☆ 4.8 Editorial Material

Cholangiocarcinoma risk factors and the potential role of aspirin

HEPATOLOGY (2016)

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HEPATOLOGY

卷 64, 期 3, 页码 708-710

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WILEY-BLACKWELL

DOI: 10.1002/hep.28613

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Gastroenterology & Hepatology

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A potential role for aspirin in the prevention and treatment of cholangiocarcinoma

Xizi Shen, Xingping Shen

Summary: Aspirin shows potential chemopreventive and adjuvant effects on cholangiocarcinoma, but further studies are needed to confirm its benefits and establish a cause-and-effect relationship.

INTERNATIONAL JOURNAL OF CANCER (2021)

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Article Pharmacology & Pharmacy

Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study

Lanlan Chen, Zhongqi Fan, Xiaodong Sun, Wei Qiu, Wentao Mu, Kaiyuan Chai, Yannan Cao, Guangyi Wang, Guoyue Lv

Summary: This study using Mendelian randomization identified gallstone and liver fat accumulation as two independent risk factors of CCA, suggesting two modifiable ways of preventing CCA.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Genetics & Heredity

Exploring the role of tumor stemness and the potential of stemness-related risk model in the prognosis of intrahepatic cholangiocarcinoma

Yuan Yue, Jie Tao, Dan An, Lei Shi

Summary: This study investigates the role of tumor stemness in intrahepatic cholangiocarcinoma and establishes an mRNAsi-related risk model for predicting prognosis and guiding clinical treatment in patients with this type of cancer.

FRONTIERS IN GENETICS (2023)

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Article Oncology

Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development

Ludovica Ceci, Tianhao Zhou, Ilaria Lenci, Vik Meadows, Lindsey Kennedy, Ping Li, Burcin Ekser, Martina Milana, Wenjun Zhang, Chaodong Wu, Keisaku Sato, Sanjukta Chakraborty, Shannon S. Glaser, Heather Francis, Gianfranco Alpini, Leonardo Baiocchi

Summary: This review provides an overview of the research progress on the risk factors and mechanisms of cholangiocarcinoma. These studies contribute to understanding the etiology and treatment options for cholangiocarcinoma.

CANCERS (2022)

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Editorial Material Oncology

Cholangiocarcinoma Risk factors Open the floodgates for Gut Microbes and Immunosuppressive Myeloid cells

Sharmeen Chagani, Lawrence N. Kwong

Summary: Intestinal barrier impairment plays a key role in promoting cholangiocarcinoma in patients with primary sclerosing cholangitis and colitis.

CANCER DISCOVERY (2021)

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Article Gastroenterology & Hepatology

Risk factors, epidemiology and prognosis of cholangiocarcinoma in Finland

Nina Barner-Rasmussen, Eero Pukkala, Kishor Hadkhale, Martti Farkkila

Summary: The study estimated the incidence of CCA in Finland, confirming PSC as the highest risk factor and poor survival rates.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2021)

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Review Biochemistry & Molecular Biology

The Role of microRNAs in Cholangiocarcinoma

Tingting Shi, Asahiro Morishita, Hideki Kobara, Tsutomu Masaki

Summary: miRNAs play crucial roles in the pathogenesis of cholangiocarcinoma, their potential as biomarkers for diagnosis and prognosis, and their utilization as novel therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Potential Role of Inflammation-Promoting Biliary Microbiome in Primary Sclerosing Cholangitis and Cholangiocarcinoma

Katsuyuki Miyabe, Vinay Chandrasekhara, Nicha Wongjarupong, Jun Chen, Lu Yang, Stephen Johnson, Nicholas Chia, Marina Walther-Antonio, Janet Z. Yao, Sean C. Harrington, Cynthia K. Nordyke, John E. Eaton, Andrea A. Gossard, Sharad Oli, Hamdi A. Ali, Sravanthi Lavu, Nasra H. Giama, Fatima A. Hassan, Hawa M. Ali, Felicity T. Enders, Sumera I. Ilyas, Gregory J. Gores, Mark D. Topazian, Purna C. Kashyap, Lewis R. Roberts

Summary: This study investigated the microbiota profiles in bile and stool samples of patients with PSC and CCA, and found that bile and stool have different microbiota profiles. The abundance of Fusobacteria in bile was correlated with the duration of PSC in CCA patients. These findings suggest a potential role for microbiota-driven inflammation in the pathogenesis of perihilar CCA.

CANCERS (2022)

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Article Obstetrics & Gynecology

The potential risk factors of placenta increta and the role of octamethylcyclotetrasiloxane

Yan Long, Min Jiang, Fei Gao, Mengru Han, Qiangsheng Gan, Fangling Zeng, Shanshui Zeng, Yanwei Hu, Xianhui Dong, Weitao Ye, Chunyan Zhu, Hongling Yang

Summary: This study identified potential risk factors for the placenta accreta spectrum (PAS) and highlighted the association between PAS risk and factors such as fasting blood glucose levels, history of endometrial injury, and plasma octamethylcyclotetrasiloxane (OMCTS) concentrations. Additionally, the study showed that OMCTS may promote trophoblast cell proliferation and migration, and a diagnostic model combining clinical factors and OMCTS had a high predictive value for PAS. Early diagnosis of PAS in pregnant women should involve evaluation of risk factors, metabolic status, and fasting blood glucose levels before 20 weeks of gestation.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2022)

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Article Medicine, General & Internal

Estimated Prevalence of Risk Factors for Preeclampsia Among Individuals Giving Birth in the US in 2019

Sarahn M. Wheeler, Sabrena O. Myers, Geeta K. Swamy, Evan R. Myers

Summary: The study found that in 2019, out of 3,695,019 pregnancies in the United States, 528,778 had no risk factors, 169,540 had one or more high-risk factors, and 2,996,701 had one or more moderate-risk factors. Multifetal gestation was the most common high-risk factor, while low socioeconomic status was the most common moderate-risk factor. According to the 2021 criteria, 3,166,241 pregnant patients (85.7%) were eligible for LDA for preeclampsia prevention.

JAMA NETWORK OPEN (2022)

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Article Gastroenterology & Hepatology

Controversial risk factors for cholangiocarcinoma

Firas Baidoun, Muhammad Talal Sarmini, Zahi Merjaneh, Muhamad Alhaj Moustafa

Summary: The study using a national inpatient database found that diabetes mellitus is associated with cholangiocarcinoma, while alcohol abuse, smoking, and obesity are inversely associated with cholangiocarcinoma. Compared to Whites, Hispanic and Asian/Pacific Islander races are more likely to have cholangiocarcinoma, whereas African American race is less likely to have cholangiocarcinoma.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Immunology

Potential causal association between aspirin use and the reduced risk of hayfever or allergic rhinitis: a Mendelian randomization study

Li Li, Yuanding Zhang, Xiangliang Liu, Junxin Li, Qiuyu Yang, Jiajia Jiang, Hong Liu, Zhongying Fu, Weilun Chen

Summary: This study using Mendelian randomization analysis found a potential causal relationship between aspirin use and reduced risk of hayfever or allergic rhinitis.

FRONTIERS IN IMMUNOLOGY (2023)

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Article Obstetrics & Gynecology

The impact of risk factors on aspirin's efficacy for the prevention of preterm birth

Emily E. Nuss, Matthew K. Hoffman, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud, Manjunath Somannavar, Jean Okitawutshu, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Abigail Mwapule Tembo, Elwyn Chomba, Waldemar A. Carlo, Lester Figueroa, Nancy F. Krebs, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Kunal Kurhe, Prabir Das, Patricia L. Hibberd, Emmah Achieng, Paul Nyongesa, Fabian Esamai, Edward A. Liechty, Sherri Bucher, Norman Goco, Jennifer Hemingway-Foday, Janet Moore, Elizabeth M. McClure, Robert M. Silver, Richard J. Derman

Summary: This study aimed to compare the differential benefits of low-dose aspirin in preventing preterm birth and hypertensive disorders of pregnancy in nulliparous women with and without additional risk factors. The study found that low-dose aspirin similarly reduced the risk of preterm birth and hypertensive disorders of pregnancy in both groups. However, it was significantly more effective in reducing preterm birth before 34 weeks of gestation in women without additional risk factors.

AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM (2023)

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Article Gastroenterology & Hepatology

Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial

Suzanne E. Mahady, Karen L. Margolis, Andrew Chan, Galina Polekhina, Robyn L. Woods, Rory Wolfe, Mark R. Nelson, Jessica E. Lockery, Erica M. Wood, Christopher Reid, Michael E. Ernst, Anne Murray, L. T. P. Thao, John J. McNeil

Summary: The study found that aspirin increases the risk of gastrointestinal bleeding in older people by 60%, but the risk of serious bleeding in younger, healthy individuals over a 5-year period is relatively low. Factors such as age, smoking, hypertension, chronic kidney disease, and obesity can increase the risk of bleeding.

