Article
Cardiac & Cardiovascular Systems
Estelle Gandjbakhch, Mikael Laredo, Antonio Berruezo, Jean-Basptiste Gourraud, Jean-Marc Sellal, Raphael Martins, Frederic Sacher, Laurent Pison, Etienne Pruvot, Beatriz Jauregui, Antonio Frontera, Saurabh Kumar, Tom Wong, Paolo DellaBella, Philippe Maury
Summary: In patients with ARVC, well-tolerated MVT without a back-up ICD did not lead to fatal arrhythmic event after RCA despite VT recurrences in some. Our data suggest that RCA may be an alternative to ICD in selected ARVC patients.
Review
Cardiac & Cardiovascular Systems
Ann-Kathrin Kahle, Christiane Jungen, Fares-Alexander Alken, Katharina Scherschel, Stephan Willems, Helmut Purerfellner, Shaojie Chen, Lars Eckardt, Christian Meyer
Summary: Sudden cardiac death caused by ischaemic cardiomyopathy is a major concern, with implantation of cardioverter-defibrillator being a common preventive measure. Catheter ablation has been shown to reduce ventricular tachycardia recurrences in patients with ICM, and emerging concepts like sympathetic cardiac denervation hold promise for expanding therapeutic options in therapy-refractory VT. Further research is needed to investigate the potential benefits of these novel strategies for improving patient outcomes.
Article
Cardiac & Cardiovascular Systems
Angel Arenal, Pablo Avila, Javier Jimenez-Candil, Luis Tercedor, David Calvo, Fernando Arribas, Javier Fernandez-Portales, Jose Luis Merino, Antonio Hernandez-Madrid, Francisco J. Fernandez-Aviles, Antonio Berruezo
Summary: In patients with ischemic cardiomyopathy and an implantable cardioverter-defibrillator (ICD), catheter ablation and antiarrhythmic drugs (AADs) reduce ICD shocks, but the most effective approach remains uncertain.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michelle Samuel, Lena Rivard, Isabelle Nault, Lorne Gula, Vidal Essebag, Ratika Parkash, Laurence D. Sterns, Paul Khairy, John L. Sapp
Summary: The study investigates the impact of infarct location on the effectiveness of VT ablation treatment, showing that differences in MI location may affect treatment outcomes.
Article
Cardiac & Cardiovascular Systems
Michelle Samuel, Jeff S. Healey, Isabelle Nault, Laurence D. Sterns, Vidal Essebag, Christopher Gray, Tomasz Hruczkowski, Martin Gardner, Ratika Parkash, John L. Sapp
Summary: This study compared the effects of catheter ablation and escalated antiarrhythmic drug (AAD) therapy on ventricular tachycardia (VT) events and implantable cardioverter-defibrillator (ICD) therapy burden in patients with previous myocardial infarction (MI) and drug-refractory VT. The results showed that patients in the ablation group had significantly lower burden of shock-treated VT events and appropriate ICD therapy compared to those in the escalated AAD therapy group.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Khi Yung Fong, Yiong Huak Chan, Yue Wang, Colin Yeo, Eric Tien Siang Lim, Vern Hsen Tan
Summary: This study investigated the effectiveness of catheter ablation (CA) of ventricular tachycardia (VT) in patients with an implantable cardioverter-defibrillator (ICD). The results showed that CA significantly reduced the recurrence of VT and decreased the rates of adverse events. The findings were consistent in patients who underwent prophylactic CA.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marc W. Deyell, Steve Doucette, Ratika Parkash, Isabelle Nault, Lorne Gula, Christopher Gray, Martin Gardner, Laurence D. Sterns, Jeff S. Healey, Vidal Essebag, John L. Sapp
Summary: This study found that VT cycle length and presentation with electrical storm can predict the response to catheter ablation and escalated antiarrhythmic therapy. Patients with slower VT cycle length had better outcomes with ablation. For patients with electrical storm, catheter ablation combined with amiodarone had better efficacy compared to escalated drug therapy.
Article
Cardiac & Cardiovascular Systems
Lorne J. Gula, Asher Frydman, Habib R. Khan, George J. Klein, Peter Leong-Sit, Jaimie Manlucu, Jason D. Roberts, Anthony S. L. Tang, Raymond Yee, Allan C. Skanes
Summary: Patients with mildly impaired LV function and hemodynamically tolerated VT receive appropriate ICD therapies over the 3 years following implant. Recurrent VT/VF rates can be much more rapid after ICD placement, with 23% of patients going on to receive appropriate ICD shocks.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Bharat K. Kantharia
Summary: The effectiveness and limitations of ICD in preventing VT in patients with ICM need further research.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nour Shaheen, Ahmed Shaheen, Mohamed Elmasry, Abdulqadir J. Nashwan
Summary: Endocardial-epicardial catheter ablation is more effective than endocardial catheter ablation alone in reducing the risk of ventricular arrhythmia recurrence in patients with structural heart disease, especially those with arrhythmogenic right ventricular cardiomyopathy and ischemic cardiomyopathy.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Engineering, Biomedical
Philippe Maury, Maxime Beneyto, Pierre Mondoly, Hubert Delasnerie, Anne Rollin
Summary: This article reviews the natural course of patients with structural heart disease and sustained ventricular tachycardia who have not received ICD implantation and explores the potential role of catheter ablation alone in this population.
EXPERT REVIEW OF MEDICAL DEVICES
(2022)
Article
Cardiac & Cardiovascular Systems
Artak Margkarian, Harilaos Bogossian, Dirk Bandorski, Atisha Khan, Fuad Hasan, Tobias Fortmann, Klothilda Jahaj, Bernd Lemke, Markus Zarse
Summary: This study examined the long-term effects of substrate modification in patients undergoing electrical storm (ES) ablation, considering factors such as age, gender, heart function, scare location, VT documentation, postprocedural electrical stimulation (PES), and induced VTs. The findings showed that VT recurrences and mortality rates followed different patterns, with an initial steep decline and then a plateau. Gender, age, scare localization, and missing VT documentation did not affect outcomes significantly, while the induction of more than three VTs and the lack of PES due to hemodynamic instability decreased the effectiveness of the treatment. The study concluded that ES ablation is safe and feasible, and further advancements in understanding the reentry mechanism can improve long-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Luigi Di Biase, Jorge Romero, Xianfeng Du, Sanghamitra Mohanty, Chintan Trivedi, Domenico G. Della Rocca, Kavisha Patel, Javier Sanchez, Ruike Yang, Isabella Alviz, Prasant Mohanty, Carola Gianni, Nicola Tarantino, Xiao-Dong Zhang, Rodney Horton, Amin Al-Ahmad, Dhanunjaya Lakkireddy, David J. Burkhardt, Minglong Chen, Andrea Natale
Summary: The study found that patients taking amiodarone achieved VT noninducibility faster with less radiofrequency time and less need for epicardial ablation after substrate catheter ablation, but had significantly higher VT recurrence at long-term follow-up when this medication was discontinued.
Article
Cardiac & Cardiovascular Systems
Fatima M. Ezzeddine, Konstantinos C. Siontis, John Giudicessi, Michael J. Ackerman, Ammar M. Killu, Abhishek J. Deshmukh, Malini Madhavan, Martin van Zyl, Vaibhav R. Vaidya, Roshan Karki, Andrew Tseng, Thomas M. Munger, Christopher J. McLeod, Samuel J. Asirvatham, Freddy Del-Carpio Munoz
Summary: Catheter ablation is effective in reducing recurrence of ventricular arrhythmias in patients with Mitral Annular Disjunction (MAD). Substrate mapping and ablation may be considered in these patients to reduce the need for repeat ablation.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Karl-Heinz Kuck, Dmitry S. Lebedev, Evgeny N. Mikhaylov, Alexander Romanov, Laszlo Geller, Oskars Kalejs, Thomas Neumann, Karapet Davtyan, Young Keun On, Sergey Popov, Maria Grazia Bongiorni, Michael Schlueter, Stephan Willems, Feifan Ouyang
