Article
Immunology
Lingli Xin, Fengsheng Li, Huijie Yu, Qi Xiong, Qingxiang Hou, Yuanguang Meng
Summary: HKL effectively ameliorated IR-induced POF by inhibiting cell death and inflammatory cell death, enhancing Nrf2 expression and translocation. It also protected fertility, GSI, hormone levels, and follicle numbers.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xinning Li, Xuelan Li, Ling Deng
Summary: Chrysin regulates hormone expression and weight, inhibits inflammation and oxidative stress, improves ovarian function in animals with POF, and inhibits apoptosis of ovarian granulosa cells. Furthermore, Chrysin targets ER beta and activates its expression. This suggests that Chrysin has potential for the treatment of POF.
Review
Physiology
Tuo Zhang, Meina He, Jingjing Zhang, Yuntong Tong, Tengxiang Chen, Chao Wang, Wei Pan, Ziwen Xiao
Summary: Primordial follicles serve as the starting point for follicular development and are crucial for female reproduction. Once formed around birth, most primordial follicles enter a dormant state that cannot be reversed, leading to limited fertility and ovarian aging. Inhibiting the activation rate of primordial follicles can slow down follicle consumption and preserve fertility. The development of in vitro activation (IVA) techniques based on the understanding of primordial follicle activation mechanisms holds promise for treating infertility in different patient populations. This review explores the recent advances in understanding primordial follicle activation mechanisms and their clinical applications.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zijing Shang, Meiling Fan, Jingtian Zhang, Zi Wang, Shuang Jiang, Wei Li
Summary: This study evaluated the ameliorative effect and molecular mechanism of red ginseng extract on D-galactose-induced premature ovarian failure using network pharmacology analysis. Ginsenosides, sugar, and amino acid derivatives in red ginseng were identified as important active ingredients. The study constructed a protein-protein interaction network and identified core targets related to premature ovarian failure. In vivo experiments confirmed that red ginseng extract can increase estradiol levels and reduce follicle-stimulating hormone levels by reducing oxidative stress, apoptosis, and senescence signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Oren Kashi, Dror Meirow
Summary: This manuscript reviews the impact of chemotherapy on ovarian reserve and the preventive measures. Chemotherapy can deplete dormant follicles and potentially lead to ovarian insufficiency. Ideal drugs for fertility preservation can be found by intervening in ovarian toxic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Siheng Liu, Yunbing Jia, Shirui Meng, Yiran Luo, Qi Yang, Zezheng Pan
Summary: Granulosa cells play a crucial role in follicle initiation and development, and their abnormal function or apoptosis can lead to follicular atresia. Oxidative stress, caused by an imbalance between reactive oxygen species production and the antioxidant system regulation, is a major cause of granulosa cell dysfunction and apoptosis. Studies have identified several signaling pathways, including PI3K-AKT, MAPK, FOXO, Nrf2, NF-?B, and mitophagy, that are closely linked to oxidative stress in granulosa cells. Certain drugs, such as sulforaphane, Periplaneta americana peptide, and resveratrol, have been found to alleviate the functional damage caused by oxidative stress in granulosa cells. This paper reviews the mechanisms involved in oxidative stress in granulosa cells and discusses the pharmacological treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Maki Fukami
Summary: Ovarian dysfunction is a common feature in women with Turner syndrome, in which oocyte apoptosis is accelerated and leads to streak gonads formation. The accelerated germ cell loss in 45,X ovaries may be caused by chromosomal pairing failure, impaired coupling between oocytes and granulosa cells, and reduced dosage of certain genes on the X chromosome. Further research on the mechanisms of ovarian dysfunction is necessary to improve reproductive outcomes in women with Turner syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Mingyue Qu, Qican He, Baoshi Guo
Summary: Lycopene has a protective effect against testicular damage induced by ionizing radiation, and the mechanism may involve inhibition of the mitochondrial apoptotic pathway and maintenance of mitochondrial respiration and biogenesis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hao Xu, Xiaoyu Mao, Zhentao Nie, Yun Li
Summary: This study reveals that Oxidation Resistance 1a (Oxr1a), an ortholog of mammalian Oxr1, protects the oocytes of female zebrafish against oxidative stress and represses the phenotype of Premature Ovarian Failure (POF). Oxr1a participates in the process of oxidative stress by regulating the mRNA expression levels of antioxidant enzymes Cat and Sod1, metabolizing intracellular ROS and avoiding mitochondrial oxidative damage, thus ensuring the normal development and maturation of oocytes.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Lili Zhang, Bin Mao, Xiaodong Zhao, Yue Yuan, Wei Wang, Shaohua Lin
Summary: This study suggests that TRERNA1 may suppress granulosa cell apoptosis in POF by directly interacting with miR-23a.
