期刊
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
卷 30, 期 3, 页码 591-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.hoc.2016.01.011
关键词
Sickle cell disease; Red blood cell transfusion; Alloimmunization; Iron overload
Red blood cell (RBC) transfusion therapy is a key component of comprehensive management of patients with sickle cell disease (SCD) and has increased over time as a means of primary and secondary stroke prevention. RBC transfusions also prove to be lifesaving for many acute sickle cell related complications. Although episodic and chronic transfusion therapy has significantly improved the morbidity and mortality of patients with SCD, transfusions are not without adverse effects. This review addresses RBC transfusion methods, evidence-based and/or expert panel based consensus on indications for chronic and episodic transfusion indications, and strategies to prevent and manage transfusion related complications.
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