Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vivo vitamin C deficiency in guinea pigs increases ascorbate transporters in liver but not kidney and brain

(2014) Ditte Søgaard et al.   NUTRITION RESEARCH

Ascorbic Acid and the Brain: Rationale for the Use against Cognitive Decline

(2014) Fiona Harrison et al.   Nutrients

Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C Transport and Antioxidant Enzyme Function

(2013) Alexander J. Michels et al.   Annual Review of Nutrition

Does Vitamin C Deficiency Increase Lifestyle-Associated Vascular Disease Progression? Evidence Based on Experimental and Clinical Studies

(2013) Pernille Tveden-Nyborg et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of embryonic neurotransmitter and tyrosine hydroxylase protein levels by ascorbic acid

(2013) M.Elizabeth Meredith et al.   BRAIN RESEARCH

Human choroid plexus papilloma cells efficiently transport glucose and vitamin C

(2013) Viviana Ulloa et al.   JOURNAL OF NEUROCHEMISTRY

Validation of the isotropic fractionator: Comparison with unbiased stereology and DNA extraction for quantification of glial cells

(2013) Jami Bahney et al.   JOURNAL OF NEUROSCIENCE METHODS

Cerebrospinal fluid neopterin is brain-derived and not associated with blood-CSF barrier dysfunction in non-inflammatory affective and schizophrenic spectrum disorders

(2013) Leonie K. Kuehne et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo

(2013) Alan Mortensen et al.   NUTRITION RESEARCH

Regulation of Vitamin C Homeostasis during Deficiency

(2013) Maiken Lindblad et al.   Nutrients

Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine

(2012) James M. May et al.   BRAIN RESEARCH BULLETIN

The Glutamate Aspartate Transporter (GLAST) Mediates l-Glutamate-Stimulated Ascorbate-Release Via Swelling-Activated Anion Channels in Cultured Neonatal Rodent Astrocytes

(2012) Darius J. R. Lane et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Authors' Perspective: What is the Optimum Intake of Vitamin C in Humans?

(2012) Balz Frei et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Behavioral and monoamine changes following severe vitamin C deficiency

(2012) Margaret S. Ward et al.   JOURNAL OF NEUROCHEMISTRY

Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used

(2012) Jens Lykkesfeldt   NUTRITION RESEARCH

Maternal Vitamin C Deficiency during Pregnancy Persistently Impairs Hippocampal Neurogenesis in Offspring of Guinea Pigs

(2012) Pernille Tveden-Nyborg et al.   PLoS One

Differential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion

(2011) M. Elizabeth Meredith et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic expression of sodium-dependent vitamin C transporters: ontogeny, subtissular distribution and effect of chronic liver diseases

(2011) Rocio I. R. Macias et al.   BRITISH JOURNAL OF NUTRITION

Genetic variation at the SLC23A1 locus is associated with circulating concentrations of l-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants

(2010) Nicholas J Timpson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency

(2010) Leah E Cahill et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

(2010) Emily Flashman et al.   BIOCHEMICAL JOURNAL

Vitamin C distribution and retention in the mouse brain

(2010) Fiona E. Harrison et al.   BRAIN RESEARCH

High dietary fat and cholesterol exacerbates chronic vitamin C deficiency in guinea pigs

(2010) Henriette Frikke-Schmidt et al.   BRITISH JOURNAL OF NUTRITION

Low vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2

(2010) F.E. Harrison et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice

(2010) Christopher P. Corpe et al.   JOURNAL OF CLINICAL INVESTIGATION

Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cells

(2010) Jack C. Reidling et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs

(2009) Pernille Tveden-Nyborg et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)

(2009) Rosemary L Schleicher et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Is vitamin C supplementation beneficial? Lessons learned from randomised controlled trials

(2009) Jens Lykkesfeldt et al.   BRITISH JOURNAL OF NUTRITION

Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency

(2009) Kuniko Hara et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Estimated prevalence and predictors of vitamin C deficiency within UK's low-income population

(2008) A. Mosdol et al.   JOURNAL OF PUBLIC HEALTH