GUT (2021)

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Article Surgery

Venous thromboembolism in patients undergoing distal cholangiocarcinoma surgery: Prevalence, risk factors, and outcomes

Qing Chen, Songping Cui, Jincan Huang, Jing Wang, Di Wang, Hanxuan Wang, Shaocheng Lyu, Ren Lang

Summary: This study investigated the prevalence, risk factors, and prognosis of venous thromboembolism (VTE) in distal cholangiocarcinoma (dCCA) surgery patients. The study found a high prevalence of VTE, which was associated with adverse outcomes. A nomogram assessing VTE risk was developed to help identify high-risk individuals and implement preventive measures.

ASIAN JOURNAL OF SURGERY (2023)

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Article Gastroenterology & Hepatology

Minimally Invasive Liver Resection for Early-Stage Hepatocellular Carcinoma: Inconsistent Outcomes from Matched or Weighted Cohorts

Lu Wu, Diamantis Tsilimigras, Katiuscha Merath, J. Madison Hyer, Anghela Z. Paredes, Rittal Mehta, Kota Sahara, Fabio Bagante, Eliza W. Beal, Feng Shen, Timothy M. Pawlik

JOURNAL OF GASTROINTESTINAL SURGERY (2020)

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Evaluation of the ACS NSQIP Surgical Risk Calculator in Elderly Patients Undergoing Hepatectomy for Hepatocellular Carcinoma

Kota Sahara, Anghela Z. Paredes, Katiuscha Merath, Diamantis Tsilimigras, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Eliza W. Beal, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Workneh Aklile, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M. Pawlik

JOURNAL OF GASTROINTESTINAL SURGERY (2020)

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Article Gastroenterology & Hepatology

Effect of Surgical Margin Width on Patterns of Recurrence among Patients Undergoing R0 Hepatectomy for T1 Hepatocellular Carcinoma: An International Multi-Institutional Analysis

Diamantis Tsilimigras, Kota Sahara, Dimitrios Moris, J. Madison Hyer, Anghela Z. Paredes, Fabio Bagante, Katiuscha Merath, Ayesha S. Farooq, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Daniel Azoulay, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M. Pawlik

JOURNAL OF GASTROINTESTINAL SURGERY (2020)

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Short-Term Outcomes of Patients Undergoing Portal Vein Embolization: an ACS-NSQIP Procedure-Targeted Hepatectomy Analysis

Fabio Bagante, Gaya Spolverato, Elizabeth Gleeson, Katiuscha Merath, Aslam Ejaz, Jordan Cloyd, Allan Tsung, Mary Dillhoff, Henry A. Pitt, Timothy M. Pawlik

JOURNAL OF GASTROINTESTINAL SURGERY (2020)

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Article Oncology

A Machine-Based Approach to Preoperatively Identify Patients with the Most and Least Benefit Associated with Resection for Intrahepatic Cholangiocarcinoma: An International Multi-institutional Analysis of 1146 Patients

Diamantis Tsilimigras, Rittal Mehta, Dimitrios Moris, Kota Sahara, Fabio Bagante, Anghela Z. Paredes, Amika Moro, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Olivier Soubrane, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik

ANNALS OF SURGICAL ONCOLOGY (2020)

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Early Versus Late Recurrence of Hepatocellular Carcinoma After Surgical Resection Based on Post-recurrence Survival: an International Multi-institutional Analysis

Tao Wei, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Silvia Silva, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Razvan Grigorie, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Yi Lv, Luca Aldrighetti, Timothy M. Pawlik

Summary: The study found that setting the time point for recurrence at 8 months is beneficial for distinguishing early from late recurrence, with early recurrence patients typically having shorter survival time and post-recurrence survival, as well as less likely to receive curative treatment. Curative-intent retreatment for late recurrence patients is associated with similar overall survival compared to patients without recurrence.

JOURNAL OF GASTROINTESTINAL SURGERY (2021)

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Multigene mutational profiling of biliary tract cancer is related to the pattern of recurrence in surgically resected patients

Simone Conci, Andrea Ruzzenente, Michele Simbolo, Fabio Bagante, Borislav Rusev, Giulia Isa, Rita T. Lawlor, Corrado Pedrazzani, Calogero Iacono, Alfredo Guglielmi, Aldo Scarpa

UPDATES IN SURGERY (2020)

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Simultaneous approach for patients with synchronous colon and rectal liver metastases: Impact of site of primary on postoperative and oncological outcomes

Simone Conci, Andrea Ruzzenente, Corrado Pedrazzani, Giulia Isa, Giulia Turri, Tommaso Campagnaro, Alessandro Valdegamberi, Fabio Bagante, Ivan Marchitelli, Alfredo Guglielmi

Summary: The study found that simultaneous resection of the primary tumor and liver metastases is feasible and safe for patients with colon and rectal cancer with synchronous liver metastases. This approach led to satisfactory oncological outcomes for both colon and rectal cancer. Right-sided colon cancer had a worse prognosis compared to left-sided colon cancer and rectal cancer.

EJSO (2021)

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Prediction of tumor recurrence by α-fetoprotein model after curative resection for hepatocellular carcinoma

Hong-Fan Ding, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Yi Lv, Timothy M. Pawlik

Summary: The study found that the AFP model is more accurate in identifying which HCC patients may benefit the most from surgical resection, and is superior to the BCLC system in predicting tumor recurrence and patient survival.

EJSO (2021)

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Article Oncology

Surgery for Bismuth-Corlette Type 4 Perihilar Cholangiocarcinoma: Results from a Western Multicenter Collaborative Group

Andrea Ruzzenente, Fabio Bagante, Pim B. Olthof, Luca Aldrighetti, Ruslan Alikhanov, Matteo Cescon, Bas Groot Koerkamp, William R. Jarnagin, Silvio Nadalin, Johann Pratschke, Moritz Schmelzle, Ernesto Sparrelid, Hauke Lang, Calogero Iacono, Thomas M. van Gulik, Alfredo Guglielmi

Summary: In this study comparing short- and long-term outcomes for patients with Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) versus BC types 2 and 3 pCCA undergoing surgical resection, the results showed significant differences in clinicopathologic characteristics between the two groups. However, the type of BC was not associated with prognosis for survival, indicating that resection remains a viable curative treatment option for selected patients with BC type 4 pCCA.

ANNALS OF SURGICAL ONCOLOGY (2021)

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Artificial neural networks for multi-omics classifications of hepato-pancreato-biliary cancers: towards the clinical application of genetic data

Fabio Bagante, Gaya Spolverato, Andrea Ruzzenente, Claudio Luchini, Diamantis Tsilimigras, Tommaso Campagnaro, Simone Conci, Vincenzo Corbo, Aldo Scarpa, Alfredo Guglielmi, Timothy M. Pawlik

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EUROPEAN JOURNAL OF CANCER (2021)

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Colorectal cancer with microsatellite instability: Right-sided location and signet ring cell histology are associated with nodal metastases, and extranodal extension influences disease-free survival

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PATHOLOGY RESEARCH AND PRACTICE (2021)

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Role of Inflammatory and Immune-Nutritional Prognostic Markers in Patients Undergoing Surgical Resection for Biliary Tract Cancers

Simone Conci, Tommaso Campagnaro, Elisa Danese, Ezio Lombardo, Giulia Isa, Alessandro Vitali, Ivan Marchitelli, Fabio Bagante, Corrado Pedrazzani, Mario De Bellis, Andrea Ciangherotti, Alfredo Guglielmi, Giuseppe Lippi, Andrea Ruzzenente

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CANCERS (2021)

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Article Pharmacology & Pharmacy

Molecular characterization of extrahepatic cholangiocarcinoma: perihilar and distal tumors display divergent genomic and transcriptomic profiles

Michele Simbolo, Samantha Bersani, Caterina Vicentini, Sergio Taormina, Chiara Ciaparrone, Fabio Bagante, Borislav Rusev, Giovanni Centonze, Marina Montresor, Matteo Brunelli, Serena Pedron, Andrea Mafficini, Gaetano Paolino, Paola Mattiolo, Simone Conci, Massimo Milione, Alfredo Guglielmi, Andrea Ruzzenente, Aldo Scarpa, Claudio Luchini

Summary: PHCC demonstrated more frequent KRAS mutations, while TP53 mutations were more common in DECC. Potentially actionable alterations included high tumor mutational burden and/or microsatellite instability (7.1%), PI3KCA mutations (8.1%), and MYC (10.1%) and ERBB2 amplification (5.1%). Transcriptomic profiles revealed three distinct clusters, corresponding to anatomical origin and differing in immune microenvironment. DECC appeared to consist of two distinct tumor subgroups, one enriched for druggable alterations and one lacking actionable opportunities.

EXPERT OPINION ON THERAPEUTIC TARGETS (2021)

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Article Oncology

Impact of time-to-surgery on outcomes of patients undergoing curative-intent liver resection for BCLC-0, A and B hepatocellular carcinoma

Diamantis I. Tsilimigras, J. Madison Hyer, Adrian Diaz, Demetrios Moris, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M. Pawlik

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JOURNAL OF SURGICAL ONCOLOGY (2021)

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Cholangiocarcinoma risk factors and the potential role of aspirin

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WILEY-BLACKWELL

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