Article
Agriculture, Dairy & Animal Science
Michele Berlanda, Giada Innocente, Barbara Simionati, Barbara Di Camillo, Sonia Facchin, Maria Cecilia Giron, Edoardo Savarino, Federico Sebastiani, Francesca Fiorio, Ilaria Patuzzi
Summary: Chronic enteropathies are common long-term gastrointestinal diseases in dogs, impacting quality of life. The gut microbial community plays a key role in defining host health, and faecal microbiota transplantation aims to restore a healthy gut ecosystem. Successful faecal transplantation in a 9-year-old dog with chronic enteropathy highlights the potential for clinical applications in veterinary practice.
Article
Agriculture, Dairy & Animal Science
Melanie Le Bon, Laura Carvell-Miller, Zoe Marshall-Jones, Phillip Watson, Gregory Amos
Summary: Senior pets can suffer from a wide range of age-related diseases that impact their quality of life. This study demonstrated that a novel blend of prebiotic fibres improved the gut health of senior dogs, highlighting its potential future dietary applications.
Article
Agriculture, Dairy & Animal Science
Camilla M. M. Souza, Tais S. Bastos, Gislaine C. B. Kaelle, Marcelino Bortolo, Simone G. de Oliveira, Ananda P. Felix
Summary: The effects of fine cassava fibre on kibble characteristics, digestibility, palatability, faecal metabolites, and microbiota of dogs were evaluated through three experiments. The results showed that the addition of fine cassava fibre improved kibble expansion, palatability, production of short-chain fatty acids, and modulation of the faecal microbiota of dogs.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Agriculture, Dairy & Animal Science
Tsz Ching Kwong, Eddie Chung Ting Chau, Mark Chi Ho Mak, Chi Tung Choy, Lee Tung Chan, Chun Keung Pang, Junwei Zhou, Phoebe Hoi Ching Poon, Yuqiong Guan, Stephen Kwok Wing Tsui, Shun Wan Chan, George Pak Heng Leung, William Chi Shing Tai, Yiu Wa Kwan
Summary: The gut microbiome of diabetic dogs differs from that of healthy controls at the genera, species, functional, and network levels. This study provides valuable insights into the association between the canine gut microbiome and diabetes mellitus, and its implications for disease control.
Article
Food Science & Technology
Nikol Modrackova, Ivana Copova, Adam Stovicek, Marie Makovska, Dagmar Schierova, Jakub Mrazek, Monika Sabolova, Eva Vlkova, Ondrej Hradsky, Jiri Bronsky, Jiri Nevoral, Vera Neuzil-Bunesova
Summary: The study found that cultivable commensal groups (bifidobacteria, lactobacilli, Escherichia coli) in fecal samples were able to grow in different polymeric enteral nutrition formulas, with their counts varying depending on individual donors and formula types. Analysis of metabolites and microbiota composition showed that prebiotics and micronutrients may have an effect on gut microbiota modulation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Veterinary Sciences
Joao C. Alves, Ana Santos, Patricia Jorge, Angelo Pitaes
Summary: This study aimed to investigate whether faecal microbiome transplant has a similar effect in alleviating clinical signs in dogs with chronic large bowel diarrhea. The results showed that both psyllium husk and FMT had similar effects in improving clinical signs, but no differences were observed in faecal scores, defaecation frequency, and time of appearance of episodes of diarrhea. Time played a significant positive role in the results observed across both groups.
Article
Agriculture, Dairy & Animal Science
Celina Hofmann, Ellen Kienzle, Britta Dobenecker
Summary: This study aimed to investigate the impact of faecal dry matter excretion on the faecal losses of calcium and phosphorus in dogs. The results showed a significant increase in faecal dry matter and mineral excretion, with a highly significant correlation. Additionally, the apparent digestibility of calcium varied between the two trials, potentially due to differences in faecal dry matter intake and digestibility.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Rachel Gilroy, Joy Leng, Anuradha Ravi, Evelien M. Adriaenssens, Aharon Oren, Dave Baker, Roberto M. La Ragione, Christopher Proudman, Mark J. Pallen
Summary: By using metagenomic sequencing on thoroughbred equine faecal samples, this study provides new insights into the bacterial, archaeal and bacteriophage components of the horse gut microbiome. The resulting datasets serve as an important resource for future high-resolution taxonomic and functional studies on the equine gut microbiome.
Article
Agriculture, Dairy & Animal Science
C. H. Gaukroger, S. A. Edwards, J. Walshaw, A. Nelson, I. P. Adams, C. J. Stewart, I Kyriazakis
Summary: Knowledge of the periparturient longitudinal changes in sow microbiota composition is crucial to understanding the sow's role in piglet microbiota development and improving her gut health during lactation. The study found that primiparous sows had lower microbiota diversity during the periparturient period, while multiparous sows showed an increase in relative abundance of certain bacterial genera.
Article
Microbiology
Mayilvahanan Bose, Henry Wood, Caroline Young, Philip Quirke, Ramakrishan Ayloor Seshadri
Summary: It has been found that changes in the gut microbiome can be either a cause or a correlation of colorectal cancer. Most of this research has been conducted in developed countries with high incidence of CRC, and it is unknown if lower incidence countries like India have similar microbial associations. This study collected and sequenced microbial samples from 46 Indian CRC patients and 43 healthy volunteers, demonstrating similarities to other Asian samples and a global CRC microbiome, but also highlighting regional variation and the importance of developing protocols and infrastructure for microbiome research in different countries.
Article
Veterinary Sciences
Elisa Scarsella, Giorgia Meineri, Misa Sandri, Holly H. Ganz, Bruno Stefanon
Summary: Recent studies have shown the presence of bacterial DNA in the blood of healthy individuals, highlighting the need for further research on the origin and relationship of blood bacteria to host health. This study characterized the blood microbiome in healthy dogs and dogs with gastrointestinal disease, comparing it to the fecal microbiome. The results demonstrated significant differences between the blood and fecal microbiome of healthy and unhealthy groups, suggesting bacteria can translocate from the gut to the blood. Further investigation is required to determine the origin and viability of blood bacteria.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Feriel Yasmine Mahiddine, Inhwan You, Heekee Park, Min Jung Kim
Summary: This study investigated the effects of oral administration of three commensal Lactobacillus spp. on the sperm quality of healthy dogs. The results showed that supplementation with commensal lactobacilli significantly improved the qualitative parameters and motility of sperm. Furthermore, the study revealed a positive correlation between the regulation of gut microbiota and sperm quality.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Pamela Thomson, Rodrigo Santibanez, Camila Rodriguez-Salas, Carla Flores-Yanez, Daniel Garrido
Summary: Obesity is a prevalent nutritional disorder in dogs, with over 40% suffering from it. The gut microbiome of obese dogs is different from that of normal weight dogs, with an increase in Firmicutes and a decrease in Bacteroidetes. Additionally, obese dogs show enrichment in pathways related to transport, chemotaxis, and flagellar assembly. Modulating the gut microbiome may be a potential way to improve the health of dogs.
Article
Immunology
Daniella Frances Susic, Leanne Wang, Lynne Margaret Roberts, Michelle Bai, Andrew Gia, Emily McGovern, Xiao-Tao Jiang, Gregory K. Davis, Emad El-Omar, Amanda Henry
Summary: This study found that hypertension during pregnancy may have an impact on the postpartum microbiota of mothers and infants. Although the sample size was small, these preliminary findings provide important insights for further research and contribute to understanding the changes in the microbiota of offspring from women with hypertensive disorders of pregnancy and their possible association with cardiovascular disease.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Nur Masirah M. Zain, Danielle ter Linden, Andrew K. Lilley, Paul G. Royall, Sophia Tsoka, Kenneth D. Bruce, James Mason, Grace B. Hatton, Elizabeth Allen, Simon D. Goldenberg, Ben Forbes
Summary: This study aimed to develop a well-controlled, standardised method for manufacturing lyophilised FMT capsules and provide stability data allowing extended storage. Preliminary clinical experience showed that these capsules produced clinical cure in patients with CDI without any adverse events.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Neurosciences
Caitlyn G. Edwards, Anne M. Walk, Sharon Thompson, Ginger E. Reeser, Ryan N. Dilger, John W. Erdman, Nicholas A. Burd, Hannah D. Holscher, Naiman A. Khan
Summary: Among middle-aged adults with overweight and obesity, higher intake of choline and lutein+zeaxanthin was associated with faster performance on a cognitive flexibility task. Dietary intake and biomarker data had an impact on cognitive outcomes, but were not related to the N2 and P3 ERP components.
NUTRITIONAL NEUROSCIENCE
(2022)
Review
Veterinary Sciences
Jan S. Suchodolski
Summary: The gut microbiome plays a crucial role in maintaining immune and metabolic functions, with impact on intestinal and overall organ health. Dysbiosis concept continues to evolve, with molecular tools becoming the standard for microbiome analysis, though challenges in standardization and result consistency persist. The Dysbiosis Index is a useful tool for assessing microbiome status in clinical patients.
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Veterinary Sciences
Sarah E. Cocker, Yuri A. Lawrence, Jonathan A. Lidbury, Jan S. Suchodolski, Jorg M. Steiner, Keith P. Richter
Summary: Long-term administration of supraphysiologic doses of GCs significantly increases serum cPLI concentrations in sick dogs, although the change is small and often clinically insignificant, it may pose a clinical interpretation dilemma in some dogs.
VETERINARY CLINICAL PATHOLOGY
(2022)
Article
Veterinary Sciences
Elisabeth Skotnitzki, Jan S. Suchodolski, Kathrin Busch, Melanie Werner, Yury Zablotski, Bianca D. Ballhausen, Felix Neuerer, Stefan Unterer
Summary: The study reported a higher prevalence of signs of chronic GI disease in dogs after an episode of acute hemorrhagic diarrhea (AHD), possibly due to severe intestinal mucosal damage and associated barrier dysfunction triggering chronic GI disease later in life.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Victoria C. Daniels, Marcia H. Monaco, Mei Wang, Johanna Hirvonen, Henrik Max Jensen, Arthur C. Ouwehand, Ratna Mukherjea, Ryan N. Dilger, Sharon M. Donovan
Summary: This study investigated the effects of supplementing piglet formula with 2'-fucosyllactose (2'-FL) and Bifidobacterium longum subsp. infantis Bi-26 (Bi-26) on piglet growth and intestinal development. The results showed that the addition of 2'-FL and/or Bi-26 supported piglet growth without detrimental effects on body weight, organ weight, or intestinal structure and function.
