Article
Cardiac & Cardiovascular Systems
Qian Zhang, Fang Zhu, Guocheng Shi, Chen Hu, Weituo Zhang, Puzhen Huang, Chunfeng Zhu, Hong Gu, Dong Yang, Qiangqiang Li, Yonghua Niu, Hao Chen, Ruixiang Ma, Ziyi Pan, Huixian Miao, Xin Zhang, Genxia Li, Yabing Tang, Guyuan Qiao, Yichen Yan, Zhongqun Zhu, Hao Zhang, Fengzhen Han, Yanna Li, Jianhua Lin, Huiwen Chen
Summary: This study evaluated the pregnancy outcomes in women with congenital heart disease (CHD) with and without pulmonary hypertension (PH). The results showed that women with CHD-associated mild PH had better pregnancy outcomes compared to those with moderate-to-severe PH, with similar outcomes to women with CHD and no PH.
Article
Medicine, General & Internal
Susanne J. Maurer, Veronika Habdank, Juergen Horer, Peter Ewert, Oktay Tutarel
Summary: This study aimed to investigate the risk factors for poor outcome in patients with pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD). The results showed that NT-proBNP is an independent predictor of all-cause mortality in PAH-CHD patients. The role of CRP and uric acid should be further studied.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Maolin Zhao, Jian Liu, Mei Xin, Ke Yang, Honghao Huang, Wenxin Zhang, Jinbao Zhang, Siyi He
Summary: Pulmonary arterial hypertension associated with congenital heart disease (PAH-CHD) is a progressive condition with uncertain physiological course. Omics technology, such as genomics, transcriptomics, epigenomics, proteomics, metabolomics, and multi-omics integration, has provided advanced techniques for comprehensive assessment of the disease and identification of treatment strategies. Recent research has made significant progress in understanding PAH-CHD through the application of omics approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hongyang Pi, Lu Xia, David D. Ralph, Samuel G. Rayner, Ali Shojaie, Peter J. Leary, Sina A. Gharib
Summary: In this study, metabolic profiling was used to identify the association between plasma metabolomic profiles and right ventricular dilation, mortality, and measures of disease severity in patients with pulmonary arterial hypertension (PAH). The polyamine, histidine, and sphingomyelin metabolic pathways were found to be associated with RV dilation, mortality, and disease severity.
CIRCULATION RESEARCH
(2023)
Review
Medicine, General & Internal
Amalia Baroutidou, Alexandra Arvanitaki, Adam Hatzidakis, Georgia Pitsiou, Antonios Ziakas, Haralambos Karvounis, George Giannakoulas
Summary: Haemoptysis is a severe bleeding manifestation in the clinical course of pulmonary arterial hypertension associated with congenital heart disease. Dysfunction of the pulmonary vascular bed increases the risk of haemoptysis episodes, and despite treatment strategies like BAE, bleeding recurrences are prevalent. There is currently no clear guideline regarding the use of oral anticoagulation in patients with haemoptysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Reem Gaheen, Doaa El Amrousy, Hossam Hodeib, Shimaa Elnemr
Summary: The study found that plasma copeptin levels are elevated in children with PAH-CHD and can serve as a good predictive marker for the severity of PAH and poor prognosis in these children. Plasma copeptin levels are positively correlated with mean pulmonary pressure, pulmonary vascular resistance, and pulmonary blood flow, while negatively correlated with right ventricular diastolic function.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Haitao Li, Yanna Li, Jun Zhang, Hong Gu, Jiangang Wang, Qiang Wang
Summary: In this study, we retrospectively analyzed clinical data of pregnant women with pulmonary hypertension (PH) admitted to Anzhen Hospital from 2010 to 2019. The results showed that different types of PH had an impact on pregnancy outcomes, with complications such as heart failure and higher fetal mortality rate. Therefore, women with idiopathic PH and Eisenmenger syndrome are not recommended to have children.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cell Biology
Jing-jing Zhou, Huang Li, Li Li, Yue Li, Pei-he Wang, Xian-min Meng, Jian-guo He
