Article
Otorhinolaryngology
Seong Hoon Bae, Sang Hyun Kwak, Jee Eun Yoo, Kyu Min Kim, Young Min Hyun, Jae Young Choi, Jinsei Jung
Summary: Resident macrophages in spiral ligaments of the cochlea predominantly locate in areas away from the stria vascularis, and this distribution pattern remains consistent even under inflammatory conditions.
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xue Bai, Kai Xu, Le Xie, Yue Qiu, Sen Chen, Yu Sun
Summary: Clinically, thyroid-related diseases are associated with hearing loss, suggesting thyroid hormones are essential for normal hearing. Triiodothyronine (T3) is the main active form of thyroid hormone and its effect on the remodeling of the organ of Corti remains unclear. This study explores the effect and mechanism of T3 on the remodeling of the organ of Corti and supporting cells development. The findings suggest the dual roles of T3 in regulating both hair cells and supporting cell development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Teng-Wei Huang, Amrita A. Iyer, Jeanne M. Manalo, Junsung Woo, Navish A. Bosquez Huerta, Melissa M. McGovern, Heinrich Schrewe, Fredrick A. Pereira, Andrew K. Groves, Kevin K. Ohlemiller, Benjamin Deneen
Summary: Mutations in the Mediator protein complex subunit 12 gene lead to changes in astrocyte morphology, hearing loss, and degeneration of the cochlea in the adult central nervous system. This results in the disruption of auditory function by affecting the structural integrity of the stria vascularis.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yiming Gao, Fan Wu, Wuhui He, Ziyi Cai, Jiaqi Pang, Yiqing Zheng
Summary: This study aimed to investigate the cochlear pathology and underlying mechanisms of radiation-induced sensorineural hearing loss (RISNHL). The results showed functional and morphological impairment in the stria vascularis (SV) and later loss of outer hair cells (OHCs) after irradiation. Reactive oxygen species (ROS)-related damage was found to contribute to SV damage and OHC loss. N-acetylcysteine (NAC) was able to reduce ROS levels and attenuate auditory threshold shifts and OHC loss, suggesting its potential as a protective agent against RISNHL.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Medicine, Research & Experimental
Seong Hoon Bae, Jee Eun Yoo, Young Ho Choe, Sang Hyun Kwak, Jae Young Choi, Jinsei Jung, Young-Min Hyun
Summary: Intravital imaging of the cochlea revealed that neutrophil recruitment and infiltration during inflammation are spatially controlled and exclusively observed in the spiral ligament but not in the stria vascularis and organ of Corti in live mice. The differential reactivity of ICAM-1 is likely responsible for the different neutrophil recruitment pattern in the cochlea during LPS-induced inflammation. Neutrophil migration to the spiral ligament in the lateral wall was observed 2 days after LPS inoculation, mimicking acute otitis media.
Review
Clinical Neurology
Taku Ito, Natsuko Kurata, Yoko Fukunaga
Summary: Tissue-resident macrophages in the cochlea play a crucial role in maintaining tissue homeostasis, immune defense, and repair. Perivascular macrophages, a unique subset associated with blood vessels, regulate blood vessel permeability and clear pigment granules in the cochlea.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Teresa Nicolson
Summary: Inherited forms of deafness make up a significant percentage of hearing loss in both children and adults. This article reviews peripheral hereditary hearing loss and discusses studying these impairments in various animal models or patient-derived cells to gain knowledge and potentially treat hearing loss.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Junmin Chen, Penghui Chen, Baihui He, Tianyu Gong, Yue Li, Jifang Zhang, Jingrong Lv, Fabio Mammano, Shule Hou, Jun Yang
Summary: This study established a new Cx30 knockout mouse model using CRISPR/Cas9 technology, and found that the lack of Cx30 can cause mild hearing loss with approximately 30% reduction of Cx26. This suggests that Cx30 may play an important role in hearing development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Phuong Thi Thanh Nguyen, Hayoung Song, Boyoung Kim, Yoo Yeon Kim, Chulho Kim, Jun Ho Lee, Jun Gyo Suh
Summary: This study investigated the etiology of age-related hearing loss (ARHL) associated with diabetes and dyslipidemia. The results showed that diabetes and dyslipidemia accelerated ARHL by damaging the spiral ganglion neurons and stria vascularis in the cochlea of mice.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Adriana Ximenes-da-Silva, Daniela Capra, Carolina Kaminski Sanz, Carmelita Bastos Mendes, Juliana de Mattos Coelho Aguiar, Vivaldo Moura-Neto, Marcos F. DosSantos
Summary: The inner ear, along with peripheral and central auditory pathways, plays a crucial role in hearing processing. Aquaporins (AQP) are integral membrane proteins that regulate water and ionic flow in the inner ear, and their expression changes are essential to auditory physiology and pathophysiological processes.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Cell Biology
Hao Li, Karin Staxang, Monika Hodik, Karl-Gunnar Melkersson, Helge Rask-Andersen
Summary: This study investigates the fine structure of the crocodile auditory organ and describes the presence of a vascularized epithelium separate from the tegmentum vasculosum. It is believed that this vascularized epithelium secretes endolymph and generates a low grade endocochlear potential in crocodiles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Clinical Neurology
Joseph McClellan, Wenxuan He, Joseline Raja, Gemaine Stark, Tianying Ren, Lina Reiss
Summary: This study investigates the impact of cochlear implantation on hearing loss in guinea pigs, finding a significant threshold shift and decreased endocochlear potential in the implanted animals. However, the study concludes that changes in strial vascular density or reductions in EP do not explain the hearing loss after implantation.
OTOLOGY & NEUROTOLOGY
(2021)
Review
Cell Biology
Matthew W. Kelley
Summary: The cellular specification in the cochlea, particularly the organ of Corti, is still not well understood due to the small size of the organ and limited number of each cell type. Recent technical advances in single cell RNA sequencing have provided new opportunities to study cellular specification in the cochlea.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Dorit Samocha-Bonet, Buffy Wu, David K. Ryugo
Summary: Diabetes (type 2) and sensorineural hearing loss are common health problems associated with ageing, with individuals with diabetes having twice the incidence of hearing loss compared to those without diabetes. The relationship between hearing loss and diabetes is complex and still requires further research to determine whether hearing loss is associated with diabetes independent of glycemic control.
AGEING RESEARCH REVIEWS
(2021)
Review
Neurosciences
Wenting Yu, Shimin Zong, Peiyu Du, Peng Zhou, Hejie Li, Enhao Wang, Hongjun Xiao
Summary: This review examines the role of the stria vascularis in the pathogenesis of sensorineural hearing loss, focusing on molecular events and signaling pathways at cellular and molecular biological levels. With advancements in scientific technology, new opportunities are emerging to better understand and potentially improve the prevention, early diagnosis, and treatment of sensorineural hearing loss.
FRONTIERS IN NEUROSCIENCE
(2021)