State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References

Evaluation of Excipient Risk in BCS Class I and III Biowaivers

(2022) Melissa Metry et al.   AAPS Journal

Use of Physiologically Based Pharmacokinetic Modeling for Predicting Drug–Food Interactions: Recommendations for Improving Predictive Performance of Low Confidence Food Effect Models

(2021) Christian Wagner et al.   AAPS Journal

The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds

(2021) Tim Brecklinghaus et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System (BDDCS)

(2020) Wei Liu et al.   PHARMACOTHERAPY

Organic Anion Transporter 2 mediated Hepatic Uptake Contribute to the Clearance of High Permeability - Low Molecular Weight Acid and Zwitterion Drugs: Evaluation using 25 drugs.

(2018) Emi Kimoto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Novel high/low solubility classification methods for new molecular entities

(2016) Rutwij A. Dave et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs

(2015) Chelsea M. Hosey et al.   AAPS Journal

Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain

(2015) Yi Zheng et al.   CLINICAL PHARMACOKINETICS

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

(2015) Manthena V. Varma et al.   PHARMACEUTICAL RESEARCH

Drug Discovery and Regulatory Considerations for Improving In Silico and In Vitro Predictions that Use Caco-2 as a Surrogate for Human Intestinal Permeability Measurements

(2013) Caroline A. Larregieu et al.   AAPS Journal

BDDCS Applied to Over 900 Drugs

(2011) Leslie Z. Benet et al.   AAPS Journal

Improving the prediction of the brain disposition for orally administered drugs using BDDCS

(2011) Fabio Broccatelli et al.   ADVANCED DRUG DELIVERY REVIEWS

Transporter-Mediated Efflux Influences CNS Side Effects: ABCB1, from Antitarget to Target

(2010) Fabio Broccatelli et al.   Molecular Informatics

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

(2009) Sarah Shugarts et al.   PHARMACEUTICAL RESEARCH

Using Measured pKa, LogP and Solubility to Investigate Supersaturation and Predict BCS Class

(2008) K. Box et al.   CURRENT DRUG METABOLISM

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

(2007) Joseph M. Custodio et al.   ADVANCED DRUG DELIVERY REVIEWS