期刊
HEART
卷 102, 期 23, 页码 1909-1914出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/heartjnl-2016-309458
关键词
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资金
- UK National Health Service
- British Lung Foundation
- Aerocrine
- AKL
- Almirall
- AstraZeneca plc
- Boehringer Ingelheim
- Chiesi
- Eli Lilly
- GlaxoSmithKline plc
- Meda
- Merck Co.
- Mundipharma
- Napp
- Novartis International AG
- Orion
- Pfizer
- Respiratory Effectiveness Group
- Takeda
- Teva
- Zentiva
- Cipla
- Kyorin
- SkyePharma
- Medical Research Council
- Efficacy and Mechanism Evaluation programme
- HTA
Objective Although beta-blockers are an established therapy in heart failure (HF) guidelines, including for patients with chronic obstructive pulmonary disease (COPD), there remain concerns regarding bronchoconstriction even with cardioselective beta-blockers. We wished to assess the real-life use of beta-blockers for patients with HF and comorbid COPD. Methods We evaluated data from the Optimum Patient Care Research Database over a period of 1 year for co-prescribing of beta-blockers with either an ACE inhibitor (ACEI) or angiotensin-2 receptor blocker (ARB) in patients with HF alone versus HF+COPD. Association with inhaler therapy was also evaluated. Results We identified 89 861 patients with COPD, 24 237 with HF and 10 853 with both conditions. In patients with HF+COPD, the mean age was 79 years; 60% were male, and 27% had prior myocardial infarction. Of patients with HF+COPD, 22% were taking a beta-blocker in conjunction with either ACEI/ARB (n=2416) compared with 41% of patients with HF only (n=10 002) (adjusted OR 0.54, 95% CI 0.51 to 0.58, p< 0.001). Among HF+COPD patients taking inhaled corticosteroid (ICS) with long-acting beta-agonist (LABA) and long-acting muscarinic antagonist, 27% of patients were taking an ACEI/ARB with beta-blockers (n=778) versus 46% taking an ACEI/ARB without beta-blockers (n=1316). Corresponding figures for those patients taking ICS/LABA were 20% (n=583) versus 48% (n=1367), respectively. Conclusions These data indicate a substantial unmet need for patients with COPD who should be prescribed beta-blockers more often for concomitant HF.
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