Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Oncology
Maria Gonzalez-Gonzalez, Maria Laura Gutierrez, Jose Maria Sayagues, Luis Munoz-Bellvis, Alberto Orfao
Summary: Sporadic colorectal cancer (sCRC) is the third leading cause of cancer death in the Western world, with approximately a quarter of patients presenting metastatic dissemination at the time of diagnosis. Patients with sCRC generally have a worse prognosis compared to those with primary colorectal tumors, and there are still many genetic alterations involved in the metastatic process that need to be further identified and studied.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Giorgia Mori, Maria Rosalia Pasca
Summary: Colorectal cancer is the third most common cancer worldwide and is mainly classified as either sporadic or hereditary. Screening for hereditary-related cancers is important for prevention in individuals at risk. Studying the correlation between colorectal cancer and gut microbiota, especially in hereditary syndromes, may have implications for both prevention and potential therapeutic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Viviane A. Lin, Robin Lohse, Michael T. Madsen, Tina Fransgaard, Feza H. Remzi, Ismail Goegenur
Summary: This study found no significant differences in long-term outcomes between patients with ulcerative colitis-associated colorectal cancer and those with sporadic colorectal cancer. However, the results are limited by potential residual confounding and heterogeneity in confounding adjustment during the meta-analysis.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Carla Debernardi, Laura Libera, Enrico Berrino, Nora Sahnane, Anna Maria Chiaravalli, Cristiana Laudi, Mattia Berselli, Anna Sapino, Fausto Sessa, Tiziana Venesio, Daniela Furlan
Summary: The study found that hypomethylation of LINE-1 and L1-MET in colorectal adenomas is associated with a higher risk of developing CRC, and these two forms of hypomethylation are independent markers. Combining global and intragenic hypomethylation tests can significantly improve the differentiation between high and low-risk lesions.
CLINICAL EPIGENETICS
(2021)
Article
Pathology
Yan Wang, Jing Zhang, Hui Cao, Fengyan Han, Honghe Zhang, Enping Xu
Summary: This study found that ADAM12 promoter hypermethylation is likely a mechanism for ADAM12 epigenetic silencing in colorectal cancer, as evidenced by significantly lower expression levels in hypermethylated cell lines and tissues compared to hypomethylated ones. Bisulfitepyrosequencing results also showed significantly higher methylation levels of ADAM12 in CRC tissues compared to normal tissues, with a statistically significant negative correlation between ADAM12 protein expression and methylation levels.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jacqueline I. Keenan, Frank A. Frizelle
Summary: Colorectal cancer is a leading cause of mortality worldwide, highlighting the need for better early detection techniques. The use of noninvasive biomarkers can accurately determine which patients should undergo clinical investigation, ultimately improving the survival rate of those with curable-stage colorectal cancer.
Article
Biochemistry & Molecular Biology
Melania Scarpa, Cesare Ruffolo, Andromachi Kotsafti, Fabio Canal, Francesca Erroi, Silvia Basato, Lucia Dall'Agnese, Alain Fiorot, Anna Pozza, Paola Brun, Nicolo Bassi, Angelo Dei Tos, Carlo Castoro, Ignazio Castagliuolo, Marco Scarpa
Summary: Research has shown that patients with MMR-deficient colorectal cancer have a more favorable prognosis, possibly due to the interplay between MMR genes and TLR4/MyD88 signaling, with TLR4 expression depending on MMR status and correlating directly with MLH1 expression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Fanny Andric, Ala Al-Fairouzi, Yvonne Wettergren, Louis Szeponik, Elinor Bexe-Lindskog, James C. Cusack Jr, Gerald Tumusiime, Marianne Quiding-Jarbrink, David Ljungman
Summary: The incidence of non-hereditary cancer in the left colon and rectum is increasing in young patients worldwide, and the reasons for this are unknown. In this study, the immune response to tumors was investigated in a highly representative group of patients under 45 years old and compared to those aged 70-75 years old. The results showed that the distribution of T cells in tumors and the expression of immune-related genes were similar between the two age groups. This suggests that the immune response in left colon and rectal cancer is not age-dependent and that early-onset colorectal cancer is likely not related to immune response deficiencies.
Article
Biochemistry & Molecular Biology
Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattova, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Summary: Oxidative stress, oxidative DNA damage, and its repair are closely related to the development of colorectal cancer, but cannot solely explain the onset of sporadic colorectal cancer. Other factors, especially the microenvironment, need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Katarzyna Klonowska, Elizabeth A. Thiele, Joannes M. Grevelink, Aaron R. Thorner, David J. Kwiatkowski
Summary: Tuberous sclerosis complex (TSC) is a genetic syndrome causing hamartomatous tumors due to mutations in TSC1 or TSC2. A study found that two different lesions in a patient were not due to the same underlying mutation but likely sporadic events.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Oncology
Renata L. Sandoval, Miki Horiguchi, Chinedu Ukaegbu, C. Sloane Furniss, Hajime Uno, Sapna Syngal, Matthew B. Yurgelun
Summary: Currently, diagnosing Lynch syndrome (LS) involves complex and costly molecular tumor tests. This study investigated the use of the clinical LS prediction tool PREMM5 as an alternative approach to screen for LS. The results showed that PREMM5 accurately identified LS in patients without the need for additional somatic molecular testing. These findings are particularly important for limited-resource settings where advanced molecular diagnostics may be unavailable.
Review
Medicine, General & Internal
Oscar Hernandez Dominguez, Sumeyye Yilmaz, Scott. R. R. Steele
Summary: Colorectal cancer is a significant global health concern, and understanding the evolving treatment options for metastatic colorectal cancer is crucial for improving patient outcomes. Surgical resection and systemic therapy are the standard of care, but there are also targeted therapy and immunotherapy options available. Personalized treatment plans based on molecular profiling are essential for optimizing outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Thaer S. A. Abdalla, Jan Meiners, Sabine Riethdorf, Alexandra Koenig, Nathaniel Melling, Tobias Gorges, Karl-F. Karstens, Jakob R. Izbicki, Klaus Pantel, Matthias Reeh
Summary: The detection of circulating tumor cells in patients with colorectal cancer before surgery is an independent and strong prognostic factor for overall survival. This study suggests that it could improve the identification of high-risk patients in future clinical trials.
Article
Gastroenterology & Hepatology
Alka A. Potdar, Dalin Li, Talin Haritunians, Kelli L. VanDussen, Marie F. Fiorino, Ta-Chiang Liu, Thaddeus S. Stappenbeck, Phillip Fleshner, Stephan R. Targan, Dermot P. B. McGovern, Janine Bilsborough
JOURNAL OF CROHNS & COLITIS
(2019)
Article
Cell Biology
Gerard E. Kaiko, Feidi Chen, Chin-Wen Lai, I-Ling Chiang, Jacqueline Perrigoue, Aleksandar Stojmirovic, Katherine Li, Brian D. Muegge, Umang Jain, Kelli L. VanDussen, Bridie J. Goggins, Simon Keely, Jessica Weaver, Paul S. Foster, Daniel A. Lawrence, Ta-Chiang Liu, Thaddeus S. Stappenbeck
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Acoustics
Jon N. Marsh, Kevin M. Korenblat, Ta-Chiang Liu, John E. Mccarthy, Samuel A. Wickline
ULTRASOUND IN MEDICINE AND BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yi Wang, I-Ling Chiang, Takahiro E. Ohara, Satoru Fujii, Jiye Cheng, Brian D. Muegge, Aaron Ver Heul, Nathan D. Han, Qiuhe Lu, Shanshan Xiong, Feidi Chen, Chin-Wen Lai, Hana Janova, Renee Wu, Charles E. Whitehurst, Kelli L. VanDussen, Ta-Chiang Liu, Jeffrey I. Gordon, L. David Sibley, Thaddeus S. Stappenbeck
Article
Infectious Diseases
Ta-Chiang Liu, Kelley VanBuskirk, Syed A. Ali, M. Paul Kelly, Lori R. Holtz, Omer H. Yilmaz, Kamran Sadiq, Najeeha Iqbal, Beatrice Amadi, Sana Syed, Tahmeed Ahmed, Sean Moore, I. Malick Ndao, Michael H. Isaacs, John D. Pfeifer, Hannah Atlas, Phillip Tarr, Donna M. Denno, Christopher A. Moskaluk
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Pathology
Rehan Rais, Jiani Chai, Elizabeth Blaney, Ta-Chiang Liu
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2020)
Article
Medicine, General & Internal
Lulu Sun, Jon N. Marsh, Matthew K. Matlock, Ling Chen, Joseph P. Gaut, Elizabeth M. Brunt, S. Joshua Swamidass, Ta-Chiang Liu
Article
Microbiology
Ta-Chiang Liu, Justin T. Kern, Umang Jain, Naomi M. Sonnek, Shanshan Xiong, Katherine F. Simpson, Kelli L. VanDussen, Emma S. Winkler, Talin Haritunians, Atika Malique, Qiuhe Lu, Yo Sasaki, Chad Storer, Michael S. Diamond, Richard D. Head, Dermot P. B. McGovern, Thaddeus S. Stappenbeck
Summary: Western diet can lead to dysfunction of Paneth cells and inhibit gut innate immunity. Obesity and high-fat diet may affect Paneth cells through microbiota and biological signaling pathways, contributing to diseases such as Crohn's disease.
