Article
Nutrition & Dietetics
Kaiqing Liu, Xin Liu, Yaqin Deng, Zesong Li, Aifa Tang
Summary: Adipose tissue is a potential target for the treatment of metabolic illnesses, and understanding the roles of circular RNAs (circRNAs) in brown adipose tissue (BAT) and white adipose tissue (WAT) can provide insights into lipid metabolism. In this study, circRNA expression profiling of mouse BAT and WAT revealed differentially expressed circRNAs that are associated with mitochondria and are involved in thermogenesis and lipid metabolism pathways. Furthermore, a novel circRNA circOgdh was discovered to be highly expressed in BAT and to have regulatory effects on lipolysis and lipid droplet accumulation.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Zhengyan Zhang, Di Yang, Junwei Xiang, Jingwen Zhou, Hua Cao, Qishi Che, Yan Bai, Jiao Guo, Zhengquan Su
Summary: Thermogenic organs in mammals play a crucial role in increasing heat production and energy regulation. Targeting specific signalling pathways to enhance energy expenditure via brown adipose tissue may be a potential strategy for treating obesity and related diseases. Studies have shown that various natural products can promote thermogenesis through different signalling pathways, offering potential for future research on weight-loss nutraceuticals or drugs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Review
Endocrinology & Metabolism
Yali Zheng, Ni Yang, Yueshan Pang, Yanju Gong, Hong Yang, Weijun Ding, Hongya Yang
Summary: A systematic review analysis was conducted to evaluate the role of mitochondria in adipose tissue regulation and the potential use of mitochondrial pathway intervention in obesity. Three databases were searched for relevant literature, and 82 papers were included in the review. The findings suggest that mitochondria play a crucial role in adipose tissue metabolism and energy homeostasis and may serve as therapeutic agents for obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Karla J. Suchacki, Roland H. Stimson
Summary: The recent discovery of brown adipose tissue in adult humans offers a new strategy to treat obesity and associated metabolic diseases by increasing energy expenditure. Brown adipose tissue acts as a thermogenic organ that improves insulin sensitivity and lipid clearance, highlighting its beneficial role in metabolic health. Exercise, dietary macronutrients, and bioactive compounds can impact brown adipose tissue activity, and dietary interventions may represent a nonpharmacological means to enhance brown adipose tissue mass and activity for weight loss and improved metabolic health.
Article
Endocrinology & Metabolism
Alana Deutsch, Kosaku Shinoda
Summary: Studies have shown that prolonged exposure to cold can increase the thermogenic capacity of brown adipose tissue through the recruitment of new brown adipocytes. Shamsi et al. and Angueira et al. have identified novel cellular origins of cold-induced brown adipocytes and elucidated the molecular mechanism regulating the expansion of brown adipose tissue.
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Rajan Singh, Albert Barrios, Golnaz Dirakvand, Shehla Pervin
Summary: Obesity-related metabolic abnormalities affect over 650 million people globally, with various treatment approaches proving ineffective in reducing prevalence rates. Brown adipose tissue (BAT) may serve as a promising therapeutic target for obesity, enhancing energy expenditure and potentially reducing incidence of metabolic diseases.
Article
Biotechnology & Applied Microbiology
Xin Liu, Yuehua Zhu, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Jiaxue Cao, Li Li, Hongping Zhang, Linjie Wang
Summary: This study provides a detailed landscape of miRNA expression in goat brown adipose tissue (BAT) and white adipose tissue (WAT). It is found that miR-433 acts as a negative regulator in controlling brown adipocyte differentiation and thermogenesis in goats.
Article
Biochemistry & Molecular Biology
Takuya Sakurai, Toshiyuki Fukutomi, Sachiko Yamamoto, Eriko Nozaki, Takako Kizaki
Summary: The study found that the abnormal expression of fluid factors in the BAT of obese mice can be alleviated through physical activity, and Lgals3 and Lgals3bp may be involved in brown adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tamara Camino, Nerea Lago-Baameiro, Aurelio Sueiro, Susana Belen Bravo, Ivan Couto, Francisco Fernando Santos, Javier Baltar, Felipe F. Casanueva, Maria Pardo
Summary: Brown adipose tissue extracellular vesicles (EVs) play an important role in promoting energy expenditure and could potentially serve as biomarkers of thermogenesis activity. This study isolated EVs from lean and obese rats and found that the protein cargo of BAT EVs is affected by metabolic status and contains potential obesity biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tingting Jiang, Duo Su, Xin Liu, Yan Wang, Linjie Wang
Summary: This study found that FGF11 is enriched in brown adipose tissue of goats and promotes differentiation and thermogenesis in brown adipocytes by promoting UCP1 gene expression through EBF2 binding to the UCP1 promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Gisela Geoghegan, Judith Simcox
Summary: Body temperature regulation plays a crucial role in maintaining glucose homeostasis. In a recent study published in Cell, Meng et al. identified a regulatory pathway in which light activates retinal ganglion cells to inhibit thermogenesis in brown adipose tissue, leading to impaired glucose homeostasis. This finding provides an explanation for the metabolic effects of chronic exposure to light.
Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Shinsuke Nirengi, Kristin Stanford
Summary: Aging is a significant risk factor for type 2 diabetes and cardiovascular disease, while regular physical activity can help delay, prevent, or manage the onset and development of various chronic diseases in older adults. Brown adipose tissue (BAT) is thermogenic and protects against age-related diseases, but its activity decreases with age. This review discusses how aging impairs BAT function by inducing whitening and altering signaling pathways, gene expression, and mitochondrial function, as well as potential mechanisms for exercise to counteract these effects.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Sport Sciences
Andrea Mendez-Gutierrez, Concepcion M. Aguilera, Francisco J. Osuna-Prieto, Borja Martinez-Tellez, Ma Cruz Rico Prados, Francisco M. Acosta, Jose M. Llamas-Elvira, Jonatan R. Ruiz, Guillermo Sanchez-Delgado
Summary: This study analyzed the acute and chronic effects of exercise on the circulating concentrations of exerkines in humans. The results showed that acute endurance exercise releases exerkines that regulate BAT metabolism and WAT browning, while low-intensity resistance exercise and long-term training programs did not significantly alter plasma levels of these molecules.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Lidia Robles-Gonzalez, Millan Aguilar-Navarro, Alvaro Lopez-Samanes, Carlos Ruiz-Moreno, Alejandro Munoz, David Varillas-Delgado, Jorge Gutierrez-Hellin, Jorn W. Helge, Jonatan R. Ruiz, Francisco J. Amaro-Gahete
Summary: This study found that maximal fat oxidation and the intensity that elicits it remain consistent throughout the day in healthy women, regardless of the time of exercise testing. These results have clinical relevance in understanding the differences between men and women in terms of fat oxidation during exercise.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Nutrition & Dietetics
Juan M. A. Alcantara, Guillermo Sanchez-Delgado, Lucas Jurado-Fasoli, Jose E. Galgani, Idoia Labayen, Jonatan R. Ruiz
Summary: The purpose of this study was to evaluate the day-to-day reproducibility of energy expenditure and respiratory exchange ratio (RER) in response to an oral glucose tolerance test (OGTT), and investigate the effect of a simulation-based postcalorimetric correction on day-to-day reproducibility. The results showed that while the RER and EE had good reproducibility in different periods, the reproducibility of the areas under the curve for RER and EE were relatively low. Furthermore, the postcalorimetric correction procedure did not improve day-to-day reproducibility.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Pediatrics
Francisco Javier Ruiz-Ojeda, Augusto Anguita-Ruiz, Maria C. Rico, Rosaura Leis, Gloria Bueno, Luis A. Moreno, Mercedes Gil-Campos, Angel Gil, Concepcion M. Aguilera
Summary: This study aimed to evaluate the association between serum levels of the novel insulin-like adipokine isthmin-1 (ISM1) and obesity-related phenotypes in Spanish children, as well as investigate the molecular alterations behind the alteration of ISM1 levels in children with obesity. The results showed that boys with obesity had higher serum ISM1 levels compared to normal weight and overweight boys. ISM1 levels were positively associated with BMI Z-score and fat mass in boys, and negatively associated with myeloperoxidase (MPO). Although no associations were found in girls, fat mass was positively associated with ISM1 levels in all children. DNA methylation levels of two CpG sites in ISM1 were associated with serum levels of ISM1 in children. In conclusion, ISM1 is associated with obesity in boys during puberty and may serve as a biomarker of obesity in children.
