Article
Medicine, Research & Experimental
Cheng Cheng, Hui Li, Lian Liang, Tao Jin, Guozhen Zhang, Jennifer L. Bradley, Mary Ann Peberdy, Joseph P. Ornato, Dayanjan S. Wijesinghe, Wanchun Tang
Summary: Studies have shown that administration of ω-3 PUFA or AA following cardiac arrest improves survival rates in rats, with the combination of ω-3 PUFA and AA showing better effects on myocardial function post-cardiac arrest.omega-3 PUFA or AA treatment reduces inflammation, lipid peroxidation, and improves myocardial function in rats after resuscitation, with a combination of ω-3 PUFA and AA having synergistic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Environmental Sciences
Shuangfei Li, Boyu Wang, Liangxu Liu, Yingjie Song, Chuhan Lv, Xingyu Zhu, Yanqing Luo, Christopher H. K. Cheng, Huapu Chen, Xuewei Yang, Tao Li
Summary: The study demonstrates that adding Aurantiochytrium sp. to diets can significantly improve the growth performance and immune response of Trachinotus ovatus. With increased microalgae content, the growth rate and feed utilization efficiency of fish were enhanced, along with increased fatty acid content in blood and tissues, resulting in improved immunity and disease resistance in fish.
FRONTIERS IN MARINE SCIENCE
(2021)
Review
Nutrition & Dietetics
Lan Jiang, Jinyu Wang, Ke Xiong, Lei Xu, Bo Zhang, Aiguo Ma
Summary: This meta-analysis found an inverse association between fish consumption and CVD mortality risk, as well as a reduced risk of CVD mortality with higher intake of marine n-3 PUFA. Increasing daily intake of fish and marine n-3 PUFA was associated with a decrease in the risk of CVD mortality.
Review
Food Science & Technology
Yi Wang, Ke Liu, Tingting Long, Jieyi Long, Ying Li, Jiaoyuan Li, Liming Cheng
Summary: Through a meta-analysis of observational studies, we found that dietary fish and marine omega-3 PUFA consumption are associated with improved cancer prognosis and reduced mortality in patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Oncology
Ayako Kato, Chika Okada, Ehab S. Eshak, Hiroyasu Iso, Akiko Tamakoshi
Summary: This study found that higher intake of alpha-linolenic acid (ALA) may be beneficial in lowering the risk of distal colon cancer. However, the intake of marine-derived n-3 polyunsaturated fatty acids (PUFA) was not associated with colorectal cancer (CRC) risk.
Article
Cell Biology
Florina Zakany, Mate Szabo, Gyula Batta, Levente Karpati, Istvan M. Mandity, Peter Fulop, Zoltan Varga, Gyorgy Panyi, Peter Nagy, Tamas Kovacs
Summary: The article introduces a novel method for measuring the intramembrane dipole potential (DP) and identifies several substances that affect DP. ALA is suggested as a compound that lowers DP and facilitates the entry of penetratin into the cytoplasm.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lorena Ortega, Lorena Lobos-Gonzalez, Mauricio Reyna-Jeldes, Daniela Cerda, Erwin De la Fuente-Ortega, Patricio Castro, Giuliano Bernal, Claudio Coddou
Summary: This study demonstrated that docosahexaenoic acid (DHA) has a selective antiproliferative effect on gastric cancer (GC), primarily driven by apoptosis induction. DHA treatment consistently reduced tumor size, ascitic fluid volume, and liver metastasis in an in vivo mouse model. These findings provide promising potential for DHA as a therapeutic agent in GC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Gael Nana, Suparna Mitra, Henry Watson, Caroline Young, Henry M. Wood, Sarah L. Perry, Amanda D. Race, Philip Quirke, Giles J. Toogood, Paul M. Loadman, Mark A. Hull
Summary: Oral administration of omega-3 PUFAs leads to increased luminal omega-3 PUFA concentrations and changes to the microbiome in the ileum of individuals with a temporary ileostomy. There is large variability in ileal microbiome over time and between individuals, with no consistent change associated with acute omega-3 PUFA dosing.
JOURNAL OF NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Janine Mett
Summary: Alzheimer's disease is closely related to dysregulated cerebral lipid metabolism and changes in brain fatty acid composition. Dietary medium chain fatty acids and polyunsaturated omega-3-fatty acids may help improve brain energy metabolism, reduce oxidative stress, and lessen cerebral A beta deposition.
Article
Nutrition & Dietetics
Hao Chen, Xuebing Leng, Shaohui Liu, Ziqi Zeng, Feng Huang, Rongjie Huang, Yunfeng Zou, Yunan Xu
Summary: This study found that dietary intake of omega-3 polyunsaturated fatty acids (N3-PUFA), particularly alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosapentaenoic acid (DPA), was associated with lower risk of all-cause and cardiovascular mortality among hypertensive adults in the U.S.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Claudia Sanfilippo, Angela Patti
Summary: The biocatalytic epoxidation of ethanolamides of omega-3 fatty acids EPA and DHA was investigated in the presence of a peroxygenase-containing preparation from oat flour. Good regio- and steroselectivity were observed, and acetone as cosolvent improved the concentration of starting substrates and selectivity in the epoxidation of DHA-EA. This method offers a valuable strategy for obtaining oxyfunctionalized derivatives of fatty acids due to the easy availability of the enzymatic preparation.