Summary: Research has shown that CYLD plays a crucial role in the development of CHD-PAH by modulating HPASMC dysfunction and inflammation, thus influencing the progression of PAH. Inhibiting CYLD expression can attenuate PAH levels in rats and prevent pulmonary vascular remodeling.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ayako Chida-Nagai, Naoki Masaki, Kay Maeda, Konosuke Sasaki, Hiroki Sato, Jun Muneuchi, Yoshie Ochiai, Hiroomi Murayama, Masahiro Tahara, Atsuko Shiono, Atsushi Shinozuka, Fumihiko Kono, Daisuke Machida, Shinichi Toyooka, Seiichiro Sugimoto, Kazufumi Nakamura, Satoshi Akagi, Maiko Kondo, Shingo Kasahara, Yasuhiro Kotani, Junichi Koizumi, Katsuhiko Oda, Masako Harada, Daisuke Nakajima, Akira Murata, Hazumu Nagata, Koichi Yatsunami, Tomio Kobayashi, Yoshikiyo Matsunaga, Takahiro Inoue, Hiroyuki Yamagishi, Naomi Nakagawa, Katsuki Ohtani, Masaki Yamamoto, Yushi Ito, Tatsunori Hokosaki, Yuta Kuwahara, Satoshi Masutani, Koji Nomura, Tsutomu Wada, Hirofumi Sawada, Masayuki Abiko, Tatsunori Takahashi, Yuichi Ishikawa, Seigo Okada, Atsushi Naitoh, Takako Toda, Tatsuya Ando, Akihiro Masuzawa, Shinsuke Hoshino, Masaaki Kawada, Yuichi Nomura, Kentaro Ueno, Naoki Ohashi, Tsuyoshi Tachibana, Yuchen Cao, Hideaki Ueda, Sadamitsu Yanagi, Masaaki Koide, Norie Mitsushita, Kouji Higashi, Yoshihiro Minosaki, Tomohiro Hayashi, Takashi Okamoto, Kenji Kuraishi, Eiji Ehara, Hidekazu Ishida, Hitoshi Horigome, Takashi Murakami, Kohta Takei, Taku Ishii, Gen Harada, Yasutaka Hirata, Jun Maeda, Shunsuke Tatebe, Chiharu Ota, Yasunobu Hayabuchi, Hisanori Sakazaki, Takashi Sasaki, Keiichi Hirono, Sayo Suzuki, Masahiro Yasuda, Atsuhito Takeda, Madoka Sawai, Kagami Miyaji, Atsushi Kitagawa, Yosuke Nakai, Nobuyuki Kakimoto, Kouta Agematsu, Atsushi Manabe, Yoshikatsu Saiki
Summary: The IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yanna Li, Jun Zhang, Wenjuan Zhao, Zhaoliang Bao, Xiaolong Ma, Yichen Zhao, Cheng Zhao, Kemin Liu, Qing Ye, Lixiao Su, Yao Yang, Jing Yang, Gang Li, Xiangming Fan, Jiangang Wang
Summary: This study conducted a comparative analysis of complications and outcomes in pregnant women with and without congenital heart disease (CHD) in Beijing. The results indicated that women with CHD had longer hospital stays, higher death rates, and greater risks of comorbidities and adverse events compared to women without CHD. Greater attention should be paid to pregnant women with CHD and their infants.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Yanna Li, Jun Zhang, Yichen Zhao, Kemin Liu, Jiachen Li, Mingming Zhao, Hong Gu, Xiangming Fan, Jiangang Wang
Summary: This study retrospectively analyzed and followed up on pregnant women with Eisenmenger syndrome (ES) admitted to Beijing Anzhen Hospital between 2010 and 2019 to explore the outcomes of the mothers and their offspring. The study found significant differences in age, gestational age, percutaneous oxygen saturation, Apgar score, and heart failure between the maternal death and non-death groups. The study recommends pregnancy termination if ES occurs during early pregnancy and highlights the importance of multidisciplinary cooperation to improve the prognosis of the mothers and their offspring.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Raquel Luna-Lopez, Teresa Segura de la Cal, Fernando Sarnago Cebada, Irene Martin de Miguel, Williams Hinojosa, Alejandro Cruz-Utrilla, Maria Teresa Velazquez, Juan F. Delgado, Alberto Mendoza, Fernando Arribas Ynsaurriaga, Pilar Escribano-Subias
Summary: This study assessed the long-term effects of triple therapy with prostanoids on patients with PAH-CHD. The results showed that this treatment approach improved patients' exercise capacity, functional class, and NT-proBNP levels, with manageable side effects. It was particularly effective for patients with pre-tricuspid defects and non-Eisenmenger PAH-CHD.
Article
Medicine, General & Internal
Runwei Ma, Liming Cheng, Yi Song, Yi Sun, Wenting Gui, Yao Deng, Chao Xie, Min Liu
Summary: This study found that the lung microbiome and metabolites are disturbed in children with PAH-LTRS, and these disturbances might contribute to the progression and outcomes of PAH-LTRS.
