Article
Materials Science, Multidisciplinary
Zhou Ye, Irawan Pramuyda, Yuanhui Xiang, Sihan Yu, Teng Chi, Dongping Liu, Bo Su, Christopher J. Addonizio, Sijie Xian, Lei Zou, Matthew J. Webber
Summary: Point-of-use devices are needed to conveniently deliver protein therapeutics. Microneedles offer a method to deliver biopharmaceuticals across the skin and avoid injection or oral administration. A microneedle platform combining a PEG-based supramolecular polymer network with a mechanical biopolymer network can penetrate the skin and deliver sustained release of insulin. This approach simplifies the fabrication of detachable microneedles using polymer formulations with supramolecular bonding.
ACS MATERIALS LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Han Wu, Zuobing Chen, Shaolong Qi, Bing Bai, Jiajun Ye, Dan Wu, Jie Shen, Fei Kang, Guocan Yu
Summary: The study confirmed the stability of host-guest complexation between CB[8] and 4,4'-bipyridinium and napththyl guest in physiological environment, leading to the successful construction of a supramolecular nanomedicine based on this molecular recognition with promising potentials in anticancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Teresa Cordeiro, Ines Matos, Florence Danede, Joao C. Sotomayor, Isabel M. M. Fonseca, Marta C. C. Corvo, Madalena Dionisio, Maria Teresa Viciosa, Frederic Affouard, Natalia T. Correia
Summary: A rational design of drug delivery systems requires in-depth knowledge of the physical state and molecular mobility of the drug itself, as well as its distribution among carriers and interactions with the host matrix. This study investigates the behavior of simvastatin loaded in mesoporous silica MCM-41 matrix, showing that it exists in an amorphous state and interacts strongly with the MCM silanol groups. Molecular Dynamics simulations predict that simvastatin molecules anchor to the inner pore wall through multiple hydrogen bonds. MCM-41 loading proves to be a suitable strategy for the long-term stabilization of simvastatin in the amorphous form.
Article
Chemistry, Multidisciplinary
Kai Yang, Bin Hua, Shaolong Qi, Bing Bai, Chunyang Yu, Feihe Huang, Guocan Yu
Summary: Suprasomes, assembled from molecules based on host-guest recognition, show potential as a new generation of vesicular drug delivery systems. Encapsulating drugs in suprasomes can achieve excellent anticancer efficacy and anti-metastasis effects, providing a promising alternative to traditional liposomes and polymersomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Karan Bansal, Dean Webster, Mohiuddin Quadir
Summary: We studied the self-assembly and colloidal properties of poly(ethylene glycol) conjugated sucrose soyate polyols. The synthesized PSSP products showed amphiphilicity and reduced water surface tension. The nanoparticles formed by PSSP self-assembly in water can encapsulate hydrophobic compounds.
Article
Chemistry, Applied
Shujuan Yang, Wenqi Qin, Xinyu Zhao, Furui He, Houkui Gong, Yuanyuan Liu, Yuhong Feng, Yang Zhou, Gaobo Yu, Jiacheng Li
Summary: The study introduces a β-cyclodextrin-grafted alginate/azobenzene-functionalized dodecyl polymeric supra-amphiphile for the preparation of multifunctional Pickering emulsions. The amphiphilic assemblies derived from this compound show great amphiphilicity and can be easily regulated to achieve optimal interfacial structures for emulsification. The interfacial microstructures transform with pH and exhibit enhanced emulsifying efficiency due to steric hindrance.
CARBOHYDRATE POLYMERS
(2021)
Review
Chemistry, Inorganic & Nuclear
Guihua Fang, Xuewen Yang, Sumeng Chen, Qiuxiang Wang, Aiwen Zhang, Bo Tang
Summary: This review summarizes the application of CD-based host-guest supramolecular hydrogels in local drug delivery. It covers the formation of supramolecular hydrogels with different types of CD, the physicochemical characteristics of these hydrogels, and their application in various administration routes. The review also discusses the challenges and future directions for the clinical translation of CD-based host-guest supramolecular hydrogels.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Inorganic & Nuclear
Xi Yang, Di Yuan, Jinhong Hou, Adam C. Sedgwick, Suying Xu, Tony D. James, Leyu Wang
Summary: The field of supramolecular chemistry has rapidly expanded and become highly influential in various areas like biomedicine, energy materials, catalysis, and sensing. The combination of host/guest chemistry with functional inorganic nanoparticles has led to many new applications in drug delivery, bioimaging, and sensing. Recent progress in the development of organic/inorganic supramolecular nano-systems incorporating host/guest chemistry has been summarized, highlighting their applications in drug delivery, biological imaging, and sensing.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Edward Britton, Richard J. Ansell, Mark J. Howard, Michaele J. Hardie
Summary: New photoswitchable pyridyl-azo-phenyl-decorated tripodal host ligands (L-az) have been synthesized, showing a remarkable 7-fold Borromean-weave entanglement and forming metallo-cryptophanes cages with less robust photoswitching behavior.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiao Xiao, Zhirui Xu, Wenkai Wang, Siyuan Sun, Yan Qiao, Lingxiang Jiang, Yun Yan, Jianbin Huang
Summary: A versatile supramolecular platform was reported to construct enzyme-responsive nanosystems via host-guest interactions, leading to the formation of various nanostructures capable of actively releasing water-soluble molecules or functional nanoparticles in the presence of alpha-amylase.
