Heritable disorders of oxygen sensing

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancer

(2020) Ellen C. de Heer et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

Re-evaluation of hematocrit as a determinant of thrombotic risk in erythrocytosis

(2019) Victor R. Gordeuk et al.   HAEMATOLOGICA

Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis

(2019) Nan Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis

(2019) Nan Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIF-1α is required for development of the sympathetic nervous system

(2019) Romana Bohuslavova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients

(2019) Kevin D Courtney et al.   CLINICAL CANCER RESEARCH

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

(2018) Kevin D. Courtney et al.   JOURNAL OF CLINICAL ONCOLOGY

A Gain-of-Function Mutation in EPO in Familial Erythrocytosis

(2018) Jakub Zmajkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Formation of Renal Cysts and Tumors inVhl/Trp53-Deficient Mice Requires HIF1α and HIF2α

(2016) Désirée Schönenberger et al.   CANCER RESEARCH

A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma

(2016) Eli M. Wallace et al.   CANCER RESEARCH

Genetic Evidence of a Precisely Tuned Dysregulation in the Hypoxia Signaling Pathway during Oncogenesis

(2014) S. Couve et al.   CANCER RESEARCH

The homozygousVHLD126Nmissense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension

(2014) Susmita Sarangi et al.   PEDIATRIC BLOOD & CANCER

Activation of HIF2  in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but not Tumorigenesis

(2013) L. Fu et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1 

(2011) L. Fu et al.   CANCER RESEARCH

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Genetic and Functional Studies Implicate HIF1  as a 14q Kidney Cancer Suppressor Gene

(2011) C. Shen et al.   Cancer Discovery

Novel exon 12 mutations in the HIF2A gene associated with erythrocytosis

(2008) M. J. Percy et al.   BLOOD

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

PHD2Mutation and Congenital Erythrocytosis with Paraganglioma

(2008) Charline Ladroue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE