Article
Cardiac & Cardiovascular Systems
Branka Vulesevic, Naozumi Kubota, Ian G. Burwash, Claire Cimadevilla, Sarah Tubiana, Xavier Duval, Virginia Nguyen, Dimitri Arangalage, Kwan L. Chan, Erin E. Mulvihill, Luc Beauchesne, David Messika-Zeitoun
Summary: This study found that aortic valve area indexed to height may be more accurate in defining severe AS compared to the indexed to body surface area. The results suggest that AVA/H is better correlated with AVA than AVA/BSA and may provide a better predictive accuracy for severe AS.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Jerry Ash, Gurmandeep S. Sandhu, Jose Arriola-Montenegro, Dzhalal Agakishiev, Marie-Annick Clavel, Philippe Pibarot, Sue Duval, Prabhjot S. Nijjar
Summary: This study investigated the usefulness of CT-derived aortic valve areas (AVAs) in determining the severity of aortic stenosis (AS). The results showed that CT-derived AVAs have poor discrimination for AS severity, and using an AVA(CT) <1.2-cm(2) threshold to define severe AS can lead to significant error. However, larger AVA(CT) thresholds improve specificity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Patimat Murtazalieva, Darya Ryzhkova, Eduard Malev, Ekaterina Zhiduleva, Olga Moiseeva
Summary: The study aimed to assess the prognostic value of valvular inflammation and calcification measured by F-18-FDG and F-18-NaF PET/CT in patients with TAV and BAV. The results suggest that F-18-NaF PET/CT may be a valuable predictor for hemodynamic progression of calcific AS in TAV patients, while F-18-FDG PET/CT does not play a significant role in predicting AS progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Jan-Christian Reil, Christoph Marquetand, Claudia Busch-Tilge, Maria Ivannikova, Volker Rudolph, Anas Aboud, Stephan Ensminger, Hans-Joachim Schaefers, Ulrich Stierle, Gert-Hinrich Reil
Summary: This study evaluated the effect of aortic cross-sectional area on pressure recovery and effective aortic valve orifice area in patients with ascending aortic aneurysm and mildly diseased aortic valves. It was found that after valve-sparing surgery, there was a significant reduction in aortic cross-sectional area and an increase in pressure recovery.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Giovanni Benfari, Stefano Nistri, Federico Marin, Luca F. Cerrito, Luca Maritan, Elvin Tafciu, Ilaria Franzese, Francesco Onorati, Martina Setti, Michele Pighi, Andrea Rossi, Flavio L. Ribichini
Summary: The study found that the progression rate of aortic valve stenosis (AS) is an individual, almost unpredictable feature. Rapid progression is an incremental marker of excess mortality in asymptomatic patients with AS, independent of clinical and hemodynamic characteristics.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2021)
Article
Cardiac & Cardiovascular Systems
Eigir Einarsen, Dana Cramariuc, Edda Bahlmann, Helga Midtbo, John B. Chambers, Eva Gerdts
Summary: The study found that in asymptomatic nonsevere aortic valve stenosis and low-gradient severe AS, a higher AT/ET ratio is associated with increased cardiovascular morbidity and mortality.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Lisa Q. Rong, Irbaz Hameed, Antonino Di Franco, Mohamed M. Rahouma, Faiza M. Khan, Michelle Demetres, Jonathan W. Weinsaft, Richard B. Devereux, Mario Gaudino
Summary: This study compared different imaging techniques for measuring aortic valve area and found that planimetric techniques tend to overestimate the area when compared to hemodynamic methods, which may have implications for clinical diagnosis and management.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ying-Hwa Chen, Hsiao-Huang Chang, Tan-Wei Liao, Hsin-Bang Leu, I-Ming Chen, Po-Lin Chen, Su-Man Lin
Summary: This study suggests that preprocedural assessment of membranous septum length should be routinely adopted to determine the optimal implant depth, mitigating the risk of conduction disturbances after transcatheter aortic valve replacement (TAVR) with self-expanding valves.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Yannick Kaiser, Janine E. van der Toorn, Sunny S. Singh, Kang H. Zheng, Maryam Kavousi, Eric J. G. Sijbrands, Erik S. G. Stroes, Meike W. Vernooij, Yolanda B. de Rijke, S. Matthijs Boekholdt, Daniel Bos
Summary: The study aims to evaluate the relationship between Lp(a) and the occurrence and progression of aortic valve calcium (AVC). The results indicate that high serum levels of Lp(a) are associated with baseline and new-onset AVC, but not with AVC progression.
