Article
Endocrinology & Metabolism
Jun Xia Zhang, Xue Lin, Jinxiu Xu, Feng Tang
Summary: The study aimed to investigate the association between uric acid and fructose-induced obesity hypertension in rats. Results showed that inhibiting hyperuricemia effectively prevented adipose RAS overactivation, adipose inflammation and the development of obesity hypertension. Urate-lowering therapy protected rats against fructose-induced obesity hypertension by downregulating adipose RAS and reducing inflammation in adipose tissue.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2021)
Article
Cardiac & Cardiovascular Systems
Lusi Xu, Gaizun Hu, Jiahe Qiu, Yuxuan Fan, Yixuan Ma, Takahiro Miura, Masahiro Kohzuki, Osamu Ito
Summary: High-fructose diet induces hypertension and renal damage, which are exaggerated in salt-sensitive Dahl salt-sensitive rats through renal renin-angiotensin system activation. The effects can be controlled by renin-angiotensin system inhibitors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Nutrition & Dietetics
Simonetta Genovesi, Marco Giussani, Antonina Orlando, Francesca Orgiu, Gianfranco Parati
Summary: The prevalence of essential arterial hypertension in children and adolescents has increased significantly in recent decades, with incorrect eating habits being one of the contributing factors. Excessive intake of salt and sugar has been linked to the development of hypertension in children, especially those who are overweight. Maintaining correct eating habits is crucial for the prevention and non-drug treatment of essential hypertension in children and adolescents.
Review
Urology & Nephrology
Laura G. Sanchez-Lozada, Magdalena Madero, Marilda Mazzali, Daniel Feig, Takahiko Nakagawa, Miguel A. Lanaspa, Mehmet Kanbay, Masanari Kuwabara, Bernardo Rodriguez-Iturbe, Richard J. Johnson
Summary: Despite being discovered more than 150 years ago, the cause of primary hypertension remains unknown. Recent studies suggest that fructose metabolism may play a role in the development of primary hypertension. Restricting salt and sugar intake, as well as staying hydrated, may be helpful in preventing primary hypertension.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Medicine, Research & Experimental
Chuanxin Su, Jinhua Xue, Chao Ye, Aidong Chen
Summary: Hypertension, present in over one billion adults, is closely related to the disruption of the renin-angiotensin system (RAS). The AT1R receptor is the most important angiotensin II receptor, playing a critical role in vasoconstriction and being associated with multiple signaling pathways, including AT1R/JAK/STAT and Ras/Raf/MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Chuanming Xu, Jun Yu
Summary: In recent years, research has shown that excessive fructose consumption is linked to high blood pressure, and high fructose and high salt intake can induce salt-sensitive hypertension. The mechanisms behind these events include activation of the intrarenal renin-angiotensin system, gut dysbiosis, enhanced oxidative stress, among others.
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Raul Loera-Valencia, Francesca Eroli, Sara Garcia-Ptacek, Silvia Maioli
Summary: The article explores the role of the brain renin-angiotensin system in cognition and Alzheimer's disease pathogenesis, as well as its relationship with risk factors such as hypercholesterolemia. Current RAS inhibition therapy's efficacy in improving cognition in AD patients is uncertain, with only one therapy under consideration in clinical trials. Additionally, research on novel drugs may offer potential for highly specific treatments targeting the brain RAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Hongyin Chen, Jiangyun Peng, Tengyao Wang, Jielu Wen, Sifan Chen, Yu Huang, Yang Zhang
Summary: Cardiovascular disease is the leading cause of death and disability, with hypertension as the most common risk factor. Excessive activation of the renin-angiotensin system (RAS) is closely related to cardiovascular dysfunction, leading to vascular remodeling and inflammation. The counter-regulatory axis of the RAS, including ACE2 and other components, has been shown to counteract the effects of the overactivated RAS. This review summarizes the complexity and interplay of the counter-regulatory RAS axis in hypertension, with a focus on the role of ACE2 in linking hypertension and COVID-19, and discusses the potential of targeting this axis to prevent and treat hypertension during the COVID-19 pandemic.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ya-Hui Chang, Wan-Hsuan Chen, Chung-Hao Su, Hong-Ren Yu, You-Lin Tain, Li-Tung Huang, Jiunn-Ming Sheen
Summary: Hypertension is a common public health challenge globally. This study found that maternal low-iron diet during pregnancy and lactation resulted in increased blood pressure and abnormalities in the renal renin-angiotensin system, oxidative stress, inflammation, and sodium transporters in adult male offspring. Improving the iron status of pregnant mothers could influence the development of hypertension in their offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Biwash Ghimire, Sana Khajeh Pour, Elizabeth Middleton, Robert A. Campbell, Mary A. Nies, Ali Aghazadeh-Habashi
Summary: This study investigated whether RAS components and ArA metabolites can be considered biomarkers of COVID-19. The results showed that Ang 1-7 levels were significantly lower and Ang II levels were higher in COVID-19 patients compared to healthy individuals. Evaluating these biomarkers could provide helpful information for early detection of high-risk groups and improve patient outcomes.