Article
Pharmacology & Pharmacy
Ying Peng, Lu Sun, Wentong Guo, Zhigang Liu, Tianxiang Wang, Tingfeng Zou, Jie Zhou, Xiaoxiao Yang, Xiaodong Fan
Summary: In this study, the role of berberine (BBR) on ovarian function decline in a premature ovarian insufficiency (POI) mouse model was investigated. The results showed that BBR can effectively improve ovarian function by reducing oxidative stress and inflammatory response.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Jingyang Zhou
Summary: Premature ovarian failure, also known as premature menopause, is a condition where menstruation stops and oocyte formation occurs before the age of 40. The role of ovarian granulosa cells in premature ovarian failure is being investigated, with theories suggesting apoptosis of these cells may be a contributing factor. Ursolic acid, known for its ability to relieve hypoxia and endoplasmic reticulum stress, has been proposed as a potential treatment option for premature ovarian failure.
MEDICAL HYPOTHESES
(2021)
Review
Oncology
Zelin Li, Haodong Qi, Zhengyang Li, Yuxuan Bao, Kangping Yang, Qinghua Min
Summary: Cisplatin is a common anticancer drug that can kill tumor cells but also causes adverse reactions in various systems. It acts by binding to tumor cell DNA to prevent replication, leading to cell damage and death. However, its therapeutic selectivity is poor, and it can harm normal cells, particularly affecting ovarian function in reproductive-age women.
FRONTIERS IN ONCOLOGY
(2023)
Article
Veterinary Sciences
Beibei Zhang, Guanggang Qu, Yuchen Nan, En-Min Zhou
Summary: The study found that infertility caused by ZP3 vaccination is associated with ovarian oxidative stress and follicle loss. Antioxidant stress drugs can reduce oxidative stress and apoptosis levels, restore follicle numbers, and improve fertility.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Cell Biology
Seung Joo Chon, Zobia Umair, Mee-Sup Yoon
Summary: Premature ovarian insufficiency (POI) is a condition characterized by the loss of normal ovarian function before the age of 40, affecting a small percentage of women under 40. The condition is biochemically defined by amenorrhea, low estrogen levels, and high gonadotropin levels, potentially leading to infertility. POI has a heterogeneous etiology, including both genetic and non-genetic factors, and current research focuses on genetic basis, non-coding RNA, and animal models to uncover pathogenesis and potential treatment targets. Despite recent advances, understanding gene regulatory networks and exploring therapies remain critical for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xiaoxing Xu, Birendra Mishra, Ning Qin, Xue Sun, Shumin Zhang, Jinzeng Yang, Rifu Xu
ANIMAL BIOTECHNOLOGY
(2019)
Review
Endocrinology & Metabolism
Birendra Mishra, Ulrike Luderer
NATURE REVIEWS ENDOCRINOLOGY
(2019)
Review
Agriculture, Dairy & Animal Science
Sanjeev Wasti, Nirvay Sah, Birendra Mishra
Article
Biotechnology & Applied Microbiology
Nirvay Sah, Donna Lee Kuehu, Vedbar Singh Khadka, Youping Deng, Rajesh Jha, Sanjeev Wasti, Birendra Mishra
Summary: This study identified novel genes involved in egg-white synthesis and secretion, along with well-known functional genes. These findings help to understand the mechanisms involved in albumen biosynthesis.
