4.8 Article

Adaptive Control of Nanomotor Swarms for Magnetic-Field-Programmed Cancer Cell Destruction

期刊

ACS NANO
卷 15, 期 12, 页码 20020-20031

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c07615

关键词

magnetic nanomotors; swarms; magneto-mechanical actuation; adaptive behaviors; cancer treatment

资金

  1. Major Program of National Key Research and Development Project [2020YFA0112600]
  2. NSFC [82022039, 31870997, 61825303, U1713215]
  3. National Key Research and Development Program of China Stem Cell and Translational Research [2016YFA0101202]
  4. Shanghai Municipal Education Commission Innovative Program [2017-01-07-00-07E00038]
  5. Shanghai Science and Technology Committee [20dz1101200]
  6. Major Project of Special Development Fund for Shanghai Zhangjiang National Independent Innovation Demonstration Zone [ZJ2019-ZD-003]
  7. Shanghai Science and Technology Commission Project [18DZ1205706, 18DZ1202703]

向作者/读者索取更多资源

This study designs adaptive control behaviors of Cy5-tagged caspase-3-specific peptide-modified MNMs, inducing cancer cell apoptosis in lysosomes under the action of a rotating magnetic field. A predicted magneto-programmed vortex is observed around swarms under RMF using a finite element method model, with critical rotating frequency correlated to assembling and swarming properties. Real-time frequency-adapted controllability of MNM swarms for cancer cell apoptosis is demonstrated both in vitro and in vivo.
Magnetic nanomotors (MNMs), powered by a magnetic field, are ideal platforms to achieve versatile biomedical applications in a collective and spatiotemporal fashion. Although the programmable swarm of MNMs that mimics the highly ordered behaviors of living creatures has been extensively studied at the microscale, it is of vital importance to manipulate MNM swarms at the nanoscale for on-demand tasks at the cellular level. In this work, a Cy5-tagged caspase-3-specific peptide-modified MNM is designed, and the adaptive control behaviors of MNM swarms are revealed in lysosomes to induce the cancer cell apoptosis under a rotating magnetic field (RMF). A magneto-programmed vortex is predicted to occur with swarms under RMF by the finite element method model and verified in vitro. According to the dynamic model and numerical simulation, the critical rotating frequency under which MNMs are out of step is strongly correlated to their assembling and swarming properties. The adaptivity of swarms maximizes the synchronous rotation to achieve an optimal energy conversion rate. The frequency-adapted controllability of MNM swarms for cancer cell apoptosis is observed in real time in vitro and in vivo. This work provides theoretical and experimental insights to adaptively control MNM swarms for cancer treatment.

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