Summary: The study indicates that radiofrequency ablation is more effective than antiarrhythmic drug therapy in delaying the progression from paroxysmal to persistent atrial fibrillation. Patients aged 65 and above may have an increased risk of progressing to persistent atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Ling Kuo, Yasuhiro Shirai, Daniele Muser, Jackson J. Liang, Simon A. Castro, Pasquale Santangeli, Robert D. Schaller, Gregory E. Supple, David Lin, Saman Nazarian, Sanjay Dixit, David J. Callans, Francis E. Marchlinski, David S. Frankel
Article
Cardiac & Cardiovascular Systems
Andres Enriquez, David Briceno, Carlos Tapias, Yasuhiro Shirai, Daniele Muser, Jackson Liang, Tatsuya Hayashi, Pasquale Santangeli, David S. Frankel, Gregory E. Supple, Robert D. Schaller, Jeffrey Arkles, Diego Rodriguez, David J. Callans, Francis E. Marchlinski, Luis Saenz, Fermin C. Garcia
Review
Cardiac & Cardiovascular Systems
Carlos Ruben Lopez Perales, Harriette G. C. Van Spall, Shingo Maeda, Alejandro Jimenez, Decebal Gabriel Latcu, Anat Milman, Fati Kirakoya-Samadoulougou, Mamas A. Mamas, Daniele Muser, Ruben Casado Arroyo
Summary: Through a systematic review of the literature, it was found that mobile health devices have some level of accuracy in diagnosing and screening for atrial fibrillation, with iECG and PPG sensors being the most commonly used technologies. While the evidence for clinical effectiveness is limited, these devices may be useful in detecting atrial fibrillation. Further investigations are needed to explore the clinical, economic, and policy implications of mHealth and to compare its effectiveness with traditional medical devices.
Review
Biochemistry & Molecular Biology
Viraj Patel, Babken Asatryan, Bhurint Siripanthong, Patricia B. Munroe, Anjali Tiku-Owens, Luis R. Lopes, Mohammed Y. Khanji, Alexandros Protonotarios, Pasquale Santangeli, Daniele Muser, Francis E. Marchlinski, Peter A. Brady, C. Anwar A. Chahal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cardiac & Cardiovascular Systems
Daniele Muser, Gaetano Nucifora, Maurizio Pieroni, Simon A. Castro, Ruben Casado Arroyo, Shingo Maeda, Daniel A. Benhayon, Ioan Liuba, Mouhannad Sadek, Silvia Magnani, Andres Enriquez, Jackson J. Liang, Biagio Sassone, Benoit Desjardins, Sanjay Dixit, Rajat Deo, Fermin C. Garcia, David J. Callans, David S. Frankel, Joseph B. Selvanayagam, Francis E. Marchlinsk, Pasquale Santangeli
Summary: The study showed that in patients with apparently idiopathic nonsustained ventricular arrhythmias, a specific phenotype of LV scar characterized by a ringlike pattern is associated with malignant arrhythmic events and higher prognostic risk.
Editorial Material
Medicine, General & Internal
Daniele Muser, Pasquale Santangeli, Gaetano Nucifora
Article
Cardiac & Cardiovascular Systems
Andres Enriquez, Jackson Liang, Jeffrey Smietana, Daniele Muser, Pablo Salazar, Rajan Shah, Nitish Badhwar, Frank Bogun, Francis Marchlinski, Fermin Garcia, Adrian Baranchuk, Roderick Tung, Damian Redfearn, Pasquale Santangeli
Summary: This study evaluated the outcomes of patients with TTN-related cardiomyopathy undergoing VT ablation, finding that after ablation some patients still experienced VT recurrence and required transplant or mechanical circulatory support.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Biagio Sassone, Santo Virzi, Matteo Bertini, Giovanni Pasanisi, Lamberto Manzoli, Jonathan Myers, Giovanni Grazzi, Daniele Muser
Summary: The study found that the nationwide lockdown during the COVID-19 pandemic in Italy did not have a significant impact on the incidence of arrhythmias in patients with defibrillators in Ferrara. However, there was a decrease in the number of patients experiencing non-sustained ventricular tachycardias during the lockdown period.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Review
Medicine, Legal
Francesco Simonit, Daniele Muser, Giorgio Morocutti, Lorenzo Desinan
Summary: Sudden cardiac death in young athletes poses a challenge in forensic practice, requiring pathologists to determine the cause of death based on anatomical findings. Arrhythmogenic right ventricular cardiomyopathy is a common cause of sudden cardiac death during sports, but recent findings suggest that left ventricle involvement is also associated with high risk.
