Article
Medicine, Research & Experimental
Lu-Lu Yu, Bi-Wen Hu, Han-Xue Huang, Bing Yu, Qi Xiao, Qiao-Li Lv, Chen-Hui Luo, Cheng-Xian Guo, Jin-Gao Li, Xiao-Xue Xie, Ji-Ye Yin
Summary: This study identified a genetic variant rs11130424 in the CACNA2D3 gene associated with sensitivity to radiotherapy in patients with nasopharyngeal carcinoma (NPC).
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian'an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellstrom, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Voelker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguez-Manas, Francisco J. Garcia, Jose A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Summary: Low muscle strength is a heritable indicator of poor health in older people, with genetic loci associated with muscle weakness identified through genome-wide meta-analysis. Possible causal relationships with diabetes susceptibility, hematological parameters, and the immune system were also discovered using Mendelian randomization. The distinct mechanisms of muscle weakness from continuous strength were highlighted, shedding light on potential pathways involved in ageing.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Summary: Prognostication in CLL patients is challenging due to its heterogeneous clinical course. This study identifies two genomic locations associated with disease progression, highlighting the impact of constitutional genetic variation on CLL prognosis. Additionally, functional genes implicated in modulating key pathways in CLL pathogenesis are identified.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Olav B. Smeland, Alexey Shadrin, Shahram Bahrami, Iris Broce, Martin Tesli, Oleksandr Frei, Katrine Wirgenes, Kevin S. O'Connell, Florian Krull, Francesco Bettella, Nils Eiel Steen, Leo Sugrue, Yunpeng Wang, Per Svenningsson, Manu Sharma, Lasse Pihlstrom, Mathias Toft, Michael O'Donovan, Srdjan Djurovic, Rahul Desikan, Anders M. Dale, Ole A. Andreassen
Summary: The study reveals genetic overlap between PD and SCZ, identifying novel risk loci and shared genomic loci. These findings suggest common molecular mechanisms contributing to overlap in pathophysiological and clinical features between the disorders.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemical Research Methods
Chong Wu, Jonathan Bradley, Yanming Li, Lang Wu, Hong-Wen Deng
Summary: The study developed a novel gene-level association testing method that integrates genetically regulated DNA methylation and enhancer-target gene pairs; through simulations, it showed well controlled type I error rates and achieved higher statistical power than competing methods; the CMO method identified more novel genetic loci for AD compared to existing TWAS methods when analyzing GWAS results.
Article
Biochemistry & Molecular Biology
Chanwoo Kim, Young Jin Kim, Wanson Choi, Hye-Mi Jang, Mi Yeong Hwang, Sunwoo Jung, Hyunjoon Lim, Sang Bin Hong, Kyungheon Yoon, Bong-Jo Kim, Hyun-Young Park, Buhm Han
Summary: This study conducted research on human leukocyte antigen (HLA) gene variants in the major histocompatibility complex (MHC) region in the Korean population. By analyzing the associations between genetic variants and phenotypes, new association signals were discovered, and the heritability explained by MHC variants and genetic correlations among phenotypes were analyzed.
HUMAN MOLECULAR GENETICS
(2022)
Article
Rheumatology
Elena Lopez-Isac, Samantha L. Smith, Miranda C. Marion, Abigail Wood, Marc Sudman, Annie Yarwood, Chenfu Shi, Vasanthi Priyadarshini Gaddi, Paul Martin, Sampath Prahalad, Stephen Eyre, Gisela Orozco, Andrew P. Morris, Carl D. Langefeld, Susan D. Thompson, Wendy Thomson, John Bowes
Summary: In a large-scale JIA GWAS, five novel risk loci were identified, and the potential function of JIA association signals was described. This information will be informative for future experimental works and therapeutic strategies.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Genetics & Heredity
Wenlong Carl Chen, Jean-Tristan Brandenburg, Ananyo Choudhury, Mahtaab Hayat, Dhriti Sengupta, Yaniv Swiel, Chantal Babb de Villiers, Lucien Ferndale, Colleen Aldous, Cassandra C. Soo, Sang Lee, Charles Curtis, Rob Newton, Tim Waterboer, Fredd Sitas, Debbie Bradshaw, Christian C. Abnet, Michele Ramsay, M. Iqbal Parker, Elvira Singh, Cathryn M. Lewis, Christopher G. Mathew
Summary: Esophageal squamous cell carcinoma (ESCC) has a high disease burden in sub-Saharan Africa and has a very poor prognosis. This study conducted a genome-wide association study (GWAS) in African individuals with ESCC and identified significant genetic risk loci, including FAM120A and MYO1B genes. A trans-ethnic meta-analysis also identified additional risk loci for ESCC, suggesting both shared and distinct genetic factors between African and Asian populations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biotechnology & Applied Microbiology
Mo Li, Yi Hu, Baihui Zhao, Luan Chen, Hailiang Huang, Cong Huai, Xiaoqing Zhang, Jinghong Zhang, Wei Zhou, Lu Shen, Qi Zhen, Bao Li, Wenjun Wang, Lin He, Shengying Qin
Summary: A two-stage study identified genetic markers associated with TB susceptibility in 616 TB patients and 709 healthy controls. The study confirmed 6 nominally significant SNPs and a HLA-II allele as predisposing factors for TB. The research provides insight into the genetic variants linked to TB susceptibility and sheds light on tuberculosis pathogenesis.
Article
Biochemistry & Molecular Biology
Tarunveer S. Ahluwalia, Bram P. Prins, Mohammadreza Abdollahi, Nicola J. Armstrong, Stella Aslibekyan, Lisa Bain, Barbara Jefferis, Jens Baumert, Marian Beekman, Yoav Ben-Shlomo, Joshua C. Bis, Braxton D. Mitchell, Eco de Geus, Graciela E. Delgado, Diana Marek, Joel Eriksson, Eero Kajantie, Stavroula Kanoni, John P. Kemp, Chen Lu, Riccardo E. Marioni, Stela McLachlan, Yuri Milaneschi, Ilja M. Nolte, Alexandros M. Petrelis, Eleonora Porcu, Maria Sabater-Lleal, Elnaz Naderi, Ilkka Seppala, Tina Shah, Gaurav Singhal, Marie Standl, Alexander Teumer, Anbupalam Thalamuthu, Elisabeth Thiering, Stella Trompet, Christie M. Ballantyne, Emelia J. Benjamin, Juan P. Casas, Catherine Toben, George Dedoussis, Joris Deelen, Peter Durda, Jorgen Engmann, Mary F. Feitosa, Harald Grallert, Ann Hammarstedt, Sarah E. Harris, Georg Homuth, Jouke-Jan Hottenga, Sirpa Jalkanen, Yalda Jamshidi, Magdalene C. Jawahar, Tine Jess, Mika Kivimaki, Marcus E. Kleber, Jari Lahti, Yongmei Liu, Pedro Marques-Vidal, Dan Mellstrom, Simon P. Mooijaart, Martina Muller-Nurasyid, Brenda Penninx, Joana A. Revez, Peter Rossing, Katri Raikkonen, Naveed Sattar, Hubert Scharnagl, Bengt Sennblad, Angela Silveira, Beate St Pourcain, Nicholas J. Timpson, Julian Trollor, Jenny van Dongen, Diana Van Heemst, Sophie Visvikis-Siest, Peter Vollenweider, Uwe Volker, Melanie Waldenberger, Gonneke Willemsen, Delilah Zabaneh, Richard W. Morris, Donna K. Arnett, Bernhard T. Baune, Dorret Boomsma, Yen-Pei C. Chang, Ian J. Deary, Panos Deloukas, Johan G. Eriksson, David M. Evans, Manuel A. Ferreira, Tom Gaunt, Vilmundur Gudnason, Anders Hamsten, Joachim Heinrich, Aroon Hingorani, Steve E. Humphries, J. Wouter Jukema, Wolfgang Koenig, Meena Kumari, Zoltan Kutalik, Deborah A. Lawlor, Terho Lehtimaki, Winfried Marz, Karen A. Mather, Silvia Naitza, Matthias Nauck, Claes Ohlsson, Jackie F. Price, Olli Raitakari, Ken Rice, Perminder S. Sachdev, Eline Slagboom, Thorkild I. A. Sorensen, Tim Spector, David Stacey, Maria G. Stathopoulou, Toshiko Tanaka, S. Goya Wannamethee, Peter Whincup, Jerome Rotter, Abbas Dehghan, Eric Boerwinkle, Bruce M. Psaty, Harold Snieder, Behrooz Z. Alizadeh
Summary: This study identified novel genetic loci influencing circulating IL-6 levels, uncovering new immunological and inflammatory pathways that may impact the pathobiology of IL-6.
HUMAN MOLECULAR GENETICS
(2021)
Article
Multidisciplinary Sciences
Parsa Akbari, Dragana Vuckovic, Luca Stefanucci, Tao Jiang, Kousik Kundu, Roman Kreuzhuber, Erik L. Bao, Janine H. Collins, Kate Downes, Luigi Grassi, Jose A. Guerrero, Stephen Kaptoge, Julian C. Knight, Stuart Meacham, Jennifer Sambrook, Denis Seyres, Oliver Stegle, Jeffrey M. Verboon, Klaudia Walter, Nicholas A. Watkins, John Danesh, David J. Roberts, Emanuele Di Angelantonio, Vijay G. Sankaran, Mattia Frontini, Stephen Burgess, Taco Kuijpers, James E. Peters, Adam S. Butterworth, Willem H. Ouwehand, Nicole Soranzo, William J. Astle
Summary: The authors identify genetic variation associated with properties of the internal biological structures of blood cells and demonstrate how this can contribute to our understanding of the cellular mechanisms causing disease.
NATURE COMMUNICATIONS
(2023)
Article
Virology
Chang-Mi Deng, Tong-Min Wang, Yong-Qiao He, Wen-Li Zhang, Wen-Qiong Xue, Dan-Hua Li, Da-Wei Yang, Qiao-Ling Wang, Ying Liao, Hua Diao, Cheng-Tao Jiang, Jiang-Bo Zhang, Lei-Lei Yuan, Xue-Yin Chen, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Miao Xu, Mu-Sheng Zeng, Lin Feng, Wei-Hua Jia
Summary: This study investigated the association between HLA-bound EBV peptides and NPC risk through in silico HLA-peptide binding prediction. It found that NPC-associated EBV peptides were significantly enriched in immunogenic proteins and core LD proteins related to evolution. HLA supertype A02 and A03 were found to have an NPC-risk effect and NPC-protective effect respectively.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dongli Zhu, Shi Yao, Hao Wu, Xin Ke, Xiaorong Zhou, Songmei Geng, Shanshan Dong, Hao Chen, Tielin Yang, Ying Cheng, Yan Guo
Summary: A transcriptome-wide association study identified multiple novel candidate genes associated with psoriasis, which were further validated through public databases and knockout mice models. These genes were found to be enriched in known GO terms related to skin development, providing valuable insights into the genetic mechanism of psoriasis.
HUMAN MOLECULAR GENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Lauren E. Petty, Renato Silva, Leticia Chaves de Souza, Alexandre R. Vieira, Douglas M. Shaw, Jennifer E. Below, Ariadne Letra
Summary: This study is the first genome-wide association study of apical periodontitis (AP) in a large and well-characterized population. It identified novel genes/loci associated with AP and specific contributions to AP risk in men and women. Additionally, it revealed significant associations with other systemic conditions. These findings provide strong evidence for host-mediated effects on AP susceptibility.
JOURNAL OF ENDODONTICS
(2023)
Article
Genetics & Heredity
Corina Lesseur, Aida Ferreiro-Iglesias, James D. McKay, Yohan Bosse, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C. Christiani, Neil C. Caporaso, Stig E. Bojesen, Christopher I. Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K. Field, Marion Dawn Teare, Lambertus A. Kiemeney, Brenda Diergaarde, Robert L. Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F. Olshan, Mark C. Weissler, Martin Lacko, Angela Risch, Heike Bickeboller, Andy R. Ness, Steve Thomas, Loic Le Marchand, Matthew B. Schabath, Victor Wunsch-Filho, Eloiza H. Tajara, Angeline S. Andrew, Gary M. Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnstrom, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma'en Obeidat, Xiangjun Xiao, Richard S. Houlston, Rayjean J. Hung, Paul Brennan
Summary: Squamous cell carcinomas (SqCC) of the aerodigestive tract share common etiological risk factors and genetic susceptibility. A meta-analysis of GWAS data identified novel and pleiotropic risk variants, highlighting the importance of cross-cancer analyses. Gene-based association and gene set enrichment revealed SqCC-related genes involved in DNA damage and epigenetic regulation pathways. The study suggests overlap in genetic factors influencing aerodigestive SqCC risk in European populations.
Letter
Infectious Diseases
Ying Xing, Lijing Wang, Yating Li, Yuling Wang, Leilei Han, Guiqin Huang, Jingwan Han, Wenjun Zhang, Lei Jia, Yongjian Liu, Xiaolin Wang, Tianyi Li, Jingyun Li, Li Yang, Xiaojing Qu, Yingxia Li, Erhei Dai, Hanping Li, Lin Li
JOURNAL OF INFECTION
(2022)
Article
Statistics & Probability
Wei Liu, Huazhen Lin, Shurong Zheng, Jin Liu
Summary: This article introduces a generalized factor model, algorithm, and theory for ultra-high dimensional mixed types of variables. The proposed method demonstrates advantages over existing factor models in terms of predictive and interpretable estimators for loadings and factors.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Statistics & Probability
Xingyu Zhou, Yuling Jiao, Jin Liu, Jian Huang
Summary: We propose a deep generative approach to sampling from a conditional distribution, using neural networks for nonparametric estimation. Our method has advantages in handling high-dimensional and continuous/discrete variables, and achieves good results in numerical experiments.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
To-Nhu Vu, Chachrit Khunsriraksakul, Yakov Vorobeychik, Alison Liu, Renan Sauteraud, Ganesh Shenoy, Dajiang J. Liu, Steven P. Cohen
Summary: This study found that under real-life conditions, spinal cord stimulation (SCS) was associated with small, clinically questionable associations with opioid discontinuation and not starting opioids in patients with postlaminectomy syndrome (PLS).
Article
Multidisciplinary Sciences
Xiaofeng Zheng, Qing Wei Calvin Ho, Minni Chua, Olga Stelmashenko, Xin Yi Yeo, Sneha Muralidharan, Federico Torta, Elaine Guo Yan Chew, Michelle Mulan Lian, Jia Nee Foo, Sangyong Jung, Sunny Hei Wong, Nguan Soon Tan, Nanwei Tong, Guy A. Rutter, Markus R. Wenk, David L. Silver, Per-Olof Berggren, Yusuf Ali
Summary: Western-type diets, high in saturated fatty acids (SFAs), are associated with obesity and diabetes. This study reveals that SFAs, but not unsaturated fatty acids (USFAs), reduce lipid droplets (LDs) in pancreatic beta cells. SFAs induce the degradation of fat storage-inducing transmembrane protein 2 (FIT2), inhibiting LD formation. Reduction of FIT2 in beta cells impairs cellular functions and exacerbates diet-induced diabetes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Andrea Bonassi, Ilaria Cataldo, Giulio Gabrieli, Moses Tandiono, Jia Nee Foo, Bruno Lepri, Gianluca Esposito
Summary: This study applies a model from behavioral genetics to explore the impact of individual development on behavior on Instagram social networks. The findings suggest a gene-environment interaction, where individuals with a gene genotype more sensitive to environmental influences showed higher social desirability on Instagram when experiencing positive maternal care.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Chenlin Zhang, Huazhen Lin, Li Liu, Jin Liu, Yi Li
Summary: This article proposes a new functional regression model that links the covariance structures of response curves to external covariates. By allowing the variances of random scores to be dependent on covariates, it identifies eigenfunctions for each individual, resulting in improved interpretability and prediction power. The utility of the developed method is demonstrated through simulations and an analysis of real data concerning parental effects on offspring growth curves, yielding biologically interesting results.
Article
Microbiology
Jingwan Han, Yan-Heng Zhou, Yingying Ma, Guoxin Zhu, Dong Zhang, Bo Zhu, Tong Cheng, Lanfeng Wang, Jian-Hua Wang, Lin Li, Chiyu Zhang
Summary: A new K28E32 variant of HIV-1 CRF07_BC was identified, showing rapid expansion among MSM and higher in vitro replication ability compared to the wild type.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Mengying Liu, Lei Jia, Xing Guo, Xiuli Zhai, Hanping Li, Yongjian Liu, Jingwan Han, Bohan Zhang, Xiaolin Wang, Tianyi Li, Yanglan Wang, Jingyun Li, Changyuan Yu, Lin Li
Summary: This study provides a comprehensive analysis of the presence and distribution of HERV-K HML-8 sequences within the human genome and hominoids, as well as the characterization of their structure and evolution. The results show that HML-8 elements were integrated into the primate lineage around 35 to 42 million years ago during primates evolutionary speciation. These findings offer a detailed background for future functional studies.
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2023)
Article
Surgery
Wei-Jian Mei, Xiao-Zhong Wang, Yun-Feng Li, Yue-Ming Sun, Chun-Kang Yang, Jun-Zhong Lin, Zu-Guang Wu, Rui Zhang, Wei Wang, Yong Li, Ye-Zhong Zhuang, Jian Lei, Xiang-Bin Wan, Ying-Kun Ren, Yong Cheng, Wen-Liang Li, Zi-Qiang Wang, Dong-Bo Xu, Xian-Wei Mo, Hai-Xing Ju, Sheng-Wei Ye, Jing-Lin Zhao, Hong Zhang, Yuan-Hong Gao, Zhi-Fan Zeng, Wei-Wei Xiao, Xiao-Peng Zhang, Xuan Zhang, E. Xie, Yi-Fei Feng, Jing-Hua Tang, Xiao-Jun Wu, Gong Chen, Li-Ren Li, Zhen-Hai Lu, De-Sen Wan, Jin-Xin Bei, Zhi-Zhong Pan, Pei-Rong Ding
Summary: This study compared the efficacy of neoadjuvant chemotherapy alone and neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer. The results showed that neoadjuvant chemotherapy achieved similar rates of pathological complete response and downstaging compared to neoadjuvant chemoradiotherapy, but with lower incidence of perioperative distant metastasis and preventive ileostomy. CAPOX could be an effective alternative treatment option for patients with locally advanced rectal cancer.
Article
Genetics & Heredity
Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel Chasman, Sameer Chavan, Yii-Der Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de Las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi'a Sefuiva Reupena, Stephen S. Rich, Jerome Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu
Summary: Most TWASs conducted so far have focused on European ancestry and lacked diversity. To address this limitation, researchers aggregated GWAS summary statistics, whole-genome sequences, and eQTL data from diverse ancestries. They developed a new approach called TESLA, which integrates eQTL datasets with multi-ancestry GWAS, improving power and identifying more genes associated with tobacco use phenotypes compared to alternative TWAS methods. The study also suggests potential drug repurposing options for treating nicotine addiction.
Article
Endocrinology & Metabolism
Xuling Chang, Kevin Yiqiang Chua, Fang Lin Ng, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, Rajkumar Dorajoo, Woon-Puay Koh
Summary: This study investigated the relationship between body mass index (BMI) in midlife and functional mobility in late life. The results showed a causal effect of obesity on mobility dysfunction, with high BMI leading to poorer performance in the Timed Up-and-Go test (TUG). Genetic analyses also indicated potential neuronal dysfunctions in regulating the link between obesity and mobility dysfunction.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Chemistry, Multidisciplinary
Jinbang Zhang, Jingwan Han, Hui Li, Zhengyang Li, Pengfei Zou, Jiaxin Li, Te Zhao, Junwei Che, Yang Yang, Meiyan Yang, Yuli Wang, Wei Gong, Zhiping Li, Lin Li, Chunsheng Gao, Haihua Xiao
Summary: A new system is constructed by functionalizing siRNA delivery lipid nanoparticles with the lymphocyte membrane and 12p1, which can escape immune recognition, has HIV-1 neutralizing capacity, and the ability to deliver siRNA specifically into HIV-1-infected cells. This system can escape uptake by the mononuclear phagocyte system, exhibits strong binding ability with gp120, and shows significant gene silencing effect on HIV-1-infected cells.
Article
Urology & Nephrology
Ming Li, Yan-Na Wang, Ling Wang, Wee-Yang Meah, Dian-Chun Shi, Khai-Koon Heng, Li Wang, Chiea-Chuen Khor, Jin-Xin Bei, Ching-Yu Cheng, Tin Aung, Yun-Hua Liao, Qin-Kai Chen, Jie-Ruo Gu, Yao-Zhong Kong, Jimmy Lee, Siow-Ann Chong, Mythily Subramaniam, Jia-Nee Foo, Feng-Tao Cai, Geng-Ru Jiang, Gang Xu, Jian-Xin Wan, Meng-Hua Chen, Pei-Ran Yin, Xiu-Qing Dong, Shao-Zhen Feng, Xue-Qing Tang, Zhong Zhong, Eng-King Tan, Nan Chen, Hong Zhang, Zhi-Hong Liu, E. Shyong Tai, Jian-Jun Liu, Xue-Qing Yu
Summary: This study identified two novel risk variants for IgA nephropathy in VEGFA and PKD1L3, and found that a rare variant in VEGFA was associated with increased risk of kidney disease progression in IgA nephropathy.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cell Biology
Xiao-Chen Xu, Jia-Xin Jiang, Ya-Qing Zhou, Shuai He, Yang Liu, Yi-Qi Li, Pan-Pan Wei, Jin-Xin Bei, Jian Sun, Chun-Ling Luo
Summary: In this study, the dysregulation and functional role of SRSF3 and AMOTL1 in nasopharyngeal carcinoma (NPC) were investigated. The upregulation of SRSF3 was found to be associated with worse prognosis in NPC. It was further revealed that SRSF3 promotes the generation of the long isoform of AMOTL1 (AMOTL1-L), which promotes NPC cell proliferation and migration by interacting with YAP1 and promoting nucleus translocation. These findings suggest that the SRSF3/AMOTL1 axis could serve as potential prognostic biomarkers and therapeutic targets for NPC.
CELL DEATH & DISEASE
(2023)