Review
Genetics & Heredity
Mostafa Saleban, Erica L. Harris, James A. Poulter
Summary: D-type cyclins encode G1/S cell cycle checkpoint proteins, which are crucial for determining cell cycle exit and progression. Proper control of cell cycle exit is essential during embryonic development, and defects in the regulation of intracellular D-type cyclins can lead to abnormal initiation of stem cell differentiation in various organ systems. Additionally, abnormal stabilization of D-type cyclins is observed in diseases characterized by excessive cell proliferation, such as cancer and overgrowth disorders. In this review, we will summarize and compare the roles of each D-type cyclin in development and provide examples of how their dysregulation can contribute to disease.
Article
Oncology
Swapna Asuthkar, Sujatha Venkataraman, Janardhan Avilala, Katherine Shishido, Rajeev Vibhakar, Bethany Veo, Ian J. Purvis, Maheedhara R. Guda, Kiran K. Velpula
Summary: Medulloblastoma (MB) is the most common malignant pediatric brain tumor, and the standard of care for MB patients includes maximum safe resection, postoperative craniospinal irradiation, and chemotherapy. Recent research has identified SMYD3 as a crucial epigenetic regulator, which activates the transcription of cyclin D3 and drives the growth of Group 3 Myc+ MB cells.
Article
Biotechnology & Applied Microbiology
Xin Chen, Chang Liu, Meng Zhang, Yumei Zhang
Summary: Maduramicin inhibits cell growth and proliferation, alters the cell cycle, decreases Cyclin D1 expression, and suppresses AKT-Cyclin D1 signaling, leading to myocardial cell toxicity.
Article
Oncology
Arwa Aldaalis, Maria T. Bengoechea-Alonso, Johan Ericsson
Summary: The transcription factor SREBP1 positively regulates the expression of cyclin D1 by binding to an E-box in the cyclin D1 promoter. Inactivation of SREBP1 reduces cyclin D1 expression and attenuates Rb phosphorylation, while activation of SREBP1 increases cyclin D1 expression and enhances Rb phosphorylation. The regulation of cyclin D1 by SREBP1 coordinates cell proliferation with enhanced lipid synthesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ying Hou, Rong Liu, Mengwei Xia, Chong Sun, Bingling Zhong, Jie Yu, Nana Ai, Jin-Jian Lu, Wei Ge, Bo Liu, Xiuping Chen
Summary: NAN triggers G1 phase cell cycle arrest and caspase-independent apoptosis in CRC cells through downregulation of cyclin D1 and inhibition of eEF1A-targeted translation.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Shuang Han, Peng Wu, Meng Duan, Fei Yang, Wei He, Nannan Wu, Xueqing Hu, Da Gan, Guowei Wang, Min Yang, Wenguang Wang, Zhuo-Xian Meng, Shankuan Zhu
Summary: Platelets play a crucial role in promoting the proliferation of pre-adipocytes, especially in obese mice. They enhance pre-adipocyte proliferation by accelerating cell cycle progression and activating the mTOR pathway.
CLINICAL NUTRITION
(2021)
Editorial Material
Cell Biology
Luca Di Leo, Daniela De Zio
Summary: AMBRA1 plays an anti-tumorigenic role in melanoma, regulating cellular processes beyond autophagy and providing potential therapeutic targets for AMBRA1 low-expressing melanoma.
Article
Biochemistry & Molecular Biology
Paulina Kober, Beata Joanna Mossakowska, Natalia Rusetska, Szymon Baluszek, Emilia Grecka, Ryszard Konopinski, Ewa Matyja, Artur Ozieblo, Tomasz Mandat, Mateusz Bujko
Summary: This study reveals the involvement of MIR193B gene hypermethylation in the pathogenesis of meningiomas, leading to downregulation of two miRNAs and subsequent inhibition of meningioma cell proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Weijie Liang, Jie Wu, Xinguang Qiu
Summary: This study revealed that LINC01116 is overexpressed in CRC tissues and its high expression is negatively correlated with postoperative survival. In vitro experiments demonstrated that LINC01116 can enhance CRC progression by regulating EZH2 to inhibit TPM1 promoter, leading to increased cell proliferation, migration, and angiogenesis. Further in vivo experiments validated the findings from the in vitro study.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jia-Xing Sun, Guo-Rui Dou, Zi-Yan Yang, Liang Liang, Juan-Li Duan, Bai Ruan, Man-Hong Li, Tian-Fang Chang, Xin-Yuan Xu, Juan-Juan Chen, Yu-Sheng Wang, Xian-Chun Yan, Hua Han
Summary: The study demonstrates that miR-218 acts as a downstream effector of Notch signaling in quiescent endothelial cells, inhibiting cell proliferation and sprouting, and could be a potential treatment for angiogenesis-related diseases.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Orthopedics
Yunshan Guo, Jinzhu Fan, Shuguang Liu, Dingjun Hao
Summary: This study reveals that downregulation of Orai1 may reduce cyclin D1 expression by inactivating the Ras-NF-kappa B signaling pathway, thus blocking osteoblast proliferation and cell cycle.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Hao Xu, Jiani Guan, Zhichun Jin, Cheng Yin, Shengnan Wu, Wen Sun, Hanwen Zhang, Bin Yan
Summary: This study demonstrates that mechanical force can induce macrophage proliferation in periodontal tissue and orthodontic tooth movement. The mechanosensory ion channel Piezo1 plays a crucial role in mediating the response of macrophages to mechanical stimuli and promotes their proliferation. The Piezo1-AKT-Ccnd1 axis is identified as an important mechanism in regulating macrophage proliferation during orthodontic tooth movement.
Article
Engineering, Biomedical
Xuanzhe Liu, Yuange Li, Shuo Wang, Mingkuan Lu, Jian Zou, Zhongmin Shi, Binbin Xu, Wei Wang, Bo Hu, Tuo Jin, Fei Wu, Shen Liu, Cunyi Fan
Summary: This study investigates the use of a PDGF-loaded microneedle patch for enhancing tendon healing through angiogenesis. The results showed enhanced tendon healing quality and improved biomechanical properties, along with the involvement of the MAPK/p38/Cyclin D1 pathway and angiogenesis in the healing process.
MATERIALS TODAY BIO
(2022)
Editorial Material
Cell Biology
Emiliano Maiani, Giacomo Milletti, Francesco Cecconi
Summary: AMBRA1 is a key scaffold protein that regulates early autophagosome formation, cell growth, and G1/S phase transition, and its deficiency is associated with neurodevelopmental defects and cancer. By controlling the expression of D-type cyclins, AMBRA1 plays a crucial role in maintaining genome integrity during DNA replication and represents a novel mechanism of cell cycle regulation interconnected with genomic stability in development and cancer.
