期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.646306
关键词
pre-clinical evidence; molecular mechanisms; systematic review; berberine; myocardial ischemia/reperfusion injury
资金
- National Natural Science Foundation of China [81803906]
- Capital's Funds for Health Improvement and Research [2020-4-4204]
- Fundamental Research Funds for the Central Universities [2019-JYB-TD-008]
The systematic review showed that Berberine (BBR) has significant protective effects against myocardial ischemia/reperfusion (I/R) injury, reducing myocardial infarct size, improving cardiac function, and decreasing myocardial apoptosis and biomarker levels of myocardial infarction. Future clinical studies are needed to further investigate BBR's potential as a therapeutic agent for myocardial I/R injury.
Objective: Myocardial ischemia/reperfusion (I/R) injury is one of the causes of most cardiomyocyte injuries and deaths. Berberine (BBR) has been suggested a potential to exert protective effects against myocardial I/R injury. This systematic review aims to determine the intrinsic mechanisms of BBR's protective effects in myocardial I/R injury. Methods: Seven databases were searched for studies performed from inception to July 2020. Methodological quality was assessed by SYRCLE's-RoB tool. Results: Ten studies including a total of 270 animals were included in this study. The methodology quality scores of the included studies ranged from 5 to 7 points. The meta-analysis we conducted demonstrated that BBR significantly reduced myocardial infarct size and the incidence of ventricular arrhythmia, compared to control groups (P < 0.00001). Cardiac function of animals in the BBR treatment group was also markedly increased (P < 0.00001). The index of myocardial apoptosis and the levels of biomarkers of myocardial infarction (LDH and CK) were also decreased in the BBR treatment groups compared to the control groups (P < 0.00001). Conclusions: The pre-clinical evidence, according to our study, showed that BBR is a promising therapeutic agent for myocardial I/R injury. However, this conclusion should be further investigated in clinical studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据