Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

Declining lamin B1 expression mediates age-dependent decreases of hippocampal stem cell activity

(2021) Muhammad Khadeesh bin Imtiaz et al.   Cell Stem Cell

Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice

(2020) Matthew J. Yousefzadeh et al.   AGING CELL

Differential annualized rates of hippocampal subfields atrophy in aging and future Alzheimer's clinical syndrome

(2020) Louis Nadal et al.   NEUROBIOLOGY OF AGING

Astrocyte senescence promotes glutamate toxicity in cortical neurons

(2020) Chandani Limbad et al.   PLoS One

Cellular Senescence in Neurodegenerative Diseases

(2020) Carmen Martínez-Cué et al.   Frontiers in Cellular Neuroscience

No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience

(2020) Francisco Pestana et al.   Brain Sciences

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Selective Neuronal Vulnerability in Alzheimer’s Disease: A Network-Based Analysis

(2020) Jean-Pierre Roussarie et al.   NEURON

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

(2020) Lilianne Barbar et al.   NEURON

Interleukin-1β Drives Cellular Senescence of Rat Astrocytes Induced by Oligomerized Amyloid β Peptide and Oxidative Stress

(2020) Dongsheng Shang et al.   Frontiers in Neurology

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Radiation-induced astrocyte senescence is rescued by Δ133p53

(2019) Casmir Turnquist et al.   NEURO-ONCOLOGY

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia

(2019) Francesco Paonessa et al.   Cell Reports

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis

(2019) Nayuta Saito et al.   JOURNAL OF IMMUNOLOGY

Astrocyte senescence: Evidence and significance

(2019) Justin Cohen et al.   AGING CELL

Cell‐type‐specific role of lamin‐B1 in thymus development and its inflammation‐driven reduction in thymus aging

(2019) Sibiao Yue et al.   AGING CELL

α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF ‐β1 signaling in a Parkinson's disease model

(2019) Luan Pereira Diniz et al.   JOURNAL OF NEUROCHEMISTRY

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

(2019) Peisu Zhang et al.   NATURE NEUROSCIENCE

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

TGF-β Signaling in Cellular Senescence and Aging-Related Pathology

(2019) Kana Tominaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation

(2018) Yanan Zhang et al.   Nature Communications

Astrocytes’ Contribution to Adult Neurogenesis in Physiology and Alzheimer’s Disease

(2018) Frédéric Cassé et al.   Frontiers in Cellular Neuroscience

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

(2017) Luan Pereira Diniz et al.   JOURNAL OF NEUROSCIENCE

Loss of lamin B1 is a biomarker to quantify cellular senescence in photoaged skin

(2017) Audrey Shimei Wang et al.   Scientific Reports

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Flavonoid Hesperidin Induces Synapse Formation and Improves Memory Performance through the Astrocytic TGF-β1

(2017) Isadora Matias et al.   Frontiers in Aging Neuroscience

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies

(2016) Bess Frost et al.   CURRENT BIOLOGY

Hippocampal Astrocyte Cultures from Adult and Aged Rats Reproduce Changes in Glial Functionality Observed in the Aging Brain

(2016) Bruna Bellaver et al.   MOLECULAR NEUROBIOLOGY

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

(2016) Lana M. Osborn et al.   PROGRESS IN NEUROBIOLOGY

Long-term Neuroglial Cocultures as a Brain Aging Model: Hallmarks of Senescence, MicroRNA Expression Profiles, and Comparison With In Vivo Models

(2015) Elisabetta Bigagli et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Astrocytes from adult Wistar rats aged in vitro show changes in glial functions

(2015) Débora Guerini Souza et al.   NEUROCHEMISTRY INTERNATIONAL

Concentration-dependent lamin assembly and its roles in the localization of other nuclear proteins

(2014) Yuxuan Guo et al.   MOLECULAR BIOLOGY OF THE CELL

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isolation of Neural Progenitor Cells From the Human Adult Subventricular Zone Based on Expression of the Cell Surface Marker CD271

(2014) Miriam E. van Strien et al.   Stem Cells Translational Medicine

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Lamins at a glance

(2012) C. Y. Ho et al.   JOURNAL OF CELL SCIENCE

Lamin B1 loss is a senescence-associated biomarker

(2012) Adam Freund et al.   MOLECULAR BIOLOGY OF THE CELL

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Long-Term Culture of Astrocytes Attenuates the Readily Releasable Pool of Synaptic Vesicles

(2012) Hiroyuki Kawano et al.   PLoS One

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype

(2011) Antero Salminen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

A pathophysiological framework of hippocampal dysfunction in ageing and disease

(2011) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE