期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 177, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.113941
关键词
Combination therapy; Photodynamic therapy; Antibiotic; Bacterial infections; Antibiotic resistance
资金
- Department of Defense/Air Force Office of Scientific Research, US [FA9550-20-1-0063, FA9550-17-1-0277]
Combination therapy of PDT and antibiotics shows promising potential in overcoming the limitations of antibiotic treatment and PDT, exerting increased disinfection efficacy on multidrug-resistant bacterial pathogens.
Antibiotic treatment, the mainstay for the control of bacterial infections, is greatly hampered by the global prevalence of multidrug-resistant (MDR) bacteria. Photodynamic therapy (PDT) is effective against MDR infections, but PDT-induced bacterial inactivation is often incomplete, causing the relapse of infections. Combination of PDT and antibiotics is a promising strategy to overcome the limitation of both antibiotic treatment and PDT, exerting increased disinfection efficacy on MDR bacterial pathogens versus either of the monotherapies alone. In this review, we present an overview of the therapeutic effects of PDT/antibiotic combinations that have been developed. We further summarize the influencing factors and the governing molecular mechanisms of the therapeutic outcomes of PDT/antibiotic combinations. In the end, we provide concluding remarks on the strengths, limitations, and future research directions of PDT/antibiotic combination therapy to guide its appropriate usage and further development. (c) 2021 Elsevier B.V. All rights reserved.
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