Article
Cardiac & Cardiovascular Systems
Annika Hess, Tobias Borchert, Tobias L. Ross, Frank M. Bengel, James T. Thackeray
Summary: This study utilized molecular imaging to evaluate the immune response and cardiac healing following myocardial infarction (MI) and found that suppression of macrophages resulted in a prolonged inflammatory response and adverse outcomes.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Mathematics, Applied
Barbara Katharina Geist, Helmut Neufeld
Summary: By employing the continuity equation and linear response theory, efficient mathematical tools were developed for analyzing dynamic PET data. The approach allows for a probabilistic description of tracer particle fate in any organ and extraction of detailed information on underlying physiological processes' chronology. The study illustrated the procedure by applying it to renal data obtained from a PET/MRI scan using a sugar analogue radio tracer.
APPLIED MATHEMATICS AND COMPUTATION
(2021)
Article
Oncology
Julian L. Goggi, Shivashankar Khanapur, Boominathan Ramasamy, Siddesh V. Hartimath, Tang Jun Rong, Peter Cheng, Yun Xuan Tan, Xin Yi Yeo, Sangyong Jung, Stephanie Shee Min Goay, Seow Theng Ong, You Yi Hwang, K. George Chandy, Edward G. Robins
Summary: This study developed a new Kv1.3 targeting radiopharmaceutical that successfully predicted the response to immune checkpoint inhibitors in a murine model of colon cancer.
Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Editorial Material
Oncology
Hannah M. Linden, David A. Mankoff
Summary: [F-18]fluoroestradiol (FES) PET is an FDA-approved imaging biomarker that predicts clinical benefit of endocrine therapy and measures target activity in drug development. A recent study showed that tumor heterogeneity of expression predicts clinical benefit, and serial FES monitoring can assess estrogen receptor blockade and posttreatment release.
CLINICAL CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yongxing Jiang, Jingxue Fan, Yong Li, Guodong Wu, Yuanqi Wang, Jiemei Yang, Mengjiao Wang, Zhengyu Cao, Qiannan Li, Hui Wang, Zhengyan Zhang, Yu Wang, Bicheng Li, Fengyu Sun, Haiyu Zhang, Zhiguo Zhang, Kang Li, Ye Tian
Summary: Sonodynamic therapy significantly decreased plaque inflammation and improved walking performance among symptomatic PAD patients, showing potential and efficacy.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christophe van de Wiele, Sezgin Ustmert, Bart De Spiegeleer, Pieter-Jan De Jonghe, Mike Sathekge, Maes Alex
Summary: Various potential PET-apoptosis imaging radiopharmaceuticals have been developed to assess the response to cancer treatment. Some of these radiopharmaceuticals showed enhanced uptake in xenografted tumors in mice, but to varying degrees. Two validated radioligands showed favorable characteristics in healthy individuals, but did not significantly affect bone marrow. Further research is needed to evaluate the clinical value of these radiopharmaceuticals for apoptosis imaging in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Shiyong Li, Ye Wang, Miaojin Wu, Muhsin H. Younis, Aeli P. Olson, Todd E. Barnhart, Jonathan W. Engle, Xingen Zhu, Weibo Cai
Summary: This study found that glabridin-loaded nanoparticles can regulate M-o/M-phi polarization, reduce inflammatory damage, protect neurons, and improve nervous system function. Spleen-targeted nanoparticles have a protective effect against cerebral ischemia-reperfusion injury.
ADVANCED MATERIALS
(2022)
Review
Neurosciences
Aleksi Kokkonen, Emma A. Honkanen, Daniel T. Corp, Juho Joutsa
Summary: Deep brain stimulation (DBS) is an effective treatment for various brain disorders, but its mechanisms of action and detailed molecular effects still need further investigation.
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Caiting Deng, Meichen Zheng, Shupeng Han, Yuanjie Wang, Jingqi Xin, Omer Aras, Liang Cheng, Feifei An
Summary: Sonodynamic therapy (SDT) is a promising cancer therapy that uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS) with excellent tissue penetration depth. However, the spread of the sonosensitizer to healthy tissue beyond the tumor can cause undesired side effects. In this study, a GSH-activatable sonosensitizer prodrug is designed by attaching a quencher to tetraphydroxy porphyrin, which shows high tumor selectivity and activation in the presence of overexpressed GSH. The prodrug demonstrates effective tumor growth inhibition under ultrasound irradiation, highlighting its potential as a highly effective cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Julian L. Goggi, Siddesh V. Hartimath, Shivashankar Khanapur, Boominathan Ramasamy, Zan Feng Chin, Peter Cheng, Hui Xian Chin, You Yi Hwang, Edward G. Robins
Summary: Studies suggest that using metformin as an adjuvant therapy can enhance the immunological memory response in cancer treatment with immune checkpoint inhibitors (ICI). However, some combination therapies may exacerbate the immune response and lead to adverse immune-related events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Zi Fu, Zhuang Liu, Jiaxing Wang, Lianfu Deng, Han Wang, Wei Tang, Dalong Ni
Summary: Researchers have developed hafnium-based nanoscale metal-organic frameworks (Hf-nMOFs) loaded with 3-bromopyruvate (3-BrPA) to overcome resistance to radiation therapy and improve its effectiveness. The Hf-nMOFs enhance the deposition of X-rays, leading to stronger DNA damage, while the loaded 3-BrPA reduces energy supply and interferes with protein biosynthesis, decreasing DNA damage repair. This strategy enhances the curative effect of radiation therapy and provides new perspectives on cancer treatment by reducing radiation doses.