Article
Agriculture, Dairy & Animal Science
Sudhir Yadav, Kayla D. Caliboso, Jannel E. Nanquil, Jiachao Zhang, Helmut Kae, Kabi Neupane, Birendra Mishra, Rajesh Jha
Summary: Commercial chickens showed higher diversity in cecal bacteria, while feral chickens had more unique bacterial species but lower diversity, with a more functional microbiota. This may be attributed to the scavenging behavior of feral birds, diverse feed ingredients, and distinct rearing localities.
Article
Agriculture, Dairy & Animal Science
Sanjeev Wasti, Nirvay Sah, Amit K. Singh, Chin N. Lee, Rajesh Jha, Birendra Mishra
Summary: The study suggests that dietary supplementation of dried plum effectively improves growth performance and gut health parameters in heat-stressed broiler chickens.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sanjeev Wasti, Nirvay Sah, Chin N. Lee, Rajesh Jha, Birendra Mishra
Summary: Heat stress negatively impacts chicken growth and performance, but dietary supplementation of alpha-lipoic acid can mitigate these effects by improving body weight, intestinal health, and microbiota diversity.
Article
Agriculture, Dairy & Animal Science
Xue Sun, Xiaotian Niu, Ning Qin, Xuesong Shan, Jinghua Zhao, Chang Ma, Rifu Xu, Birendra Mishra
Summary: LATS2 plays a crucial role in the development of hen prehierarchical follicles by regulating GC proliferation, differentiation, steroidogenesis, and follicle selection. The study revealed differential expression of LATS2 in various sized follicles and GCs, affecting the expression of genes involved in these processes.
Review
Biology
Karim El-Sabrout, Sarah Aggag, Birendra Mishra
Summary: The global demand for table eggs is growing, requiring advances in hen genetics, nutrition, and husbandry procedures. Improving hens' welfare and egg quality, as well as incorporating functional and designer foods, are important to consumers. Modifications in hen diets can impact egg nutritional composition and quality. Enriched egg products have shown potential benefits to human health. However, producers face challenges in optimizing breeding, housing, and dietary strategies.
Review
Agriculture, Dairy & Animal Science
Karim El-Sabrout, Ayman Khalifah, Birendra Mishra
Summary: The poultry industry faces challenges such as feedstuff availability, banning of antibiotics, and environmental stressors. To sustain the industry, it is necessary to include nutraceuticals in the diet. Botanical products, such as fenugreek seeds and ginger roots, have gained popularity due to their benefits in nutrition and therapeutic properties.
Article
Agriculture, Dairy & Animal Science
Ajay Chaudhary, Pravin Mishra, Sadid Al Amaz, Prem Lal Mahato, Razib Das, Rajesh Jha, Birendra Mishra
Summary: Heat stress in poultry is a serious concern, but supplementing their diet with microalgae can improve their health and productivity. This study aimed to investigate the effects of microalgae supplementation on heat-stressed broilers. The results showed that microalgae supplementation improved the growth performance and gene expression of heat-stressed broilers, as well as increased microbial diversity.
Article
Agriculture, Dairy & Animal Science
Pravin Mishra, Razib Das, Ajay Chaudhary, Birendra Mishra, Rajesh Jha
Summary: This study evaluated the effects of microalgae with or without xylanase supplementation on the growth performance and gut health of broiler chickens. The results showed that adding microalgae with or without xylanase could promote the growth performance and improve gut health parameters of broilers.
Article
Agriculture, Dairy & Animal Science
Sanjeev Wasti, Nirvay Sah, Donna L. Kuehu, Yong S. Kim, Rajesh Jha, Birendra Mishra
ANIMAL SCIENCE JOURNAL
(2020)
Review
Veterinary Sciences
Birendra Mishra, Rajesh Jha
FRONTIERS IN VETERINARY SCIENCE
(2019)
Review
Veterinary Sciences
Rajesh Jha, Amit Kumar Singh, Sudhir Yadav, Julio Francisco Diaz Berrocoso, Birendra Mishra
FRONTIERS IN VETERINARY SCIENCE
(2019)