Article
Gastroenterology & Hepatology
Isabelle Ollivier-Hourmand, Yohann Repesse, Pierre Nahon, Cendrine Chaffaut, Thong Dao, Thi Thu Nga Nguyen, Patrick Marcellin, Dominique Roulot, Victor De Ledinghen, Stanislas Pol, Dominique Guyader, Isabelle Archambeaud, Fabien Zoulim, Frederic Oberti, Albert Tran, Jean-Pierre Bronowicki, Louis D'Alteroche, Denis Ouzan, Jean-Marie Peron, Jean-Pierre Zarski, Marc Bourliere, Dominique Larrey, Alexandre Louvet, Paul Cales, Armand Abergel, Philippe Mathurin, Ariane Mallat, Jean-Frederic Blanc, Eric Nguyen-Khac, Ghassan Riachi, Laurent Alric, Lawrence Serfaty, Teresa Antonini, Christophe Moreno, Pierre Attali, Dominique Thabut, Christophe Pilette, Jean-Didier Grange, Christine Silvain, Nicolas Carbonell, Brigitte Bernard-Chabert, Odile Goria, Claire Wartelle, Romain Moirand, Christos Christidis, Gabriel Perlemuter, Violaine Ozenne, Jean Henrion, Sophie Hillaire, Vincent Di Martino, Xavier Amiot, Angela Sutton, Nathalie Barget, Sylvie Chevret, Nathalie Ganne-Carrie
Summary: The study indicates that non-O blood type does not influence the disease outcome, disease progression, or overall survival in Child-Pugh A cirrhotic patients.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Yichen Wei, Jie Gong, Xin He, Bo Liu, Tiejun Liu, Shuohui Yang, Zhipeng Zhou, Lingyan Liang, Songhua Zhan, Ziqiang Xia, Gaoxiong Duan, Bin Lin, Qiuli Han, Shasha Li, Wei Qin, Perry J. Pickhardt, Demao Deng
Summary: A radiomic nomogram based on baseline magnetic resonance imaging and clinical data was developed and validated for the individualized prediction of hepatocellular carcinoma in HBV cirrhosis patients. The radiomic combined nomogram showed good discrimination ability in predicting HCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Liangliang Xu, Fuzhen Dai, Peng Wang, Lian Li, Ming Zhang, Mingqing Xu
Summary: This study developed individual prognostic models for predicting the prognosis of HCC patients with hepatitis B virus-associated cirrhosis, which showed good performance in predicting the prognoses of these patients.
Article
Oncology
Zuyuan Lin, Huigang Li, Chiyu He, Modan Yang, Hao Chen, Xinyu Yang, Jianyong Zhuo, Wei Shen, Zhihang Hu, Linhui Pan, Xuyong Wei, Di Lu, Shusen Zheng, Xiao Xu
Summary: This study identified three novel markers for the diagnosis of AFP negative HCC using metabolomic profiling. A three-marker diagnostic model and nomogram were established, which could serve as potential non-invasive tools for the diagnosis of AFP negative HCC. Additionally, the level of MG(18:2/0:0/0:0) showed good prognosis prediction performance for AFP negative HCC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Tatsuya Minami, Masaya Sato, Hidenori Toyoda, Satoshi Yasuda, Tomoharu Yamada, Takuma Nakatsuka, Kenichiro Enooku, Hayato Nakagawa, Hidetaka Fujinaga, Masashi Izumiya, Yasuo Tanaka, Motoyuki Otsuka, Takamasa Ohki, Masahiro Arai, Yoshinari Asaoka, Atsushi Tanaka, Kiyomi Yasuda, Hideaki Miura, Itsuro Ogata, Toshiro Kamoshida, Kazuaki Inoue, Ryo Nakagomi, Masatoshi Akamatsu, Hiroshi Mitsui, Hajime Fujie, Keiji Ogura, Koji Uchino, Hideo Yoshida, Kazuyuki Hanajiri, Tomonori Wada, Kiyohiko Kurai, Hisato Maekawa, Yuji Kondo, Shuntaro Obi, Takuma Teratani, Naohiko Masaki, Kayo Nagashima, Takashi Ishikawa, Naoya Kato, Hiroshi Yotsuyanagi, Kyoji Moriya, Takashi Kumada, Mitsuhiro Fujishiro, Kazuhiko Koike, Ryosuke Tateishi
Summary: A machine learning model has been developed to predict the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C after achieving a sustained virologic response (SVR). The model showed good discriminative ability in external validation and can generate individualized predictive curves for each patient using an online application.
JOURNAL OF HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Kenneth I. Zheng, Ming-Hua Zheng
Summary: This article is linked to the paper by Estes et al. Visit the link to view the article.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Yang Wo, Yizhou Peng, Zhigang Wu, Pengcheng Liu, Yan Shang, Xuxia Shen, Yihua Sun
Summary: This study developed a novel predictive model for individualized prediction of the survival benefit of postoperative radiotherapy in malignant pleural mesothelioma patients. The model was able to compensate for the weaknesses in the TNM staging system.
Article
Gastroenterology & Hepatology
Heechul Nam, Sung Won Lee, Jung Hyun Kwon, Hae Lim Lee, Sun Hong Yoo, Hee Yeon Kim, Do Seon Song, Pil Soo Sung, U. Im Chang, Chang Wook Kim, Soon Woo Nam, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jin Mo Yang, Nam Ik Han, Jeong Won Jang
Summary: Antiviral therapy can improve hepatic fibrosis and reduce the incidence of hepatocellular carcinoma (HCC). This study found that changes in noninvasive fibrosis markers (NFM) during therapy are an independent indicator of HCC risk, and the FSAC model incorporating NFM response is a reliable risk score for HCC with better predictive performance than other models.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ji H. Nahm, Hye S. Lee, Haeryoung Kim, Sun Y. Yim, Ji-hyun Shin, Jeong E. Yoo, Sang H. Ahn, Jin S. Choi, Ju-Seog Lee, Young N. Park
Summary: This study developed a nomogram for predicting late recurrence of hepatocellular carcinoma (HCC) based on clinicopathological and molecular factors. The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis was found to predict late HCC recurrence.
LIVER INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Man Luo, Xiaodi Liu, Juanjuan Yong, Bing Ou, Xiaolin Xu, Xinbao Zhao, Ming Liang, Zizhuo Zhao, Jingliang Ruan, Baoming Luo
Summary: This study developed a preoperative prediction model to identify MTM-HCC and evaluated its diagnostic performance in differentiating MTM-HCC from HCC. BMUS and CEUS can be used for identifying patients suspected of having MTM-HCC, and a noninvasive diagnosis of MTM-HCC can be achieved by combining clinical information, BMUS, and CEUS features.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Simona Lattanzi, Stefano Meletti, Eugen Trinka, Francesco Brigo, Gianni Turcato, Claudia Rinaldi, Claudia Cagnetti, Nicoletta Foschi, Serena Broggi, Davide Norata, Mauro Silvestrini
Summary: This study aimed to develop a model and nomogram to predict drug resistance in patients with post-stroke epilepsy (PSE). The study identified age, intracerebral hemorrhage, stroke severity, latency of PSE, and status epilepticus as independent predictors of drug resistance. The nomogram showed good predictive accuracy and may serve as a practical tool for personalized prediction of drug-resistant PSE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Ran Cheng, Xiaoyuan Xu
Summary: This study aimed to investigate the effectiveness of risk assessment models for hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related cirrhosis undergoing antiviral therapy. The results showed that the REAL-B score had a high prognostic capability in predicting HCC risk, and there were significant differences in HCC risk assessment between the intermediate-risk group and the high-risk group at 1, 3, and 5 years.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Lei Liang, Bing Quan, Han Wu, Yong-Kang Diao, Jie Li, Ting-Hao Chen, Yao-Ming Zhang, Ya-Hao Zhou, Wan-Guang Zhang, Hong Wang, Matteo Serenari, Matteo Cescon, Myron Schwartz, Yong-Yi Zeng, Ying-Jian Liang, Hang-Dong Jia, Hao Xing, Chao Li, Ming-Da Wang, Wen-Tao Yan, Wan-Yuan Chen, Wan Yee Lau, Cheng-Wu Zhang, Timothy M. Pawlik, Dong-Sheng Huang, Feng Shen, Tian Yang
Summary: An individualized patient-specific tool was developed and validated to predict the benefit of surgery for hepatocellular carcinoma (HCC) patients. The tool showed good performance in identifying patients at highest risk of death within 6 months of surgery, which may help guide surgical decision-making to avoid futile surgery.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Jie Fu, Wei Qin, Qing Tong, Zhenghao Li, Yaoli Shao, Zhiqiang Liu, Chun Liu, Zicheng Wang, Xundi Xu
Summary: This study identified a novel DNA methylation-driver gene risk score signature and efficient nomogram for long-term survival prediction in hepatitis-positive HCC patients.
Article
Gastroenterology & Hepatology
Silvia Chang, Charlotte Hedskog, Bandita Parhy, Ross Martin, Hongmei Mo, Evguenia Maiorova, Fabien Zoulim
Summary: Antiviral nucleos(t)ide analogue therapies can inhibit HBV replication and reduce HBV DNA levels, but HBV RNA levels may remain high. HBV RNA can be used as a viral biomarker for treatment outcome and disease progression. This study characterized the sequence of extracellular HBV RNA in plasma samples of patients with chronic HBV infection, and found that it closely resembles HBV DNA sequence. Additionally, RNA splice forms, different polyA tails start positions, and HBV-human chimeric transcript were identified.
JOURNAL OF VIRAL HEPATITIS
(2023)
Letter
Gastroenterology & Hepatology
Thierry Thevenot, Maxime Desmarets, Delphine Weil, Vincent Di Martino
Review
Rheumatology
Vincent Di Martino, Delphine Weil Verhoeven, Frank Verhoeven, Francois Aubin, Jerome Avouac, Lucine Vuitton, Frederic Liote, Thierry Thevenot, Daniel Wendling
Summary: Methotrexate is an important treatment for inflammatory rheumatic diseases, especially rheumatoid arthritis. Liver toxicity is a concern for long-term methotrexate therapy, particularly in patients with non-alcoholic fatty liver disease (NAFLD). Understanding the mechanisms of hepatotoxicity and liver fibrosis is crucial for pretreatment screening and long-term monitoring in patients with chronic liver disease.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Virology
Nadjet Lebsir, Fabien Zoulim, Boyan Grigorov
Summary: Heparanase-1 is an important enzyme involved in viral infections and cancer, and its inhibitors can be used as both anti-cancer drugs and antiviral agents, potentially solving drug resistance issues in current antiretroviral therapies.
Article
Gastroenterology & Hepatology
Maria Paola Anolli, Elisabetta Degasperi, Lena Allweiss, Angelo Sangiovanni, Marco Maggioni, Caroline Scholtes, Valerie Oberhardt, Christoph Neumann-Haefelin, Maura Dandri, Fabien Zoulim, Pietro Lampertico
Summary: Bulevirtide has received conditional approval from the EMA for treating chronic hepatitis delta, but the optimal duration of therapy remains unknown. In this study, a patient with compensated cirrhosis and esophageal varices achieved hepatitis delta cure after 3 years of bulevirtide monotherapy. Virological and biochemical responses were maintained during the 72-week off-therapy follow-up, and significant improvements were observed in liver biopsy results.