Review
Biochemistry & Molecular Biology
Krishna Manjari Sahu, Swapnita Patra, Sarat K. Swain
Summary: This review critically analyzes the host-guest mechanism for drug release from polysaccharide-supported beta-CD inclusion complex. It compares various polysaccharides such as cellulose, alginate, chitosan, dextran, etc. and their association with beta-CD in relevant to drug delivery. The drug release capacity, mode of drug release, and characterization techniques of individual polysaccharide-based CD complexes are comparatively established in tabular form. This review provides better visibility for researchers working in the area of controlled release of drugs by carrier consisting of beta-CD associated polysaccharide composite through host-guest mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Organic
Man-Ping Li, Nan Yang, Wen-Rong Xu
Summary: A new water-soluble derivative was synthesized and used for supramolecular drug delivery, showing promising results in releasing anticancer drugs. The drugs could be effectively released by overexpressed molecules in cancer cells.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Dalia Ramos, Javier Aguila-Rosas, Carlos T. Quirino-Barreda, Alfonso Santiago-Tellez, Hugo A. Lara-Garcia, Ariel Guzman, Ilich A. Ibarra, Enrique Lima
Summary: Linezolid (LNZ), a new-generation synthetic molecule, is being explored for antibacterial treatment, with research focusing on its release within MOFs (MOF-74(Zn) and MOF-74(Cu)) as a potential antimicrobial system for combating antimicrobial resistance.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Alexandra N. Edelbrock, Tristan D. Clemons, Stacey M. Chin, Joshua J. W. Roan, Eric P. Bruckner, Zaida Alvarez, Jack F. Edelbrock, Kristen S. Wek, Samuel I. Stupp
Summary: The study reports a supramolecular system where interactions between peptide amphiphiles and beta-cyclodextrin with adamantane lead to the formation of a mechanically robust hydrogel with highly porous architecture, which can be 3D printed and exhibits significant bioactivity towards neurons. This nanostructured hydrogel based on supramolecular assembly has potential applications in neuronal research and biomaterial design.
Article
Chemistry, Analytical
Xinyi Lin, Jingjing Jiang, Jing Wang, Jili Xia, Ruonan Wang, Guowang Diao
Summary: A novel ratiometric electrochemical biosensor was developed for sensitive detection of miRNA-21 by combining DNAzyme-cleavage cycling with competitive host-guest inclusion. The biosensor showed wide concentration range, low detection limit, high sensitivity, good selectivity, satisfactory reproducibility, and stability under optimal conditions. This sensing strategy may offer a new approach in molecular diagnosis and bioanalysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Multidisciplinary Sciences
Shuo Li, Kun Liu, Xue-Chen Feng, Zhao-Xian Li, Zhi-Yuan Zhang, Bin Wang, Minjie Li, Yue-Ling Bai, Lei Cui, Chunju Li
Summary: This study presents a strategy for enhancing the solid-state emission of luminophores through macrocyclization-induced emission enhancement (MIEE). By linking luminophores to form macrocycles, the fluorescence intensity in the solid state is significantly increased, leading to improved device performance in OLED applications. The MIEE strategy is universal and can be applied to different luminophores.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Liang Zhao, Junyi Chen, Long Tian, Yahan Zhang, Longming Chen, Xinbei Du, Mengke Ma, Jian Li, Qingbin Meng, Chunju Li
Summary: This study introduces a novel detoxification method for macromolecular biotoxins using a large macrocycle. The complexation between the macrocycle and a peptide biotoxin reduces its cytotoxicity and shows therapeutic effects in poisoned mice.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Physical
Shuo Li, Zhi-Yuan Zhang, Jing-Fang Lv, Ling Li, Jian Li, Chunju Li
Summary: This study presents a strategy for enhancing organic room temperature phosphorescence (RTP) through the macrocyclization of phosphorescent pyridine/pyridinium units. The macrocycles exhibited enhanced phosphorescence with significantly prolonged lifetime and increased quantum yields compared to the monomers. Mechanism study revealed that macrocyclization restrained rotation/vibration and slowed down decay processes, leading to the phosphorescence enhancement. This macrocyclization-induced phosphorescence enhancement (MIPE) offers a novel and general strategy for enhancing RTP with potential applications beyond phosphorescence.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Multidisciplinary
Bin Li, Yuan Wang, Lingling Liu, Ming Dong, Chunju Li
Summary: This article reports a new and energy-efficient adsorptive separation method using reversible solid-state structural transformations in MCCs. The selectivity of CHA-one and CHA-ol is achieved by triggering solid-state structural transformations through CHA-one vapor.
