Review
Chemistry, Multidisciplinary
Chao Wang, Mei Liu, Zhifei Wang, Song Li, Yan Deng, Nongyue He
Summary: The COVID-19 pandemic has highlighted the importance of developing point-of-care (POC) diagnostics, which offer advantages such as faster diagnostic speed, lower cost, and higher efficiency. Development of POC detection methods and devices using microfluidics, MEMS technology, nanotechnology and materials science is key to providing timely prevention and control of infectious diseases.
Article
Biophysics
Shikha Jain, Monika Nehra, Rajesh Kumar, Neeraj Dilbaghi, Tony Y. Hu, Sandeep Kumar, Ajeet Kaushik, Chen-Zhong Li
Summary: The current global pandemic situation highlights the urgent need for fast and real-time diagnostic tools for infectious diseases, as well as timely medical interventions to control the spread of the outbreak. Medical Internet of Things (IoMT) technology is playing a crucial role in supporting this, enabling wireless connectivity of Point-of-Care Testing (POCT) devices with health experts and medical centers to facilitate timely actions in combating infectious diseases.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Nanoscience & Nanotechnology
Sandeep Kumar, Monika Nehra, Sakina Khurana, Neeraj Dilbaghi, Vanish Kumar, Ajeet Kaushik, Ki-Hyun Kim
Summary: Advancements in POC diagnostic systems have gained attention due to their rapid operation and affordable cost. Smart sensing components are being developed to meet patient care needs, while technologies like smartphone-based operation and paper-based sensing assays are making POC diagnostics more sensitive and informative.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Pharmacology & Pharmacy
Rachael Dixon, Eldhose Skaria, Wing Man Lau, Philip Manning, Mark A. Birch-Machin, S. Moein Moghimi, Keng Wooi Ng
Summary: Recent infectious disease outbreaks have emphasized the importance of rapid and accurate diagnosis for effective treatment and prevention of transmission. Point-of-care microneedle diagnostic devices offer a promising solution by providing minimally invasive, real-time diagnosis. Further development in this field holds significant potential for improving infectious disease diagnostics.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Chemistry, Analytical
Leyla Karadurmus, S. Irem Kaya, Ahmet Cetinkaya, Sibel A. Ozkan
Summary: Lack of timely detection or proper monitoring of diseases is still a leading cause of death. Developing a portable device similar to a portable laboratory for rapid disease diagnosis is crucial. Electroanalytical methods, particularly using nanomaterials like Mxenes, are cost-effective and highly sensitive for point-of-care diagnostics. This review provides an overview of recent studies on electrochemical POC diagnostics using Mxenes and offers insights into improving selectivity and sensitivity in sensor studies.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Analytical
Georgios Manessis, Athanasios Gelasakis, Ioannis Bossis
Summary: POC diagnostics for animal diseases face challenges in terms of validation, simplicity, and portability, but emerging technologies and advanced materials are expected to overcome these challenges and promote their popularity.
Review
Chemistry, Analytical
Jane Y. Zhang, Andrew T. Bender, David S. Boyle, Paul K. Drain, Jonathan D. Posner
Summary: The COVID-19 pandemic has emphasized the importance of integrated nucleic acid tests, especially those that are fast, cost-effective, and accurate for use near patients. Regulatory processes from FDA and WHO have allowed more NAT systems to be developed and deployed in infectious disease detection, paving the way for future development and technology transfer.
Article
Economics
F. Antonanzas, C. A. Juarez-Castello, R. Rodriguez-Ibeas
Summary: The study found that the use of POCT can reduce the number of antibiotic prescriptions, especially when physicians internalize the costs of antimicrobial resistances. Physicians with high levels of uncertainty are more likely to use POCT, while those with low uncertainty prefer empirical therapy. The acceptance of POCT among physicians depends on the distribution of levels of uncertainty.
HEALTH ECONOMICS REVIEW
(2021)
Review
Chemistry, Multidisciplinary
Hatice Ceren Ates, Anna Brunauer, Felix von Stetten, Gerald A. Urban, Firat Guder, Arben Merkoci, Susanna Maria Fruh, Can Dincer
Summary: Integrated diagnostic devices are recognized as the ultimate solution to simplify healthcare testing, accelerating intervention and improving patient outcomes. The combination of non-invasive sampling and integrated devices is of substantial interest for improving patient comfort and safety. Factors affecting the transition of integrated devices from academia to market, such as technology readiness levels and survival rates, are crucial for success.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Biotechnology & Applied Microbiology
Arpana Parihar, Shalu Yadav, Mohd Abubakar Sadique, Pushpesh Ranjan, Neeraj Kumar, Ayushi Singhal, Vedika Khare, Raju Khan, Sathish Natarajan, Avanish K. K. Srivastava
Summary: Microbial pathogens pose a threat to the world, but traditional laboratory-based diagnostics have limitations such as high cost, bulky instruments, and skilled personnel requirements. Biosensors offer potential for faster, cost-effective, and user-friendly detection. This review discusses design and fabrication of point-of-care testing devices, advances in electrochemical techniques, and integration with smartphone and Internet-of-Things systems. The integration of biosensors with IoT/IoMT can track infectious disease spread and help prevent social and economic losses.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea Costantino, Alessandra Piagnani, Nicoletta Nandi, Valentina Sciola, Marco Maggioni, Francesca Donato, Maurizio Vecchi, Pietro Lampertico, Giovanni Casazza, Mirella Fraquelli
Summary: This study evaluated the feasibility, reproducibility, and diagnostic accuracy of pocket-sized ultrasound devices (PUDs) in assessing liver surface nodularity (LSN) in chronic liver disease patients. The results showed that PUD performed well in excluding advanced liver disease and had excellent reproducibility, making it a preferred tool for screening patients.
EUROPEAN RADIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tian Zhang, Shuai Guo, Fangzhou Li, Xinmiao Lan, Yaru Jia, Jinchao Zhang, Yuanyu Huang, Xing-Jie Liang
Summary: This review emphasizes the importance of timely and accurate assessment and diagnosis for various diseases, introduces the application of molecular imaging technology in disease diagnosis and treatment, and aims to promote the development of related technologies and fields.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Analytical
Yingxue Li, Xin Chen, Yongjuan Zhao, Zhenzhou Wan, Yi Zeng, Yingying Ma, Lianqun Zhou, Gaolian Xu, Julien Reboud, Jonathan Cooper, Chiyu Zhang
Summary: HIV remains a major burden on global public health, with rapid and sensitive point-of-care tests being crucial for disease control. The highly variable nature of the virus poses important challenges for diagnosis, but the new variant-tolerant HIV-1 RT-LAMP diagnostic test shows high sensitivity and specificity, demonstrating future potential for timely and cost-effective HIV diagnostics.
Article
Chemistry, Multidisciplinary
Maha Alafeef, Dipanjan Pan
Summary: The COVID-19 pandemic has highlighted the limitations of existing virological tests and the need for developing simpler, more economically feasible, and accessible diagnostic technology to enable early diagnosis and reduce the spread of the virus. Nanomaterials play a crucial role in developing COVID-19 diagnostic kits and enhancing the performance of existing tests.
Review
Chemistry, Analytical
Tugba Ozer, Charles S. Henry
Summary: Paper-based devices (PADs) have emerged as a leading alternative for point-of-care testing in virus detection, especially during the COVID-19 pandemic. This review discusses the development strategies and applications of nucleic acid-based, antibody/antigen-based PADs, identifying advantages and drawbacks, and providing insights for future perspectives. State-of-the-art technologies are considered for further development and improvement in PADs performance for virus detection.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)