Article
Materials Science, Multidisciplinary
Tansza Setiana Putri, Devi Rianti, Priyawan Rachmadi, Anita Yuliati
Summary: A composite scaffold was successfully fabricated using beta-tricalcium phosphate (beta TCP) extracted from limestone, mixed with chitosan and gelatin. The study optimized the fabrication process and evaluated the effect of glutaraldehyde on scaffold characteristics. Results showed that lower porosity led to higher compressive strength in the cross-linked scaffolds.
Article
Polymer Science
Aniek Setiya Budiatin, Junaidi Khotib, Samirah Samirah, Chrismawan Ardianto, Maria Apriliani Gani, Bulan Rhea Kaulika Hadinar Putri, Huzaifah Arofik, Rizka Nanda Sadiwa, Indri Lestari, Yusuf Alif Pratama, Erreza Rahadiansyah, Imam Susilo
Summary: The study found that oral BHA supplementation combined with BHA-GEL pellet implants can accelerate the healing of bone defects.
Article
Multidisciplinary Sciences
Gonggong Lu, Yang Xu, Quanying Liu, Manyu Chen, Huan Sun, Peilei Wang, Xing Li, Yuxiang Wang, Xiang Li, Xuhui Hui, En Luo, Jun Liu, Qing Jiang, Jie Liang, Yujiang Fan, Yong Sun, Xingdong Zhang
Summary: In this study, an instantly fixable and self-adaptive scaffold was engineered to promote cranial reconstruction by calcium chelation and interface integration, while also regulating macrophage M2 polarization and recruiting endogenous stem cells.
NATURE COMMUNICATIONS
(2022)
Article
Polymer Science
Ana Iglesias-Mejuto, Carlos A. Garcia-Gonzalez
Summary: In this study, reinforced alginate-hydroxyapatite (HA) aerogel scaffolds were successfully fabricated for bone tissue engineering (BTE) applications by combining extrusion-based 3D-printing and supercritical CO2 gel drying. Intermediate and post-processing strategies such as gel ageing in CaCl2 solutions and glutaraldehyde (GA) chemical crosslinking were utilized to achieve highly crosslinked aerogel scaffolds. The resulting aerogels were dual porous, bio- and hemocompatible, and had high bioactivity dependent on the HA content, marking a significant advance towards optimizing advanced biomaterials and their sterilization.
Article
Agriculture, Multidisciplinary
Songmin Cao, Zixu Wang, Lujuan Xing, Lei Zhou, Wangang Zhang
Summary: This study evaluated the effects of bovine bone gelatin-derived peptides (BGPs) on hypertension in rats and found that they significantly reduced blood pressure and improved dyslipidemia, suggesting their potential as a nutraceutical for hypertension and dyslipidemia.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yang Liu, Manoj Puthia, Eamon J. Sheehy, Ines Ambite, Jitka Petrlova, Sujeethkumar Prithviraj, Maria Wimer Oxborg, Sujeesh Sebastian, Corina Vater, Stefan Zwingenberger, Andre Struglics, Paul E. Bourgine, Fergal J. O'Brien, Deepak Bushan Raina
Summary: This study compared the osteoinductive potential of BMP-2 ho-modimer with a heterodimer of BMP-2/7 in a collagen-hydroxyapatite (CHA) scaffold delivery system. The results showed that CHA + BMP-2/7 had higher osteoinductive ability than CHA + BMP-2, and the CHA scaffold provided sustained release of BMP-2/7 for at least 20 days. Additionally, a low dose of BMP-2/7 accelerated fracture healing and performed at a level comparable to a 20-times higher BMP-2 dose, bringing hope for the use of physiological growth factor doses in fracture healing.
ACTA BIOMATERIALIA
(2023)
Article
Cell & Tissue Engineering
Chung-Kai Sun, Pei-Wei Weng, Jenny Zwei-Chieng Chang, Yi-Wen Lin, Fon-Yih Tsuang, Feng-Huei Lin, Tung-Hu Tsai, Jui-Sheng Sun
Summary: Tissue engineering and regenerative medicine have emerged as a promising therapeutic approach for aging and diseased populations. This study developed a novel nano-gelatin/hydroxyapatite fibrous scaffold with metformin incorporation, showing enhanced healing potential in critical-size bone defects. The scaffold demonstrated proper structure and cellular compatibility, leading to improved bone regeneration outcomes in both in vitro and in vivo studies. More validation is needed before potential clinical applications.