Review
Physiology
Tlili Barhoumi, Stephen Todryk
Summary: The renin-angiotensin system (RAS) is a central regulator of cardiovascular physiology, and its hyper-activation is common in hypertension. Recent studies have highlighted the crucial role of the immune system, particularly monocyte/macrophage cells, in hypertension and its related pathology. Targeting RAS components in these cells may present an innovative strategy for the treatment of hypertension.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nasim Kiaie, Armita Mahdavi Gorabi, Zeljko Reiner, Tannaz Jamialahmadi, Massimiliano Ruscica, Amirhossein Sahebkar
Summary: Statins not only lower serum LDL-cholesterol, but also have important effects on the renin-angiotensin system pathway, offering new therapeutic possibilities beyond cholesterol lowering.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Article
Nutrition & Dietetics
Francois-Guillaume Debray, Kevin Seyssel, Marjorie Fadeur, Luc Tappy, Nicolas Paquot, Christel Tran
Summary: The study showed that overfeeding on fructose can lead to increased uric acid and insulin resistance, with a more significant impact on carriers of hereditary fructose intolerance.
CLINICAL NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
Sarah M. Nwia, Ana Paula O. Leite, Xiao Chun Li, Jia Long Zhuo
Summary: Cardiovascular disease demonstrates significant biological sex differences, allowing for tailored approaches to prevention and treatment. Hypertension, a major risk factor for various diseases, affects a significant percentage of the American population. Women have lower rates of hypertension during reproductive years, but this protection diminishes after menopause. Treatment-resistant hypertension remains a challenge, suggesting unknown mechanisms in blood pressure regulation. Understanding the genetic and hormonal differences in hypertension can lead to sex-specific treatments and improved outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physiology
Chuanming Xu, Yanting Chen, Nirupama Ramkumar, Chang-Jiang Zou, Curt D. Sigmund, Tianxin Yang
Summary: This study investigates the role of intrarenal RAAS in potassium homeostasis, specifically focusing on the action of renin in the collecting duct. The study found that mice with renal-specific deletion of renin had impaired potassium excretion and elevated plasma potassium levels when fed a high potassium diet. Additionally, the expression of intrarenal aldosterone and related proteins were also decreased.
Review
Oncology
Xin Ouyang, Chuanming Xu
Summary: Cancer is a major global public health problem that affects hundreds of millions of people worldwide, and currently lacks reliable biomarkers for predicting its clinical outcomes. Recent research has shown that (pro)renin receptor (PRR) acts as a novel biomarker in various types of cancer. This review summarizes the current understanding of PRR in cancer, including its expression levels in different cancers, potential mechanisms in cancer progression, and its role in cancer treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chuanming Xu, Xiaoli Yi, Manman Qin, Shuhan Chu, Chunju Liu, Jianhua Xiong, Xin Ouyang, Jun Yu
Summary: It has been found that PGE2 increases aldosterone synthesis in the collecting duct through the EP1 receptor via the PKC/cAMP/sPRR/beta-catenin pathway.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Urology & Nephrology
Jamie R. Privratsky, Shintaro Ide, Yanting Chen, Hiroki Kitai, Jiafa Ren, Helene Fradin, Xiaohan Lu, Tomokazu Souma, Steven D. Crowley
Summary: Regulatory systems can stimulate financial innovation. Banks with lighter regulatory pressure are more inclined to launch new financial products and are also more willing to face financial risks.
KIDNEY INTERNATIONAL
(2023)
Article
Engineering, Environmental
Xingxing Wang, Zhipeng Shu, Haohua He, Ming Zhou, Xiaohan Lu, Jiajia Wang, Liwu Zhang, Zezhen Pan, Zimeng Wang
Summary: The oxidative dissolution of arsenopyrite, an important arsenic mineral, is a environmental concern in reducing conditions. The presence of natural ligands and coexisting metals can affect the release of Fe species, which is crucial for the dissolution of arsenopyrite.
Article
Nuclear Science & Technology
Haisheng Xu, Cai Meng, Yuemei Peng, Saike Tian, Na Wang, Xiaohao Cui, Chongchong Du, Zhe Duan, Yuanyuan Guo, Ping He, Xiyang Huang, Daheng Ji, Hongfei Ji, Yi Jiao, Jingyi Li, Nan Li, Xiaoyu Li, Xiaohan Lu, Pengfei Liang, Weimin Pan, Huamin Qu, Bin Wang, Jiuqing Wang, Yuanyuan Wei, Jinyu Wan, Gang Xu, Fang Yan, Chenghui Yu, Sen Yue, Xiang Zhang, Yaliang Zhao
Summary: This paper presents the physics design of the High Energy Photon Source (HEPS) and the typical equilibrium electron beam parameters corresponding to the proposed two baseline operation modes in the baseline design of HEPS.