EUROPEAN HEART JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Giuseppe Pinto, Gabriele Fragasso
Summary: This paper provides an overview of the molecular mechanisms and markers of disease progression in calcific degenerative aortic stenosis. It also reviews the drugs tested in vitro and human studies to slow down the stenosis process. Despite the existing treatments showing promising results, further efforts are needed to understand the risk factors and develop better medical solutions for this condition.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Medicine, General & Internal
Angela Lopez, Ilaria Dentamaro, Laura Galian, Francisco Calvo, Josep M. Alegret, Violeta Sanchez, Rodolfo Citro, Antonella Moreo, Fabio Chirillo, Paolo Colonna, Maria Celeste Carrero, Eduardo Bossone, Sergio Moral, Augusto Sao-Aviles, Laura Gutierrez, Gisela Teixido-Tura, Jose Rodriguez-Palomares, Arturo Evangelista
Summary: The study aimed to assess the progression of aortic dilation and valve dysfunction in BAV patients. Results showed that rapid aortic root dilation was associated with male sex, hypertension, presence of raphe, and aortic regurgitation, while rapid ascending aorta dilation was only related to hypertension.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Sergio Gamaza Chulian, Enrique Diaz Retamino, Rocio Carmona Garcia, Barbara Serrano Munoz, Javier Leon Jimenez, Soraya Gonzalez Estriegana, Jesus Oneto Otero
Summary: This study evaluated the prognostic value of aortic valve area (AVA) normalized to body size in patients with aortic stenosis. It found that an AVA/BSA < 0.50 cm²/m² was associated with significantly higher cardiovascular death risk, suggesting the potential use of 0.50 cm²/m² as a cutoff value to identify high-risk patients.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Blanca Alcon, Pablo Martinez-Legazpi, Simon Stewart, Ana Gonzalez-Mansilla, Victor Cuadrado, Geoff Strange, Raquel Yotti, Enric Cascos, Antonia Delgado-Montero, Raquel Prieto-Arevalo, Teresa Mombiela, Elena Rodriguez-Gonzalez, M. Angeles Espinosa, Andrea Postigo, Enrique Gutierrez-Ibanes, Manuel Perez-Vallina, Francisco Fernandez-Aviles, David Playford, Javier Bermejo
Summary: This study investigated the relationship between the severity of aortic stenosis (AS) and cardiovascular events and mortality, and compared the predictive ability of different echocardiographic indices. The results showed a strong linear relationship between Vmax and all-cause mortality, cardiovascular events, and heart failure. However, there was a mismatch between the risks estimated based on Vmax and AVA indices in terms of outcomes.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Jacek Kwiecinski, Evangelos Tzolos, Timothy R. G. Cartlidge, Alexander Fletcher, Mhairi K. Doris, Rong Bing, Jason M. Tarkin, Michael A. Seidman, Gaurav S. Gulsin, Nicholas L. Cruden, Anna K. Barton, Neal G. Uren, Michelle C. Williams, Edwin J. R. van Beek, Jonathon Leipsic, Damini Dey, Raj R. Makkar, Piotr J. Slomka, James H. F. Rudd, David E. Newby, Stephanie L. Sellers, Daniel S. Berman, Marc R. Dweck
Summary: The study aimed to assess the disease activity in native aortic valves and durability of bioprosthetic valves in patients who underwent TAVI, comparing them with those who had bioprosthetic SAVR. The findings suggest that TAVI patients show ongoing disease activity in their native aortic valves, but the durability of bioprosthetic valves in TAVI is similar to that in bioprosthetic SAVR in the midterm.