Article
Health Care Sciences & Services
Yang Wu, Zhemei Zhang, Jing Wu, Jinxia Hou, Guosheng Ding
Summary: This study found that multiple myeloma affects the osteoblast differentiation of bone marrow mesenchymal stem cells (BM-MSCs), and LINC00461 plays an important role in this process. By analyzing the expression of LINC00461 in the exosomes of multiple myeloma cells, it was found that LINC00461 can inhibit the osteoblast differentiation of BM-MSCs and suppress the activation of the Wnt/beta-catenin pathway.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Medicine, Research & Experimental
Okhwa Kim, Phuong Thao Tran, Minju Gal, Se Jin Lee, Sung Hun Na, Cheol Hwangbo, Jeong-Hyung Lee
Summary: The activation of RAS in breast cancer cells plays a crucial role in osteolytic bone metastasis through the exosome-mediated transfer of osteoclastogenic miRNAs. The study identifies miR-494-3p, miR-4508, and miR-6869-5p as osteoclastogenic miRNAs in exosomes secreted by RAS-activated breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Guohua Lai, Renli Zhao, Weida Zhuang, Zuoxu Hou, Zefeng Yang, Peipei He, Jiachang Wu, Hongxun Sang
Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.
Article
Biotechnology & Applied Microbiology
Ling Mei, Min Li, Tao Zhang
Summary: The study demonstrated that miR-874-3p plays a significant role in osteoporosis (OP) by promoting proliferation and differentiation of human bone marrow mesenchymal stem cells (hBMSCs) through downregulation of LEP expression.
Article
Cell Biology
Longshuai Lin, Hongjie Wang, Weihong Guo, Enjun He, Kai Huang, Qinghua Zhao
Summary: The research confirmed that osteosarcoma cell-derived exosomes promote osteoclastogenesis and aggravate bone loss through miR-501-3p, potentially regulated via the PTEN/PI3K/Akt signaling pathway.
CELLULAR SIGNALLING
(2021)
Article
Multidisciplinary Sciences
Ming Wu, Hongyan Wang, Dece Kong, Jin Shao, Chao Song, Tieyi Yang, Yan Zhang
Summary: This study revealed that miR-452-3p plays a crucial role in osteoblast differentiation by targeting Smad4. Overexpression of miR-452-3p inhibited the expression of osteoblast marker genes and decreased calcium nodules and ALP activity, while knockdown of miR-452-3p had the opposite effect.
Article
Multidisciplinary Sciences
Ziyu Wang, Hengshuo Zhang, Qinghui Li, Lu Zhang, Lu Chen, Hongliang Wang, Yunzhen Chen
Summary: In this study, it was found that the long non-coding RNA KCNQ1OT1 plays a role in alleviating postmenopausal osteoporosis (PMOP). KCNQ1OT1 regulates the functions of MC3T3-E1 cells by inhibiting the expression of miR-421-3p. Furthermore, it was revealed that miR-421-3p specifically targets mTOR.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Lai Pan, Chenyi Zhang, Haizheng Zhang, Ting Ke, Mengyao Bian, Yuxuan Yang, Lili Chen, Jingyi Tan
Summary: This study found that exosomal miR-5134-5p derived from osteoclasts inhibits osteoblastic proliferation and differentiation via the JAK2/STAT3 pathway, exacerbating periodontal tissue inflammation and alveolar bone resorption in mice with experimental periodontitis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wang
Summary: The study demonstrates that circNRIP1 contributes to keloid progression by aiding in pre-miR-503 maturation through stabilizing FXR1 and impeding its degradation. High expression of circNRIP1 in keloid tissue and fibroblasts suggests its potential as a therapeutic target for keloid treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jinhui Wang, Yanyun Xia, Jianhao Li, Wei Wang
Summary: This study investigated the role of miR-129-5p in regulating osteoblast differentiation, showing that exosomes containing miR-129-5p from the blood of DM rats inhibit osteoblast differentiation by targeting the FZD4/B-catenin signaling pathway. The findings suggest that miR-129-5p may be a regulator of BMSCs in the jaw region.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Chunhui Sheng, Xiaodong Guo, Zhuqing Wan, Xiaoqiang Bai, Hao Liu, Xiao Zhang, Ping Zhang, Yunsong Liu, Wenyue Li, Yongsheng Zhou, Longwei Lv
Summary: This study investigated the potential of exosomes derived from human adipose-derived stem cells (hASCs) in promoting osteogenic differentiation for osteoporosis treatment. The study identified the key differentially expressed microRNA between two exosomes and their potential target gene. Results showed that exosomes from osteogenic induction medium had a better effect on promoting osteogenic differentiation than those from proliferation medium. Moreover, miR-335-3p inhibitor-optimized exosomes enhanced osteogenic differentiation in vitro and bone density in vivo, suggesting the potential of engineered exosomes in optimizing exosome-based therapy for osteoporosis.