TISSUE ENGINEERING PART A
(2022)
Article
Engineering, Biomedical
Marjan Bahraminasab, Nesa Doostmohammadi, Athar Talebi, Samaneh Arab, Akram Alizadeh, Ali Ghanbari, Amir Salati
Summary: In this study, the properties of 3D-printed PLA scaffolds were improved by infilling them with gelatin-nano-hydroxyapatite (PLA/G-nHA) and subsequent coating with PRP. The scaffolds were evaluated for printing accuracy, structural characterizations, mechanical properties, degradability behavior, cell adhesion, mineralization, systemic effect on liver enzymes, osteocalcin level in blood serum, and in vivo bone regeneration capability. The results showed that PLA/G-nHA/PRP scaffolds had high printing accuracy, superior cell proliferation and adhesion, and better bone regeneration capability compared to bare PLA and PLA/G-nHA scaffolds.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Polymer Science
Janicy Arantes Carvalho, Cristiano Ceron Jayme, Flavia Sayuri Matsuo, Antonio Claudio Tedesco
Summary: Extensive injuries to bone tissue are still a significant clinical challenge, necessitating the development of new bone tissue engineering strategies. This study successfully constructed a chitosan-gelatin/hydroxyapatite-based scaffold to support the growth and differentiation of mesenchymal stem cells into osteoblasts. The scaffold exhibited high biocompatibility and significantly enhanced bone lesion closure in in vivo studies.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Mina Ghafouri Azar, Lucie Wiesnerova, Jana Dvorakova, Petra Chocholata, Omid Moztarzadeh, Jiri Dejmek, Vaclav Babuska
Summary: This research introduces a novel approach of incorporating different types of gelatins into polycaprolactone and poly (lactic-co-glycolic acid) films. The evaluation of these films includes morphology, mechanical properties, thermal stability, biodegradability, hemocompatibility, cell adhesion, proliferation, and cytotoxicity. The results show that the addition of gelatins alters the mechanical properties, biodegradability, and cell behavior of the films. These findings provide valuable insights for future tissue engineering applications involving gelatin incorporation.
Article
Polymer Science
Tufan Arslan Tut, Sumeyye Cesur, Elif Ilhan, Ali Sahin, Onur Samet Yildirim, Oguzhan Gunduz
Summary: This study successfully fabricated a novel 3D composite scaffold for bone defect repair. The scaffold exhibited favorable mechanical properties and controlled release characteristics, and showed good compatibility with bone cells.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Nanoscience & Nanotechnology
Feng Li, Jian Li, Xujun Song, Tong Sun, Lian Mi, Jian Liu, Xiaomin Xia, Na Bai, Xue Li
Summary: This study developed and evaluated an appropriate GA-nCeO2 hydrogel scaffold for bone tissue engineering. The results showed that the scaffold had a favorable structure, biocompatibility, and strong osteogenic potential. This research provides a potential new material for the treatment of bone defects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Jun Liu, Siyu Wu, Jiayi Ma, Chun Liu, Ting Dai, Xiaoyu Wu, Hongbin Zhao, Dong Zhou
Summary: This study manufactured nanofibrous scaffolds incorporating different ratios of attapulgite (ATP) and Hydroxyapatite (HA) to enhance the osteoinductive effect in bone tissue engineering. The synergistic effect of ATP and HA on bone formation was explored both in vivo and in vitro. The study found that the ATP/HA ratio of 2:1 had the most significant synergistic effect.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Materials Science, Ceramics
Jishita Ravoor, S. Renold Elsen
Summary: Bioceramic scaffolds are widely used in bone tissue engineering applications due to their ability to interact with host tissues. This study developed hydroxyapatite and multiwalled carbon nanotubes reinforced scaffolds using the robocasting technique. Vacuum sintering was used to prevent oxidation of carbon nanotubes, and the resulting scaffolds showed high compression strength and cytocompatibility.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Biomaterials
Gang Liu, Boqing Zhang, Ting Wan, Changchun Zhou, Yujiang Fan, Weidong Tian, Wei Jing
Summary: In this study, a novel bioactive scaffold loaded with platelet lysate/gelatin methacrylate (PL/GelMA) in a 3D-printed biphasic calcium phosphate (BCP) scaffold was proposed to enhance scaffold vascularization. The PL/GelMA/BCP scaffold successfully promoted cell proliferation and the formation of blood vessel-like structures in vitro. Moreover, implantation of the scaffold in vivo also resulted in increased capillary formation. These findings suggest that the PL/GelMA/BCP scaffold has the potential to promote vascularization in tissue engineering.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
