Article
Pharmacology & Pharmacy
Altaf Al-Romaiyan, Willias Masocha
Summary: Triterpenes including pristimerin inhibit human recombinant MAGL activity with varying degrees, and pristimerin can prevent the development of paclitaxel-induced mechanical allodynia and associated increase in MAGL activity, suggesting it might protect against paclitaxel-induced oxidative stress and be useful in cancer treatment and prevention of CINP.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shivani Jaiswal, Akhilesh, Ankit Uniyal, Vinod Tiwari, Senthil Raja Ayyannan
Summary: Researchers have discovered a promising lead compound for the treatment of neuropathic pain by designing and synthesizing a series of compounds. The lead compound exhibited potent inhibition activity against both FAAH and MAGL, and showed good safety profile in vivo experiments.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Rantaro Kamimura, Mohammad Zakir Hossain, Kojiro Takahashi, Isao Saito, Junichi Kitagawa
Summary: The study demonstrated that preventing the degradation of endocannabinoid 2-AG may help alleviate neuropathic orofacial pain by suppressing microglial reactivity in the trigeminal spinal subnucleus caudalis (Vc) under neuropathic pain conditions.
Article
Biochemistry & Molecular Biology
Xueyan Li, Huaqiang Tao, Jing Zhou, Liyuan Zhang, Yi Shi, Chun Zhang, Wen Sun, Miao Chu, Kai Chen, Chengyong Gu, Xing Yang, Dechun Geng, Yuefeng Hao
Summary: MAGL inhibition effectively suppresses the proliferation, invasion, and migration of FLSs and downregulates the expression of inflammatory-associated proteins. It also alleviates NOX4-mediated oxidative stress and improves tumor-like phenotypes of FLSs. In vivo studies show that MAGL inhibition modulates pain and disease progression in an OA rat model. These findings suggest that MAGL administration is an ideal therapy for treating OA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Pharmacology & Pharmacy
C. M. Diester, A. H. Lichtman, S. S. Negus
Summary: This study compared the effects of different endocannabinoid catabolic enzyme inhibitors in various pain-related, pain-depressed, and pain-independent behaviors, finding that the MAGL-selective inhibitor MJN110 was the most effective in alleviating pain behaviors, while FAAH-selective inhibitors showed reduced antinociceptive effectiveness.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Cell Biology
Felix Wittig, Liza Pannenberg, Rico Schwarz, Sander Bekeschus, Robert Ramer, Burkhard Hinz
Summary: In this study, it was found that the MAGL inhibitor JZL184 has anti-angiogenic effects in lung cancer cells and can reduce the expression of VEGF. This effect may be associated with increased levels of 2-AG and partial involvement of cannabinoid receptors.
Article
Neurosciences
Jun Li, Xue Zhang, Chu Xu, Yun-Xin Liu, Chun Ge, Zheng Zhao, Yu-Bing Zhu, Hong-Guang Bao
Summary: By enhancing inhibitory synaptic transmission, pizotifen exerts an antinociceptive effect on both neuropathic pain and inflammatory pain in the spinal cord, potentially serving as a promising remedy for chronic pain.
NEUROSCIENCE LETTERS
(2022)
Review
Cell Biology
Alessandro Papa, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, Fabrizio Vincenzi
Summary: Polypharmacology challenges the traditional paradigm of one-drug, one target, one disease by using multitarget compounds for the treatment of complex diseases. The endocannabinoid system is an attractive therapeutic target in central nervous system disorders and neurodegenerative diseases.
Article
Neurosciences
Jun Pang, Pengfei Xin, Ying Kong, Zhe Wang, Xiaopeng Wang
Summary: This preclinical study evaluates the therapeutic potential and underlying targets of RvD2 in chronic pain. The results show that RvD2 can attenuate neuropathic pain and bone cancer pain, possibly through suppression of IL-17 secretion, CXCL1 release, and astrocyte activation.
Article
Neurosciences
Fang-fang Zhang, Hao Wang, Yan-meng Zhou, Hai-yang Yu, Melanie Zhang, Xian Du, Dong Wang, Feng Zhang, Ying Xu, Ji-guo Zhang, Han-Ting Zhang
Summary: PDE4 inhibitors exert antinociceptive effects by regulating the cAMP-Cx43 signaling pathway in the spinal cord, increasing the expression of Cx43, and reducing mechanical hypersensitivity-induced pain.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Linlin Sun, Chi-Kun Tong, Travis J. Morgenstern, Hang Zhou, Guang Yang, Henry M. Colecraft
Summary: Researchers have successfully achieved posttranslational functional knockdown of high-voltage-activated calcium channels in neurons, which has alleviated neuropathic pain. This study provides new insights for the development of gene therapy targeting neuropathic pain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Simona Denaro, Lorella Pasquinucci, Rita Turnaturi, Cristiana Alberghina, Lucia Longhitano, Sebastiano Giallongo, Giuliana Costanzo, Salvatore Spoto, Margherita Grasso, Agata Zappala, Giovanni Li Volti, Daniele Tibullo, Nunzio Vicario, Rosalba Parenti, Carmela Parenti
Summary: This study investigated the therapeutic potential of the novel compound (+)-2R/S-LP2 as a sigma 1R antagonist in treating neuropathic pain. The results showed that the compound can reduce painful behavior and modulate the neuroinflammatory environment, making it an effective strategy for treating neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Vittoria Borgonetti, Nicoletta Galeotti
Summary: Combining HDAC and BET inhibitors can effectively alleviate pain sensitivity in a mouse model of neuropathic pain and inhibit neuroinflammation in the spinal cord. This combination therapy shows potential as a new therapeutic option for targeting neuropathic pain.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Oncology
Ning Yang, Houyi Sun, Yi Xue, Weicheng Zhang, Hongzhi Wang, Huaqiang Tao, Xiaolong Liang, Meng Li, Yaozeng Xu, Liang Chen, Liang Zhang, Lixin Huang, Dechun Geng
Summary: Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) remains poorly understood, with studies suggesting that monoacylglycerol lipase (MAGL) in the endocannabinoid system plays a crucial role in regulating oxidative stress and BMSC fate. Inhibition of MAGL can reduce oxidative stress, rescue BMSC apoptosis, and effectively attenuate GC-induced ONFH through the Keap1/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Therefore, MAGL may be a promising target for prevention and treatment of GC-induced ONFH.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Behavioral Sciences
Kathryn L. Schwienteck, S. Stevens Negus, Matthew L. Banks
BEHAVIOURAL PHARMACOLOGY
(2019)
Article
Neurosciences
J. A. Suyama, M. L. Banks, S. S. Negus
PSYCHOPHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Jeremy C. Cornelissen, Floyd F. Steele, Rebekah D. Tenney, Samuel Obeng, Kenner C. Rice, Yan Zhang, Matthew L. Banks
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Psychology, Biological
Kaycee E. Faunce, Matthew L. Banks
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2020)
Article
Psychology, Biological
Joshua A. Lile, Amy R. Johnson, Matthew L. Banks, Kevin W. Hatton, Lon R. Hays, Katherine L. Nicholson, Justin L. Poklis, Abner O. Rayapati, Craig R. Rush, William W. Stoops, S. Stevens Negus
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2020)
Article
Substance Abuse
E. Andrew Townsend, S. Stevens Negus, Justin L. Poklis, Matthew L. Banks
DRUG AND ALCOHOL DEPENDENCE
(2020)
Article
Medicine, Research & Experimental
E. Andrew Townsend, S. Stevens Negus, Matthew L. Banks
Summary: This review discusses preclinical evaluation methods for candidate medications to treat opioid use disorder, emphasizing the importance of drug self-administration procedures and assessment of opioid choice behavior. Additionally, the review highlights the significant impact of opioid dependence and withdrawal on the effects of candidate medications.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
E. Andrew Townsend, Paul T. Bremer, Kaycee E. Faunce, S. Stevens Negus, Alaina M. Aster, Hannah L. Robinson, Kim D. Janda, Matthew L. Banks
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Clinical Neurology
E. Andrew Townsend, Matthew L. Banks
Article
Substance Abuse
E. Andrew Townsend, Paul T. Bremer, Nicholas T. Jacob, S. Stevens Negus, Kim D. Janda, Matthew L. Banks
Summary: The study evaluated an optimized fentanyl-targeted vaccine in rhesus monkeys and found that vaccination eliminated fentanyl choice in most monkeys, supporting the potential for further clinical evaluation as a candidate Opioid Use Disorder medication.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Neurosciences
Marco Venniro, Matthew L. Banks, Markus Heilig, David H. Epstein, Yavin Shaham
NATURE REVIEWS NEUROSCIENCE
(2020)
Editorial Material
Neurosciences
S. Stevens Negus, Matthew L. Banks
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
D. E. Selley, M. L. Banks, C. M. Diester, A. M. Jali, L. P. Legakis, E. J. Santos, S. S. Negus
Summary: The pharmacodynamic efficacy of drugs in activating their receptors is crucial in determining drug effects. Fixed-proportion mixtures of an agonist and antagonist for a given receptor can be adjusted to precisely control net efficacy of the mixture in activating that receptor. Manipulation of agonist proportion in agonist/antagonist mixtures governs net mixture efficacy at the target receptor.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Biochemical Research Methods
E. Andrew Townsend, Kathryn L. Schwienteck, Hannah L. Robinson, Stephen T. Lawson, Matthew L. Banks
Summary: The study successfully transferred the intravenous drug-vs-food choice procedure from monkeys to male and female rats, and developed a surgical method suitable for long-term drug choice studies. Results showed that rats can be used to study drug choice behavior, and that choice behavior is stable in response to both environmental and pharmacological manipulations.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Editorial Material
Neurosciences
Hannah L. Robinson, Matthew L. Banks
NEUROPSYCHOPHARMACOLOGY
(2021)