RADIATION DETECTION TECHNOLOGY AND METHODS
(2023)
Article
Chemistry, Multidisciplinary
Jiaxin Xie, Siyu Lu, Yilin Zhang, Xiaohan Lu, Zhen Ding, Tingxian Tao, Maodong Xu, Zhichuan Wu
Summary: In this study, a Pd catalyst supported on amidoxime fiber was prepared and characterized. The catalyst showed good activity and stability in the Heck coupling reaction when employed in a packed-bed flow reactor. Optimal reaction conditions were identified, and a new flow reaction system with parallel reactors was established to further improve catalytic efficiency. This research provides an alternative pathway for highly efficient Heck coupling in continuous flow.
JOURNAL OF CHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaoli Yi, Chuanming Xu, Jing Yang, Chao Zhong, Huiru Yang, Le Tang, Shanshan Song, Jun Yu
Summary: This study evaluated the renoprotective effect of Tiliroside on LPS-induced AKI in mice. Results showed that Tiliroside treatment improved renal function and histological changes, suppressed inflammation, oxidative stress, and tubular cell apoptosis, promoted autophagy flux, and regulated the intrarenal renin-angiotensin system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Jiafa Ren, Kang Liu, Buyun Wu, Xiaohan Lu, Lianqin Sun, Jamie R. Privratsky, Changying Xing, Matthew J. Robson, Huijuan Mao, Randy D. Blakely, Koki Abe, Tomokazu Souma, Steven D. Crowley
Summary: This study examines the expression of IL-1 and IL-1R1 in renal cells and infiltrating immune cells during AKI and demonstrates opposing effects of IL-1 receptor signaling on AKI. Disrupting IL-1R1 activation in tubules while preserving IL-1R1 activation in endothelial cells may provide better renal protection.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pharmacology & Pharmacy
Chuanming Xu
Summary: ELABELA is an endogenous ligand for the G protein-coupled receptor APJ, which plays an important role in cardiovascular homeostasis and may be a potential therapeutic target for cardiovascular diseases (CVDs). ELABELA exhibits angiogenic, vasorelaxant, and cardioprotective effects, and is essential for heart development. It shows promise as a diagnostic biomarker for various CVDs, but its central administration can elevate blood pressure and cause cardiovascular remodeling.
VASCULAR PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yu Zhang, Xiaoyan He, Chuanming Xu
Summary: A mixed type conductive hydrogel has been designed for human running posture monitoring and mechanical energy harvesting. The hydrogel can function as a strain sensor and a nanogenerator, enabling comprehensive motion monitoring and energy collection.
Review
Endocrinology & Metabolism
Chuanming Xu
Summary: Intrarenal aldosterone, which is synthesized within the kidney, plays a vital role in various physiological and pathological processes, particularly cardiovascular events. The synthesis of renal aldosterone is regulated by various factors such as (pro)renin receptor/(pro)renin, angiotensin II/Angiotensin II type 1 receptor, wnt/beta-catenin, cyclooxygenase-2/prostaglandin E2, and klotho. Increased release of renal aldosterone promotes Na+ reabsorption and K+ excretion, contributing to the progression of diabetic nephropathy and salt-related hypertension.
Article
Physiology
Chuanming Xu, Xiaoli Yi, Le Tang, Hui Wang, Shuhan Chu, Jun Yu
Summary: Autophagy regulates urine-concentrating capability by regulating renal AQP2/V2R and ACE/ANG II signaling.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chenchen Song, Taisheng Kang, Kai Gao, Xudong Shi, Meng Zhang, Lianlian Zhao, Li Zhou, Jianguo Guo
Summary: This study evaluated the feasibility and effects of long-term treatment with a three-dimensional clinostat in C57BL/6 J mice. The mice tolerated well in the clinostat apparatus and showed significant differences in metabolome and bone loss compared to the control group. This provides a new strategy for pre-launch training of mice and conducting relevant ground-based modeling experiments.
Article
Physiology
Xiaohan Lu, Steven D. Crowley
Summary: The immune response plays a critical role in the pathogenesis of hypertension, and dendritic cells (DCs) are important in regulating immune response during hypertension and kidney disease. Activated T cells release effector cytokines in the kidney, promoting blood pressure elevation.
COMPREHENSIVE PHYSIOLOGY
(2022)
