Article
Oncology
Takuya Wada, Katsutoshi Sugimoto, Kentaro Sakamaki, Hiroshi Takahashi, Tatsuya Kakegawa, Yusuke Tomita, Masakazu Abe, Yu Yoshimasu, Hirohito Takeuchi, Takao Itoi
Summary: This study compared the outcomes of radiofrequency ablation (RFA), microwave ablation (MWA), and irreversible electroporation (IRE) in treating early stage hepatocellular carcinoma (HCC). The results showed that IRE had a significantly lower 2-year local tumor progression (LTP) rate compared to RFA. There were no significant differences in LTP rates between IRE and MWA, and between RFA and MWA. Therefore, IRE may be a better first-line treatment option for small perivascular HCC.
Article
Gastroenterology & Hepatology
Wenzhen Ding, Jie Yu, Fangyi Liu, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Ping Liang
Summary: This study compares the practicability and medium-term therapeutic efficacy between microwave ablation and robot-assisted hepatectomy for early hepatocellular carcinoma. The results showed that both treatments achieved good and comparable medium-term therapeutic effects. Microwave ablation was found to be more minimally invasive, while robot-assisted hepatectomy had better accuracy and caused less damage to the liver parenchyma.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Surgery
Hong Jae Jeon, Hyuk Soo Eun, In Sun Kwon, Byung Seok Lee, Eaum Seok Lee, Woo Sun Rou, Jae Kyu Sung, Hee Seok Moon, Sun Hyung Kang, Hyun Seok Lee, Seok-Hwan Kim, Kwangsik Chun, Seok Hyun Kim
Summary: This study compared the therapeutic outcomes of laparoscopic radiofrequency ablation (LRFA) and percutaneous radiofrequency ablation (PRFA) in patients with hepatocellular carcinoma (HCC). The results revealed that LRFA was associated with longer recurrence-free survival and favorable overall survival compared to PRFA. Therefore, LRFA should be considered as the primary therapy for eligible HCC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Hideki Saitsu
Summary: The study showed that operative microwave ablation is safe and effective for intermediate stage hepatocellular carcinoma, with better long-term outcomes observed in patients meeting up-to-7 and Child-Pugh grade A criteria.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hang Zheng, Kaiwen Liu, Yao Yang, Bo Liu, Xinya Zhao, Yong Chen, Yuemin Feng, Min Meng, Xu Tan, Qiang Zhu
Summary: Compared to RFA, MWA showed better tumor control for subcapsular HCC within the Milan criteria. There was no difference in the incidence of major complications between the two groups.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Elles M. F. van de Voort, Gerson M. Struik, Linetta B. Koppert, Adriaan Moelker, Reno Debets, Glenn Yo, Maura J. P. Macco, Renata H. J. A. Sinke, Martine Franckena, Erwin Birnie, Cornelis Verhoef, Taco M. A. L. Klem
Summary: Breast cancer is a common malignancy with a high survival rate. This study aims to compare the efficacy of radiofrequency, microwave, and cryoablation for potential treatment of breast cancer patients. The phase 2 trial will determine the most effective technique for further testing in a phase 3 trial, with a focus on complete ablation rates and patient outcomes.
Article
Surgery
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Shin Sasaki, Hajime Imamura, Hiroki Ureshino, Hideki Saitsu
Summary: This study retrospectively reviewed 81 patients with multifocal hepatocellular carcinoma who underwent combined hepatectomy and microwave ablation, finding an overall survival rate of 54% at 5 years. The major complication rate post-surgery was 10%, with certain factors like des-gamma-carboxy prothrombin level and tumor characteristics identified as independent risk factors for survival outcomes. The study concludes that the combined procedure is safe and feasible for selected patients with multifocal HCC.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao An, Wang-Zhong Li, Zhi-Mei Huang, Xiao-Ling Yu, Yu-Zhi Han, Fang-Yi Liu, Song-Song Wu, Jie Yu, Ping Liang, Jinhua Huang
Summary: In patients with small single perivascular hepatocellular carcinoma, microwave ablation exhibited better tumor control than radiofrequency ablation, with a significantly higher local tumor progression rate observed in the radiofrequency ablation group. Additionally, there was a significant interaction effect of ablation modality and type of peritumoral vessel on local tumor progression, with differences observed in periportal HCC but not perivenous HCC.