FRONTIERS IN MEDICINE
(2022)
Review
Respiratory System
Kaushiga Krishnathasan, Andrew Constantine, Isma Rafiq, Ana Barrradas Pires, Hannah Douglas, Laura C. Price, Konstantinos Dimopoulos
Summary: Pregnancy is generally contraindicated in PAH due to high maternal mortality. Specialist care and counseling are essential for women with PAH wishing to become pregnant, in order to minimize risk and improve outcomes.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Nadine Corbach, Charlotte Berlier, Mona Lichtblau, Esther I. Schwarz, Fiorenza Gautschi, Alexandra Groth, Rolf Schuepbach, Franziska Kraehenmann, Stephanie Saxer, Silvia Ulrich
Summary: This study retrospectively analyzed seven pregnancies of five women with PAH, showing that these women had favorable outcomes during and after pregnancy, resulting in successful deliveries of healthy newborns.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Asma Tajouri, Clement Batteux, Reaksmei Ly, Lucile Houyel, Sebastien Hascoet
Summary: This article reports a case of pulmonary arterial hypertension related to a rare congenital heart disease, characterized by inferior sinus venosus defect associated with left hepatic vein drainage to the coronary sinus. Accurate anatomical description was necessary for planning heart-lung transplantation in this case.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Edouard Chambon, Emmanuelle Fournier, Maha Tagorti, Florence Lecerf, Nadera Chaouche, Iolanda Ion, Mirela Bojan, Sarah Cohen, Isabelle Van-Aerschot, Meriem Mostefa-Kara, Clement Batteux, Jerome Petit, Sebastien Hascoet
Summary: This study found that riding on an electric toy car can reduce anxiety in boys and decrease parental anxiety before cardiac catheterisation in children.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Emmanuelle Fournier, Clement Batteux, Meriem Mostefa-Kara, Estibaliz Valdeolmillos, Alice Maltret, Sarah Cohen, Isabelle Van Aerschot, Lisa Guirgis, Arshid Azarine, Anne Sigal-Cinqualbre, Bastien Provost, Jelena Radojevic-Liegeois, Regine Roussin, Joy Zoghbi, Emre Belli, Sebastien Hascoet
Summary: The feasibility of CT and 3D TTE fusion in children and adults with congenital heart disease was evaluated in this study. The results demonstrated that the fusion technique can accurately visualize various intracardiac structures, providing valuable insights into the anatomical features of congenital heart disease without limitations regarding age, weight, or complexity of the defects.
REVISTA ESPANOLA DE CARDIOLOGIA
(2023)
Article
Cardiac & Cardiovascular Systems
Carles Bautista-Rodriguez, Sebastien Hascoet, Alain Fraisse
Summary: This study reported the initial experience of using Atrial Flow Regulator (AFR) in children below 10 kg. It found that AFR implantation is feasible and can be safely performed using smaller delivery sheaths in selected pediatric patients.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Raymond N. Haddad, Sebastien Hascoet, Clement Karsenty, Ali Houeijeh, Alban-Elouen Baruteau, Caroline Ovaert, Estibaliz Valdeolmillos, Zakaria Jalal, Damien Bonnet, Sophie Malekzadeh-Milani
Summary: This study aimed to evaluate the role of bare-metal Optimus and polytetrafluoroethylene (PTFE)-covered Optimus-CVS balloon-expandable, cobalt-chromium, hybrid cell-designed stents in interventions for congenital heart disease (CHD). The results showed that Optimus stents are effective tools for transcatheter treatment of simple and complex CHD, with reliable mechanical behavior and a particular covering design that promotes widespread use.
Review
Cardiac & Cardiovascular Systems
Magalie Ladouceur, Estibaliz Valdeolmillos, Clement Karsenty, Sebastien Hascoet, Pamela Moceri, Laurianne Le Gloan
Summary: Adult congenital heart disease (ACHD) is a growing population that requires life-long care. Drug therapy in ACHD is largely empiric due to the lack of clinical data, and formalized guidelines on drug therapy are currently lacking. The aging ACHD population has led to an increase in late cardiovascular complications. Recent advances in ACHD have prolonged survival, but further research is needed to determine the most effective treatment options.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Victor Waldmann, Francis Bessiere, Kevin Gardey, Sebastien Hascoet, Roland Henaine, Laurence Iserin, Magalie Ladouceur, Damien Bonnet, Eloi Marijon, Alice Maltret, Nicolas Combes, Natasja de Groot
Summary: This study aimed to investigate the main mechanisms of atrial tachyarrhythmias in patients with atrioventricular septal defect (AVSD) and analyse the outcomes after catheter ablation. The study found that most circuits involved the cavo-annular isthmus, but complex mechanisms were frequently encountered in patients who underwent repeated procedures. The acute success rate was excellent, but recurrences were common during follow-up.
