期刊
GYNECOLOGICAL ENDOCRINOLOGY
卷 32, 期 5, 页码 386-389出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/09513590.2015.1124260
关键词
ovary; Insulin resistance; polycystic ovary syndrome
Aim: We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS). Material and method: The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had < 10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup. Results: Average apelin-36 and visfatin levels in PCOS patients were 2.52 +/- 0.68 nmol/L and 72.63 +/- 22:31 ng/ml, in the control group they were 0.92 +/- 0.33 nmol/L, 24.66 +/- 6 ng/ml, respectively. The difference found in PCOS patients was statistically significant (p = 0.0001, p = 0.0001). Conclusion: In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher. Although there are different opinions in the literature on this subject, we believe that when vitamin D levels are brought to an optimal level in PCOS patient, it can prevent the negative effects of adipokines in the pathogenesis of PCOS.
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