期刊
GREEN CHEMISTRY
卷 18, 期 7, 页码 1855-1858出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5gc02935j
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资金
- Department of Chemistry at University College London
- Engineering and Physical Sciences Research Council (EPSRC), Sustainable Chemical Feedstocks programme [EP/K014897/1]
- Engineering and Physical Sciences Research Council [EP/K014897/1] Funding Source: researchfish
One-pot synthetic routes from furfurals to polysubstituted aromatic compounds have been developed in water, without the need for any organic solvents. The reaction proceeds via an uncatalysed, one-pot reaction cascade through formation of a hydrazone derivative, in situ cycloaddition with a dienophile, then aromatisation. A range of substituted phthalimides can be accessed with complete control over the substitution pattern. The reaction was also extended to other dienophiles and the diene 2-furylacrolein. The phthalimide products were further elaborated to produce a variety of polysubstituted benzenes including pharmaceutically relevant compounds.
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