Article
Cardiac & Cardiovascular Systems
Sebastien Hascoet, James R. Bentham, Luca Giugno, Pedro Betrian-Blasco, Aleksander Kempny, Ali Houeijeh, Haysam Baho, Shiv-Raj Sharma, Matthew Jones, Elzbieta Katarzyna Biernacka, Nicolas Combes, Stanimir Georgiev, Helene Bouvaist, Jose Diogo Martins, Marinos Kantzis, Mark Turner, Stephan Schubert, Zakaria Jalal, Gianfranco Butera, Sophie Malekzadeh-Milani, Estibaliz Valdeolmillos, Clement Karsenty, Ender Odemis, Philippe Aldebert, Nikolaus A. Haas, Ihab Khatib, Hakan Wahlander, Gianpiero Gaio, Alberto Mendoza, Sayqa Arif, Biagio Castaldi, Gaute Dohlen, Ronald G. Carere, Maria Jesus Del Cerro-Marin, Erwin Kitzmueller, Antony Hermuzi, Mario Carminati, Patrice Guerin, Anja Tengler, Alain Fraisse
Summary: This study investigated the outcomes of TPVI with the SAPIEN 3 valve in patients with CHD. The results showed that the outcomes of SAPIEN 3 TPVI were favorable in this patient population.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Magalie Ladouceur
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Pierre-Alexandre Fontanges, Julien Haudiquet, Julien De Jonkheere, Alexandre Delarue, Olivia Domanski, Thameur Rakza, Sebastien Hascoet, Said Bichali, Jean Benoit Baudelet, Francois Godart, Ali Houeijeh
Summary: Hypnoanalgesia is a promising non-pharmacologic adjunct technique in paediatric cardiac catheterisation. This study demonstrates that hypnoanalgesia is efficient in managing pain and stress, and it is safe and feasible even in complicated cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Marie Metairie, Louise Benoit, Meriem Koual, Enrica Bentivegna, Henri Wohrer, Pierre-Adrien Bolze, Yohan Kerbage, Emilie Raimond, Cherif Akladios, Xavier Carcopino, Geoffroy Canlorbe, Jennifer Uzan, Vincent Lavoue, Camille Mimoun, Cyrille Huchon, Martin Koskas, Helene Costaz, Francois Margueritte, Yohann Dabi, Cyril Touboul, Sofiane Bendifallah, Lobna Ouldamer, Nicolas Delanoy, Huyen-Thu Nguyen-Xuan, Anne-Sophie Bats, Henri Azais
Summary: This retrospective multicenter study assessed the prognostic impact of the FIGO staging classification and the initial metastatic location on survival in patients with ovarian cancer. The study found that patients with FIGO stage IVA had a worse prognosis than those with stage IVB, and initial pleural involvement was a poor prognostic factor. The researchers suggested modifying the current FIGO staging classification.
Article
Cardiac & Cardiovascular Systems
Clement Batteux, Vlad Ciobotaru, William Arditi, Benoit Decante, Clement Karsenty, Nicolas Combes, Sebastien Hascoet
Summary: This article reports a successful transcatheter correction of a sinus venosus defect in a 72-year-old woman with anomalous pulmonary venous return, which was performed on a challenging anatomical configuration. The procedure was facilitated by hands-on simulation training using a newly developed, perfused, 3D-printed model.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Magalie Ladouceur, Victor Waldmann, Stefano Bartoletti, Marie-A Chaix, Paul Khairy
Summary: This review discusses contemporary strategies for assessing and preventing the risk of ventricular arrhythmias in patients with systemic right ventricle (SRV) congenital heart disease (CHD). Several risk factors have been identified and a risk score model has been proposed. New technologies such as cardiac magnetic resonance imaging, biomarkers, and genetic data can further improve the predictive ability. However, the question of whether to use implantable cardioverter-defibrillators (ICDs) in this population remains unanswered.
INTERNATIONAL JOURNAL OF CARDIOLOGY CONGENITAL HEART DISEASE
(2023)