BIOORGANIC CHEMISTRY
(2021)
Article
Public, Environmental & Occupational Health
Ruohan Wang, Ying Feng, Jiahe Chen, Yingjiao Chen, Fang Ma
Summary: The intake of polyunsaturated fatty acids (PUFAs) is only slightly associated with infertility risk. Higher docosahexaenoic acid (DHA) intake is associated with a lower risk of infertility, while higher intake of alpha-linolenic acid (ALA) and linoleic acid (LA) is associated with a higher risk of primary infertility.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Melanie Gsoellpointner, Margarita Thanhaeuser, Fabian Eibensteiner, Robin Ristl, Bernd Jilma, Renate Fuiko, Sophia Brandstetter, Angelika Berger, Nadja Haiden
Summary: This study analyzed the intake of polyunsaturated fatty acids (PUFAs) during complementary feeding (CF) in very low birth weight (VLBW) infants and its impact on neurodevelopment. The results showed that higher intake of total PUFAs, docosahexaenoic acid (DHA), and arachidonic acid (AA) was associated with improved cognitive and motor function at 12 months of age. However, the dietary intake of AA and DHA did not meet the recommended levels, highlighting the need to increase PUFA, DHA, and AA intake during CF for better neurodevelopmental outcomes in VLBW infants.
Review
Biochemistry & Molecular Biology
J. McDaniel
Summary: Neutrophils play a critical role in maintaining a stable immune system, but their hypo- or hyper-activation can lead to the onset or exacerbation of inflammatory conditions. Marine omega-3 fatty acids rapidly alter neutrophil function by changing their fatty acid composition, impacting eicosanoid synthesis, blocking transcription factors, and disrupting lipid rafts to reduce pro-inflammatory gene expression. Clinical trials in the past 15 years have shown the effects of marine omega-3 fatty acid supplementation on neutrophil function.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Oncology
Tengteng Wang, Nicole M. Brown, Amber N. McCoy, Robert S. Sandler, Temitope O. Keku
Summary: This study investigates the relationship between Omega-3 PUFAs and CRAs and finds an inverse association between Omega-3 PUFAs and CRAs, which may be influenced by gut microbiota.
Letter
Gastroenterology & Hepatology
Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D. Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L. Giovannucci, Andrew T. Chan, Mingyang Song
Article
Oncology
Naohiko Akimoto, Tomotaka Ugai, Rong Zhong, Tsuyoshi Hamada, Kenji Fujiyoshi, Marios Giannakis, Kana Wu, Yin Cao, Kimmie Ng, Shuji Ogino
Summary: The global incidence of early-onset colorectal cancer is on the rise, potentially due to factors such as diet, obesity, lack of exercise, and antibiotic use. Early-onset CRC differs clinically, pathologically, and molecularly from later-onset CRC. Further research spanning childhood and young adulthood is necessary to enhance understanding and management of this disease.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Kai Wang, Wenjie Ma, Kana Wu, Shuji Ogino, Andrew T. Chan, Edward L. Giovannucci, Mingyang Song
Summary: The study found that a healthy lifestyle is associated with lower incidence and mortality of colorectal cancer, regardless of endoscopic screening. Combining a healthy lifestyle with endoscopic screening may significantly enhance colorectal cancer prevention, especially for proximal colon cancer.
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vayrynen, Shuji Ogino, Jonathan A. Nowak, Marjukka Friman, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppala, Jan Bohm, Markus J. Makinen, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vayrynen
Summary: This study evaluated the prognostic significance of tumour cell-T cell co-localisation and T cell densities in colorectal cancer patients. The findings showed that high T cell proximity score was associated with longer cancer-specific survival, indicating the potential of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.
BRITISH JOURNAL OF CANCER
(2022)
Review
Surgery
Richard Hunger, Barbara Seliger, Shuji Ogino, Rene Mantke
Summary: The study found a significant inverse relationship between the extent of risk adjustment and the volume effect, suggesting the presence of unmeasured confounding and overestimation of volume effects. Data from the research showed that patient-specific factors were the most important influencing factors for short-term mortality.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Nutrition & Dietetics
Fenglei Wang, Paulette D. Chandler, Oana A. Zeleznik, Kana Wu, You Wu, Kanhua Yin, Rui Song, Julian Avila-Pacheco, Clary B. Clish, Jeffrey A. Meyerhardt, Xuehong Zhang, Mingyang Song, Shuji Ogino, I-Min Lee, A. Heather Eliassen, Liming Liang, Stephanie A. Smith-Warner, Walter C. Willett, Edward L. Giovannucci
Summary: Red and processed meat consumption is associated with increased risk of colorectal cancer, while the association with fish intake is unclear. This study found that plasma metabolite profiles are differentially associated with red meat and fish groups, and the plasma metabolite profile of fish intake is inversely associated with colorectal cancer risk.
