Article
Obstetrics & Gynecology
Ali Ayhan, Mehmet Tunc, Huseyin Akilli, Nihan Haberal, Ali Haberal
Summary: This study evaluated the oncologic and obstetric outcomes of patients diagnosed with malignant ovarian germ cell tumors (MOGCTs). The results showed that fertility preservation should be the first treatment option in young patients due to the unilateral involvement of the disease and its chemosensitive nature.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Oncology
Hitomi Sakaguchi-Mukaida, Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Misooja Lee, Satoki Deguchi, Mina Sakata, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: This systematic review examines the effectiveness of neoadjuvant chemotherapy (NACT) for women with malignant ovarian germ cell tumors (MOGCT). The results indicate that NACT is used in approximately 40% of advanced MOGCT cases with a response rate of 95.8%. The uterine preservation rate is around 70% and the cumulative resumed menstruation rate is 100%. Comparisons with primary debulking surgery show similar overall survival, disease-free survival, recurrence rate, and adverse event rate from chemotherapy.
Article
Pediatrics
Min Yin, Jiaxin Yang, Tao Wang, Sijian Li, Xinyue Zhang
Summary: This study retrospectively analyzed the clinical features, treatment, and outcomes of infants and children with primary vaginal endodermal sinus tumor (EST) treated in a tertiary center. The results showed that the tumor is sensitive to chemotherapy, and conservative surgery combined with chemotherapy is an effective treatment method.
Article
Public, Environmental & Occupational Health
Narges Zamani, Mohadese Rezaei Poor, Sedigheh Ghasemian Dizajmehr, Shima Alizadeh, Mitra Modares Gilani
Summary: The study evaluated the reproductive outcome of fertility-sparing surgery and chemotherapy among young women diagnosed with malignant ovarian germ cell tumors. The results showed that fertility-sparing surgery with adjuvant chemotherapy is a safe and effective treatment option that can improve menstrual status and fertility outcomes in these patients, with a high pregnancy and delivery rate observed in those who attempted pregnancy.
Article
Oncology
B. J. Dicken, D. F. Billmire, B. Rich, F. K. Hazard, M. Nuno, M. Krailo, N. Fallahazad, F. Pashankar, F. Shaikh, A. L. Frazier
Summary: In pediatric and adolescent patients with malignant ovarian germ cell tumors, the use of intra-operative frozen section to guide extent of surgical staging showed a concordance with final diagnosis in most cases, highlighting its importance in operative decision-making.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Zixuan Song, Yizi Wang, Yangzi Zhou, Dandan Zhang
Summary: This study constructed a nomogram using multiple clinical indicators to predict the prognosis of malignant ovarian germ cell tumors (MOGCTs), which was more accurate than FIGO staging alone. The nomogram may assist clinicians in identifying high-risk patients and implementing personalized treatment regimens.
Article
Oncology
Ran Chu, Penglin Liu, Jingying Chen, Xiaodong Cheng, Kezhen Li, Yanci Che, Jianliu Wang, Li Li, Xi Zhang, Shu Yao, Li Song, Ying Zhao, Changzhen Huang, Ying Xue, Xiyu Pan, Junting Li, Zhongshao Chen, Jie Jiang, Beihua Kong, Kun Song
Summary: This study evaluated the impact of BEP and PC chemotherapy regimens on fertility and prognostic outcomes in MOGCT patients who underwent FSS. The results showed that there were no significant differences in fertility outcome, disease-free survival, and overall survival between the BEP and PC groups. It can be concluded that the PC regimen is as safe as the BEP regimen for preserving fertility and clinical prognosis in MOGCT patients.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Ha Kyung Oh, Seong Nam Park, Byoung Ryun Kim
Summary: Endodermal sinus tumors (ESTs) are rare malignant ovarian germ cell tumors primarily occurring in children and adolescents, comprising 20% of all malignant ovarian germ cell tumors. Surgical staging, fertility-sparing surgery, and chemotherapy are the main treatments. This case report highlights the risks associated with using uncontained power morcellation to treat solid adnexal masses.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Medicine, General & Internal
Abdullah M. Al Ghamdi, Othman M. Al Fraih, Meenal A. Al Abdulhai, Ahmed Alshaer, Yousif Al Qahtani, Natasha T. Khan, Ikram ul Haq Chaudhry
Summary: This case report describes a 16-year-old male patient with endodermal sinus tumor (EDST) presenting with nonproductive cough, chest pain, and hemoptysis. Despite initial chemotherapy and subsequent surgical resection, a large residual mass was observed on repeat CT scan, ultimately requiring radical resection of the tumor. Follow-up over 12 years post-surgery showed no recurrence based on serial serum alpha-fetoprotein (AFP) tumor marker levels and thorax CT scans.
ANNALS OF MEDICINE AND SURGERY
(2021)
Article
Oncology
Hirokazu Takami, Christopher S. Graffeo, Avital Perry, Caterina Giannini, Yoichi Nakazato, Nobuhito Saito, Masao Matsutani, Ryo Nishikawa, Koichi Ichimura, David J. Daniels
Summary: This study investigates the optimal cut-offs for tumor markers in CNS germ cell tumors (GCTs) to specify non-germinomatous GCTs. It concludes that an integrated diagnosis based on tumor markers and histopathology is key to precise diagnosis and treatment strategies for this rare and heterogeneous tumor. The study also raises questions about the treatment approach for marker-positive germinomas or teratomas and optimal treatment strategy for marker-negative immature teratomas.
Article
Clinical Neurology
Alexander G. Weil, Natalie Mathews, Jean-Pierre Farmer, Christine St Martin, Steffen Albrecht, Nada Jabado, Roy W. R. Dudley
Summary: The authors presented two cases of NGGCT in neonates, one with mixed malignant germ cell tumor and the other with pure YST. These tumors were successfully treated with either complete tumor resection or subtotal tumor resection with chemotherapy, resulting in event-free survival exceeding 5 years for both patients without the need for radiation therapy. The cases highlight the importance of radical surgery and successful treatment of neonatal YST, and emphasize the rare non-midline location of these tumors and the need to consider YSTs and mixed NGGCTs with YST components in the differential diagnosis of non-midline hemispheric or skull base tumors in newborns.
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2021)
Article
Oncology
Meerim Park, Jiwon Lim, Jun Ah Lee, Hyeon Jin Park, Byung Kiu Park, Myong Cheol Lim, Sang-Yoon Park, Young-Joo Won
Summary: Malignant ovarian germ cell tumors (MOGCTs) in Korean women demonstrated a slight increase in prevalence, with a more pronounced growth among patients aged <19 years. Patients with dysgerminoma showed significantly higher survival rates compared to those with non-dysgerminoma. Following MOGCT diagnosis, the risk of developing subsequent malignancies doubled compared with the general population.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng, Fu-Mien Wang, Chih-Ying Lee, Dong-Tsamn Lin, Bow-Wen Chen, Kai-Hsin Lin, Kang-Hsi Wu, Hsi-Che Liu, Jiann-Shiuh Chen, Shiann-Tarng Jou, Jen-Yin Hou, Yung-Li Yang, Shih-Hsiang Chen, Hsiu-Hao Chang, Shyh-Shin Chiou, Pei-Chin Lin, Rong-Long Chen, Chih-Cheng Hsiao, Hsiu-Ju Yen, Chao-Ping Yang, Te-Kau Chang, Meng-Yao Lu, Chao-Neng Cheng, Jiunn-Ming Sheen, Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh
Summary: This study retrospectively analyzed the prognostic factors and treatment outcomes of primary malignant mediastinal germ cell tumors (GCTs) in Taiwanese children. The results showed that surgical treatment was associated with better outcomes, while advanced disease stage and choriocarcinoma histology subtype were associated with poorer outcomes. Additionally, there was no difference in treatment outcomes between cisplatin-based and carboplatin-based chemotherapy.
Article
Surgery
Muhammad Jawad Zahid, Musarrat Hussain, Muhammad Zeb, Abdul Haseeb, Hira Bakhtiyar Khan
Summary: The article presents a rare case of endodermal sinus tumor occurring in the head of pancreas. The diagnosis was confirmed through CT scan and biopsy, followed by chemotherapy and surgical treatment.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2022)
Review
Oncology
Na Wu, Qiang Chen, Meng Chen, Jinbo Ning, Shulei Peng, Taotao Zhang, Wen Zhong, Song Duan, Chongjie Cheng, Yimin Xie
Summary: Yolk sac tumor (YST) is a rare malignant germ cell tumor, especially when it occurs intracranially. Complete resection is ideal, but due to the challenging location of the tumor, subtotal resection can be an effective treatment strategy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Aya S. Khairallah, Catherine Genestie, Aurelie Auguste, Alexandra Leary
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Oncology
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
Article
Cell Biology
Myriam Kossai, Alexandra Leary, Jean-Yves Scoazec, Catherine Genestie
Article
Oncology
S. Banerjee, A. M. Oza, M. J. Birrer, E. P. Hamilton, J. Hasan, A. Leary, K. N. Moore, B. Mackowiak-Matejczyk, J. Pikiel, I. Ray-Coquard, P. Trask, K. Lin, E. Schuth, A. Vaze, Y. Choi, J. C. Marsters, D. J. Maslyar, V. Lemahieu, Y. Wang, E. W. Humke, J. F. Liu
ANNALS OF ONCOLOGY
(2018)
Article
Oncology
Morgane Perrin, Enrica Bentivegna, Claire Bonneau, Catherine Uzan, Alexandra Leary, Patricia Pautier, Catherine Genestie, Philippe Morice, Sebastien Gouy