WORLD JOURNAL OF PEDIATRICS
(2023)
Article
Biology
Mireia Bustos-Aibar, Concepcion M. Aguilera, Jesus Alcala-Fdez, Francisco J. Ruiz-Ojeda, Julio Plaza-Diaz, Abel Plaza-Florido, Ines Tofe, Mercedes Gil-Campos, Maria J. Gacto, Augusto Anguita-Ruiz
Summary: This study unveils the gene expression architecture of visceral adipose tissue and skeletal muscle tissue in Spanish boys with obesity. Gene co-expression signatures associated with obesity and cardiovascular risk were identified in both tissues, some of which exceeded multiple-test correction filters. The central hub genes identified in this study could serve as potential novel molecular targets for personalized treatment.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Julio Plaza-Diaz, Francisco Javier Ruiz-Ojeda, Javier Morales, Rafael Martin-Masot, Eric Climent, Angela Silva, Juan F. Martinez-Blanch, Maria Enrique, Marta Tortajada, Daniel Ramon, Beatriz Alvarez, Empar Chenoll, Angel Gil
Summary: The World Health Organization recommends exclusive breastfeeding on demand until at least the sixth month of life. Breast milk or infant formula is the infant's primary food source until the age of one year, followed by the gradual introduction of other foods. This study aimed to determine whether a novel starting formula provides gut microbiota compositions more similar to those of breastfed infants from 6 to 12 months of age compared to a standard formula.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Andres Baena-Raya, David M. Diez-Fernandez, Amador Garcia-Ramos, Borja Martinez-Tellez, Daniel Boullosa, Alberto Soriano-Maldonado, Manuel A. Rodriguez-Perez
Summary: This study aimed to evaluate the acute effects of different interrepetition rest full-squat protocols on counter-movement jump (CMJ) height, velocity loss (VL), and skin temperature (Tsk), and determine their relationship with individual strength level. The results showed that different protocols may affect velocity and power loss, but result in a similar decrease in Tsk and CMJ height, which may be influenced more by individual strength level than VL or changes in Tsk.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Pharmacology & Pharmacy
Isaac A. Chavez-Guevara, Francisco J. Amaro-Gahete, Francisco J. Osuna-Prieto, Idoia Labayen, Concepcion M. Aguilera, Jonatan R. Ruiz
Summary: Sex differences exist in fat oxidation and adipokines levels, with women having higher levels. However, insulin resistance is similar between sexes.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Computer Science, Theory & Methods
Carmen Biedma-Rdguez, Maria Jose Gacto, Augusto Anguita-Ruiz, Rafael Alcala, Concepcion Maria Aguilera, Jesus Alcala-Fdez
Summary: Nowadays, there is an increasing demand for transparency in Artificial Intelligence models to understand their decision-making process and potential impact on human life and health. Fuzzy Rule-Based Classification Systems have been effectively used due to their easy interpretability. However, complex search spaces hinder the learning process and lead to complexity issues. Therefore, a fuzzy associative classification method is proposed to achieve a better balance between accuracy and complexity.
FUZZY SETS AND SYSTEMS
(2023)
Article
Nutrition & Dietetics
Maria Jose Arias-Tellez, Francisco M. Acosta, Elisa Merchan-Ramirez, Borja Martinez-Tellez, Guillermo-Sanchez Delgado, Jose M. Llamas-Elvira, Jonatan R. Ruiz
Summary: This study examined the effects of a 24-week concurrent exercise intervention on neck adipose tissue (NAT) and neck circumference in young adults, and the relationship between these changes and body composition, cardiometabolic risk (CMR), and inflammation. The intervention did not reduce total NAT volume, but did slightly reduce neck circumference in the vigorous-intensity exercise group.
INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
(2023)
Review
Nutrition & Dietetics
Cristina Diez-Arroyo, Monica Garcia-Garcia, Maria Jose Soto-Mendez, Esther Molina-Montes, Mercedes Gil-Campos, Angel Gil, Miriam Gutierrez-Jimeno, Angela Hernandez-Ruiz
Summary: Epilepsy is a common neurological disorder in childhood, and despite antiepileptic drugs being the preferred treatment, a significant number of children continue to experience seizures. This review examines the use of a ketogenic diet (KD) as an alternative treatment for refractory epilepsy in children.
Article
Endocrinology & Metabolism
Xinyu Di, Borja Martinez-Tellez, Elke H. J. Krekels, Lucas Jurado-Fasoli, Francisco J. Osuna-Prieto, Lourdes Ortiz-Alvarez, Thomas Hankemeier, Patrick C. N. Rensen, Jonatan R. Ruiz, Isabelle Kohler
Summary: The plasma levels of eCBs and their analogues are associated with higher adiposity and worse cardiometabolic profile.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