JOURNAL OF HEPATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Vincent Di Martino
JOURNAL OF HEPATOLOGY
(2023)
Article
Virology
Caroline Charre, Hadrien Regue, Paul Deny, Laurence Josset, Isabelle Chemin, Fabien Zoulim, Caroline Scholtes
Summary: This study presents a workflow to amplify, sequence, and analyze the whole HDV genome in a single fragment. The HDV genome was successfully amplified and fully sequenced, allowing accurate subtyping and identification of a new HDV genotype 1 subtype. This workflow overcomes genome assembly issues and helps to identify modifications throughout the whole HDV genome.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Gastroenterology & Hepatology
Clemence Moreau, Marine Roux, Jeremie Riou, Clemence M. Canivet, Etienne Audureau, Clovis Lusivika-Nzinga, Pierre Nahon, Fabrice Carrat, Jerome Boursier
Summary: This study aimed to evaluate whether the dynamics of multiple measurements of simple parameters after sustained viral response (SVR) enable the development of a personalized prediction of prognosis in patients with hepatitis C virus (HCV) chronic infection. The study found that FIB4 was a biomarker associated with liver-related complications (LRC) occurrence after SVR. The results suggest that dynamic modeling using repeated measurements of simple parameters predicts the individual residual risk of LRC and improves personalized medicine after SVR in HCV patients.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Endocrinology & Metabolism
Cyrielle Caussy, Charlene Telliam, Bader Al-Nuaimi, Marianne Maynard-Muet, Jerome Dumortier, Fabien Zoulim, Emmanuel Disse, Cyrille Colin, Massimo Levrero, Philippe Moulin
Summary: A pathway-referral using transient elastography (TE) performed in diabetology and nutrition clinics significantly improves the liver fibrosis risk stratification and avoids over-referral. However, collaboration between diabetologists, nutritionists, and hepatologists is needed to avoid under-referral.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2023)
Article
Gastroenterology & Hepatology
Jordan J. Feld, Anna S. Lok, Fabien Zoulim
Summary: Current therapy for chronic hepatitis B rarely achieves a functional cure, but novel treatments are being developed. Understanding the mechanisms of hepatitis B virus persistence has helped identify new treatment targets and evaluate novel agents in clinical trials. Combining different agents appears to be a promising strategy to reduce viral replication, invigorate immune responses, and induce specific adaptive immune responses.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Infectious Diseases
Lorin Begre, Anders Boyd, Luisa Salazar-Vizcaya, Franziska Suter-Riniker, Charles Beguelin, Juergen K. Rockstroh, Huldrych F. Guenthard, Alexandra Calmy, Matthias Cavassini, Marcel Stoeckle, Patrick Schmid, Enos Bernasconi, Massimo Levrero, Fabien Zoulim, Gilles Wandeler, Andri Rauch, Swiss HIV Cohort Study SHCS
Summary: In HIV patients with HBsAg loss, qHBsAg levels decline rapidly at the beginning and then show diverse trajectories during long-term tenofovir therapy. In patients without HBsAg loss, qHBsAg levels remain relatively stable over time.
Letter
Gastroenterology & Hepatology
Tangui Barre, David Zucman, Fabienne Marcellin, Clemence Ramier, Camelia Protopopescu, Raphaelle Tardieu, Karine Ory, Dominique Salmon-Ceron, Patrizia Carrieri
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Gastroenterology & Hepatology
Man-Fung Yuen, Tarik Asselah, Ira M. Jacobson, Maurizia Rossana Brunetto, Harry L. A. Janssen, Tetsuo Takehara, Jin Lin Hou, Thomas N. Kakuda, Tom Lambrecht, Maria Beumont, Ronald Kalmeijer, Carine Guinard-Azadian, Cristiana Mayer, John Jezorwski, Thierry Verbinnen, Oliver Lenz, Umesh Shukla, Michael Biermer
Summary: This study evaluated the efficacy and safety of JNJ-73763989 (JNJ-3989) and JNJ-56136379 (JNJ-6379) in combination with nucleos(t)ide analogues for the treatment of chronic hepatitis B. The results showed that a higher proportion of patients in the JNJ-3989 dual and triple groups met the nucleos(t)ide analogue-stopping criteria at 48 weeks, with good safety profile.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Microbiology
Rayana Maryse Toye, Carmen Luisa Loureiro, Rossana Celeste Jaspe, Fabien Zoulim, Flor Helene Pujol, Isabelle Chemin
Summary: HBV genotypes E to J are understudied and have specific distributions across different regions. Genotype F is the most divergent and has further subgenotypes. There is a lack of data from sub-Saharan Africa and Latin America due to under-representation in clinical and research cohorts.
Article
Gastroenterology & Hepatology
Barbara Testoni, Armando Andres Roca Suarez, Arianna Battisti, Marie-Laure Plissonnier, Marintha Heil, Thierry Fontanges, Francois Villeret, Yasmina Chouik, Massimo Levrero, Upkar Gill, Patrick Kennedy, Fabien Zoulim
Summary: This study validated the possibility to quantify cccDNA and assess its transcriptional activity in patients with chronic hepatitis B by combining FNA and droplet digital PCR. The use of FNA in clinical trials to evaluate the intrahepatic viral reservoir during the development of new antivirals and immunomodulatory agents is supported.