ANTICANCER RESEARCH
(2018)
Correction
Oncology
Catherine Genestie, Alexandra Leary, Mojgan Devouassoux, Aurelie Auguste
BULLETIN DU CANCER
(2018)
Article
Oncology
Jennifer J. Mueller, Henrik Lajer, Berit Jul Mosgaard, Slim Bach Hamba, Philippe Morice, Sebastien Gouy, Yaser Hussein, Robert A. Soslow, Brooke A. Schlappe, Qin C. Zhou, Alexia Iasonos, Claus Hogdall, Alexandra Leary, Roisin E. O'Cearbhaill, Nadeem R. Abu-Rustum
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Article
Oncology
Sebastien Gouy, Alexandra Arfi, Amandine Maulard, Patricia Pautier, Enrica Bentivegna, Alexandra Leary, Cyrus Chargari, Catherine Genestie, Philippe Morice
Article
Oncology
Olivier Colomban, Michel Tod, Alexandra Leary, Isabelle Ray-Coquard, Alain Lortholary, Anne Claire Hardy-Bessard, Jacobus Pfisterer, Andreas Du Bois, Christian Kurzeder, Alexander Burges, Julien Peron, Gilles Freyer, Benoit You
CLINICAL CANCER RESEARCH
(2019)
Article
Oncology
Alexandra Leary, Catherine Genestie, Felix Blanc-Durand, Sebastien Gouy, Ariane Dunant, Amandine Maulard, Francoise Drusch, Bianca Cheaib, Judith Michels, Enrica Bentivegna, Audrey LeFormal, Soizick Mesnage, Philippe Morice, Patricia Pautier, Aya S. Khairallah
Summary: This study demonstrates that neoadjuvant chemotherapy significantly impacts the balance of immune subpopulations, with high CD8+/FOXP3+, CD3+/FOXP3+, and CD68+/CD163+ ratios post-chemotherapy associated with improved outcomes. A greater shift towards effector TILs versus regulatory TILs correlates with better survival rates for patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Amit M. Oza, Domenica Lorusso, Carol Aghajanian, Ana Oaknin, Andrew Dean, Nicoletta Colombo, Johanne I. Weberpals, Andrew R. Clamp, Giovanni Scambia, Alexandra Leary, Robert W. Holloway, Margarita Amenedo Gancedo, Peter C. Fong, Jeffrey C. Goh, David M. O'Malley, Deborah K. Armstrong, Susana Banerjee, Jesus Garcia-Donas, Elizabeth M. Swisher, David Cella, Juliette Meunier, Sandra Goble, Terri Cameron, Lara Maloney, Ann-Christin Moerk, Josh Bedel, Jonathan A. Ledermann, Robert L. Coleman
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Review
Oncology
Lola Paulet, Alexis Trecourt, Alexandra Leary, Julien Peron, Francoise Descotes, Mojgan Devouassoux-Shisheboran, Karen Leroy, Benoit You, Jonathan Lopez
Summary: DNA double-strand breaks are critical DNA damages for cells, and some cancers with homologous recombination deficiency (HRD) exhibit increased sensitivity to PARP inhibitors (PARPi). A major challenge is the development of tests capable of detecting HRD phenotype and predicting sensitivity to PARPi.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Paul DiSilvestro, Susana Banerjee, Nicoletta Colombo, Giovanni Scambia, Byoung-Gie Kim, Ana Oaknin, Michael Friedlander, Alla Lisyanskaya, Anne Floquet, Alexandra Leary, Gabe S. Sonke, Charlie Gourley, Amit Oza, Antonio Gonzalez-Martin, Carol Aghajanian, William Bradley, Cara Mathews, Joyce Liu, John McNamara, Elizabeth S. Lowe, Mei-Lin Ah-See, Kathleen N. Moore
Summary: Maintenance therapy with olaparib showed sustained progression-free survival benefit in newly diagnosed advanced ovarian cancer patients with a BRCA mutation. After a 7-year follow-up, there was a clinically meaningful improvement in overall survival. The incidence of myelodysplastic syndrome and acute myeloid leukemia was low.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Oncology
Vincent Marmouset, Pierre-Marie Morice, Arnaud Pages, Alexandra Leary, Jean-Baptiste Micol
CLINICAL CANCER RESEARCH
(2023)
Article
Pathology
Claire J. H. Kramer, Alba Llop-Guevara, Elisa Yaniz-Galende, Benedetta Pellegrino, Natalja T. ter Haar, Andrea Herencia-Ropero, Nicoletta Campanini, Antonino Musolino, Tjalling Bosse, Alexandra Leary, Violeta Serra, Maaike P. G. Vreeswijk
Summary: The RAD51 test shows promise as a biomarker for assessing functional homologous recombination deficiency (HRD). However, the robustness and reproducibility of the immunofluorescence-based RAD51 test in different academic laboratories have not been thoroughly investigated. This study tested the performance of the RAD51 assay in FFPE HGSOC samples and found that subtle differences in staining procedures resulted in low variability of RAD51 and γH2AX scores, but there was substantial variability in RAD51 scoring, likely due to technical and biological factors. Improving technical issues and identifying tissue quality requirements are essential to guide individual treatment for HGSOC patients.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