Article
Pharmacology & Pharmacy
Minhui Yang, Changxiao Hu, Yibo Cao, Wanling Liang, Xiangdong Yang, Tianbao Xiao
Summary: The study explores the biological functions of CCNB1 in COAD and investigates the therapeutic effects of UA on COAD cells. UA effectively inhibits COAD cell proliferation and induces cell cycle arrest in S phase. The molecular mechanisms of UA involve downregulation of CCNB1 and its interacting genes and proteins, contributing to cell cycle blocking and COAD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Obstetrics & Gynecology
M. Yano, K. Kai, T. Hirakawa, A. Yuge, N. Yada, H. Narahara
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2016)
Article
Obstetrics & Gynecology
Harunobu Matsumoto, Kaei Nasu, Kentaro Kai, Masakazu Nishida, Hisashi Narahara, Haruto Nishida
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2016)
Article
Obstetrics & Gynecology
Hiroshi Makino, Shin Nishio, Hiroshi Tsubamoto, Muneaki Shimada, Ryutaro Nishikawa, Kentaro Kai, Kimihiko Ito, Tomoko Mizuno, Kimio Ushijima, Ken-ichiro Morishige
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2016)
Article
Obstetrics & Gynecology
Chiharu Mizoguchi, Harunobu Matsumoto, Kaei Nasu, Motoki Arakane, Kentaro Kai, Hisashi Narahara
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2016)
Article
Obstetrics & Gynecology
Yoko Aoyagi, Kaei Nasu, Kentaro Kai, Tomoko Hirakawa, Mamiko Okamoto, Yasushi Kawano, Wakana Abe, Yoshiyuki Tsukamoto, Masatsugu Moriyama, Hisashi Narahara
REPRODUCTIVE SCIENCES
(2017)
Article
Obstetrics & Gynecology
Mitsutake Yano, Yoshihiro Nishida, Kentaro Kai, Terukazu Ishii, Naohiko Takahashi, Hisashi Narahara
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Kaei Nasu, Yukie Kawano, Kentaro Kai, Yoko Aoyagi, Wakana Abe, Mamiko Okamoto, Hisashi Narahara
FRONTIERS IN BIOSCIENCE-LANDMARK
(2014)
Article
Obstetrics & Gynecology
K. Kai, K. Shimamoto, H. Matsumoto, H. Narahara
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2014)
Article
Obstetrics & Gynecology
Kaei Nasu, Kentaro Kai, Tomoko Hirakawa, Masakazu Nishida, Harunobu Matsumoto, Yasushi Kawano, Hisashi Narahara
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2014)
Article
Endocrinology & Metabolism
Tomoko Hirakawa, Kaei Nasu, Kentaro Kai, Yoko Aoyagi, Terukazu Ishii, Tetsuya Uemura, Mitsutake Yano, Hisashi Narahara
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2014)
Article
Oncology
Nobuhiro Takeshima, Maki Matoda, Masakazu Abe, Yasuyuki Hirashima, Kentaro Kai, Kaei Nasu, Masashi Takano, Kenichi Furuya, Seiya Sato, Hiroaki Itamochi, Hiroshi Tsubamoto, Kosei Hasegawa, Kiminari Terao, Takeo Otsuki, Keiko Kuritani, Kimihiko Ito
SUPPORTIVE CARE IN CANCER
(2014)
Article
Obstetrics & Gynecology
Kentaro Kai, Kaori Koga, Makoto Yamamoto, Satoshi Nakagawa, Takashi Kojima, Kazue Togashi, Yasushi Kurihara, Hiroki Sato, Makio Shozu
Summary: The experience of observing deliveries may encourage medical students to choose a career in obstetrics and gynecology.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Kentaro Kai, Niraj R. Joshi, Gregory W. Burns, Samantha M. Hrbek, Erin L. Vegter, Maria Ariadna Ochoa-Bernal, Yong Song, Genna E. Moldovan, Lorenzo F. Sempere, Eduardo H. Miyadahira, Paulo C. Serafini, Asgerally T. Fazleabas
Summary: This study explores the role of miR-210 and its targets, IGFBP3 and COL8A1, in the growth and development of endometriosis. It was found that miR-210 expression was decreased in ectopic lesions, while IGFBP3 and COL8A1 expression was increased. MiR-210 overexpression suppressed IGFBP3 expression and attenuated cell proliferation and migration.
REPRODUCTIVE SCIENCES
(2023)
Article
Oncology
Harunobu Matsumoto, Mototsugu Shimokawa, Kaei Nasu, Ayumi Shikama, Takaya Shiozaki, Masayuki Futagami, Kentaro Kai, Hiroaki Nagano, Taisuke Mori, Mitsutake Yano, Norihiro Sugino, Etsuko Fujimoto, Norihito Yoshioka, Satoshi Nakagawa, Muneaki Shimada, Hideki Tokunaga, Yuki Yamada, Tomohiko Tsuruta, Kazuto Tasaki, Ryutaro Nishikawa, Shiho Kuji, Takashi Motohashi, Kimihiko Ito, Takashi Yamada, Norihiro Teramoto
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)