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ioan Liuba, Daniele Muser, Anwar Chahal, Cory Tschabrunn, Pasquale Santangeli, Ling Kuo, David S. Frankel, David J. Callans, Fermin Garcia, Gregory E. Supple, Robert D. Schaller, Sanjay Dixit, David Lin, Saman Nazarian, Ramanan Kumareswaran, Jeffrey Arkles, Michael P. Riley, Matthew C. Hyman, Katie Walsh, Gustavo Guandalini, Martin Arceluz, Naga Venkata K. Pothineni, Erica S. Zado, Francis Marchlinski
Summary: In patients with left ventricular nonischemic cardiomyopathy and VT, the substrate may be confined to the epicardial region, especially in the basal inferolateral left ventricle. Endocardial unipolar low-voltage areas and normal amplitude bipolar split electrograms can help identify epicardial low-voltage areas. Ablation targeting epicardial VT and substrate leads to good long-term VT-free survival. Greater endocardial unipolar low-voltage areas and more inducible VTs predict VT recurrence.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Review
Medicine, General & Internal
Daniele Muser, Massimo Tritto, Marco Valerio Mariani, Antonio Di Monaco, Paolo Compagnucci, Michele Accogli, Roberto De Ponti, Fabrizio Guarracini
Summary: Premature ventricular contractions (PVCs) are common arrhythmias in clinical practice, with well-defined sites of origin in the ventricles. This review discusses the mechanisms, prevalence, diagnostic work-up, prognosis, and treatment of PVCs based on current scientific evidence.
Article
Cardiac & Cardiovascular Systems
Ravi A. Shah, Babken Asatryan, Ghaith Sharaf Dabbagh, Nay Aung, Mohammed Y. Khanji, Luis R. Lopes, Stefan van Duijvenboden, Anthony Holmes, Daniele Muser, Andrew P. Landstrom, Aaron Mark Lee, Pankaj Arora, Christopher Semsarian, Virend K. Somers, Anjali T. Owens, Patricia B. Munroe, Steffen E. Petersen, C. Anwar A. Chahal
Summary: This study aimed to investigate the phenotype and penetrance of dilated cardiomyopathy (DCM) gene variants in the general population. Analysis of UK Biobank data revealed that approximately 1 in 6 adults with putative pathogenic variants in DCM genes exhibited early DCM features potentially associated with DCM genotype, with arrhythmias being the most common manifestation.
Review
Cardiac & Cardiovascular Systems
Fabrizio Guarracini, Massimo Tritto, Antonio Di Monaco, Marco Valerio Mariani, Alessio Gasperetti, Paolo Compagnucci, Daniele Muser, Alberto Preda, Patrizio Mazzone, Sakis Themistoclakis, Corrado Carbucicchio
Summary: Ventricular tachycardia in patients with structural heart disease is a significant cause of morbidity and mortality. Current guidelines recommend cardioverter defibrillator implantation, antiarrhythmic drugs, and catheter ablation as standard therapies, but their efficacy is limited in some cases. Stereotactic arrhythmia radioablation provides a promising alternative non-invasive and painless therapeutic strategy for patients with refractory ventricular tachycardia.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Medicine, General & Internal
Igor Vendramin, Andrea Lechiancole, Daniela Piani, Sandro Sponga, Concetta Di Nora, Daniele Muser, Uberto Bortolotti, Ugolino Livi
Summary: With increasing experience and a more aggressive approach, including total arch replacement, repair of type A acute aortic dissection can be performed with low operative mortality and high survival rates in many patients. Patient care and treatment by a specific team organization allows faster diagnosis and referral for surgery, further improving early and late outcomes.
MEDICINA-LITHUANIA
(2021)
Review
Cardiac & Cardiovascular Systems
Igor Vendramin, Andrea Lechiancole, Daniela Piani, Gaetano Nucifora, Giovanni Benedetti, Sandro Sponga, Daniele Muser, Uberto Bortolotti, Ugolino Livi
Summary: Sutureless and rapid-deployment bioprostheses have been shown to be effective alternatives in complex redo procedures, suitable for replacing degenerated valves, with all patients surviving postoperatively.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