Article
Chemistry, Physical
Yongzhou Lu, Chuanlong Jia, Chengchen Gong, Han Wang, Qin Xiao, Jinxiao Guo, Dalong Ni, Nan Xu
Summary: Delayed or non-healing wounds have a significant impact on patients' quality of life and pose a financial burden on public health systems worldwide. A hydrogel containing low-valence-state molybdenum nanomaterials has been developed to scavenge reactive oxygen species (ROS) and promote wound healing. In vitro and in vivo studies have shown that this novel Mo hydrogel accelerates wound healing, stimulates angiogenesis, and enhances growth factor expression. Due to the essentiality of molybdenum in all organisms, this Mo hydrogel holds great potential for clinical translation in wound healing applications.
Article
Engineering, Biomedical
Hao Wei, Dawei Jiang, Bo Yu, Dalong Ni, Mengting Li, Yin Long, Paul A. Ellison, Cerise M. Siamof, Liang Cheng, Todd E. Barnhart, Hyung-Jun Im, Faquan Yu, Xiaoli Lan, Xiaohua Zhu, Qianjun He, Weibo Cai
Summary: A series of controllable PVP-curcumin nanoparticles are designed for efficient treatment of acute kidney injury, enabling precise PET image-guided drug delivery.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Zi Fu, Kun Li, Han Wang, Yuhan Li, Jian Zhang, Jingwei Zhou, Jiajia Hu, Dong Xie, Dalong Ni
Summary: Osteosarcoma is an aggressive bone tumor commonly found in children and adolescents. Dual-energy CT (DECT) is a promising tool for accurately detecting and guiding the treatment of osteosarcoma. In this study, BiOI nanosheets were synthesized as a superior DECT contrast agent compared to iodine agents for clinical detection of osteosarcoma. In addition, the synthesized BiOI nanosheets demonstrated good biocompatibility and enhanced X-ray dose deposition at the tumor site, leading to DNA damage and inhibition of tumor growth. This research offers a promising new avenue for DECT imaging-guided treatment of osteosarcoma.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
Yuhan Li, Xiaoxue Tan, Han Wang, Xiuru Ji, Zi Fu, Kai Zhang, Weijie Su, Jian Zhang, Dalong Ni
Summary: This study proposes a strategy using dual-energy CT imaging-guided photothermal therapy (PTT) for the diagnosis and treatment of osteosarcoma (OS). By utilizing bismuth sulfide nanorods as contrast agents, the method provides high imaging performance and photothermal conversion rates. Real-time monitoring allows for precise control of the distribution of the nanomaterials in the tumor, avoiding damage to normal tissues.
Article
Multidisciplinary Sciences
Haoyi Chen, Tianwen Ye, Fangqiong Hu, Kaizhe Chen, Bin Li, Minglong Qiu, Zhijie Chen, Yao Sun, Wenkai Ye, Han Wang, Dalong Ni, Lei Guo
Summary: Osteoarthritis (OA) is a common degenerative joint disease, and gene therapy using microRNAs (miRNAs) shows potential for its treatment. However, poor cellular uptake and stability limit the effects of miRNAs. In this study, a miRNA called microRNA-224-5p (miR-224-5p) was identified from clinical samples of OA patients, which can protect articular cartilage from degeneration. Urchin-like ceria nanoparticles (NPs) were synthesized to load miR-224-5p for enhanced gene therapy of OA. These NPs promote transfection of miR-224-5p and exhibit excellent scavenging of reactive oxygen species (ROS), thereby improving the microenvironment of OA. The combination of these NPs and miR-224-5p not only shows a favorable curative effect for OA but also provides a promising approach for translational medicine.
Article
Biotechnology & Applied Microbiology
Hongbo Gao, Li Sun, Dalong Ni, Libo Zhang, Han Wang, Wenbo Bu, Jinjin Li, Qianwen Shen, Ya Wang, Yanyan Liu, Xiangpeng Zheng
Summary: In radiation therapy, the cytotoxic effects of excited electrons generated from water radiolysis are often underestimated due to biochemical factors, especially recombination between electrons and hydroxyl radicals (& BULL;OH). We constructed WO3 nanocapacitors to store and release electrons, which effectively blocked the recombination and increased the yield of & BULL;OH during radiolysis. The discharged electrons from WO3 nanocapacitors resulted in NAD(+) consumption and impairment of NAD(+)-dependent DNA repair, thereby improving the radiotherapeutic effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Han Wang, Zi Fu, Xiuru Ji, Min Lu, Lianfu Deng, Zhuang Liu, Bo Yin, Dalong Ni
Summary: A simple and practical method using dimercaptosuccinic acid (DMSA) is developed to convert hydrophobic nanoparticles into hydrophilic ones. This method involves replacing the long-chain ligands with DMSA through the coordination abilities of sulphydryls and carboxyls. It widens the applications of hydrophobic nanoparticles and facilitates further modifications.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Jiayang Yan, Zhongmin Tang, Yanan Li, Han Wang, Jessica C. Hsu, Mengmeng Shi, Zi Fu, Xiuru Ji, Weibo Cai, Dalong Ni, Jieming Qu
Summary: This study developed molybdenum nanodots as a functional nanomaterial for the treatment of acute lung injury. Through scavenging reactive oxygen species and inhibiting inflammatory responses, the nanodots significantly improved the condition of mice with acute lung injury and protected lung tissues. The findings offer a promising therapeutic agent for patients suffering from acute respiratory disease syndrome.
Article
Materials Science, Biomaterials
Xiuru Ji, Lan Zhu, Jessica C. Hsu, Han Wang, Jingwei Zhou, Qingbing Wang, Yuhan Li, Weibo Cai, Dalong Ni, Zhiyuan Wu
Summary: A novel class of tungsten-based contrast agents (WO3-x NPs) with excellent biocompatibility and minimal systemic toxicity for DECT was designed and presented a promising method for the accurate diagnosis of liver cancer.
BIOMATERIALS SCIENCE
(2023)
