Electrochemically Mediated Direct C(sp3)-H Sulfonylation of Xanthene Derivatives

The construction of C(sp(3))-sulfonyl bonds through direct sulfonylation of C(sp(3))-H bond presents a number of challenges, so an electrochemical oxidation-induced direct sulfonylation of the xanthene C(sp(3))-H bond was developed. Significant advantages of this method are high atom efficiency, functional group tolerance, transition metal- and oxidant-free conditions. The in vitro cytotoxicity of all product is evaluated by MTT assay against human cancer cell lines. The results reveal that most of the compounds 3 da and 3 af have good inhibitory activity on tumor cell lines.

Automated summary

A new method was developed for the construction of C(sp(3))-sulfonyl bonds through electrochemical oxidation-induced direct sulfonylation of the xanthene C(sp(3))-H bond. In vitro evaluation showed that most of the compounds exhibit good inhibitory activity against human cancer cell lines.