Article
Obstetrics & Gynecology
Jaden R. Kohn, Payam Katebi Kashi, Stefany Acosta-Torres, Anna L. Beavis, Mindy S. Christianson
Summary: Fertility-sparing treatment is a viable option for women with gynecologic cancers, with different surgical and non-surgical approaches available depending on the type and stage of the cancer. Strategies such as progestin therapy, ovarian preservation, and assisted reproductive technology can help preserve fertility while ensuring effective cancer treatment. Ongoing research into methods such as oocyte or embryo cryopreservation provides promising possibilities for the future of fertility preservation in gynecologic oncology.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Oncology
R. C. J. van der Plas, A. M. E. Bos, I. M. Jurgenliemk-Schulz, C. G. Gerestein, R. P. Zweemer
Summary: Many young cervical cancer survivors desire parenthood and have successful reproductive outcomes after fertility-sparing treatments. Vaginal Radical Trachelectomy (VRT) shows good reproductive outcomes in early-stage disease without compromising oncological safety. Fertility preservation and gestational surrogacy provide promising alternatives for those requiring gonadotoxic treatments to achieve a biological offspring.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Medicine, General & Internal
Krzysztof Galczynski, Piotr Olcha, Katarzyna Romanek-Piva, Maciej Jozwik, Andrzej Semczuk
Summary: Endometrial cancer (EC) is rare in adolescents in developed countries, with the increasing rate of obesity in children and adolescents being held responsible for the rising prevalence in younger patients. Diagnosis of EC can have devastating consequences on future fertility due to standard treatment protocols involving hysterectomy. Genetic screening should be considered in very young patients with EC, as there is a high proportion of cases with genetic backgrounds such as Cowden syndrome and Turner syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Kirsten Jorgensen, Clare Meernik, Chi-Fang Wu, Caitlin C. Murphy, Valerie L. Baker, Peiton Jarmon, Paula C. Brady, Roni Nitecki, Hazel B. Nichols, Jose Alejandro Rauh-Hain
Summary: The study aims to assess the presence of sociodemographic and clinical disparities in fertility-sparing treatment and ART use among patients with a history of cervical, endometrial, or ovarian cancer. The study found that there are sociodemographic disparities related to cancer type in fertility-sparing treatment and ART use.
OBSTETRICS AND GYNECOLOGY
(2023)
Review
Oncology
Levent Mutlu, Diego D. Manavella, Giuseppe Gullo, Blair McNamara, Alessandro D. Santin, Pasquale Patrizio
Summary: Young women diagnosed with endometrial cancer face unique challenges, but preserving fertility is possible in early and low-grade cases. Data suggest that conservative approaches with close monitoring do not compromise oncologic outcomes. For patients unable to preserve fertility, assisted reproductive technologies can help achieve fertility goals.
Review
Oncology
Carlo Ronsini, Lavinia Mosca, Irene Iavarone, Roberta Nicoletti, Davide Vinci, Raffaela Maria Carotenuto, Francesca Pasanisi, Maria Cristina Solazzo, Pasquale De Franciscis, Marco Torella, Marco La Verde, Nicola Colacurci, Luigi Cobellis, Giuseppe Vizzielli, Stefano Restaino
Summary: Conservative management can be considered as an option for young women with grade 2, stage IA endometrial cancer who wish to preserve their fertility. The combination of levonorgestrel-releasing intra-uterine device and systemic therapy can result in a high rate of complete response. However, fertility-sparing treatment is not the current standard of care for young women with endometrial cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Wei Lin, Dongyan Cao, Xiaohua Shi, Yan You, Jiaxin Yang, Keng Shen
Summary: Fertility-sparing surgery is a suitable option for young patients with early-stage mucinous ovarian carcinoma, achieving acceptable oncological outcomes and meaningful pregnancy rates. Re-staging should be considered for patients who undergo incomplete staging surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dan Wang, Wei Cang, Shan Zhu, Congwei Jia, Dongyan Cao, Jiaxin Yang, Yang Xiang
Summary: The study evaluated the oncological and reproductive outcomes in patients with advanced-stage ovarian immature teratoma (IMT). The results showed that IMT has a favorable prognosis. Fertility-sparing surgery (FSS) is feasible for patients who wish to preserve their fertility.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Satoshi Tamauchi, Hiroaki Kajiyama, Satoko Osuka, Yoshinori Moriyama, Masato Yoshihara, Fumitaka Kikkawa
Summary: The response to controlled ovarian stimulation decreased after radical trachelectomy, as evidenced by lower estradiol concentration and number of retrieved oocytes compared to the control group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Public, Environmental & Occupational Health
Tao Chen, Jia Li, Yan Zhu, An-Wei Lu, Li Zhou, Jian-San Wang, Ying Zhang, Jun-Tao Wang
Summary: This study examined the oncological and obstetric outcomes of radical trachelectomy in early-stage cervical cancer patients. The results showed that radical trachelectomy is a safe and effective treatment for preserving fertility in women with early-stage cervical cancer, particularly for those with tumor size ≤ 4 cm.