CELL HOST & MICROBE
(2021)
Article
Gastroenterology & Hepatology
Shanshan Xiong, Charles E. Whitehurst, Li Li, Gyu Seong Heo, Chin-Wen Lai, Umang Jain, Brian D. Muegge, Scott T. Espenschied, Ryan J. Musich, Minhu Chen, Yongjian Liu, Ta-Chiang Liu, Thaddeus S. Stappenbeck
Summary: The study identified a transcriptional signature of mesenteric fibrosis in Crohn's disease patients and modeled a mouse model to simulate this condition. They found differentially expressed genes enriched in the mesenteric fat of CD subjects with high levels of fibrosis and identified a 24-gene set associated with inflammatory fibroblasts and treatment response.
Article
Immunology
Erika Feutz, Wieger Voskuijl, Peter J. Finch, Ta-Chiang Liu, Robert H. J. Bandsma, Phillip Tarr, Christopher Alan Moxon, Kelley VanBuskirk, Sarah Lawrence, Grace Umutesi, Kirkby D. Tickell, James A. Berkley, Judd L. Walson, Steve Kamiza, Donna M. Denno
Summary: This study demonstrates the feasibility of minimally invasive postmortem intestinal sampling in LMICs and its potential to identify histopathology related to mortality factors, such as duodenal cell depletion and chronic inflammation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Matthew J. Wood, Jeffrey N. Marshall, Victoria L. Hartley, Ta-Chiang Liu, Kazuhiro Iwai, Thaddeus S. Stappenbeck, Donna A. MacDuff
Summary: Patients with mutations in HOIL1 may experience immune disorders including intestinal inflammation. This study found that HOIL1 plays a key role in regulating type 2 inflammation in the small intestine, affecting cell proliferation and gene expression. Commensal microbes may also contribute to intestinal inflammation.
MUCOSAL IMMUNOLOGY
(2022)
Article
Pediatrics
Lori R. Holtz, Julie Hoffmann, Laura Linneman, Mai He, Thomas C. Smyrk, Ta-Chiang Liu, Nurmohammad Shaikh, Cynthia Rodriguez, Roy B. Dyer, Ravinder J. Singh, William A. Faubion
Summary: This study aimed to explore the correlation between different measures of gut permeability and the severity of duodenal histopathology in children. The results showed that L:R was associated with biopsy evidence in children undergoing small bowel biopsy, while L:M was not. Despite increased intestinal permeability, there was scant evidence of systemic exposure to gut microbes in these children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pathology
Marianna B. Ruzinova, Changqing Ma, Elizabeth M. Brunt, Charles W. Goss, Neeta Vachharajani, William C. Chapman, Ta-Chiang Liu
Summary: The expression of SOX9 is associated with poor prognosis in hepatocellular carcinoma and can be used as an independent prognostic factor.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Saeed Soleymanjahi, Valerie Blanc, Elizabeth A. Molitor, David M. Alvarado, Yan Xie, Vered Gazit, Jeffrey W. Brown, Kathleen Byrnes, Ta-Chiang Liu, Jason C. Mills, Matthew A. Ciorba, Deborah C. Rubin, Nicholas O. Davidson
Summary: RNA-binding protein 47 (RBM47) plays an important role in embryonic endoderm development, and this study found that it also has implications in adult intestine function. Knockout mice lacking Rbm47 showed increased cell proliferation and abnormal morphology in the intestine, while Rbm47-deficient mice were protected against colitis-associated cancer. The findings suggest that RBM47 is a cell-intrinsic modifier of intestinal growth, inflammatory, and tumorigenic pathways.
Article
Multidisciplinary Sciences
Do-Hyun Kim, Yilin Wang, Haerin Jung, Rachael L. Field, Xinya Zhang, Ta-Chiang Liu, Changqing Ma, James S. Fraser, Jonathan R. Brestoff, Steven J. Van Dyken
Summary: This study describes a mammalian adaptation to dietary chitin through gastric immune activation and acidic mammalian chitinase, which facilitates chitin digestion. This adaptation is preserved in germ-free mice and leads to enhanced metabolic health and resistance to obesity.