Article
Endocrinology & Metabolism
Georgia E. Kirkpatrick, Paige M. Dingess, Jake A. Aadland, Travis E. Brown
Summary: This study investigates whether forced exercise can attenuate the incubation of high-fat food craving. The results suggest that high-intensity exercise can prevent the establishment of incubation of craving for high-fat foods and may reduce cue-induced maladaptive food-seeking behaviors.
Article
Neurosciences
Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Charles D. Blaha, Kevin E. Bennet, Kendall H. Lee, Yoonbae Oh, Hojin Shin
Summary: Although dopamine is the most implicated neurotransmitter in addiction, serotonin also plays a vital role. This study used N-shaped fast-scan cyclic voltammetry to investigate the acute effects of cocaine on phasic serotonin release in the nucleus accumbens core. The findings contribute to our understanding of the mechanism of action of cocaine and provide a baseline for further research in cocaine addiction.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Kelle E. Nett, Alexa R. Zimbelman, Matthew S. McGregor, Vanessa Alizo Vera, Molly R. Harris, Ryan T. LaLumiere
Summary: Previous evidence suggests that the infralimbic cortex (IL) plays a role in inhibiting cocaine seeking behavior in rats. In this study, the researchers investigated whether IL activity and its outputs to the nucleus accumbens shell (NAshell) and amygdala are involved in encoding extinction contingencies following cocaine self-administration. They used optogenetic techniques to silence IL-NAshell or IL-amygdala activity after an unreinforced lever press during extinction training and found that inhibition of IL-NAshell or IL-amygdala activity impaired extinction retention.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Pratima Pandey, Anuradha Singh, Harjot Kaur, Anindya Ghosh-Roy, Kavita Babu
Summary: Ethanol abuse can lead to dysfunction of memory, attention, speech and locomotion, with dopamine signaling playing a crucial role. Mutants in the D2-like dopamine autoreceptor, DOP-2, show a sedative phenotype in the presence of ethanol. DOP-2 functions in the posterior PDE dopaminergic neuron to modulate locomotion in ethanol-induced movement, increasing dopamine release and affecting cholinergic motor neurons.
Article
Biochemistry & Molecular Biology
S. B. Jameie, A. Kazemian, Z. Sanadgol, S. Asadzadeh Bayqara, Mana Sadat Jameie, M. Farhadi
Summary: This study demonstrated that the use of CoQ10 in animals treated with METH significantly altered the expression of pro-apoptotic proteins, benefiting the survival of NAc neurons and restoring neuronal damage. Therefore, CoQ10 may reduce the neurodegenerative effects induced by METH, suggesting that antioxidants like CoQ10 could be a promising approach for drug abuse treatment in the future.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Neurosciences
Dan P. Covey, Edith Hernandez, Miguel A. Lujan, Joseph F. Cheer
Summary: The study found that dopamine release in the nucleus accumbens responds differently to cues signaling increasing cost of reward. Endocannabinoid signaling facilitates goal-seeking and nucleus accumbens dopamine release, while chronic MAGL treatment stably facilitates goal-seeking and dopamine encoding without the development of tolerance.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Jason Yuen, Abhinav Goyal, Aaron E. E. Rusheen, Abbas Z. Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. J. Tye, Charles D. D. Blaha, Kevin E. E. Bennet, Kendall H. Lee, Hojin Shin, Yoonbae Oh
Summary: Cocaine increases dopamine levels in the nucleus accumbens (NAc) by stimulating the ventral tegmental area (VTA). This study found that high frequency stimulation (HFS) of the VTA or NAcc can modulate the effects of cocaine on dopamine levels. HFS of the VTA decreased dopamine levels, while HFS of the NAcc initially decreased levels and then returned to baseline. HFS following cocaine administration prevented the increase in dopamine levels. This suggests the potential of deep brain stimulation (DBS) in the treatment of substance use disorders (SUDs) by abolishing cocaine-induced dopamine release.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Gianmaria Zita, Dawid Gawlinski, Kinga Gawlinska, Karolina Wydra, Edmund Przegalinski, Fabio Fumagalli
Summary: Drug addiction is a devastating disorder that poses a huge economic and social burden on modern society, with adolescents being particularly vulnerable. Research has shown that exposure to cocaine during adolescence confers a vulnerable endophenotype primarily by inducing changes in neuroplasticity.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Dinesh Y. Gawande, Gajanan P. Shelkar, Jinxu Liu, Anna D. Ayala, Ratnamala Pavuluri, Diane Choi, Yoland Smith, Shashank M. Dravid
Summary: GluD1 regulates inhibitory neurotransmission in the NAc through a combination of pre- and postsynaptic mechanisms, which is critical for motor control and behaviors relevant to neuropsychiatric disorders.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemical Research Methods
Kyle D. Ketchesin, Darius D. Becker-Krail, Xiangning Xue, Rashaun S. Wilson, TuKiet T. Lam, Kenneth R. Williams, Angus C. Nairn, George C. Tseng, Ryan W. Logan
Summary: Substance use disorders disrupt sleep and circadian rhythms, increasing the risk of relapse. This study investigates the effects of cocaine and morphine on the diurnal rhythms of proteome in the nucleus accumbens (NAc), a key brain region for reward and motivation. The results show that cocaine and morphine differentially alter proteome diurnal rhythms in the NAc, with distinct proteins expressed at different times of the day. Cocaine altered proteins related to glucocorticoid signaling and metabolism, while morphine was associated with neuroinflammation. These findings provide insights into the regulation of NAc proteome and the differential effects of cocaine and morphine.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Neurosciences
Maya Opendak, Charlis Raineki, Rosemarie E. Perry, Millie Rincon-Cortes, Soomin C. Song, Roseanna M. Zanca, Emma Wood, Katherine Packard, Shannon Hu, Joyce Woo, Krissian Martinez, K. Yaragudri Vinod, Russell W. Brown, Gerald A. Deehan, Robert C. Froemke, Peter A. Serrano, Donald A. Wilson, Regina M. Sullivan
Summary: Social interaction deficits seen in psychiatric disorders are closely linked to aberrant neural circuit function and often emerge early in life. Research using invasive procedures in awake infant rats found that factors like harsh maternal care and repeated shock can lead to elevated dopamine levels in the basolateral amygdala, resulting in social behavior pathology.
Article
Pharmacology & Pharmacy
Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gomez-A, Todd K. O'Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Summary: Research has shown that allopregnanolone can reduce dopamine release in both male and female rats, with its effects modulated by sex and estrous cycle stages.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Florence Allain, Benoit Delignat-Lavaud, Marie-Pierre Beaudoin, Vincent Jacquemet, Terry E. Robinson, Louis-Eric Trudeau, Anne-Noel Samaha
Summary: D-amphetamine maintenance therapy shows promise in reducing cocaine use by preventing sensitization-related changes in cocaine potency at the dopamine transporter (DAT).
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Benjamin M. Siemsen, Sarah M. Barry, Kelsey M. Vollmer, Lisa M. Green, Ashley G. Brock, Annaka M. Westphal, Raven A. King, Derek M. DeVries, James M. Otis, Christopher W. Cowan, Michael D. Scofield
Summary: This study identified and characterized a specific subpopulation of nucleus accumbens neurons that receive dense prelimbic cortical input. These neurons play a crucial role in regulating cue-induced cocaine seeking behavior, but not sucrose seeking. Additionally, they undergo morphological changes during the peak of cocaine seeking. These findings provide insights into the neural mechanisms of drug relapse and offer a novel target for addiction therapeutics.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Lucia Caffino, Francesca Mottarlini, Giorgia Targa, Michel M. M. Verheij, Fabio Fumagalli, Judith R. Homberg
Summary: This study investigates the influence of SERT deletion on glutamate homeostasis in the NAc, and finds that SERT deletion leads to a reduction in glutamate signaling and further dysregulation in the glutamatergic synapse after cocaine self-administration.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)