Review
Biochemistry & Molecular Biology
Nayanar-Adela Contreras, Jordi Sabadell, Paula Verdaguer, Carla Julia, Maria-Eulalia Fernandez-Montoli
Summary: Endometrial cancer is the fourth most common cancer in women in developed countries. Its incidence has increased in young women, possibly due to factors such as delayed childbearing and obesity. The new molecular classification of the disease helps personalize treatment. Current evidence suggests that oral progestin alone or in combination with other drugs is a feasible and safe option for the conservative management of early-stage endometrial cancer limited to the endometrium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Alexandros Laios, Sara Duarte Portela, Argyro Papadopoulou, Ioannis D. Gallos, Mohamed Otify, Thomas Ind
Summary: Cervical cancer is the fourth most common female malignancy worldwide, and ovarian transposition remains a safe option for preserving ovarian function, but its usage is controversial due to the scarcity of data and clinical trials.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Review
Medicine, General & Internal
Simone Garzon, Stefano Uccella, Pier Carlo Zorzato, Mariachiara Bosco, Massimo P. Franchi, Vladimir Student, Andrea Mariani
Summary: Fertility preservation appears feasible in young patients with grade 1 EC limited to the endometrium or atypical endometrial hyperplasia. Progestins are the mainstay of such management. The addition of Metformin and hysteroscopic resection seems to provide some improvements. However, fertility preservation is not the standard approach for staging and treatment, potentially worsening oncologic outcomes.
Article
Oncology
Ida Pino, Anna Daniela Iacobone, Ailyn Mariela Vidal Urbinati, Maria Di Giminiani, Davide Radice, Maria Elena Guerrieri, Eleonora Petra Preti, Silvia Martella, Dorella Franchi
Summary: This article discusses the experience of fertility-sparing treatment for endometrial cancer and compares the oncological and reproductive outcomes of different hormonal therapies. The study suggests that the combination of LNG-IUD and metformin showed a significantly lower risk of recurrence compared to other treatment regimens.
Article
Obstetrics & Gynecology
Marin Lefton, Aurelie Rives-Feraille, Maria Letailleur, Claire Helene Petrovic, Barbara Martin, Loic Marpeau, Fabrice Jardin, Moutaz Aziz, Aspasia Stamatoulas-Bastard, Ludovic Dumont, Christine Rondanino, Nathalie Rives
Summary: The study found that young adult women had a high satisfaction rate with ovarian tissue cryopreservation (OTC) and believed that the experience was beneficial. Most patients believed that OTC had a positive impact on their health during disease treatment. The majority of women successfully planned a pregnancy after treatment, with a natural pregnancy rate close to 53%.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Elsa Delgado-Sanchez, Francesco Fanfani, Mario Malzoni, Aldina Couso, Alvaro Zapico, Stefano Bogliolo, Damian A. Sanchez-Torres, Barbara Gardella, Israel John Thuissard-Vasallo, Ignacio Zapardiel
Summary: This retrospective multicentric study compared laparoendoscopic single-site surgery (LESS) and mini-laparoscopic surgery (Mini-LPS) in terms of surgical time, postoperative pain, and hospital stay for patients undergoing simple hysterectomy for a benign condition. The results showed shorter surgical time and hospital stay in the Mini-LPS group compared to the LESS group. However, the Mini-LPS group had a higher rate of conversion to standard laparoscopy due to instrumentation flaws. Both ultra-minimally invasive techniques were found to be safe for performing hysterectomy for a benign condition.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2023)
Review
Oncology
Ignacio Zapardiel, Marcello Ceccaroni, Lucas Minig, Michael J. Halaska, Shingo Fujii
Summary: This review aims to synthesize currently used anatomical landmarks with relation to surgical avascular spaces for the performance of radical hysterectomy. A comprehensive computer-based review of various databases and guidelines was conducted to gather relevant data. The manuscript includes a clear definition of avascular spaces, methods of dissection, and anatomical limits, and provides a better understanding of the surgical procedure.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Health Care Sciences & Services
Ignacio Cristobal Quevedo, Ignacio Cristobal Garcia, Myriam Gracia, Virginia Garcia-Pineda, Maria Alonso-Espias, Jaime Siegrist, Maria Dolores Diestro, Alicia Hernandez, Ignacio Zapardiel
Summary: The study aimed to compare the effectiveness of indocyanine green (ICG) as a single tracer versus Technetium99 + ICG for bilateral sentinel lymph node detection in endometrial cancer. The results showed that ICG as a single tracer achieved higher rates of bilateral detection, and the oncological outcomes were not affected by the type of tracer used.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Obstetrics & Gynecology
Filippo Maria Ubaldi, Alberto Vaiarelli, Danilo Cimadomo, Maria Cerrillo, Laura Rienzi, Juan A. Garcia-Velasco
HUMAN REPRODUCTION
(2023)
Letter
Obstetrics & Gynecology
Juan A. Garcia-Velasco, Danilo Cimadomo, Maria Cerrillo, Alberto Vaiarelli, Filippo Maria Ubaldi
HUMAN REPRODUCTION
(2023)
Article
Oncology
Ignacio Zapardiel, Myriam Gracia Segovia, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Giacomo Corrado, Arnoldas Bartusevicius, Vladyslav Sukhin, Juan C. Muruzabal, Pluvio J. Coronado Martin, Barbara Gardella, Jurgen M. Piek, Nicole Concin, Clemente Arab, Dimitrios Papatheodorou, Stephan Polterauer, Sara Iacoponi, Teresa Nieto, Martha C. Lopez-Sanclemente, Hanna Trukhan, Maria M. Gil, Irina Bakinovskaya, Alena Dalamanava, Marc Cucurull, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Marcin Mardas, Siarhei Anatolievich Mavrichev, Jaroslav Klat, Carlos A. Lopez de la Manzanara, Yusuf Yildirim, SARCUT Study Grp
Summary: This retrospective study analyzed 683 patients with uterine sarcoma to identify and evaluate the impact of different prognostic factors on overall survival and disease-free survival. The results showed variations in 5-year overall survival and disease-free survival rates among different subtypes of uterine sarcoma. The presence of residual disease after surgery was identified as the most significant factor affecting overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Mustafa Onur Kamani, Maria Kyrgiou, Elmar Joura, Ignacio Zapardiel, Mihaela Grigore, Marc Arbyn, Mario Preti, Francois Planchamp, Murat Gultekin
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Cyrus Chargari, Kari Tanderup, Francois Planchamp, Luis Chiva, Pauline Humphrey, Alina Sturdza, Li T. Tan, Elzbieta van der Steen-banasik, Ignacio Zapardiel, Remi A. Nout, Christina Fotopoulou
Summary: The European Society of Gynaecological Oncology (ESGO) and the European SocieTy for Radiotherapy and Oncology (ESTRO) have developed a list of quality indicators for radiation therapy of cervical cancer. These indicators aim to improve the quality of care for cervical cancer patients and provide a quantitative basis for practitioners and administrators to improve clinical practice. The list includes 19 indicators based on scientific evidence and expert consensus.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Biology
A. M. Portillo, E. Varela, J. A. Garcia-Velasco
Summary: This paper proposes a discrete model for the temporal evolution of a population of cells sorted according to their telomeric length. The model assumes asymmetric distribution of genetic material during cell division, with one daughter cell having the same telomere length as the mother and the other having shorter telomeres. The model takes into account telomerase activity, cell death, and the Hayflick limit. A partial differential equation with boundary conditions is derived to represent the continuous model. The model is applied to study the aging rate of human follicular growth.
MATHEMATICAL BIOSCIENCES
(2023)
Article
Oncology
Alessandro Buda, Cristiana Paniga, Salih Taskin, Michael Mueller, Ignacio Zapardiel, Francesco Fanfani, Andrea Puppo, Jvan Casarin, Andrea Papadia, Elena De Ponti, Tommaso Grassi, Jessica Mauro, Hasan Turan, Dogan Vatansever, Mete Gungor, Firat Ortag, Sara Imboden, Virginia Garcia-Pineda, Stefan Mohr, Franziska Siegenthaler, Stefania Perotto, Fabio Landoni, Fabio Ghezzi, Giovanni Scambia, Cagatay Taskiran, Robert Fruscio
Summary: This study aimed to assess the impact of low-volume metastasis on disease-free survival in women with apparent early-stage endometrial cancer. The results showed that micrometastases in the lymph nodes were associated with a lower disease-free survival rate.
Article
Oncology
Myriam Gracia, Yusuf Yildirim, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Stephan Polterauer, Sara Iacoponi, Ignacio Zapardiel, SARCUT Study Grp
Summary: Uterine carcinosarcoma is a rare disease that accounts for less than 5% of uterine malignancies but contributes to approximately 16% of uterine cancer-related deaths. In this study, prognostic factors, such as incomplete cytoreduction, advanced disease stage, presence of residual tumor, extrauterine disease, and tumor size, were found to significantly impact disease-free survival and overall survival among patients with uterine carcinosarcoma.
Article
Health Care Sciences & Services
Virginia Garcia-Pineda, Alicia Hernandez, Sonia Garrido-Mallach, Elena Rodriguez-Gonzalez, Maria Alonso-Espias, Myriam Gracia, Rocio Arnedo, Ignacio Zapardiel
Summary: This study evaluated the impact of surgical treatment of endometrial cancer with sentinel lymph node biopsy (SLNB) on patients' quality of life (QoL). The results showed that the SLNB group had a better QoL in terms of functional and symptom aspects, as well as sexual health.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Maria Alonso-Espias, Mikel Gorostidi, Myriam Gracia, Virginia Garcia-Pineda, Maria Dolores Diestro, Jaime Siegrist, Alicia Hernandez, Ignacio Zapardiel
Summary: The benefit of adjuvant radiotherapy (RT) after radical hysterectomy in cervical cancer patients remains controversial. This study found that adjuvant RT did not significantly impact survival in early-stage cervical cancer patients who met Sedlis criteria. However, further studies are needed to determine if adjuvant RT is necessary for patients with intermediate risk factors.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ronalds Macuks, Yusuf Yildirim, Rosanna Mancari, Patriciu K. Achimas-Cadariu, Thumuluru K. Madhuri, Eugenia Ortega, Michael Mallmann, Oliver Zivanovic, Ignacio Zapardiel, SARCUT Study Grp
Summary: The purpose of this study was to analyze the prognostic factors related to the recurrence rate and overall survival of patients with undifferentiated uterine sarcoma. The results showed that FIGO stage was the most important prognostic factor, adjuvant radiotherapy was associated with better disease-free and overall survival, while chemotherapy was associated with shorter disease-free survival.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Medicine, General & Internal
Barbara Gardella, Mattia Dominoni, Andrea Gritti, Liliana Mereu, Stefano Bogliolo, Marco Torella, Francesco Fanfani, Mario Malzoni, Aldina Couso, Alvaro Zapico, Ignacio Zapardiel
Summary: This study compared the surgical outcomes of single-site hysterectomy for benign conditions between the traditional laparoendoscopic approach and robotic surgery. The results showed that laparoendoscopic surgery outperformed robotic surgery in terms of operative time and intraoperative blood loss.
MEDICINA-LITHUANIA
(2023)
