Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

(2014) C-C Lin et al.   BRITISH JOURNAL OF CANCER

Discovery and development of the Polo-like kinase inhibitor volasertib in cancer therapy

(2014) B T Gjertsen et al.   LEUKEMIA

SPARC independent drug delivery and antitumour effects ofnab-paclitaxel in genetically engineered mice

(2013) Albrecht Neesse et al.   GUT

A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas – a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network

(2012) K Mross et al.   BRITISH JOURNAL OF CANCER

Disputed Paternity: The Uncertain Ancestry of Pancreatic Ductal Neoplasia

(2012) Anirban Maitra et al.   CANCER CELL

Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

(2012) Matthias Sendler et al.   GUT

Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer

(2012) B. Song et al.   MOLECULAR CANCER THERAPEUTICS

Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery

(2011) Omid Veiseh et al.   BIOMATERIALS

In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model

(2011) Ivo L Partecke et al.   BMC CANCER

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

(2011) Monika Raab et al.   Nature Communications

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Endosomal escape pathways for delivery of biologicals

(2010) Amir K. Varkouhi et al.   JOURNAL OF CONTROLLED RELEASE

Finding the tumor copycat: Approximating a human cancer

(2010) Terry Van Dyke   NATURE MEDICINE

Pancreatic iron loading predicts cardiac iron loading in thalassemia major

(2009) L. J. Noetzli et al.   BLOOD

The expression of PLK-1 in cervical carcinoma: a possible target for enhancing chemosensitivity

(2009) Yuan Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeted Depletion of Polo-Like Kinase (Plk) 1 Through Lentiviral shRNA or a Small-Molecule Inhibitor Causes Mitotic Catastrophe and Induction of Apoptosis in Human Melanoma Cells

(2009) Travis L. Schmit et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors

(2008) Antonio Jimeno et al.   JOURNAL OF CLINICAL ONCOLOGY

Proton-Sponge Coated Quantum Dots for siRNA Delivery and Intracellular Imaging

(2008) Maksym V. Yezhelyev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY