Article
Clinical Neurology
Oguz Oren, Cemile Haki, Halil Kaya, Melih Yuksel
Summary: This study aimed to investigate whether the baseline neutrophil/lymphocyte ratio (NLR) predicts symptomatic intracranial hemorrhage (SICH) due to intravenous thrombolytic therapy. However, the results showed that NLR did not provide strong specificity and sensitivity for predicting SICH, and a precise cut-off value could not be found to predict hemorrhagic transformation.
NEUROLOGICAL SCIENCES
(2022)
Article
Oncology
Jiyun Park, Jun Park, Jung Hee Shin, Young-Lyun Oh, Hyun-Ae Jung, Man-Ki Chung, Jun-Ho Choe, Yong-Chan Ahn, Sun-Wook Kim, Jae-Hoon Chung, Tae-Hyuk Kim, Jae-Myoung Noh
Summary: The study found that high NLR before and after radiotherapy was associated with poor survival in patients with anaplastic thyroid cancer (ATC), indicating the importance of host immunity in ATC patients. This suggests that this finding may provide important information for designing future investigations on the impact of immune system modulating therapy in ATC.
Article
Multidisciplinary Sciences
Aysun Firat, Aysegul Ercan, Cengiz Mordeniz, Fatma Ferda Verit Atmaca
Summary: This study aimed to investigate whether the pretreatment hemogram parameters and their ratios can predict the endometrial transformation in patients with abnormal uterine bleeding. The study found that age, postmenopausal state, obesity, diabetes, and increased estrogen exposure were risk factors for endometrial atypia and carcinoma. Hemoglobin and hematocrit levels were significantly higher in early and advanced endometrial cancer groups, while platelet value was significantly higher in atypia and carcinoma groups.
Article
Oncology
Jing-Houng Wang, Yen-Yang Chen, Kwong-Ming Kee, Chih-Chi Wang, Ming-Chao Tsai, Yuan-Hung Kuo, Chao-Hung Hung, Wei-Feng Li, Hsiang-Lan Lai, Yen-Hao Chen
Summary: Atezolizumab plus bevacizumab has been approved as the first-line treatment for unresectable hepatocellular carcinoma. This study examined the efficacy and safety of this treatment in real-world clinical practice and found that it is effective and well-tolerated. In addition, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were identified as independent prognostic factors for progression-free survival (PFS).
Article
Endocrinology & Metabolism
Peng Ning, Fan Yang, Jun Kang, Jing Yang, Jiaxing Zhang, Yi Tang, Yanghong Ou, Haiyan Wan, Hongyi Cao
Summary: This study found that platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) were associated with arterial stiffness in patients with diabetes. Among them, NLR showed higher accuracy in predicting arterial stiffness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Ming-Yang Ge, Zhi-Peng Liu, Yu Pan, Jiao-Yang Wang, Xiang Wang, Hai-Su Dai, Shu-Yang Gao, Shi-Yun Zhong, Xiao-Yu Che, Jing-Hua Zuo, Yun-Hua Liu, Xing-Chao Liu, Hai-Ning Fan, Wei-Yue Chen, Zi-Ran Wang, Xian-Yu Yin, Jie Bai, Yan-Qi Zhang, Yan Jiang, Yi Gong, Zhi-Yu Chen
Summary: This study found that both NLR and PLR could be used to effectively predict long-term survival in patients with pCCA who underwent curative resection. High NLR and high PLR were associated with poor overall survival and recurrence-free survival in pCCA patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Veterinary Sciences
Ryan C. Fries, Saki Kadotani, Jonathan P. Stack, Leah Kruckman, Gabrielle Wallace
Summary: This study assessed the predictive value of NLR for cardiac death in cats with hypertrophic cardiomyopathy. The results showed that cats with higher NLR had a higher risk of cardiac death, and NLR was significantly associated with echocardiographic measurements.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Shihai Yang, Shangdong Li
Summary: This study aimed to establish a predictive model using neutrophil-lymphocyte ratio (NLR) to predict the survival prognosis of patients with gastric signet ring cell carcinoma (GSRC). The results showed that patients with NLR < 2.8 had significantly better overall survival and tumor recurrence rates compared to those with NLR > 2.8. After adjusting for other risk factors, NLR < 2.8, tumor size, and tumor metastasis remained independent predictors of tumor recurrence rate and overall survival. The study confirmed the value of NLR in predicting the prognosis of GSRC patients.
Article
Oncology
Weihao Kong, Mingwei Yang, Jianfeng Zhang, Ya Cheng, Tianxing Dai, Jian Zhang, Guoying Wang, Jianlin Zhang
Summary: This study investigated the prognostic value of the combination of neutrophil to lymphocyte ratio and platelet distribution width in post-operation patients with resectable hepatocellular carcinoma. The results demonstrated that this combination index is a valuable biomarker for predicting the survival of patients with HCC.
Review
Oncology
Hytham K. S. Hamid, George N. Davis, Mario Trejo-Avila, Patrick O. Igwe, Andres Garcia-Marin
Summary: This study quantified the prognostic value of NLR in rectal cancer patients undergoing curative-intent surgery, finding that high NLR was associated with worse overall survival and disease-free survival. NLR had a greater impact on prognosis compared to PLR, and was similar to LMR. High NLR was also linked to a lower rate of pathologic complete response.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Infectious Diseases
Shixiao Li, Sufei Yu, Jiajia Qin, Minfei Peng, Jiao Qian, Peng Zhou
Summary: The study evaluated the association between CPR, NLPR, FPR, and the prognoses of PLA patients. Higher levels of CPR, NLPR, and FPR were associated with a higher risk of poor outcomes. Among the three biomarkers, CPR was found to be the best predictor of clinical outcomes in PLA patients.
BMC INFECTIOUS DISEASES
(2022)
Article
Oncology
Deba Song, Xiaoxu Li, Xiaojian Zhang
Summary: This study explored the value of inflammatory markers, such as NLR, PLR, and LMR, in predicting the pathological features and prognosis of patients with BC. The findings suggest that these markers could become biological indicators for prognosis in invasive BC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Clinical Neurology
Jian Zhang, Chunlong Liu, Yaofeng Hu, Aoran Yang, Yonghui Zhang, Yang Hong
Summary: This study retrospectively collected baseline characteristics and laboratory findings of spontaneous intracerebral hemorrhage patients undergoing surgery, and found that high neutrophil-to-lymphocyte ratio (NLR) within 48 hours after surgery was an independent risk factor for poor prognosis at 30 days post-operation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Wentao Wang, Yilin Tong, Shulan Sun, Yuen Tan, Zexing Shan, Fan Sun, Chengyao Jiang, Yanmei Zhu, Jianjun Zhang
Summary: This study found that pretreatment neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) can independently predict tumor regression grade (TRG) after neoadjuvant chemotherapy in patients with locally advanced gastric cancer. Patients with high NLR and PLR values may benefit from alternative treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Alex K. K. Bryant, Kamya Sankar, Garth W. W. Strohbehn, Lili Zhao, David Elliott, Angel Qin, Sarah Yentz, Nithya Ramnath, Michael D. D. Green
Summary: This study demonstrates that pre-treatment NLR is a prognostic factor in stage III NSCLC patients treated with adjuvant immunotherapy, and it may also serve as a predictive biomarker of immunotherapy benefit.