Article
Chemistry, Organic
Zhao-Xian Li, Xu-Sheng Du, Jing Wang, Zhuo-Qian Wu, Zhe Zheng, Shibo Yao, Bin Wang, Chunju Li
Summary: Modular synthesis of novel biphen-[n]-arenes with customizable heterocycle blocks, functional skeletons, binding sites, and topological structures was achieved through rational design and replacement of reaction modules, functional modules, and linking modules. The properties were characterized by various techniques and thoroughly studied.
Article
Chemistry, Multidisciplinary
Yahan Zhang, Longming Chen, Xinbei Du, Xiang Yu, Han Zhang, Zhao Meng, Zhibing Zheng, Junyi Chen, Qingbin Meng
Summary: A novel synthesis method for pillar[n]arene derivatives was reported in this study, and a water-soluble pillar[5]arene with fluorescence sensing capability was prepared. The pillar[5]arene exhibited ultrasensitive detection of iron ions in aqueous solution with specific selectivity. Moreover, the sensor could operate properly in a simulated sewage sample containing multiple interference ions.
Article
Chemistry, Multidisciplinary
Zhi-Yuan Zhang, Chun-Yun Deng, Chen-Chen Shen, Rong-Yao Xu, Xi-Zhen Wang, Yan-Hao Wang, Bo Ding, Bin Li, Jian Li, Chunju Li
Summary: A phosphorescence enhancement of pyridinium macrocycle/monomer phosphors is achieved by doping into a poly(vinylalcohol) (PVA) matrix, resulting in up to a 14.7-fold prolongation of phosphorescence lifetimes and visible afterglow. The abundant hydrogen-bonding interactions and electrostatic interactions between the phosphors and PVA suppress nonradiative decay processes, slow down the radiative and nonradiative decay of triplet states, consequently promoting long-lived RTP.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Ming Dong, Wanru Qi, Guang Sun, Kaidi Xu, Yixin Ma, Jing-Fang Lv, Liya Zhao, Zhi-Yuan Zhang, Chunju Li
Summary: This article presents the synthesis of a naphthalene-based macrocycle with anionic carboxylato groups on its rims, and investigates its complexation with cationic guests in aqueous media. The macrocycle exhibits strong binding to the guests in a molecular clip model, with association constants ranging from 10^6 to 10^7 M-1.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yibo Zhao, Longming Chen, Junyi Chen, Jian Li, Qingbin Meng, Andrew C. -H. Sue, Chunju Li
Summary: In this report, we describe the development of a water-soluble terphen[3]arene derivative functionalised with sulfate acid ester groups. This terphen[3]arene host effectively encapsulates a wide range of neuromuscular blocking agents (NMBAs) with high affinity, demonstrating its potential as a reversal agent for NMBAs in pharmaceutical research.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Qin Cheng, Taoran Wang, Jing Zhang, Long Tian, Chunlan Zeng, Zhao Meng, Changhao Zhang, Qingbin Meng
Summary: Gene therapy is a promising strategy for treating HCC, but it often lacks specificity in gene transfection. In this study, a series of peptide-based gene delivery vectors were designed and synthesized to specifically bind receptors highly expressed on HCC cell membranes. The results showed that peptide vectors containing targeted fragments for ACE2 and c-Met receptors were able to efficiently transfect HCC cells in vitro. Furthermore, the liver-targeting function of these peptides was evaluated in vivo using fluorescence imaging.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Organic
Mengke Ma, Junyi Chen, Yahan Zhang, Xinbei Du, Longming Chen, Xiang Yu, Zhengui Zhou, Yang Liu, Qingbin Meng
Summary: This study describes a supramolecular synergistic antibacterial strategy involving the direct complexation of azelaic acid (AzA), a commercial antibacterial agent, with a cationic pillar[5]arene (WP5A). The formation of the AzA/WP5A complex exhibited a synergistic antibacterial effect, promoting wound healing efficacy and reducing bacterial burden in S. aureus-infected mouse models.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ao Liu, Xin Meng, Chen-Chen Shen, Zhi-Yuan Zhang, Chunju Li
Summary: Heterogeneous macrocycles with fluorenone and fluorenol functional groups were synthesized using two facile methods. The resulting macrocycles exhibited intriguing intramolecular energy transfer and fluorescence enhancement, attributed to the well-matched absorption/emission spectra and close proximity of the fluorenone/fluorenol moieties.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yao Xiao, Xin Peng, Jie Shen, Lei Cui, Shanya Lu, Xueshun Jia, Chunju Li, Jian Li
Summary: This research has developed a simple and efficient method to synthesize structurally unusual compounds, providing new ideas and strategies for the field of chemical synthesis.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Shuo Li, Zhi-Yuan Zhang, Haichang Zhang, Yue-Ling Bai, Lei Cui, Chunju Li
Summary: This study reports interesting macrocycle crystals with switchable luminescence and structure-adaptive transformation by combining macrocycle chemistry and crystal engineering. Luminescent switching between orange and yellow emissions has been achieved through the adsorption and desorption of aromatic volatile organic compounds. The macrocyclic framework plays a critical role in these stimuli-responsive crystalline materials, providing spaces for motion and adsorption.
ORGANIC CHEMISTRY FRONTIERS
(2022)