Article
Oncology
Ruitong Li, Tomotaka Ugai, Lantian Xu, David Zucker, Shuji Ogino, Molin Wang
Summary: This paper presents an extended Cox regression model to investigate the effects of risk factors on disease subtypes defined by continuous biomarkers. The method is easily applicable to cancer studies and can be accessed by researchers using user-friendly R scripts. It demonstrates how continuous biomarker data can be utilized to study etiological heterogeneity and improve our understanding of biological and pathogenic mechanisms.
Article
Gastroenterology & Hepatology
Kentaro Inamura, Tsuyoshi Hamada, Susan Bullman, Tomotaka Ugai, Shinichi Yachida, Shuji Ogino
Summary: Cancer should be regarded as a systemic and environmental disease, beyond the localised tumour microenvironment. The exposome, which includes various exposures, can alter the microbiome and immune system, affecting tumour phenotypes. To understand the complex role of the exposome, microbiome, and immunome, it is important to conduct interdisciplinary human population research integrated with advanced methodologies like artificial intelligence and molecular pathological epidemiology.
Article
Oncology
Wan-Jie Gu, Jun-Peng Pei, Jun Lyu, Naohiko Akimoto, Koichiro Haruki, Shuji Ogino, Chun-Dong Zhang
Summary: The global incidence, death, and DALY rates of early-onset colorectal cancer (CRC) have increased from 1990 to 2019, with significant variations at regional and national levels. In 2019, low-milk or low-calcium diets and alcohol use were the main risk factors. The importance of high body mass index and high fasting plasma glucose has increased among both males and females, while the importance of smoking and low-fiber diets has decreased, especially among females. These findings provide policymakers with a quantification of the burden of early-onset CRC and help identify and target high-risk individuals to mitigate the disease burden.
Article
Oncology
Kai Wang, Wenjie Ma, Yang Hu, Markus Dines Knudsen, Long H. Nguyen, Kana Wu, Kimmie Ng, Molin Wang, Shuji Ogino, Qi Sun, Edward L. Giovannucci, Andrew T. Chan, Mingyang Song
Summary: Current recommendations for colorectal cancer screening do not take into account the presence of type 2 diabetes (T2D). This study found that the absolute benefit of endoscopic screening for colorectal cancer prevention may be higher for individuals with T2D compared to those without T2D. Additionally, individuals with T2D reached the threshold risk level for colorectal cancer at a younger age than those without T2D, suggesting the consideration of earlier endoscopic screening in individuals with T2D.
CANCER PREVENTION RESEARCH
(2022)
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vaeyrynen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppaelae, Jan Boehm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vaeyrynen
Summary: The expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. This study found that PD-L1(+) macrophages and PD-1(+) T cells were associated with better clinical outcomes in colorectal cancer patients. These findings enhance the understanding of immune checkpoints in the tumor microenvironment and could contribute to the development of improved immunotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Zhangyan Lyu, Dong Hang, Xiaosheng He, Kana Wu, Yin Cao, Bernard Rosner, Andrew T. Chan, Shuji Ogino, Ni Li, Min Dai, Edward L. Giovannucci, Mingyang Song
Summary: A simple prediction model based on five major risk factors for high-risk serrated polyps (SPs) was developed and validated, which may be useful for providing healthy lifestyle recommendations and tailored colorectal cancer screening.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Shanshan Shi, Kai Wang, Tomotaka Ugai, Marios Giannakis, Jules Cazaubiel, Andrew T. Chan, Edward L. Giovannucci, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Shuji Ogino, Mingyang Song
Summary: The association between vitamin C intake and colorectal cancer survival varies depending on the KRAS or BRAF mutation status, suggesting potential benefits for patients with mutated tumors.
BRITISH JOURNAL OF CANCER
(2023)
Review
Gastroenterology & Hepatology
Kosuke Mima, Tsuyoshi Hamada, Kentaro Inamura, Hideo Baba, Tomotaka Ugai, Shuji Ogino
Summary: There has been a significant increase in the incidence of early-onset cancers, particularly in the digestive system. While some of these cancers are associated with genetic variants, the majority are sporadic and multifactorial. Factors such as diets, lifestyle, environment, and the microbiome from early life to adulthood may play a role in the development of these cancers, but their exact contributions are still uncertain. To address this rising trend, interdisciplinary research approaches are needed to improve our understanding of the etiology and develop better prevention and treatment strategies.
Article
Medicine, General & Internal
Markus Dines Knudsen, Kai Wang, Liang Wang, Georgios Polychronidis, Paula Berstad, Kana Wu, Xiaosheng He, Dong Hang, Zhe Fang, Shuji Ogino, Andrew T. Chan, Edward Giovannucci, Molin Wang, Mingyang Song
Summary: This study developed an effective risk stratification tool for predicting post-polypectomy colorectal cancer (PPCRC) based on three population-based cohorts and validated the tool in a clinical cohort. By collecting detailed data on demographics, endoscopic history, polyp features, and lifestyle factors, the researchers developed an 11-predictor risk score for PPCRC, which can guide tailored colonoscopy surveillance strategies.
