期刊
ADVANCED MATERIALS
卷 33, 期 49, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202102562
关键词
2D materials; bismuthene; hypoxia; lateral nano-heterostructures; photodynamic therapy
类别
资金
- Instrumental Analysis Center of Shenzhen University (Xili Campus)
- Institute for Lasers, Photonics and Biophotonics at The University at Buffalo
- National Natural Science Foundation of China [U1801254, 61961136001, U1803128]
- State Key Research Development Program of China [2019YFB2203503]
- Taishan Scholar Project of Shandong Province [tsqn201909054]
- Science and Technology Innovation Commission of Shenzhen [KQTD2015032416270385, JCYJ20150625103619275, JCYJ20180305124854790, JCYJ20180507181817604]
- Natural Science Foundation of Guangdong Province [2018A030310500]
Optoelectronic science and 2D nanomaterial technologies are leading multidisciplinary research with applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in nanomaterials can provide important therapeutic modalities for healthcare. A lateral nano-heterostructure based on bismuthene/bismuth oxide (Bi/BiOx) synthesized using regioselective oxidation process shows promising results in photodynamic therapy, offering improvements in tumor ablation and biocompatibility.
Optoelectronic science and 2D nanomaterial technologies are currently at the forefront of multidisciplinary research and have numerous applications in electronics and photonics. The unique energy and optically induced interfacial electron transfer in these nanomaterials, enabled by their relative band alignment characteristics, can provide important therapeutic modalities for healthcare. Given that nano-heterostructures can facilitate photoinduced electron-hole separation and enhance generation of reactive oxygen species (ROS), 2D nano-heterostructure-based photosensitizers can provide a major advancement in photodynamic therapy (PDT), to overcome the current limitations in hypoxic tumor microenvironments. Herein, a bismuthene/bismuth oxide (Bi/BiOx)-based lateral nano-heterostructure synthesized using a regioselective oxidation process is introduced, which, upon irradiation at 660 nm, effectively generates O-1(2) under normoxia but produces cytotoxic center dot OH and H-2 under hypoxia, which synergistically enhances PDT. Furthermore, this Bi/BiOx nano-heterostructure is biocompatible and biodegradable, and, with the surface molecular engineering used here, it improves tumor tissue penetration and increases cellular uptake during in vitro and in vivo experiments, yielding excellent oxygen-independent tumor ablation with 660 nm irradiation, when compared with traditional PDT agents.
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