Article
Health Care Sciences & Services
Xiaoyan Zhang, Lijun Zhang, Liqun Xu, Gaozhi Li, Ke Wang, Tong Xue, Quan Sun, Hao Tang, Xinsheng Cao, Zebing Hu, Shu Zhang, Fei Shi
Summary: The secretion of exosomes with high expression of miR-92b-3p by microvascular endothelial cells (MVECs) under mechanical unloading conditions was found to inhibit the differentiation of MC3T3-E1 cells into mature osteoblasts. Further experiments showed that miR-92b-3p was transferred into MC3T3-E1 cells by exosomes, leading to the suppression of osteogenic differentiation. This discovery provides a potential strategy for studying and preventing mechanical unloading-induced bone loss and disuse osteoporosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Endocrinology & Metabolism
Henry C. Hrdlicka, Renata C. Pereira, Bongjin Shin, Siu-Pok Yee, Alix C. Deymier, Sun-Kyeong Lee, Anne M. Delany
Summary: miR-29-3p plays a crucial role in regulating gene expression in osteoblasts and osteoclasts. Inhibition of miR-29-3p can affect bone formation, while miR-29-3p inhibition combined with intermittent PTH treatment can enhance bone anabolism.
Article
Engineering, Environmental
Yonggang Ma, Di Ran, Ying Cao, Hongyan Zhao, Ruilong Song, Hui Zou, Jianhong Gu, Yan Yuan, Jianchun Bian, Jiaqiao Zhu, Zongping Liu
Summary: Long-term exposure to cadmium inhibits osteogenesis of bone marrow stem cells and differentiation of bone marrow macrophages, leading to osteoporosis. P2X7 plays a crucial role in this process, with its deletion or overexpression affecting bone cell differentiation. Short-term exposure to cadmium inhibits bone formation, increases osteoclast numbers, but does not result in osteoporosis.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Cell Biology
Hengshuo Zhang, Lu Chen, Ziyu Wang, Zhenqian Sun, Yu Shan, Qinghui Li, Linzeng Qi, Hongliang Wang, Yunzhen Chen
Summary: KCNQ1OT1 regulates osteoclast differentiation via the miR-128-3p/NFAT5 axis.
Article
Cell Biology
Abril Alondra Barrientos-Bonilla, Paola Belem Pensado-Guevara, Abraham Puga-Olguin, Rasajna Nadella, Aurora del Carmen Sanchez-Garcia, Laura Mireya Zavala-Flores, Arnulfo Villanueva-Olivo, Iliana Tamara Cibrian-Llanderal, Maria de Jesus Rovirosa-Hernandez, Daniel Hernandez-Baltazar
Summary: This study evaluated the impact of BrdU on liver function and found that multiple injections of BrdU did not induce hepatocellular damage.
Article
Cell Biology
Pan Zhang, Qun Feng, Wenxiao Chen, Xizhuang Bai
Summary: It was found that catalpol antagonizes LPS-mediated inflammation and suppressive osteoblast differentiation by inhibiting inflammation and promoting osteoblast differentiation. This finding contributes to a better understanding of the pathogenesis of osteoporosis.