EUROPEAN RADIOLOGY
(2021)
Review
Oncology
Yasunori Minami, Tomoko Aoki, Satoru Hagiwara, Masatoshi Kudo
Summary: Thermal ablation therapy, including RFA and MWA, is a widely used treatment for hepatocellular carcinomas. It achieves good outcomes with minimal invasiveness. Successful thermal ablation therapy requires understanding the principles and characteristics of the treatment, assessing the benefits and risks, precise needle control and visualization, utilizing imaging guidance techniques, and evaluating therapeutic response. This overview provides essential information for the clinical application of thermal ablation.
Review
Oncology
Peiman Habibollahi, Rahul A. Sheth, Erik N. K. Cressman
Summary: Liver cancer is a growing global concern with limited treatment options. The most common treatment methods are ablation techniques such as radiofrequency ablation and microwave ablation. However, difficulties in completely identifying residual cancer cells remain in these procedures, highlighting the need for further advancements in treatment strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberto Iezzi, Roberto Cioni, Domenico Basile, Nevio Tosoratti, Alessandro Posa, Marco Busso, Carla Cappelli, Stefano Margaritora, Marcello Carlo Ambrogi, Alessandra Cassano, Rossella Scandiffio, Marco Calandri, Laura Crocetti, Vincenzo Valentini, Riccardo Manfredi, Andrea Veltri
Summary: This study confirmed the reproducibility, safety, and efficacy of microwave ablation (MWA) for primary and secondary pulmonary tumors up to 4 cm in diameter. Immediate post-MWA CT scans showed slightly smaller ablation dimensions compared to ex vivo models, but a significant volumetric increase in the treated area was observed at 1 month post-ablation.
EUROPEAN RADIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tomoki Ryu, Yuko Takami, Yoshiyuki Wada, Hideki Saitsu
Summary: The study examined the long-term outcomes of operative microwave ablation for hepatocellular carcinoma within 3 cm and 3 nodules, revealing good overall survival rates and recurrence-free survival rates. Independent risk factors for prognosis were identified, and a prognostic staging model based on these factors was developed to predict outcomes.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Ancelin Preel, Margaux Hermida, Carole Allimant, Eric Assenat, Chloe Guillot, Cecilia Gozzo, Serge Aho-Glele, Georges-Philippe Pageaux, Christophe Cassinotto, Boris Guiu
Summary: The study found that in Western patients, bi- and trifocal HCC significantly increased the risk of distant recurrence, especially very early recurrence. Overall survival after PTA of trifocal HCC was significantly below what was expected after curative treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Zensen, Arno Buecker, Mathias Meetschen, Johannes Haubold, Marcel Opitz, Jens M. Theysohn, Sara Schramm, Leonie Jochheim, Stefan Kasper, Michael Forsting, Benedikt Michael Schaarschmidt
Summary: A total of 7228 liver tumor ablations from 136 centers in Germany and Austria were analyzed. The technical success rate is high, with microwave ablation showing a higher success rate than radiofrequency ablation, but the latter has a lower rate of complications.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Emily South, Ros Wade, Sumayya Anwer, Sahar Sharif-Hurst, Melissa Harden, Helen Fulbright, Sofia Dias, Mark Simmonds, Ian Rowe, Patricia Thornton, Tze Min Wah, Alison Eastwood
Summary: It is unclear which treatment is most effective for patients with small HCC due to limited evidence. The impact of these treatments on quality of life is also unknown. Further high-quality RCTs are needed to provide robust evidence, although they may be challenging to conduct.