Article
Agriculture, Dairy & Animal Science
Katelyn N. Gaffield, Dustin D. Boler, Ryan N. Dilger, Anna C. Dilger, Bailey N. Harsh
Summary: Feeding growing-finishing pigs high oleic soybean oil (HOSO) can improve feed efficiency and growth performance, but may also lead to increased fatness in carcasses. Pigs fed HOSO exhibited differences in growth performance and carcass traits compared to those fed diets containing dried distiller's grains with solubles (DDGS).
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Erin E. Bryan, Xuenan Chen, Brooke Nicole Smith, Ryan Neil Dilger, Anna C. Dilger
Summary: Maternal PRRSV infection can impact offspring immune responses and organ growth, while supplementation with soy isoflavones does not mitigate these effects.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Veterinary Sciences
Panagiotis G. Xenoulis, Romy M. Heilmann, Eva M. Stavroulaki, Denise S. Riggers, Laura J. Gneipel, Jan S. Suchodolski, Jorg M. Steiner
Summary: This study investigated the association between HTGL and IR as well as the subclinical inflammatory phenotype in Miniature Schnauzers. It was found that HTGL in these dogs was associated with increased serum calprotectin concentrations, and dietary intervention led to a decrease in serum insulin concentrations.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Karl Fraser, Leigh Ryan, Ryan N. Dilger, Kelly Dunstan, Kelly Armstrong, Jason Peters, Hedley Stirrat, Neill Haggerty, Alastair K. H. MacGibbon, James Dekker, Wayne Young, Nicole C. Roy
Summary: The study investigated the effects of dietary MFGM supplement on lipid profiles in different brain regions of neonatal piglets. The results showed that MFGM consumption did not significantly alter lipid composition in most brain regions, except for an increase in triglycerides in the hippocampus of high-supplemented piglets. Furthermore, significant differences in lipid profiles were found between different brain regions.
Article
Veterinary Sciences
Chee-Hoon Chang, Jonathan A. Lidbury, Jan S. Suchodolski, Joerg M. Steiner
Summary: This study found that oral supplementation is an alternative to injectable supplementation for cobalamin supplementation in dogs with hypocobalaminemia caused by chronic enteropathy or exocrine pancreatic insufficiency.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Veterinary Sciences
F. C. Droes, J. S. Suchodolski, J. M. Steiner, J. A. Lidbury
Summary: This study aimed to estimate the prevalence and describe the clinical and laboratory data of dogs with chronic hepatitis and portal vein thrombosis and splanchnic venous thrombosis. The study found that portal vein and splanchnic venous thrombosis are potentially serious complications that were identified in a relatively low proportion of dogs with chronic hepatitis.
JOURNAL OF SMALL ANIMAL PRACTICE
(2023)
Article
Veterinary Sciences
Michael Hung, Justin Heinz, Jorg M. Steiner, Jan Suchodolski, Jonathan Lidbury
Summary: This study evaluated serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or nonparvoviral acute enteropathy. The results showed that juvenile dogs with parvoviral enteritis or nonparvoviral acute enteropathy had lower serum cobalamin concentrations than healthy juvenile dogs, but cellular cobalamin deficiency was not apparent based on serum MMA concentrations.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Rae Mcatee, Sarah M. Schmid, M. Katherine Tolbert, Scott Hetzel, Jan S. Suchodolski, Jessica C. Pritchard
Summary: In healthy dogs, concurrent administration of a probiotic does not mitigate the adverse effects caused by esomeprazole administration. However, it does lead to an increase in fecal dysbiosis index.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Sharon Kuzi, Soha Zgairy, Barbara A. Byrne, Jan Suchodolski, Sondra C. Turjeman, So Young Park, Itamar Aroch, Mike Hong, Omry Koren, Eran Lavy
Summary: This study investigated the fecal microbiome features in dogs with giardiasis and found that the fecal microbial composition of symptomatic and asymptomatic dogs with giardiasis is similar. Giardiasis is not characterized by prominent dysbiosis based on fecal dysbiosis index (DI).
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Patrick C. Barko, Stanley I. Rubin, Kelly S. Swanson, Maureen A. McMichael, Marcella D. Ridgway, David A. Williams
Summary: Exocrine pancreatic insufficiency (EPI) is a digestive disorder in dogs caused by insufficient secretion of digestive enzymes. In this study, untargeted metabolomics analysis was used to identify metabolic disturbances associated with EPI. 114 serum metabolites were found to differ significantly between dogs with EPI and healthy controls, suggesting malnourishment, micronutrient deficiencies, altered gut microbiome composition, and intestinal inflammation in dogs with EPI.
