期刊
ACS NANO
卷 15, 期 11, 页码 17870-17884出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c06123
关键词
lactate catabolism; biohybrid materials; metabolic therapy; tumor tropism; chemotherapy
类别
资金
- National Natural Science Foundation of China [52073218, 51833007, 51873162, 51988102]
- Jiangsu Province Science Foundation for Youths [BK20200241]
- Fundamental Research Funds for the Central Universities [2042020kf0038]
In this study, a self-driven bioreactor called SO@MDH was constructed to sensitize chemotherapy through active targeting, lactate degradation, rapid drug release, and inhibition of multidrug resistance. The research demonstrated high tumor specificity and promising therapeutic prospects, indicating the potential of SO@MDH in cancer therapy.
The excessive lactate in the tumor microenvironment always leads to poor therapeutic outcomes of chemotherapy. In this study, a self-driven bioreactor (defined as SO@ MDH, where SO is Shewanella oneidensis MR-1 and MDH is MIL-101 metal-organic framework nanoparticles/doxorubicin/hyaluronic acid) is rationally constructed via the integration of doxorubicin (DOX)-loaded metal-organic framework (MOF) MIL-101 nanoparticles with SO to sensitize chemotherapy. Owing to the intrinsic tumor tropism and electron-driven respiration of SO, the biohybrid SO@MDH could actively target and colonize hypoxic and eutrophic tumor regions and anaerobically metabolize lactate accompanied by the transfer of electrons to Fe3+, which is the key component of the MIL-101 nanoparticles. As a result, the intratumoral lactate would undergo continuous catabolism coupled with the reduction of Fe3+ to Fe2+ and the subsequent degradation of MIL-101 frameworks, leading to an expeditious drug release for effective chemotherapy. Meanwhile, the generated Fe2+ will be promptly oxidized by the abundant hydrogen peroxide in the tumor microenvironment to reproduce Fe3+, which is, in turn, beneficial to circularly catabolize lactate and boost chemotherapy. More importantly, the consumption of intratumoral lactic acid could significantly inhibit the expression of multidrug resistance-related ABCB1 protein (also named P-glycoprotein (P-gp)) for conquering drug-resistant tumors. SO@MDH demonstrated here holds high tumor specificity and promising chemotherapeutic efficacy for suppressing tumor growth and overcoming multidrug resistance, confirming its potential prospects in cancer therapy.
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