy, including the formation and effects of advanced glycation end-products, metabolic memory, and non-coding RNA, as well as potential therapeutic strategies.
Article
Multidisciplinary Sciences
Xi Yao, Xiaoting Pei, Yingrui Yang, Hongmei Zhang, Mengting Xia, Ranran Huang, Yuming Wang, Zhijie Li
Summary: The study found that different age, region, disease duration, and DR severity could affect the prevalence and association rules of eye diseases in diabetic patients. Patients in rural areas and older age groups are more likely to develop eye diseases, and those with multiple eye diseases concurrently have a higher risk.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Abdulrahman Al-Barki, Lamia Al-Hijji, Robin High, Patrik Schatz, Diana Do, Quan D. Nguyen, Jeffrey K. Luttrull, Igor Kozak
Summary: The study aimed to compare the anatomical and functional outcomes of short-pulse continuous wavelength and infrared micropulse lasers in the treatment of diabetic macular edema (DME). The results suggest that the infrared micropulse system may improve functional outcomes, while the short-pulse system may lead to temporary reduction in edema. The study concludes that the two laser therapy methods have some differences in treating DME.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Svenja Deuchler, Ralf Schubert, Pankaj Singh, Adonis Chedid, Natallia Brui, Ninel Kenikstul, Thomas Kohnen, Hanns Ackermann, Frank Koch
Summary: This study aimed to sample vitreous fluid from patients with diabetic retinopathy (DR) to assess the expression of growth and inflammatory factors (GIF). The results showed that the expression of CD54, IL-8, and PIGF was significantly higher in patients with proliferative DR compared to those with non-proliferative DR, suggesting their potential importance in defining and monitoring the effectiveness of patient therapy.
Review
Biochemistry & Molecular Biology
Hidetaka Noma, Kanako Yasuda, Masahiko Shimura
Summary: Diabetic macular edema (DME) is a critical complication of diabetic retinopathy that can be effectively treated with intraocular anti-VEGF agents, although some patients may experience recurrence or resistance to treatment, suggesting the involvement of other factors. Research has also explored the potential role of cytokines and inflammatory mediators in DME, providing insights for novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Barbara Sabal, Slawomir Teper, Edward Wylegala
Summary: Diabetic macular edema (DME) is a common cause of visual impairment and subthreshold micropulse laser treatment shows promise as an alternative therapy. Micropulse laser selectively targets the retinal pigment epithelium, offering a safe and effective treatment for mild and moderate macular edemas. This paper reviews the safety and application of micropulse lasers in comparison to other standard treatments for DME.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Huiling Tan, Xin Wang, Kaiyou Ye, Jianmin Lin, E. Song, Lihua Gong
Summary: This study investigated the prevalence and risk factors of diabetic retinopathy (DR) in a Chinese population with type 2 diabetes mellitus (T2DM) in Qingpu, Shanghai. The prevalence of DR was 10.1%, with non-proliferative DR being more common. Higher fasting plasma glucose and glycated hemoglobinA1c were identified as known risk factors for DR, while no association was found between lipid indicators and DR. Additionally, higher levels of urea nitrogen and urinary albumin were associated with an increased risk of DR.
Review
Nutrition & Dietetics
Janika Shah, Zi Yu Cheong, Bingyao Tan, Damon Wong, Xinyu Liu, Jacqueline Chua
Summary: This systematic review comprehensively summarizes the current understanding of the associations between dietary consumption, diabetic retinopathy (DR), and diabetic macular edema (DME). The review found that higher intakes of fruits, vegetables, dietary fibers, fish, a Mediterranean diet, oleic acid, and tea were protective against DR, while high intakes of diet soda, caloric intake, rice, and choline were associated with a higher risk of DR. There was no association between vitamin C, riboflavin, vitamin D, milk, and DR. A single study assessed dietary intake and DME, and found a risk of high sodium intake for DME progression.
Article
Ophthalmology
Marc Figueras-Roca, Jessica Matas, Victor Llorens, Anna Sala-Puigdollers, Manuel Navarro, Javier Zarranz-Ventura, Alfredo Adan, Blanca Molins
Summary: This study found that serum IL-6 and IL-8 levels in peripheral blood are associated with the severity of diabetic macular edema (DME) and uveitic macular edema (UME) respectively. IL-8 appears to be independently correlated with central macular thickness and macular volume in UME cases. Such systemic implications could enhance personalized diagnostic and therapeutic approaches for DME and UME.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Riccardo Sacconi, Enrico Borrelli, Siva Balasubramanian, Giovanna Vella, Marco Battista, Kiran Kumar Vupparaboina, Jay Chhablani, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to investigate the choroidal vascularity index (CVI) in patients with leptochoroid. The results showed that the choroidal vascular and stromal components in eyes with leptochoroid secondary to reticular pseudodrusen (RPD) and high-myopia exhibited different changes. The impairment of the vascular area in RPD eyes might contribute to the lower development of RPD in patients with high myopia.
Article
Ophthalmology
Alessandro Arrigo, Maurizio Battaglia Parodi, Emanuela Aragona, Adelaide Pina, Francesca Calcagno, Francesco Bandello, Robert E. MacLaren
Summary: The diagnostic role of the external limiting membrane (ELM) in choroideremia (CHM) was explored in this study. It was found that ELM thickness and reflectivity were correlated with outer retinal atrophy progression and choriocapillaris status. Therefore, ELM can be considered as a useful imaging biomarker in CHM.
Article
Ophthalmology
Vittorio Capuano, Paolo Forte, Riccardo Sacconi, Alexandra Miere, Carl-Joe Mehanna, Caterina Barone, Francesco Bandello, Eric H. Souied, Giuseppe Querques
Summary: This study reports two cases in European countries where Acute Macular Neuroretinopathy (AMN) presented as the initial stage of SARS-CoV-2 infection during the third wave of the pandemic. The cases were characterized by sudden onset of paracentral scotoma without systemic symptoms. Structural OCT revealed multifocal retinal hyperreflective infarctions, and OCT-Angiography confirmed the diagnosis by showing hypoperfusion of the deep capillary plexus corresponding to the hyperreflective lesions visible on structural OCT.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Matias Iglicki, Marina Khoury, Javier Ignacio Melamud, Lucas Donato, Adiel Barak, Diego Jose Quispe, Dinah Zur, Anat Loewenstein
Summary: This study compares the effects of subretinal and intravitreal injections in the treatment of diabetic retinopathy, and finds that subretinal injections result in better improvement in visual acuity and central subfoveal thickness, with fewer anti-VEGF injections needed during follow-up.
Editorial Material
Ophthalmology
Ashish Sharma, Mineo Kondo, Chiharu Iwahashi, Nikulaa Parachuri, Nilesh Kumar, Francesco Bandello, Anat Loewenstein, Baruch D. Kuppermann
Review
Ophthalmology
Zheting Zhang, Sean Ng Ming Sheng, John H. Kempen, Claudia Fabiani, Atul Arora, Vishali Gupta, Edmund Tsui, Luca Cimino, Richard J. Symes, Jennifer Dell, Robert P. Finger, Carsten Heinz, Rupesh Agrawal
Summary: This review summarizes and compares current uveitis registries, emphasizing their importance in collecting patient data and improving understanding of uveitis.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Ophthalmology
Cen Amy Xie, Jayanti Singh, Mudit Tyagi, Sofia Androudi, Vivek Pravin Dave, Atul Arora, Vishali Gupta, Rupesh Agrawal, Helen Mi, Alok Sen
Summary: Endogenous endophthalmitis is a rare but potentially serious ocular infection with various symptoms such as conjunctival injection, ocular pain, and reduced visual acuity. The diagnosis can be challenging and delayed, leading to poor prognosis. Blood cultures and ocular fluid samples are helpful in identifying the causative pathogen(s), and treatment involves systemic and intravitreal antibiotic therapy, with the use of steroids being controversial. Surgical options include pars plana vitrectomy. Prognosis depends on host and pathogen factors, emphasizing the importance of early diagnosis and treatment.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Marina Montemagni, Alessandro Arrigo, Maurizio Battaglia Parodi, Lorenzo Bianco, Alessio Antropoli, Angela Malegori, Francesco Bandello, Fausto Tranfa, Ciro Costagliola
Summary: This study aimed to describe the OCTA characteristics of a patient with Bietti crystalline dystrophy (BCD). The results showed a significant reduction in vessel density in the atrophic areas of the retina, while the apparently preserved retina exhibited normal vessel density. Additionally, the area of atrophy in the retinal pigment epithelium (RPE) was larger than the area of atrophy in the choriocapillaris (CC).
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Silvia Maestroni, Arianna Belvedere, Ilaria Vigano, Cesare Meoni, Federico Di Matteo, Daniela Gabellini, Francesco Bandello, Luisa Pierro, Gianpaolo Zerbini
Summary: There is currently no effective medical treatment for diabetic retinopathy due to limited understanding of its pathogenesis. This study suggests that the early stages of diabetic retinopathy and glaucoma may share a similar neurodegenerative process, indicating potential common mechanisms. These findings are important for further research on the treatment and pathogenesis of diabetic retinopathy.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Ashish Sharma, Nilesh Kumar, Nikulaa Parachuri, Francesco Bandello, Baruch D. Kuppermann
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Editorial Material
Ophthalmology
Ashish Sharma, Arshad M. Khanani, Nikulaa Parachuri, Nilesh Kumar, Francesco Bandello, Baruch D. Kuppermann
INTERNATIONAL JOURNAL OF RETINA AND VITREOUS
(2023)
Editorial Material
Ophthalmology
Ashish Sharma, Anat Loewenstein, Nikulaa Parachuri, Nilesh Kumar, Alok Rasal, Francesco Bandello, Baruch D. Kuppermann
Article
Ophthalmology
Maria Vittoria Cicinelli, Claudia Gerosolima, Pierluigi Scandale, Sarah Touhami, Dominika Pohlmann, Audrey Giocanti, Amir Rosenblatt, Anat Loewenstein, Francesco Bandello, Elisabetta Miserocchi
Summary: This study aimed to investigate the clinical and SD-OCT biomarkers associated with pre- and post-injection visual acuity and the regression of macular edema (MO) following dexamethasone (DEX) implant injection in non-infectious uveitic (NIU) patients. The results showed that the integrity of the inner and outer retina was correlated with better visual response to DEX. Long-standing or recurrent MO was associated with reduced likelihood of both visual and anatomical response. Timely treatment is necessary to maximize the outcomes of MO in NIU patients.
Article
Ophthalmology
Lorenzo Bianco, Alessandro Arrigo, Alessio Antropoli, Maria Pia Manitto, Elisabetta Martina, Emanuela Aragona, Francesco Bandello, Maurizio Battaglia Parodi
Summary: This study investigated the correlation between genotypes and phenotypes in ABCA4-associated retinopathy. The results showed significant differences in disease severity among different genotypes. These findings are important for prognostication of patients and the design of future clinical trials.
JAMA OPHTHALMOLOGY
(2023)
Article
Nutrition & Dietetics
Damian Jaggi, Yasmin Solberg, Chantal Dysli, Joel Lincke, Oussama Habra, Adrian Wyss, Sebastian Wolf, Martin Zinkernagel
Summary: The aim of this study was to investigate the effect of oral lutein and zeaxanthin supplementation on FLIO signal in patients with early and intermediate age-related macular degeneration (AMD). The results showed that lutein and zeaxanthin supplementation can improve MPOD and decrease FLIO lifetimes in the foveal center, confirming the negative correlation between FLIO and MPOD.
CLINICAL NUTRITION ESPEN
(2023)
Editorial Material
Ophthalmology
David Cui, Ian J. Saldanha, Gavin Li, Priya M. Mathews, Michael X. Lin, Esen K. Akpek
Summary: This article reports on the heterogeneity in methodology of clinical trials submitted to the US Food and Drug Administration for approval of topical dry eye treatments. Multiple outcome measures were used in these trials, highlighting the need for standardized assessment tools to optimize the evaluation and comparison of therapeutic benefits.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Adanna Udeh, Dana Huh, Terri Young, O'rese Knight, Fasika Woreta
Summary: This study examines the rates and trends of faculty promotions within the field of ophthalmology, with a focus on the rates of promotion among underrepresented in medicine (URiM) faculty. The results show that Black faculty had lower promotion rates and were more likely to leave academic medicine, highlighting the need for strategies and policies to address equity in promotion rates and retention of URiM faculty in academic ophthalmology.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Ursula Greferath, Erica Fletcher, Judy Savige, Heather G. Mack
Summary: Retinal drusen are uncommon in IgA nephropathy, but they resemble drusen found in age-related macular degeneration. The IgA-staining deposits in the drusen are likely related to systemic deposition of IgA. The nature of cystic spaces in the drusen is still unknown. Further research on the retinas of people with glomerulonephritis is recommended.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Andrew Mihalache, Ryan S. Huang, Nikhil S. Patil, Marko M. Popovic, Ashwin Mallipatna, Peter J. Kertes, Rajeev H. Muni, Radha P. Kohly
Summary: This study examines sociodemographic predictors of poor vision in children and adolescents in the US. The findings suggest that factors such as affordability of medical care, public health insurance, age, and parental education level are associated with vision difficulty. Addressing these disparities through public health policies is crucial for achieving equity in vision health.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Johannes Birtel, Richard Caswell, Samantha R. De Silva, Philipp Herrmann, Salwah Rehman, Andrew J. Lotery, Omar A. Mahroo, Michel Michaelides, Andrew R. Webster, Robert E. Maclaren, Peter Charbel Issa
Summary: The study investigated the phenotype, variability, and penetrance of IMPG2-related maculopathy. The results showed that mono-allelic IMPG2 variants could result in haploinsufficiency manifesting as a maculopathy with variable penetrance and expressivity. Family members of patients with IMPG2-related retinitis pigmentosa may also present with vitelliform lesions. The maculopathy is usually limited to the fovea and is associated with moderate visual impairment.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Colas Nils Authie, Mylene Poujade, Alireza Talebi, Alexis Defer, Ariel Zenouda, Cecilia Coen, Saddek Mohand-Said, Philippe Chaumet-Riffaud, Isabelle Audo, Jose-Alain Sahel
Summary: MOST has been validated as a reliable mobility test for measuring the movement ability of patients with vision impairments in both real and virtual environments.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Maria Krisch, Jordan Ueberroth, Neha Gupta, Stephen Merriam, Mark p. Breazzano
Summary: Orbeez-related ocular trauma can lead to severe visual morbidity and various intraocular sequelae. Adolescents may be at higher risk for posterior segment complications. Elevated IOP and hyphema at initial presentation may indicate a need for more aggressive interventions.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Jaron Pruett, Kelly Ruland, Sean Donahue
Summary: The study aimed to validate or refute the hypothesis that infants with birthweight over 750 g and gestational age over 27 weeks, who did not have retinopathy of prematurity (ROP) at 37 weeks, would not develop treatable ROP. The findings of the study supported the termination of examination at 37 weeks in infants meeting these criteria, as the value of continued screening was minimal.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Emily Sun, Jing Tian, Loaah Eltemsah, Divya Srikumaran, Grace Sun, Jessica Chow, Fasika Woreta
Summary: This study aims to evaluate the research productivity of ophthalmology residency applicants and identify differences in productivity based on gender and race. The findings reveal that women have similar or higher research outputs compared to men, while self-identified underrepresented in medicine (URiM) students have lower research outputs in ophthalmology. Therefore, greater mentorship and support for URiM students are needed to promote the recruitment of diverse trainees in ophthalmology programs.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)
Article
Ophthalmology
Isaac A. Bernstein, Ann Caroline Fisher, Kuldev Singh, Sophia Y. Wang
Summary: This study aims to investigate the association between visual field loss and frailty in a nationally representative cohort of US adults.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2024)